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Flavonoids in safflower extract reduce cisplatin-induced damage to human follicle dermal papilla cells by inhibiting DNA damage and Rad17/Chk1/Cdc25C signaling

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BIOCELL 2023年第8期47卷 1793-1802页

作者： FU-MING TSAI ping-hsun lu lu-KAI WANG CHAN-YEN KUO MAO-LIANG CHEN CHUN-HUA WANG Department of Research Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City231Taiwan Department of Chinese Medicine Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City231Taiwan School of Post-Baccalaureate Chinese Medicine Tzu Chi UniversityHualien970Taiwan Department of Life Sciences National Science and Technology CouncilTaipei106Taiwan Department of Dermatology Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City231Taiwan School of Medicine Tzu Chi UniversityHualien970Taiwan

Background:Cisplatin is a chemotherapeutic agent commonly used clinically for the treatment of various human *** often reduce the use of cisplatin due to its side effects,which in turn affects its *** study explored the mechanism of action of safflower extract as an adjuvant traditional Chinese medicine for ***:Primary human follicle dermal papilla cells(HFDPCs)were used as target cells for cisplatininduced damage to hair *** blotting was used to investigate the molecular targets of cisplatin and safflower extract in causing HFDPCs *** survival and cell cycle were analyzed by mitochondrial staining reagent WST-1 and propidium ***:Cisplatin could reduce the viability of HFDPCs without causing cell *** increased the level of phospho-Rad17 in HFDPCs and activated the Chk1/Cdc25C signaling to reduce the expression of Cdc2 protein,thereby arresting the cells in the G2/M *** combination of safflower extract and the flavonoids could effectively inhibit the signal transduction of Rad17/Chk1/Cdc25 in cisplatin-treated cells and reduce the cell population in the G2/M ***,we also confirmed that safflower extract could effectively inhibit the damage to HFDPCs caused by cisplatin,mainly at the level of reducing the DNA damage caused by ***:Safflower extract can be used as an adjuvant Chinese medicine for chemotherapy to reduce the damage caused by chemotherapy to normal hair follicle cells.

关键词： Safflower extract Cisplatin Human hair follicle dermal papilla cells Rad17 Hair loss Cell cycle

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Self-assembled all-oxides three-phase vertically aligned nanocomposite thin film with multifunctionality

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Nano Research 2024年第9期17卷 8226-8232页

作者： Jijie Huang Yuan Fang ping lu Juanjuan lu Haiyan Wang School of Materials Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China School of Materials Engineering Purdue UniversityWest LafayetteIN 47907USA Sandia National Laboratories AlbuquerqueNew Mexico 87185USA School of Electrical and Computer Engineering Purdue UniversityWest LafayetteIN 47907USA

Multi-phase vertically aligned nanocomposite(MP-VAN)thin films represent a promising avenue for achieving complex multifunctionality,exploring novel interfacial phenomena,and enabling complex metamaterial designs and *** this study,a novel self-assembled all-oxides three-phase VAN system was conceptualized and fabricated utilizing pulsed laser deposition(PLD)with a single composite *** microstructural analysis reveals the presence of three distinct phases:LiNbO_(3),CeO_(2-x),and LiNbCe_(1-x)O_(y)within the MP-VAN ***,ferroelectric,dielectric,optical anisotropy,and magnetic properties were systematically investigated to showcase the multifunctionality inherent in these *** work presents a pioneering approach to designing and realizing MP-VAN systems,and opens up opportunities for tailoring the complex three-dimensional(3D)physical properties and property coupling of VAN films towards diverse device applications.

关键词： thin film three-phase vertically aligned nanocomposite multifunctionality ferroelectricity optical anisotropy

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Modular Synthesis of Multi-substituted Cyclobutanones Enabled by Oxyallyl Cations

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Chinese Journal of Chemistry 2024年第5期42卷 459-463页

作者： Meng Wang Zhonggui Wang ping lu Research Center for Molecular Recognition and Synthesis Department of ChemistryFudan University220 Handan LuShanghai200433 China Present address: Department of Cancer Biology Dana-Farber Cancer Institute Department of Biological Chemistry and Molecular Pharmacology Harvard Medical SchoolBostonMA 02115USA

Stereoselective synthesis of multi-substituted cyclobutanes with different substituents is still a daunting challenge in organic *** report here a practical and facile approach to synthesizing all-trans 2,3,4-trisubstituted cyclobutanones from readily available *** substitution reaction proceeds smoothly via oxyallyl cation intermediates under mild basic *** transformation to the synthesis of 1,2,3,4-tetrasubstituted cyclobutanes was also explored.

关键词： Diastereoselectivity Modular synthesis Nucleophilic substitution Organohalides Oxyallyl cation Precision functionalization Strained molecules 1,2,3,4-Tetrasubstituted cyclobutanes

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Application of a microscopic optical potential of chiral effective field theory in (p, d) transfer reactions

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Nuclear Science and Techniques 2024年第1期35卷 134-144页

作者： Yi-ping Xu Si-lu Chen Dan-Yang Pang School of Nuclear Science and Engineering North China Electric Power UniversityBeijing 102206China School of Physics Beihang UniversityBeijing 100191China

The microscopic global nucleon–nucleus optical model potential(OMP)proposed by Whitehead,Lim,and Holt,the WLH potential(Whitehead et al.,Phys Rev Lett 127:182502,2021),which was constructed in the framework of many-body per-turbation theory with state-of-the-art nuclear interactions from chiral effective field theory(EFT),was tested with(p,d)transfer reactions calculated using adiabatic wave *** target nuclei included both stable and unstable nuclei,and the incident energies reached 200 *** results were compared with experimental data and predictions using the phenomenological global optical potential of Koning and Delaroche,the KD02 ***,we found that the micro-scopic WLH potential described the(p,d)reaction angular distributions similarly to the phenomenological KD02 potential;however,the former was slightly better than the latter for radioactive *** average,the obtained spectroscopic factors(SFs)using both microscopic and phenomenological potentials were similar when the incident energies were below approxi-mately 120 ***,their difference tended to increase at higher incident energies,which was particularly apparent for the doubly magic target nucleus 40Ca.

关键词： Microscopic optical model potential (p,d)transfer Spectroscopic factors

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Rainbow Pancyclicity in a Collection of Graphs Under the Dirac-type Condition

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 269-274页

作者： lu-yi LI ping LI Xue-liang LI Center for Combinatorics and LPMC Nankai UniversityTianjin 300071China School of Mathematics and Statistics Shaanxi Normal UniversityXi’an 710062China

Let G={Gi:i∈[n]} be a collection of not necessarily distinct n-vertex graphs with the same vertex set V,where G can be seen as an edge-colored(multi)graph and each Gi is the set of edges with color i.A graph F on V is called rainbow if any two edges of F come from different Gis’.We say that G is rainbow pancyclic if there is a rainbow cycle Cℓof lengthℓin G for each integerℓ2[3,n].In 2020,Joos and Kim proved a rainbow version of Dirac’s theorem:Ifδ(Gi)≥2/n for each i∈[n],then there is a rainbow Hamiltonian cycle in *** this paper,under the same condition,we show that G is rainbow pancyclic except that n is even and G consists of n copies of Kn/2,n/*** result supports the famous meta-conjecture posed by Bondy.

关键词： rainbow Hamiltonian cycle rainbow pancyclic meta-conjecture

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Seizure as the main presenting manifestation of three patients with acute glufosinate-ammonium poisoning

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第4期25卷 354-358页

作者： ping WANG Congying SONG Xuan lu Yuanqiang lu Department of Emergency Medicine the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 3100030 China Zhejiang Key Laboratory for Diagnosis and Treatment of Physic chemical and Aging related Injuries Hangzhou 310003China Department of Geriatric Medicine the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China

Glufosinate-ammonium herbicides are the most widely used broad-spectrum,non-selective herbicides in the ***-ammonium is a structural analogue of glutamate(Glu)which can irreversibly inhibit the activity of glutamine synthetase(GS)and Glu decarboxylase in plants,thereby blocking the synthesis of glutamine(Gln)from Glu and ammonia(Hoerlein,1994).This causes the plants to die because of the nitrogen metabolism disorder and subsequent intracellular accumulation of *** humans,the characteristic features of glufosinate-ammonium herbicide poisoning include gastrointestinal symptoms and neurotoxicity(Watanabe and Sano,1998).

关键词： ammonium ammonia thereby

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Aggregation-regulated bioreduction process of graphene oxide by Shewanella bacteria

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Chinese Journal of Chemical Engineering 2024年第5期69卷 56-62页

作者： Kaixin Han Yibo Zeng Yinghua lu ping Zeng Liang Shen Department of Chemical and Biochemical Engineering College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361005China Chinese Research Academy of Environmental Sciences Beijing 100012China

The bioreduction of graphene oxide(GO)using environmentally functional bacteria such as Shewanella represents a green approach to produce reduced graphene oxide(rGO).This process differs from the chemical reduction that involves instantaneous molecular *** bioreduction,the contact of bacterial cells and GO is considered the rate-limiting *** reveal how the bacteria-GO integration regulates rGO production,the comparative experiments of GO and three Shewanella strains were carried ***-transform infrared spectroscopy,X-ray photoelectron spectroscopy,Raman spectroscopy,and atomic force microscopy were used to characterize the reduction degree and the aggregation *** results showed that a spontaneous aggregation of GO and Shewanella into the condensed entity occurred within 36 h.A positive linear correlation was established,linking three indexes of the aggregation potential,the bacterial reduction ability,and the reduction degree(ID/IG)comprehensively.

关键词： Graphene oxide Reduced graphene oxide Bioreduction Aggregation Shewanella

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Analytic Formulae for Estimating Motor Proportion of Load Model Under Small Disturbance

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1599-1607页

作者： ping Ju Shiqiu Xia Yuqing Jin lu Cao School of Electrical and Power Engineering Hohai UniversityNanjing 211100China the East China Branch of the State Grid Corporation of China Shanghai 200120China

In the composite load model(CLM),which is commonly used in China,an equivalent motor and equivalent static load are used to represent all electrical equipment and networks connected to a load *** research has determined typical values of electrical and mechanical parameters for load models of different load types,which improves the basis for load ***,the motor proportion parameter is not the same for different load buses or at different times;therefore,obtaining the actual motor proportion is key to establishing an accurate load *** the existing load modeling method,motor proportion is commonly identified along with other parameters under rare large disturbances;therefore,the value of the motor proportion is fixed by the time when a large disturbance *** this paper,formulae are derived to estimate motor proportion under small disturbances,and these formulae allow direct calculation of motor proportion without using any optimization *** proposed estimation formulae do not rely on any parameters of load model or power system but instead rely only on measurement of the voltage and active power at steady-state points before and after a small *** of universality of small disturbances in power systems,estimating time-varying motor proportion under small disturbances will be helpful for solving the time-varying problem of load ***,the proposed motor proportion estimation formulae are validated by simulations,physical experiments,and field experiments.

关键词： Composite load model load modeling motor proportion parameter estimation

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Feature Matching via Topology-Aware Graph Interaction Model

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 113-130页

作者： Yifan lu Jiayi Ma Xiaoguang Mei Jun Huang Xiao-ping Zhang the Electronic Information School Wuhan UniversityWuhan 430072China IEEE Tsinghua Berkeley Shenzhen Institute Shenzhen 518071China the Department of Electrical Computer and Biomedical EngineeringToronto Metropolitan UniversityToronto ON M5B 2K3Canada

Feature matching plays a key role in computer vision. However, due to the limitations of the descriptors, the putative matches are inevitably contaminated by massive *** paper attempts to tackle the outlier filtering problem from two aspects. First, a robust and efficient graph interaction model,is proposed, with the assumption that matches are correlated with each other rather than independently distributed. To this end, we construct a graph based on the local relationships of matches and formulate the outlier filtering task as a binary labeling energy minimization problem, where the pairwise term encodes the interaction between matches. We further show that this formulation can be solved globally by graph cut algorithm. Our new formulation always improves the performance of previous localitybased method without noticeable deterioration in processing time,adding a few milliseconds. Second, to construct a better graph structure, a robust and geometrically meaningful topology-aware relationship is developed to capture the topology relationship between matches. The two components in sum lead to topology interaction matching(TIM), an effective and efficient method for outlier filtering. Extensive experiments on several large and diverse datasets for multiple vision tasks including general feature matching, as well as relative pose estimation, homography and fundamental matrix estimation, loop-closure detection, and multi-modal image matching, demonstrate that our TIM is more competitive than current state-of-the-art methods, in terms of generality, efficiency, and effectiveness. The source code is publicly available at http://***/Yifanlu2000/TIM.

关键词： Feature matching graph cut outlier filtering topology preserving

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Advancements in S-scheme heterojunction materials for photocatalytic environmental remediation

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Journal of Materials Science & Technology 2024年第2期169卷 182-198页

作者： Changliang Nie Xiaohan Wang ping lu Yukun Zhu Xin Li Hua Tang School of Environmental Science and Engineering State Key Laboratory of Bio-fibers and Eco-textilesQingdao UniversityQingdao266071China Institute of Biomass Engineering Key Laboratory of Energy Plants Resource and UtilizationMinistry of Agriculture and Rural AffairsSouth China Agricultural UniversityGuangzhou510642China School of Environmental Science and Engineering Shandong UniversityQingdao266237China

Recently,S-scheme heterojunctions have gained considerable attention in the field of photocatalytic environmental remediation as their potential to achieve efficient spatial charge separation coupled with strong redox ***,this review provides an overview of the current state-of-the-art in the development of S-scheme-based photocatalysts for the purification of environmental *** review first covers the fundamentals of heterogeneous photocatalysis for environmental ***,an introduction to the background,mechanism,design principles,and characterization techniques of S-scheme heterojunctions is ***,the review presents a comparison and summary of using various S-scheme photocatalysts for the removal of several target pollutants,such as bacteria,heavy metals,nitrogen oxides,antibiotics,and ***,the modification strategies of S-scheme heterojunction photocatalysts are also ***,a brief discussion of the challenges and prospects associated with S-scheme photocatalytic systems is demonstrated.

关键词： S-scheme heterojunctions Photocatalyst Pollutant Environmental remediation

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