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Long noncoding RNA NALT1-induced gastric cancer invasion and metastasis via NOTCH signaling pathway

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World Journal of Gastroenterology 2019年第44期25卷 6508-6526页

作者： Hai-yan piao Shuai Guo Yue Wang Jun Zhang Medical Oncology Department of Gastrointestinal Cancer Liaoning Province Cancer Hospital&Institute(Cancer Hospital of China Medical University)Shenyang 110042Liaoning ProvinceChina Gastric Cancer Department Liaoning Province Cancer Hospital&Institute(Cancer Hospital of China Medical University)Shenyang 110042Liaoning ProvinceChina

BACKGROUNDLong noncoding RNAs (lncRNAs) are aberrant and play critical roles in gastriccancer (GC) progression and metastasis. Searching for coexpressed lncRNAclusters or representative biomarkers related to malignant phenotypes of GC mayhelp to elucidate the mechanism of tumor development and predict the prognosisof *** investigate the prognostic value of NOTCH1 associated with lncRNA in T cellacute lymphoblastic leukemia 1 (NALT1) in GC and the mechanism of itsinvolvement in GC invasion and *** sequencing and corresponding clinical data were downloaded from TheCancer Genome Atlas database. The significance module was studied byweighted gene coexpression network analysis. A total of 336 clinical sampleswere included in the study. Gene silencing, reverse transcription polymerasechain reaction, western blotting, scrape motility assay, and Transwell migrationassay were used to assess the function of *** the transcriptome level, 3339 differentially expressed lncRNAs were *** gene coexpression network analysis was used to obtain 15 lncRNAclusters and observe their coexpression. Pearson’s correlation showed that blue module was correlated with tumor grade and survival. NALT1 was the hublncRNAof blue module and was an independent risk factor for GC ***1 was overexpressed in GC and its expression was closely related toinvasion and metastasis. The mechanism may involve NALT1 regulation ofNOTCH1, which is associated with lncRNA in T cell acute lymphoblasticleukemia, through cis regulation, thereby affecting the expression of the NOTCHsignaling ***1 is overexpressed and promotes invasion and metastasis of GC. Themechanism may be related to regulation of NOTCH1 by NALT1 and its effect onNOTCH signaling pathway expression.

关键词： Gastric cancer Weighted gene coexpression network analysis NALT1 NOTCH1 Cancer survival

Development and validation of a three-long noncoding RNA signature for predicting prognosis of patients with gastric cancer

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World Journal of Gastroenterology 2020年第44期26卷 6929-6944页

作者： Jun Zhang Hai-yan piao Yue Wang Mei-Yue Lou Shuai Guo yan Zhao Department of Gastric Cancer Liaoning Province Cancer Hospital and Institute(Cancer Hospital of China Medical University)Shenyang 110042Liaoning ProvinceChina Medical Oncology Department of Gastrointestinal Cancer Liaoning Province Cancer Hospital and Institute(Cancer Hospital of China Medical University)Shenyang 110042Liaoning ProvinceChina Department of Gastroenterological Surgery Kumamoto UniversityGraduate School of Medical SciencesKumamoto 860-8556KumamotoJapan

BACKGROUND Gastric cancer(GC)is one of the most frequently diagnosed gastrointestinal cancers throughout the *** prognostic biomarkers are required to predict the prognosis of *** To identify a multi-long noncoding RNA(lncRNA)prognostic model for *** Transcriptome data and clinical data were downloaded from The Cancer Genome *** and least absolute shrinkage and selection operator regression analyses were performed to screen for prognosis associated *** operating characteristic curve and Kaplan-Meier survival analyses were applied to evaluate the effectiveness of the *** The prediction model was established based on the expression of AC007991.4,AC079385.3,and AL109615.2 Based on the model,GC patients were divided into“high risk”and“low risk”groups to compare the differences in *** model was re-evaluated with the clinical data of our *** The 3-lncRNA combination model is an independent prognostic factor for GC.

关键词： Gastric cancer Prognosis Least absolute shrinkage and selection operator Survival analysis Long noncoding RNA

Trajectory Time Series Compression Algorithm Based on Unsupervised Segmentation

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Journal of Systems Science and Information 2024年第3期12卷 360-378页

作者： Shuang SUN yan CHEN Zaiji piao School of Maritime Economics and Management Dalian Maritime University School of Software Dalian University of Foreign Languages

Aiming at the problem of ignoring the importance of starting point features of trajecory segmentation in existing trajectory compression algorithms, a study was conducted on the preprocessing process of trajectory time series. Firstly, an algorithm improvement was proposed based on the segmentation algorithm GRASP-UTS(Greedy Randomized Adaptive Search Procedure for Unsupervised Trajectory Segmentation). On the basis of considering trajectory coverage, this algorithm designs an adaptive parameter adjustment to segment long-term trajectory data reasonably and the identification of an optimal starting point for segmentation. Then the compression efficiency of typical offline and online algorithms, such as the Douglas-Peucker algorithm, the Sliding Window algorithm and its enhancements, was compared before and after segmentation. The experimental findings highlight that the Adaptive Parameters GRASP-UTS segmentation approach leads to higher fitting precision in trajectory time series compression and improved algorithm efficiency post-segmentation. Additionally, the compression performance of the Improved Sliding Window algorithm post-segmentation showcases its suitability for trajectories of varying scales, providing reasonable compression accuracy.

关键词： trajectory time series unsupervised segmentation trajectory compression greedy randomized adaptive search

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基于立体像素匹配的图像重构技术研究

光子学报 2008年第12期37卷 2560-2563页

作者：朴燕长春理工大学电子信息工程学院长春130022

为了解决目前全景成像技术中分辨率低的问题,提出了一种新的基于3D场景立体像素光线映射的全景图像计算机重构技术.在全景成像技术中,3D场景的每个立体像素点经全景成像系统的编码系统分别映射在一定区域的多个体元素图像的不同像素点上... 详细信息

为了解决目前全景成像技术中分辨率低的问题,提出了一种新的基于3D场景立体像素光线映射的全景图像计算机重构技术.在全景成像技术中,3D场景的每个立体像素点经全景成像系统的编码系统分别映射在一定区域的多个体元素图像的不同像素点上.在计算机重构全景图像时,根据逆光学路径原理,提出了从立体像素映射到的体元素图像区域中提取对应立体像素的多个2D像素点来重构全景图像,使重构的全景图像最大分辨率可达到传统成像方法图像分辨率的N倍(N为映射区域面积).提出的立体像素的匹配技术大大提高了重构的计算机全景图像分辨率.

关键词：微透镜阵列全景图像计算全景图像重建

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污泥处理与资源化虚拟仿真实验的设计与实践

造纸技术与应用 2024年第2期52卷 60-65页

作者：罗邯予李正朴海燕张兰河张庭东北电力大学化学工程学院吉林吉林132012

阐述了污泥处理与资源化虚拟仿真实验体系的设计背景、构建、实验环境及教学效果。针对好氧发酵和脱水焚烧工艺建立了虚拟仿真模块。学生操作具体分为构建工艺路线、设计计算、运行与调试仿真实验、提交操作4部分。虚拟仿真实验可以使... 详细信息

阐述了污泥处理与资源化虚拟仿真实验体系的设计背景、构建、实验环境及教学效果。针对好氧发酵和脱水焚烧工艺建立了虚拟仿真模块。学生操作具体分为构建工艺路线、设计计算、运行与调试仿真实验、提交操作4部分。虚拟仿真实验可以使学生熟悉好氧发酵和脱水焚烧工艺相关的基础知识、主要设备及工艺流程,弥补实体实验的不足。

关键词：污泥资源化利用虚拟仿真固体废物环境工程

Clinical characteristics and treatment of splenic infarction in children with systemic lupus erythematosus

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World Journal of Pediatrics 2024年第5期20卷 525-531页

作者： yan Li Yu-Rong piao Tong-Xin Han Hua-Wei Mao Department of Immunology Ministry of Education Key Laboratory of Major Diseases in ChildrenBeijing Key Laboratory for Genetics of Birth DefectsNational Center for Children’s HealthBeijing Children’s HospitalCapital Medical UniversityNo.56 Nan Li Shi LuBeijing100045China

Splenic infarction(SI)is a rare clinical phenomenon that occurs when the blood supply to the spleen is interrupted,resulting in tissue ischemia and necrosis[1].There are many causes of SI;in adult patients,cardioembolism,hematological malignancy,and infectious disease are the most common[2].Rheumatic diseases,especially systemic lupus erythematosus(SLE)and granulomatosis with polyangitis,can also lead to SI[3];however,only a few cases have been *** are currently no statistically meaningful data on the etiology of SI in *** most patients with SI can recover after conservative treatment,a small number of patients develop complications,such as splenic abscess,splenic rupture,splenic hemorrhage,and hemoperitoneum,and may even undergo splenectomy in severe cases.

关键词： erythematosus lupus treatment

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基于多尺度特征的行人重识别属性提取新方法

吉林大学学报（工学版） 2023年第4期53卷 1155-1162页

作者：于鹏朴燕长春理工大学电子信息工程学院长春130022

针对目前行人重识别存在背景混乱、遮挡干扰、姿势不对齐、解释性不足等问题,提出了一种基于多尺度特征的行人重识别属性提取新方法。通过中间层学习模块学习属性并按属性分组卷积,以增强模型的可解释性;通过选择对比中间的属性特征,减... 详细信息

针对目前行人重识别存在背景混乱、遮挡干扰、姿势不对齐、解释性不足等问题,提出了一种基于多尺度特征的行人重识别属性提取新方法。通过中间层学习模块学习属性并按属性分组卷积,以增强模型的可解释性;通过选择对比中间的属性特征,减少干扰特征的影响。本文方法在3个常用的公开数据集上测试并与其他方法进行了对比,实验结果表明,该方法可以有效提取中间层的语义信息,并且在跨数据集上测试优于其他方法。

关键词：计算机应用可解释性行人重识别多尺度特征

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基于多视差函数拟合的集成成像深度提取方法

光学学报 2015年第4期35卷 153-159页

作者：王宇朴燕长春理工大学电子信息工程学院吉林长春130022

集成成像系统采用微透镜阵列记录空间场景信息,只有一次成像过程,在获取场景深度时,不存在相机的参数设置和校准问题,简化了深度测量过程,具有很大优势。但是由于该系统采集的元素图像分辨率低,容易受记录噪声影响,元素图像之间匹配困... 详细信息

集成成像系统采用微透镜阵列记录空间场景信息,只有一次成像过程,在获取场景深度时,不存在相机的参数设置和校准问题,简化了深度测量过程,具有很大优势。但是由于该系统采集的元素图像分辨率低,容易受记录噪声影响,元素图像之间匹配困难。基于集成成像系统能够计算重构出多幅视图的优势,充分利用多幅视图提供的冗余信息来改善立体匹配情况。采用颜色相似性的自适应窗口在参考视图与其他视图之间进行立体匹配,得到参考视图与其他视图之间的视差信息,利用视差与视图对之间的抽样距离满足正比函数关系的性质,对多个视差值进行函数拟合,减少了由于记录噪声等因素产生的误匹配,物体深度层次的分辨更加准确。

关键词：成像系统集成成像深度提取立体匹配自适应匹配窗口函数拟合

Mobile mini-fluorimeter for antibiotic aptasensing based on surface-plasmonic effect of burlike nanogolds enhanced by digitized imaging diagnosis

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Chinese Chemical Letters 2024年第5期35卷 418-422页

作者： Tiantian Man Fulin Zhu Yaqi Huang Yuhao piao yan Su Shengyuan Deng Ying Wan School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China Key Laboratory of Metabolic Engineering and Biosynthesis Technology Ministry of Industry and Information TechnologySchool of Environmental and Biological EngineeringNanjing University of Science and TechnologyNanjing 210094China

Antibiotic abuse now poses a grave threat to global ecology and bestirs public concerns about the residue issue in daily *** traceability measurements along supply chain or logistic circulation have become increasingly essential given the labile nature of diverse synthetic residuals on *** an attempt to answer this urgency,here a miniaturized fluorometric aptasensor prototype was contrived that catered to the point-of-care screening norm for two typical additives:chloramphenicol and *** key target-indicating module worked in vitro based on the competitive binding-induced fluorescence recovery of fluorescein-labeled aptamers,which were photobleached beforehand in the format of double helix on burlike nanogold ***“prickly”geometry of the latter not just enriched the capture probes at preferentially substrate-accessible spires;but also contributed to a tip-enhanced surface plasmon effect,sensitizing the signal-on during the duplex dissociation even at nanomolar threshold of the *** the other hand,to encompass a full portable,a set of optical devices were mounted within a 3D-printed cartridge(adaptor)to converge the light beam and route it towards the detector,for which the smartphone camera came up in handy with a home-developed App for calibrating the emissive *** by the high-dynamic-range compression,an imaging diagnostic algorithm was built in to grid and digitize each slide in the album for augmented detection ***,a novel bio-to-silico integration was invented that capable of in situ rapid reporting on the antibiotic presence with high sensitivity and *** field practices in spiked milk on sales proved the precision and rudimentary feasibility of the well-assembled model of appliance,thus holding nice prospects in nonexpert(e.g.,family and local community)utilities for foodborne antibiotic identification.

关键词： Chloramphenicol and enrofloxacin Aptasensor Gold nanoburs Smartphone fluorimetric suite Digitized image postprocessing