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Polio eradication surveillance in Sri Lanka,2019-2023

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Asian Pacific Jou.n.l of Tropical Medicine 2024年第6期17卷 268-272页

作者： M.A.Y.Fernando n.S.Madarasinghe C.Rangana n.Weerasinghe D.C.u.D.Weligamage J.I.Abeynayake Department of Medical Microbiology and Immunology Faculty of MedicineUniversity of ColomboSri Lanka Department of Virology Medical Research InstituteColombo 08Sri Lanka Medical Research Institute Colombo 08Sri Lanka

Objective:To evaluate the polio laboratory surveillance carried out from January,2019 to May,2023 by the Polio Regional Reference Laboratory,Sri ***:This retrospective study analyzed all stool samples received under the acute flaccid paralysis(AFP)and immunodeficient vaccine-derived poliovirus(VDPV)surveillance at Polio Regional Reference Laboratory,Sri Lanka from January,2019 to May,*** results of the testing methodologies were extracted from the laboratory data system,i.e.,poliovirus virus isolation,intra-typic differentiation/VDPV real time reverse transcriptase polymerase chain reaction(ITD/VDPV rRTPCR)and sequ.n.ing,along with the data on timing of reporting results,stool adequacy and *** was analyzed using descriptive ***:A total of 2141 stool samples from 1644 cases were received for AFP surveillance from Sri Lanka(93.61%),Maldives(1.52%),and immunodeficient VDPV(4.86%)*** polioviruses(19/1644,1.15%)and non-polio enteroviruses(73/1644,4.44%)were isolated,while Sabin-like 3 virus was detected in majority(12/19,63.15%)among the poliovirus *** polioviruses or circulating VDPVs were not detected among the *** all years of the study,the non-polio AFP detection rate was>1/100000 in children aged less than 15 years,whereas stool adequacy rate was>80%.All results were reported within 14 days of receipt,ensuring timely reporting as per global ***:The Polio Regional Reference Laboratory,Sri Lanka plays a vital role in maintaining the polio-free status in the country through its robust laboratory surveillance,while adhering to the surveillance ***-detection of wild polioviruses and circulating VDPV during the study period reinforces the polio-free status in the country.

关键词： Poliovirus Polio laboratory surveillance Regional reference laboratory Polio eradication

VEPP-2000 e^+e^-对撞机上用CMD-3探测器测量e^+e^-→ηπ^+π^-和e^+e^-→ωπ^+π^-的截面（英文）

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中国科学技术大学学报 2016年第6期46卷 514-522页

作者： POPOV A.S. AKHMETSHIn R.R. AMIRKHAnOV A.n. AnISEnKOV A.V. AuLCHEnKO V.M. BAnZAROV V.S. BASHTOVOY n.S. BERKAEV D.E. BOnDAR A.E. BRAGIn A.V. EIDELMAn D.E. EPIFAnOV D.A. EPSHTEYn L.B. EROFEEV A.L. FEDOTOVICH G.V. GAYAZOV S.E. GREBEnuK A.A. GRIBAnOV S.S. GRIGORIEV D.n. GROMOV E.M. IGnATIn F.V. IVAnOV V.L. KARPOV S.V. KASAEV A.S. KORPOTIn A.n. KOOP I.A. KOVALEnKO O.A. KAZAnIn V.F. KOZYREV A.n. KOZYREV E.A. KROKOVnY P.P. KuZMEnKO A.E. KuZMIn A.S. LOGASHEnKO I.B. LIKIn P.A. MIKHAILOV K.Yu. OKHAPKIn V.S. OTBOEV A.V. pestovy u.n. PIVOVAROV S.G. RAZuVAEV G.P. ROMAnOV A.L. RuBAn A.A. RYSKuLOV n.M. RYZHEnEnKOV A.E. SHEBALIn V.E. SHEMYAKIn D.n. SHWARTZ B.A. SHWARTZ D.B. SIBIDAnLOV A.L. SHATunOV P.Yu. SHATunOVY u.M. SOLODOV E.P. TITOV V.M. TALYSHEV A.A. VOROBIOV A.I.. YuDInY u.V. ZHARInOVY u.M. 俄罗斯布德克尔核物理研究所国立新西伯利亚大学东京大学物理系国立新西伯利亚理工大学悉尼大学物理学院高能物理系

在VEPP^-2000e^+e^-对撞机上,CMD^-3探测器研究了e^+e^-→ηπ^+π^-→γγπ^+π^-,e^+e^-→ηπ^+π^-→π0π^+π^-π^+π^-以及e^+e^-→ωπ^+π^-→π0π^+π^-π^+π^-等过程.分析使用的是2011和2012年在1.2^-2.0Ge V能区收集的相应积分亮度为3×104nb^-1的数据.用η→γγ道测量了e^+e^-→ηπ^+π^-的波恩截面,结果与相关的实验结论相吻合;还用末态η→π^+π^-π0和ω→π^+π^-π0分别得到了e^+e^-→ηπ^+π^-和e^+e^-→ωπ^+π^-波恩截面的初步结果;e^+e^-→ηπ^+π^-波恩截面的数值还被用于确定τ^-→ηπ^-π0ντ的衰变分支比.

关键词：截面 ηπ+π- ωπ+π- 强子 τ

Role of marine natural products in the development of antiviral agents against SARS‑CoV‑2:potential and prospects

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Marine Life Science & Technology 2024年第2期6卷 280-297页

作者： D.P.nagahawatta n.M.Liyanage Thilina u.Jayawardena H.H.A.C.K.Jayawardhana Seong‑Hun Jeong Hyung‑Jun Kwon You‑Jin Jeon Department of Marine Life Sciences Jeju National UniversityJeju 690-756Republic of Korea Department of Chemistry Biochemistry and PhysicsUniversitédu QuébecàTrois-RivièresTrois-RivièresQC G8Z 4M3Canada Marine Science Institute Jeju National UniversityJeju 63333Republic of Korea Functional Biomaterial Research Center Korea Research Institute of Bioscience and BiotechnologyJeongeup-siRepublic of Korea

A novel coronavirus,known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has surfaced and caused global concern owing to its ***-CoV-2 is the causative agent of coronavirus disease 2019;however,it was only discovered at the end of the year and was considered a pandemic by the World Health ***,the develop-ment of novel potent inhibitors against SARS-CoV-2 and future outbreaks is urgently *** naturally occurring bioactive substances have been studied in the clinical setting for diverse *** intricate infection and replication mechanism of SARS-CoV-2 offers diverse therapeutic drug targets for developing antiviral medicines by employing natural products that are safer than synthetic *** natural products(MnPs)have received increased attention in the development of novel drugs owing to their high diversity and ***,this review article investigates the infection and replication mechanisms,including the function of the SARS-CoV-2 genome and ***,we highlighted anti-SARS-CoV-2 therapeutic intervention efforts utilizing MnPs and predicted SARS-CoV-2 inhibitor design.

关键词： SARS-CoV-2 Marine natural products Drug targets Inhibitors

Old-growth mixed dipterocarp forests show variable losses and gains in aboveground biomass and standing carbon over forty years

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Forest Ecosystems 2024年第1期11卷 14-23页

作者： Sisira Ediriweera Champika Bandara Tithira Lakkana Shanika Jayasinghe David Woodbury Arun Dayanandan B.M.P.Singhakumara Xiangcheng Mi I.A.u.n.Gunatilleke C.V.S.Gunatilleke Mark SAshton Department of Science and Technology Uva Wellassa UniversityBadullaSri Lanka The Forest School Yale School of the EnvironmentYale UniversityNew HavenCT06511USA Department of Forestry and Environmental Science University of Sri JayewardenepuraNugegodaSri Lanka State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing100093China Botany Department University of PeradeniyaPeradeniyaSri Lanka

Background:no studies have documented long-term trends in aboveground biomass(AGB)for mixed-dipterocarp forests(MDF),the dominant rain forest type in tropical wet equatorial *** our study,we sought to document such trends over forty years across three sites representing lowland to lower montane ***:To do this,we established fifty 100 m×25 m plots in 1978 across three sites sampled along an elevation gradient,identified as mature old-growth *** measured trees for diameter at breast height that we identified to species and *** took wood samples to calculate species wood-specific *** re-measured plots in 1998 and again in ***:We show standing AGB for all sites combined to be 517.52 Mg·ha^(-1)in 1978,but this declined by 17%over 40 years to 430.11 Mg·ha^(-1).no differences exist among sites in AGB primarily because of considerable within site variation;but interactions of time with site show declines across sites were not uniform,one remained about the *** few species represented a high proportion of the AGB with the top five species comprising between 34%and 65%,depending upon site and year *** species,Mesua nagassarium,represented a disproportionately large amount of AGB and decline over time,particularly at the low elevation ***:Our results are directly relevant to estimating AGB and standing carbon sequestered in *** study is the first to demonstrate varying but overall,declining trends in amounts of AGB among forests making predictions of biomass and standing carbon in MDF difficult over wide regions.

关键词： Western ghats Shorea spp. Southeast Asia Sri Lanka Tropical rain forest Wood specific gravity

Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents

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neural Regeneration Research 2024年第8期19卷 1835-1841页

作者： Irene navarro-Lobato Mariam Masmudi-Martín Manuel F.López-Aranda Ju.n.F.López-Téllez Gloria Delgado Pablo Granados-Durán Celia Gaona-Romero Marta Carretero-Rey Sinforiano Posadas María E.Quiros-Ortega Zafar u.Khan Laboratory of neurobiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Department of Medicine Faculty of MedicineUniversity of MalagaMalagaSpain Centro de Investigación Biomédica en Red de Enfermedades neurodegenerativas(CIBERnED) Institute of Health Carlos IIIMadridSpain the Donders Institute for Brain Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands the Brain Metastasis Group National Cancer Research Centre(CNIO)MadridSpain the Department of neurobiology University of California-Los AngelesLos AngelesCAUSA

Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for *** till now,all potential drug candidates have failed to produce satisfa ctory ***,in the search for a solution,we found that a treatment with the gene corresponding to the RGS14414protein in visual area V2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(ORM),can induce enhancement of *** this study,we demonstrated that the same treatment with RGS14414in visual area V2,which is relatively unaffected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of ORM in young animals and prevent ORM deficits in rodent models of aging and Alzheimer’s ***,we found that the prevention of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDnF).A knockdown of BDnF gene in RGS14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of ORM *** findings suggest that BDnF-mediated neuronal structural plasticity in area V2 is crucial in the prevention of memory deficits in RGS14414-treated rodent models of aging and Alzheimer’s ***,our findings of RGS14414gene-mediated activation of neuronal circuits in visual area V2 have therapeutic relevance in the treatment of memory deficits.

关键词： behavioral performance brain-derived neurotrophic factor cognitive dysfunction episodic memory memory circuit activation memory deficits memory enhancement object recognition memory prevention of memory loss regulator of G protein signaling

Combinations of electron and proton donors in transition-metal complex mediated nitrogen reduction reactions

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Science China Chemistry 2024年第7期67卷 2136-2154页

作者： Delong Han Li Yang Hao Hu.n. Priyanka Chakraborty Shashikant u.Dighe Kuo-Wei Hu.n. KAuST Catalysis Center and Division of Physical Science and Engineering King Abdullah University of Science and TechnologyThuwal 23955Saudi Arabia Agency for Science Technologyand ResearchInstitute of Materials Research and Engineering and Institute of Sustainability for ChemicalsEnergy and EnvironmentSingapore 138634Singapore

nitrogen fixation is a complex process involving the transfer of six electrons and *** from the conventional Haber-Bosch process,which relies on hydrogen(H_(2))to provide both electrons and protons to reduce nitrogen(n_(2)),homogeneous transition metal complex-catalyzed n_(2)reduction reactions(nRR)employ an array of electron and proton donors or even electron donors combined with *** the synthesis of diverse catalytic progress,the categories of donors have seen rapid ***,existing literature only provides summaries regarding the metal,ligands,and *** the significance of electron and proton donor combinations in nitrogen reduction reactions,no literature has thoroughly reviewed this ***,we hereby compiled a comprehensive list of commonly used reagents in n_(2)reduction and classified them according to their specific donor *** review presents clear and organized information about these combinations,along with a summary of their general performance trend in nRR with related ***,we conclude the discussion by highlighting key points for researchers to consider when selecting catalysts and donor combinations,with the ultimate goal of advancing the field of nitrogen fixation.

关键词： dinitrogen reduction reaction reducing donor combination transition metal complexes homogeneous catalysis

Predictive factors for percutaneous nephrolithotomy bleeding risks

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Asian Jou.n.l of urology 2024年第1期11卷 105-109页

作者： u Phun Loo Chun Hou Yong Gu.n.Chou Teh urology Department Sarawak General HospitalKuchingMalaysia

Objective:This study aimed to identify predictive factors for percutaneous nephrolithotomy(PCnL)bleeding *** better risk stratification,bleeding in high-risk patient can be anticipated and facilitates early ***:A prospective observational study of PCnL performed at our institution was *** adults with radio-opaque renal stones planned for PCnL were included except those with coagulopathy,planned for additional *** including gender,co-morbidities,body mass index,stone burden,puncture site,tract dilatation size,operative position,surgeon's seniority,and operative duration were studied using stepwise multivariate regression analysis to identify the predictive factors associated with higher estimated hemoglobin(Hb)***:Overall,4.86%patients(n=7)received packed cells *** mean estimated Hb deficiency was 1.3(range 0-6.5)g/dL and the median was 1.0 g/*** multivariate regression analysis revealed that absence of hypertension(p=0.024),puncture site(p=0.027),and operative duration(p=0.023)were significantly associated with higher estimated Hb ***,the effect sizes are rather small with partial eta-squared of 0.037,0.066,and 0.038,*** power obtained was 0.621,0.722,and 0.625,*** factors studied did not correlate with Hb ***:Hypertension,puncture site,and operative duration have significant impact on estimated Hb deficiency during ***,the effect size is rather small despite adequate study power ***,operative position(supine or prone),puncture number,or tract dilatation size did not correlate with Hb *** mainstay of reducing bleeding in PCnL is still meticulous operative *** study findings also suggest that PCnL can be safely done by urology trainees under supervision in suitably selected patient,without increasing risk of bleeding.

关键词： Percutaneous nephrolithotomy Predictive factor Risk factor Bleeding Blood loss

u-Pb dating of bastnäsite from the Vuoriyarvi massif:An example application for assessing the REE potential of carbonatite-related deposits

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Geoscience Frontiers 2024年第5期15卷 444-453页

作者： Evgeniy n.Kozlov Ekaterina n.Fomina Qiuli Li Jiao Li Geological Institute Kola Science Centre of the Russian Academy of SciencesApatity 184209Russia Institute of Geology and Geophysics Chinese Academy of SciencesBeijing 100029China

The Vuoriyarvi massif is a Devonian multistage alkaline-ultrabasic carbonatite complex within the Kola alkaline *** carbonatites of the Vuoriyarvi massif contain abundant rare-earth mineralization mainly represented by ancylite-(Ce)and bastnäsite-(Ce).Ancylite was previously shown to have probably formed in the Devonian(ca.365 Ma)during an early postmagmatic *** geological observations have revealed a much later crystallization of bastnäsite but have not been able to specify the exact age of the *** in situ u-Pb dating of bastnäsite allowed us to constrain its ***äsite for this study was extracted from two varieties of dolomite carbonatite breccias cemented by(1)quartz-bastnäsite and(2)strontianite aggregates(hereafter bastnäsite-rich and strontianite-rich carbonatites–BRC and SRC,respectively).The obtained age estimations(237.7±9.8 Ma and 239.9±4.1 Ma,respectively)indicate that both studied rocks were formed during a single *** revealed age difference(~125 Ma)excludes the genetic link between the bastnäsite origin and regional alkaline magmatism,pointing out an additional source for the Vuoriyarvi bastnäsite-bearing ***,the obtained u-Pb ages provide strong evidence that a Triassic event is responsible for the occurrence of bastnäsite mineralization due to hydrothermal REE redistribution from the Devonian ancylite-rich *** of the REEs released during this process via dissolution of ancylite were precipitated in situ as bastnäsite,while strontium was transported and incorporated into *** Pb isotopic characteristics of bastnäsite(^(206)Pb/^(204)Pb=18.1±0.1,^(207)Pb/^(204)Pb=15.3±0.1,and^(207)Pb/^(206)Pb=0.84±0.01)are most probably inherited from the Devonian host rocks of the Vuoriyarvi massif involved in the Triassic *** signatures of Pb,Sr,and nd show that the depleted mantle and lower crust played the leading role in formation of the Vuoriyarvi alkaline

关键词： Bastnäsite REE Carbonatites u-Pb dating Vuoriyarvi Kola alkaline province

Exact solutions for magnetohydrodynamic nanofluids flow and heat transfer over a permeable axisymmetric radially stretching/shrinking sheet

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Chinese Physics B 2024年第2期33卷 108-114页

作者： u.S.Mahabaleshwar G.P.Vanitha L.M.Pérez Emad H.Aly I.Pop Department of Studies in Mathematics Davangere UniversityShivagangothriDavangereIndia Departamento de F´ısica FACIUniversidad de Tarapac´aCasilla 7DAricaChile Department of Mathematics Faculty of EducationAin Shams UniversityRoxyCairoEgypt Department of Mathematics Babes-Bolyai University400084 Cluj-NapocaRomania

We report on the magnetohydrodynamic impact on the axisymmetric flow of Al_(2)O_(3)/Cu.n.noparticles suspended in H_(2)O past a stretched/shrinked *** the use of partial differential equations and the corresponding thermophysical characteristics of nanoparticles,the physical flow process is *** resultant nonlinear system of partial differential equations is converted into a system of ordinary differential equations using the suitable similarity *** transformed differential equations are solved *** of the magnetic parameter,solid volume fraction and stretching/shrinking parameter on momentum and temperature distribution have been analyzed and interpreted *** skin friction and nusselt number were also *** addition,existence of dual solution was deduced for the shrinking sheet and unique solution for the stretching ***,Al_(2)O_(3)/H_(2)O nanofluid flow has better thermal conductivity on comparing with Cu/H_(2)O ***,it was found that the first solutions of the stream are stable and physically realizable,whereas those of the second ones are unstable.

关键词： magnetohydrodynamic nanofluid stretching/shrinking sheet axisymmetric flow analytical solution suction/injection