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Accuracy of non-invasive liver stiffness measurement and steatosis quantification in patients with severe and morbid obesity

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Hepatobiliary Surgery and Nutrition 2021年第5期10卷 610-622,I0004-I0007页

作者： Magdalena Eilenberg petra Munda Judith Stift Felix BLanger Gerhard Prager Michael Trauner Katharina Staufer Division of General Surgery Department of SurgeryMedical University of ViennaViennaAustria Department of Visceral Surgery and Medicine InselspitalUniversity Hospital BernBernSwitzerland Division of Gastroenterology&Hepatology Department of Internal Medicine IIIMedical University of ViennaViennaAustria Clinical Institute of Pathology Medical University of ViennaViennaAustria Division of Transplantation Department of SurgeryMedical University of ViennaViennaAustria

Background:Vibration controlled transient elastography(VCTE)and controlled attenuation parameter(CAP™)have shown reliable performance predicting fibrosis and steatosis in normal-to overweight patients but have not been validated in severe to morbid *** study aimed at determining the accuracy of VCTE,CAP™and the composite score FibroScan-AST(FAST)in patients with a body mass index(BMI)of≥35 kg/m^(2).Methods:Patients scheduled for bariatric-metabolic surgery underwent preoperative VCTE/CAP™measurement,and intraoperative liver *** feasibility and accuracy of VCTE,CAP™and the composite score FAST were retrospectively analysed to evaluate fibrosis,steatosis and active fibrotic non-alcoholic steatohepatitis[NASH+non-alcoholic fatty liver disease(NAFLD)activity score≥4+fibrosis grade≥2]using per protocol(PP)and intent to diagnose(ITD)***:In total,170 patients(median BMI 44.4 kg/m²)were included in the *** biopsy showed NASH,simple steatosis,and normal livers in 60.6%(n=103),28.8%(n=49),and 10.6%(n=18),*** and CAP™delivered reliable results in 90.6%(n=154/170)and 90.5%(n=134/148).The AUC(PP)of VCTE,CAP™,and FAST were 0.687(≥F2),0.786(≥F3),0.703(≥S2),0.738(S3),and 0.780(active fibrotic NASH).The AUC increased to 0.742(≥F2),0.842(≥F3),0.712(≥S2),0.780(S3),and 0.836(active fibrotic NASH)in patients below the median BMI of 44.4 kg/m².Conclusions:VCTE,CAP™and FAST show acceptable accuracy for the detection of fibrosis,steatosis and NASH in a real-life cohort of patients with *** improves in patients with a BMI<44.4 kg/m^(2).

关键词： Transient elastography controlled attenuation parameter(CAP™) FibroScan-AST score(FAST score) obesity non-alcoholic fatty liver disease(NAFLD)

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Risk factors for carotid plaque progression after optimising the risk factor treatment: substudy results of the Atherosclerotic Plaque Characteristics Associated with a Progression Rate of the Plaque and a Risk of Stroke in Patients with the carotid Bifurcation Plaque Study (ANTIQUE)

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Stroke & Vascular Neurology 2022年第2期7卷 132-139页

作者： David Školoudik petra Kešnerova Tomaš Hrbač David Netuka Jaroslav Vomačka Kateřina Langova Roman Herzig Tomaš Belšan Center for Health Research Faculty of MedicineUniversity of OstravaOstravaCzech Republic Department of Neurology University Hospital OstravaOstravaCzech Republic Department of Neurology Second Faculty of MedicineCharles UniversityPrahaCzech Republic Department of Neurology Motol University HospitalPrahaCzech Republic Department of Neurosurgery Faculty of MedicineUniversity of OstravaOstravaCzech Republic Department of Neurosurgery University Hospital OstravaOstravaCzech Republic Department of Neurosurgery Military University Hospital PraguePrahaCzech Republic Department of Radiological Assistance Faculty of Health SciencesPalacky University OlomoucOlomoucCzech Republic Deaprtment of Radiology University Hospital OlomoucOlomoucCzech Republic Department of Biophysics Faculty of MedicinePalacky University OlomoucOlomoucCzech Republic Department of Neurology University Hospital Hradec KrálovéHradec KraloveCzech Republic Department of Neurology Faculty of Medicine in Hradec KrálovéCharles UniversityHradec KrálovéCzech Republic Department of Radiology Military University Hospital PraguePrahaCzech Republic

Background and aim Carotid plaque progression contributes to increasing stroke *** study aims to identify factors influencing carotid plaque thickness progression after changing the preventive treatment to the‘treating arteries instead of risk factors’strategy,that is,change in treatment depending on the progression of *** The study participants who completed sonographic controls over the course of 3 years were enrolled to the *** sonography of cervical arteries was performed in 6-month intervals with measurement of carotid plaque *** thickness measurement error(σ)was set as 3 *** evidently stable and progressive plaques(defined as plaque thickness difference between initial and final measurements of˂σand>2σ,respectively)were included to *** and multivariate logistic regression analysis was performed to identify factors influencing plaque *** A total of 1391 patients(466 males,age 67.2±9.2 years)were enrolled in the *** plaque in at least one carotid artery was detected in 255(18.3%)*** age,male sex,greater plaque thickness,coronary heart disease,vascular surgery/stenting history and smoking were more frequently present in patients with progressive plaque(p˂0.05 in all cases).Multivariate logistic regression analysis identified only the plaque thickness(OR 1.850 for left side,95%CI 1.398 to 2.449;and OR 1.376 for right side,95%CI 1.070 to 1.770)as an independent factor influencing plaque *** Carotid plaque thickness corresponding to stenosis severity is the only independent risk factor for plaque thickness progression after optimising the prevention treatment.

关键词： prevention treatment Duplex

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Implementing BIM in the German Architecture, Engineering and Construction Market---A Survey about the Potentials and Barriers

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Journal of Civil Engineering and Architecture 2013年第7期7卷 812-820页

作者： petra von Both Building Lifecycle Management Department Karlsruhe Institute of Technology Karlsruhe 76131 Germany

The research project ＂BIM--Potentials and Barriers＂ aims to analyze existing BIM practice and the barriers to the implementation of the approach in Germany. Overseen by an ＂advisory board＂ with high-profile field, public-authority and AEC （architecture, engineering and construction market） association representatives, a set of hypotheses has been drawn up and subjected to evaluation by means of a detailed survey. The survey, having identified the relevant stakeholders, first attempts to discover how BIM （building information modeling） is currently used. The potentials of the application of BIM in the different processes and target groups are also determined, as well as the barriers and constraints. Enhancement of the considered areas is an important project solution approach： Besides technological aspects, the analysis also focuses on contracting, norms and processes, as well as education, knowledge and role perception.

关键词： BIM survey collaborative engineering virtual engineering product modelling.

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Individualized home-monitoring of disease activity in adult patients with inflammatory bowel disease can be recommended in clinical practice: A randomized-clinical trial

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World Journal of Gastroenterology 2019年第40期25卷 6158-6171页

作者： Dorit Vedel Ankersen petra Weimers Dorte Marker Mette Bennedsen Sanaz Saboori Kristine Paridaens Johan Burisch Pia Munkholm Department of Gastroenterology North Zealand University HospitalFrederikssund 3600Capital regionDenmark Global Medical Affairs Ferring International Center S.A.Saint-Prex 1162Switzerland

BACKGROUND The optimal way to home-monitor patients with inflammatory bowel disease(IBD)for disease progression or relapse remains to be *** To determine whether an electronic health(eHealth)screening procedure for disease activity in IBD should be implemented in clinical practice,scheduled every third month(3M)or according to patient own decision,on demand(OD).METHODS Adult IBD patients were consecutively randomized to 1-year open-label eHealth interventions(3M vs OD).Both intervention arms were screening for disease activity,quality of life and fatigue and were measuring medical compliance with the constant care web-application according to the screening interventions OD or *** activity was assessed using home measured fecal calprotectin(FC)and a disease activity *** In total,102 patients were randomized(n=52/503M/OD)at baseline,and 88 patients completed the 1-year study(n=433M;n=45 OD).No difference in the two screening procedures could be found regarding medical compliance(P=0.58),fatigue(P=0.86),quality of life(P=0.17),mean time spent in remission(P>0.32),overall FC relapse rates(P=0.49),FC disease courses(P=0.61),FC time to a severe relapse(P=0.69)and remission(P=0.88)during 1 ***(interquartile range)numbers of FC home-monitoring test-kits used per patient were significantly different,3M:6.0(5.0-8.0)and OD:4.0(2.0-9.0),P=*** The two eHealth screening procedures are equally good in capturing a relapse and bringing about ***,the OD group used fewer FC home testkits per *** screening procedures can be recommended for adult IBD patients in clinical web-practice.

关键词： Inflammatory bowel disease Electronic health Screening Disease activity

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Study Fields Optimalization within the Programme Applied Mathematics

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Journal of Mathematics and System Science 2011年第1期1卷 80-87页

作者： petra Koneena Zuzana Vaclavikova Department of Mathematics University of Ostrava Ostrava 701 03 Czech Republic

The integration of the Czech Republic into the process of European space university education formation makes many demands on the higher education system--from creating new legislation and educational conception to changes in the study programme structure. With regard to the study programme structure, permeability and modular construction of the programme and the actual European Credit Transfer and Accumulation System （ECTS） implementation are some of requirements coming to the fore. The aim of this work is to present an analysis of bachelor study programme Applied Mathematics Structure at the University of Ostrava within the context of the above mentioned requirements.

关键词： European credit transfer and accumulation system (ECTS) permeability permanence modularity study programme structure.

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Kerrilee petra Barrett英国

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重庆与世界 2007年第10期 70-73页

作者： Kerrilee petra Barrett

英国(British)英国自由摄影师。British Freelance photographer

关键词：英国大不列颠及北爱尔兰联合王国 Kerrilee petra Barrett

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Minority Stress in the Face of Changes in LGB Rights in Croatia

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Psychology Research 2017年第5期7卷 274-286页

作者： Margareta Jelic petra Kozljan University ofZagreb Zagreb Croatia

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Epidemiology of hepatitis E in South-East Europe in the "One Health" concept

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World Journal of Gastroenterology 2019年第25期25卷 3168-3182页

作者： Anna Mrzljak petra Dinjar-Kujundzic Lorena Jemersic Jelena Prpic Ljubo Barbic Vladimir Savic Vladimir Stevanovic Tatjana Vilibic-Cavlek Department of Medicine Merkur University HospitalSchool of MedicineUniversity of ZagrebZagreb 10000Grad ZagrebCroatia Department of Medicine Merkur University HospitalZagreb 10000Grad ZagrebCroatia Croatian Veterinary Institute Zagreb 10000Grad ZagrebCroatia Faculty of Veterinary Medicine University of ZagrebZagreb 10000Grad ZagrebCroatia Department of Virology Croatian Institute of Public HealthSchool of MedicineUniversity of ZagrebZagreb 10000Grad ZagrebCroatia

The significance of hepatitis E virus(HEV)as an important public health problem is *** a decade ago,cases of HEV infection in Eur-ope were mainly confined to returning travelers,but nowadays,hepatitis E represents an emerging zoonotic infection in many European *** aim of this manuscript is to perform a systematic review of the published literature on hepatitis E distribution in humans,animals and environmental samples("One Health"concept)in the South-Eastern European *** of the available data showed that the anti-HEV seroprevalence in the South-Eastern Europe varies greatly,depending on the population studied,geographical area and methods *** IgG seroprevalence rates in different population groups were found to be 1.1%-24.5%in Croatia,up to 20.9%in Bulgaria,5.9-%17.1%in Romania,15%in Serbia,up to 9.7%in Greece and 2%-9.7%in *** possible risk factors,older age was the most significant predictor for HEV seropositivity in most *** seroprevalence rates were found in *** IgG antibodies in domestic pigs were detected in 20%-54.5%,29.2%-50%,38.94%-50%and 31.1%-91.7%in Serbia,Bulgaria,Romania and Croatia,*** wild boars seroprevalence rates were up to 10.3%,30.3%and 31.1%in Romania,Slovenia and Croatia,respectively.A high HEV RNA prevalence in wild boars in some countries(Croatia and Romania)indicated that wild boars may have a key role in the HEV *** are very few data on HEV prevalence in environmental *** RNA was detected in 3.3%and 16.7%surface waters in Slovenia and Serbia,*** is no evidence of HEV RNA in sewage systems in this *** available data on genetic characterization show that human,animal and environmental HEV strains mainly belong to the genotype 3.

关键词： Hepatitis E virus "One-Health" Humans Animals Environment South-East Europe

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The Relation between Performance and Flows of Mutual Funds: Case of the Croatian Fund Market

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Applied Mathematics 2014年第19期5卷 3067-3078页

作者： Darko Brborovic petra Posedel OTP Invest Zagreb Croatia Department of Mathematics and Statistics Zagreb School of Economics and Management Zagreb Croatia

With pre 2008 euphoria and present depression, inflows to open investment funds and outflows from it shaped general market conditions on the Croatian fund market. This article studies the relationship between performance of open ended investment funds and inflows (outflows) to them on Croatian funds data in an environment without long fund data history, with small number of funds and relatively illiquid underlying equity market. The results suggest that the driving forces behind funds’ flows encompass the combined influence of present month fund’s performance and persistency of past performances. At the end of our analysis we test the significance of the introduced explanatory variables on the data sets that include data for each particular fund. The significance of the introduced explanatory variables varies among different funds, although a general level of the explanatory power is maintained on average.

关键词： Asset under Management Mutual Fund Performance Fund Flows Linear Regression Emerging Economies

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Advancing Li-ion storage performance with hybrid vertical carbon/Ni_(3)S_(2)-based electrodes

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Journal of Energy Chemistry 2022年第4期31卷 8-18页

作者： Neelakandan M.Santhosh Nitheesha Shaji d petra Stražar Gregor Filipič Janez Zavašnik Chang Won Ho Murugan Nanthagopal Chang Woo Lee UrošCvelbar Department of Gaseous Electronics(F6) Jožef Stefan InstituteJamova cesta 39SI-1000 LjubljanaEUSlovenia Jožef Stefan International Postgraduate School Jamova cesta 39SI-1000 LjubljanaEUSlovenia Faculty of Mathematics and Physics University of LjubljanaJadranska cesta 19SI-1000 LjubljanaEUSlovenia Department of Chemical Engineering(Integrated Engineering) College of EngineeringKyung Hee University1732 Deogyeong-daeroGiheungYonginGyeonggi 17104South Korea Center for the SMART Energy Platform College of EngineeringKyung Hee University1732 Deogyeong-daeroGiheungYonginGyeonggi 17104South Korea

Conversion-reaction induced charge storage mechanisms of transition metal sulphides have received considerable interest in designing high-capacity electrodes for electrochemical energy storage ***,their low conductivity and structural degradation during cycling limit their applications as energy storage devices.A combination of different nickel sulphide phases tailored with carbon nanostructures is suggested to address these ***,a facile,two-step approach is demonstrated for fabricating a hybrid electrode,consisting of trinickel disulphide(Ni_(3)S_(2))formed on a metallic Ni nanoparticle supported by vertical carbon nanotubes(VCN)backbone in the form Ni_(3)S_(2)/Ni@***_(3)S_(2)/Ni@VCN electrodes were tested as anode for lithium-ion batteries,and the electrode featured outstanding lithiumstorage capabilities with a high reversible capacity(1113 m Ah g^(-1) after 100 cycles at 100 m A g^(-1)),excellent long-term cycling stability(770 m Ah g^(-1) after 500 cycles at 200 m A g^(-1)),and good rate *** resulting electrode performance is one of the best Li-ion storage capabilities in the Ni_(3)S_(2)-type anode materials described.A unique “broccoli-like”structure of polycrystalline Ni_(3)S_(2)capped on conductive VCN backbone helps the interface storage process and boosts lithium storage performance.

关键词： Ni_(3)S_(2) Vertical carbon nanostructures Hierarchical structures Binder-free electrode Lithium-ion batteries

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