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A functional study of low molecular weight IgM from patients with autoimmune disease

Journal of Microbiology and Immunology 2006年第3期4卷 207-213页

作者： HUI JUN ZHOU XIAO PING YANG WAN SHENG CHEN peter roberts thomson HU JI XU Department of Laboratory Science the Ninth People＇s Hospital School of Medicine Shanghai fiaotongUniversity Shanghai P. R. China Department of Rheumatology and Immunology Department of Pharmacology Changzheng Hospitalthe Second Military Medical University Shanghai P. R. China Department of Immunology Allergy and Arthritis Flinders Medical Centre Australia

High levels of low molecular weight (LMW) IgM in certain diseases are associated with clinical and laboratory indices which reflect the severity of the disease. These associations suggest that LMW IgM may play an important role in the immunopathogenesis of these diseases. To further approach the question concerning the functional activity of LMW IgM in disease, a panel of LMW IgM and high molecular weight (HMW) IgM preparations with or without rheumatoid factor (RF) activity were used to investigate their antibody binding activity and their effector function. It was found that LMW IgM-RF and HMW IgM-RF had a similar binding capacity to Fc fragment as there was no significant difference in the affinity index between them. It further showed that the rate of activation and total amount of utilization of complement by LMW IgM and HMW IgM was similar, although the mean fluorescence of C3 deposition by IgM-RF and HMW IgM-RF was slightly higher than that of LMW IgM-RF and other control RF antibodies. However, the current study demonstrated that LMW IgM had strong neutrophil activating properties when compared with HMW IgM. These findings suggest that one mechanism of LMW IgM contributing to the immunopathogenesis of RA may be due to the formation of circulating immune complex ( CIC) by LMW IgM with subsequent activation of neutrophils. Whether LMW IgM has other functional activity in disease is unclear and needs further investigation.

关键词： Low molecular weight IgM Antoimmune diseases Neutrophil Rheumatoid factor

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Aortic valve replacement reduces mortality in moderate aortic stenosis:a systematic review and meta-analysis

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Journal of Geriatric Cardiology 2023年第1期20卷 61-67页

作者： Kyle B Franke Dimple Bhatia Ross L roberts-thomson peter J Psaltis Adelaide Medical School The University of AdelaideAdelaideAustralia Vascular Research Centre Lifelong Health ThemeSouth Australian Health and Medical Research InstituteAdelaideAustralia Department of Cardiology Royal Adelaide HospitalAdelaideAustralia

BACKGROUND With the introduction of transcatheter aortic valve replacement and an evolving understanding of the natural progression and history of aortic stenosis,the potential for earlier intervention in appropriate patients is promising;however,the benefit of aortic valve replacement in moderate aortic stenosis remains *** Pubmed,Embase,and the Cochrane Library databases were searched up until 30th of December 2021 using keywords including moderate aortic stenosis and aortic valve *** reporting all-cause mortality and outcomes in early aortic valve replacement(AVR)compared to conservative management in patients with moderate aortic stenosis were *** ratios were generated using random-effects meta-analysis to determine effect *** 3470 publications were screened with title and abstract review,which left 169 articles for full-text *** these studies,7 met inclusion criteria and were included,totalling 4,827 *** studies treated AVR as a time-dependent co-variable in cox-regression multivariate analysis of all-cause *** with surgical or transcatheter AVR was associated with a 45% decreased risk of all-cause mortality(HR=0.55[0.42-0.68],I2=51.5%,P<0.001).All studies were representative of the overall cohort with appropriate sample sizes,with no evidence of publication,detection,or information biases in any of the *** In this systematic review and meta-analysis,we report a 45% reduction in all-cause mortality in patients with moderate aortic stenosis who were treated with early aortic valve replacement compared to a strategy of conservative *** control trials are awaited to determine the utility of AVR in moderate aortic stenosis.

关键词： aortic stenosis analysis

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Effect of restricted feeding on hen performance,egg quality and organ characteristics of individual laying hens

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Animal Nutrition 2023年第3期14卷 141-151页

作者： Doreen O.Anene Yeasmin Akter peter C.thomson peter Groves Cormac J.O'Shea Department of Animal Science School of BiosciencesUniversity of NottinghamLoughboroughLE125RDUnited Kingdom School of Life and Environmental Sciences Faculty of ScienceUniversity of SydneyCamdenNSW 2570Australia Sydney School of Veterinary Science Faculty of SciencePoultry Research FoundationUniversity of SydneyCamdenNSW 2570Australia Department of Bioveterinary and Microbial Sciences Technological University of the Shannon:Midlands MidwestDublin RoadAthloneCo WestmeathN37 HD68Ireland

This study was to assess the impact of permanent or temporary restricted feeding on laying hen production traits,physiology,and egg *** hundred and forty individually housed ISA Brown hens were monitored across 2 phases,assigned to 3 treatments:ad libitum feeding(ALF),temporary restricted feeding(TRF)and permanent restricted feeding(PRF),n=80 hens per *** Phase 1(P1),22 to40 weeks,the TRF and PRF hens were offered 115 g of feed *** Phase 2(P2),41 to 46 weeks,the TRF hens were transitioned to ALF status while the ALF and PRF hens remained as in *** 35 to 40 weeks,eggs were collected once weekly from 15 hens per treatment and assessed for differences in albumen,yolk,and shell *** 45 weeks,10 hens each from the ALF and PRF groups were euthanized and differences in organ characteristics were *** P1,feed intake,feed to egg conversion ratio and body weight(BW)change were lower(P<0.01),while albumen height and Haugh unit were higher(P<0.01)in both PRF and TRF hen treatments compared to hens allocated the ALF *** P2,TRF and ALF hens had a higher egg production and egg mass than PRF(P<0.01)than *** weight change in P2 was higher in TRF and similar in both ALF and PRF,while feed intake and feed conversion ratio were higher in TRF followed by ALF and least in the PRF treatment group(P<0.01).At 45 weeks ALF hens had a greater abdominal fat pad weight and fatty liver haemorrhagic syndrome lesion score compared to *** hens to 115 g of feed per day from point of lay restrained BW,improved feed conversion ratio and albumen quality and reduced abdominal fat pad deposition and clinical signs of fatty liver haemorrhagic syndrome in individually housed laying hens.

关键词： Restricted feeding Albumen quality Fatty liver haemorrhagic syndrome Abdominal fat Laying hen Body weight

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Single-center study comparing computed tomography colonography with conventional colonoscopy

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World Journal of Gastroenterology 2008年第3期14卷 469-473页

作者： Ian C roberts-thomson Graeme R Tucker peter J Hewett peter Cheung Ruben A Sebben EE Win Khoo Julie D Marker Wayne K Clapton Department of Gastroenterology The Queen Elizabeth Hospital South Australia Australia Department of Health South Australia Australia Department of Colorectal Surgery The Queen Elizabeth Hospital South Australia Australia Department of Radiology The Queen Elizabeth Hospital South Australia Australia

AIM:To compare the results from computed tomography (CT) colonography with conventional colonoscopy in symptomatic patients referred for colonoscopy. METHODS: The study included 227 adult outpatients, mean age 60 years, with appropriate indications for colonoscopy. CT colonography and colonoscopy were performed on the same day in a metropolitan teaching hospital. Colonoscopists were initially blinded to the results of CT colonography but there was segmental unblinding during the procedure. The primary outcome measures were the sensitivity and specificity of CT colonography for the identification of polyps seen at colonoscopy (i.e. analysis by polyp). Secondary outcome measures included an analysis by patient, extracolonic findings at CT colonography, adverse events with both procedures and patient acceptance and preference. RESULTS: Twenty-five patients (11%) were excluded from the analysis because of incomplete colonoscopy or poor bowel preparation that affected either CT colonography, colonoscopy or both procedures. Polyps and masses (usually cancers) were detected at colonoscopy and CT colonography in 35% and 42% of patients, respectively. Of nine patients with a finaldiagnosis of cancer, eight (89%) were identified by CT colonography as masses (5) or polyps (3). For polyps analyzed according to polyp, the overall sensitivity of CT colonography was 50% (95% CI, 39%-61%) but this increased to 71% (95% CI, 52%-85%) for polyps ≥ 6 mm in size. Similarly, specificity for all polyps was 48% (95% CI, 39%-58%) increasing to 67% (95% CI, 56%-76%) for polyps ≥ 6 mm. Adverse events were uncommon but included one colonic perforation at colonoscopy. Patient acceptance was high for both procedures but preference favoured CT colonography. CONCLUSION: Although CT colonography was more sensitive in this study than in some previous studies, the procedure is not yet sensitive enough for widespread application in symptomatic patients.

关键词： Colorectal polyps Colorectal cancer Computed tomography colonography Colonoscopy

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Stopping Oral Cancer Development——A Question of Risk

Stopping Oral Cancer Development——A Question of Risk

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第十四次中国口腔颌面外科学术会议

作者： peter thomson Oral & Maxillofacial Surgery University of Hong Kong

In the 21st century,oral squamous cell carcinoma(OSCC)remains a lethal and deforming disease,despite real advances in contemporaneous *** order for further improvements in outcome for patients,new approaches to early diagnosis of oral mucosal disease,particularly potentially malignant disorders(PMD),and effective interventional therapies must be targeted to those patients at

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RIGID-PLASTIC/RIGID-VISCOPLASTIC FEM BASED ON LINEAR PROGRAMMING—THEORETICAL MODELING AND APPLICATION FOR AXISYMMETRICAL PROBLEMS

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Chinese Journal of Mechanical Engineering 2001年第2期14卷 184-188页

作者： Xu Weili Shi Xiangchen Lin Zhongqin School of Mechanical Engineering,Shanghai Jiaotong University peter thomson Di Senglin Australia Monash University Australia University of Technology 上海交通大学机械工程学院上海澳大利亚蒙纳西大学澳大利亚澳大利亚悉尼理工大学澳大利亚

Compared with the traditional rigid plastic/rigid viscoplastic(RP/RVP) FEM(based on iteration solution),RP/RVP FEM based on linear programming (LP) has some remarkable advantages,such as it's free of convergence problem and its convenience in contact,rigid zone,and friction force *** numerical model of RP/RVP FEM based on LP for axisymmetrical metal forming simulation is studied,and some related key factors and its treatment methods in formulation of constraint condition are *** solution examples are provided to validate its accuracy and efficiency.

关键词： Rigid plastic/rigid viscoplastic FEM Contact treatment Linear programming

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Association between microsatellite markers and bovine tuberculosis in Chadian Zebu cattle

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Open Journal of Animal Sciences 2013年第1期3卷 27-35页

作者： Abdirahman A. Ali peter C. thomson Haja N. Kadarmideen Division of Genetics and Bioinformatics Department of Veterinary Clinical and Animal Sciences Faculty of Health and Medical Sciences University of Copenhagen Frederiksberg Denmark ReproGen—Animal Bioscience Group Faculty of Veterinary Science University of Sydney Sydney Australia

Bovine tuberculosis (BTB) is a considerable threat to livestock keepers and public health in many developing and underdeveloped countries. We investigated associations between 20 microsatellite markers and three phenotypes for BTB in a sample of the Chadian cattle population. The phenotypes measured were: 1) single intra-dermal comparative cervical tuberculin test (SICCT) performed on live animals, 2) presence of lesion post-slaughter, 3) a bacteriological tissue culture test for Mycobacterium bovis using the samples with observed lesions and 4) a predicted Bayesian model (BM) estimate of a true BTB disease status using all tested animals. All traits were recorded in binary form and as either 1 = presence or 0 = absence. A total of 224 animals for SICCT, lesion and BM traits and 96 animals with bacteriological culture test were genotyped. Generalised linear models were fitted to the binary BTB phenotypes that consisted of age (covariate), sex (2 levels), breed (2 levels) and markers (alleles: 5 - 14 levels) as explanatory variables and implemented in R using glm with a logit link function. The model was fitted for each marker, separately. Six out of 20 markers tested were significantly associated with at least one trait considered;these were ILSTS005, ILSTS006, TGLA227, BM2113 and CSRM66. Genomic regions around these markers may serve as a basis for further functional investigations. This is the first study to report association of microsatellite markers with bovine tuberculosis traits in African or Chadian cattle population.

关键词： Bovine Tuberculosis Breeding Disease-Resistant Cattle Genetic Markers Mycobaterium bovis African Cattle

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Feasibility of confocal endomicroscopy in the diagnosis of pediatric gastrointestinal disorders

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World Journal of Gastroenterology 2009年第18期15卷 2214-2219页

作者： Krishnappa Venkatesh Marta Cohen Clair Evans peter Delaney Steven Thomas Christopher Taylor Ashraf Abou-Taleb Ralf Kiesslich Mike thomson Centre for Pediatric Gastroenterology Sheffield Children's NHS Foundation TrustSheffieldS10 2THUnited Kingdom Department of Histopathology Sheffield Children's NHS Foundation TrustSheffieldS10 2THUnited Kingdom Optiscan PO Box 1066Mt WaverleyMDCVictoriaAustralia 3149Australia I.Med.Klink und Poliklinik Johannes Gutenberg University of MainzMainz 55131Germany

AIM： To evaluate the feasibility and utility of confocal laser endomicroscopy （CLE） in the description of normal gastrointestinal （GI） mucosa and in the diagnosis of GI disorders in children, in comparison to ***： Forty-four patients （19 female） median age 10.9 years （range 0.7-16.6 years） with suspected or known GI pathology underwent esophago-gastro- duodenoscopy （OGD）（n = 36） and/or ileocolonoscopy （IC）（n = 31） with CLE using sodium fluorescein and acriflavine as contrast agents. Histological sections were compared with same site confocal images by two experienced pediatric and GI histopathologists and endoscopists, ***： Duodenum and ileum were intubated in all but one patient undergoing OGD and IC. The median procedure time was 16.4 min （range 7-25 rain） for OGD and 27.9 min （range 15-45 min） for IC. A total of 4798 confocal images were compared with 153 biopsies from the upper GI tract from 36 procedures, and 4661 confocal images were compared with 188 biopsies from the ileocolon from 31 *** images were comparable to conventional histology both in normal and in pathological conditions such as esophagitis, Helicobacter pylori gastritis, celiac disease, inflammatory bowel disease, colonic heterotopia, and graft versus host ***： CLE offers the prospect of targeting biopsies to abnormal mucosa, thereby increasing diagnostic yield, reducing the number of biopsies, decreasing the burden on the histopathological services, and reducing costs.

关键词： Confocal laser endomicroscopy Histology Pediatric Gastrointestinal mucosa Gastrointestinaldisorders

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Mass Transport in Nanowire Synthesis:An Overview of Scalable Nanomanufacturing

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Journal of Materials Science & Technology 2015年第6期31卷 523-532页

作者： Matthew J.Crane peter J.Pauzauskie Department of Chemical Engineering University of WashingtonSeattleWA 98195-1750.USA Department of Materials Science & Engineering Seattle.WA 98195-2120USA Fundamental Computational Science Directorate Pacific Northwest National LaboratoryRichland.WAUSA

The ability to rationally engineer the growth and nanomanufacturing of one-dimensional nanowires in high volumes has the potential to enable applications of nanoscale materials in a diverse range of fields including energy conversion and storage,catalysis,sensing,medicine,and information *** review provides a roadmap for the development of large-scale nanowire *** myriad techniques exist for bench-scale nanowire synthesis,these growth strategies typically fall within two major categories:1) anisotropically-catalyzed growth and 2) confined,template-based ***,comparisons between growth methods with different mass transport pathways have led to confusion in interpreting observations,in particular Gibbs-thomson *** review mass transport in nanowire synthesis techniques to unify growth models and to allow for direct comparison of observations across different *** addition,we discuss the applicability of nanoscale,Gibbs-thomson effects on mass transport and provide guidelines for the development of new growth *** explore the scalability of these complex processes with dimensionless numbers and consider the effects of pressure,temperature,and precursor material on nanowire growth.

关键词： Nanowire Mass transport Modeling Scalable growth

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能说会道劝说的艺术

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丛书名：交往心理译丛

1998年

作者：（英）彼得·汤姆森（peter thomson）李小刚顾黎萍译

本书是通过征引文献中的各类关于辞令言谈的故事来分析说话的艺术，教人在生活交际中如何运用说话策略以保持良好的社交关系及维护正当权益。书中所引事例生动活泼，说理清楚明白，语言通俗，可读性很强，具有较高出版价值。

ISBN: (纸本)7801056647

关键词：言语交往学科:基本知识

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