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Taohong Siwu decoction(桃红四物汤)ameliorates atherosclerosis in rats possibly through toll-like receptor 4/myeloid differentiation primary response protein 88/nuclear factor-κB signal pathway

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Journal of Traditional Chinese Medicine 2024年第1期44卷 103-112页

作者： CHANG Fengjin ZHOU peng LI Guoying ZHANG Weizhi ZHANG Yanyan peng.daiyin CHEN Guangliang Department of Pharmacy the First Affiliated Hospital of Anhui University of Chinese MedicineHefei 230031China School of Integrated Traditional and Western Medicine Anhui University of Chinese MedicineHefei 230012China Anhui Province Key Laboratory of Chinese Medicinal Formula Hefei 230012China School of Pharmacy Anhui University of Chinese MedicineHefei 230012China

OBJECTIVE:To investigate the effect of Taohong Siwu decoction(桃红四物汤,TSD)on atherosclerosis in rats as well as investigate the underlying mechanism based on molecular ***:Sixty healthy male Sprague-Dawley rats were randomly divided into 6 groups with 10 rats in each group:control group,model group,atorvastatin group(AT,2.0 mg/kg),and TSD groups(20,10,5 g/kg)after 7 d of *** model of atherosclerosis was successfully established except the control group by high fat diet(HFD)and vitamin *** analyzers were used to detect the levels of triglyceride(TG),total cholestero(TC),low density lipoprotein-cholesterol(LDLC)and high density lipid-cholesterol(HDL-C)in blood *** levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin-1β(IL-1β)were determined by enzyme-linked immunosorbent *** IV staining and Hematoxylin and eosin staining(HE staining)were performed to observe the pathological changes in aortic *** docking technology was used to predict the best matching between the main components of TSD and the target *** expression of target proteins was further detected by quantitative real time polymerase chain reaction(q RTPCR)and Western blot ***:The results showed that TSD restricted atherosclerosis development and decreased the inflammatory cytokines in *** docking results predicted that the main components of TSD showed a strong binding ability with toll-like receptor(TLR4),myeloid differentiation primary response protein 88(My D88),and nuclear factor kappa-B(NF-κB).The results of q RT-PCR and Western blot analysis showed that the m RNA and protein expressions of TLR4,My D88 and NF-κB p65 in the aorta were reduced in atorvastatin group and TSD ***:TSD can ameliorate atherosclerosis in rats,and the underlying mechanism is supposed be related to the suppression of inflammatory response by regulating TLR4/My D88/NF-κB signal pathway.

关键词： atherosclerosis molecular docking simulation tolllike receptor 4 myeloid differentiation factor 88 NF-kappa B signal transduction Taohong Siwu decoction

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菊资源国内外专利布局现状与开发利用策略

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中草药 2024年第8期55卷 2800-2811页

作者：韦诗冰常相伟吴德玲宿树兰严辉魏丹丹彭代银安徽中医药大学药学院安徽合肥230012 省部共建安徽道地中药材品质提升协同创新中心安徽合肥230012 安徽省中医药科学院药物制剂研究所安徽合肥230012 药物制剂技术与应用安徽省重点实验室安徽合肥230012 现代药物制剂安徽省工程技术研究中心安徽合肥230012 南京中医药大学江苏省中药资源产业化过程协同创新中心江苏南京210023

我国菊资源丰富,花序为其主要药用部位,其种植、采收过程的茎叶及根等非药用部位常被废弃。菊非药用部位同样含有丰富的资源性化学成分,具有多种药理作用,开发利用前景广阔。以国家知识产权局专利数据库和Patsnap专利数据库为数据源,对... 详细信息

我国菊资源丰富,花序为其主要药用部位,其种植、采收过程的茎叶及根等非药用部位常被废弃。菊非药用部位同样含有丰富的资源性化学成分,具有多种药理作用,开发利用前景广阔。以国家知识产权局专利数据库和Patsnap专利数据库为数据源,对菊资源国内外专利进行系统整理分析,从发展趋势、全球分布、申请人构成、技术领域、技术生命曲线、技术生长率及专利质量等多个角度阐述菊资源当前专利的活动特征,揭示菊资源产业发展态势及资源化利用现状。在此基础上,进一步系统梳理菊花及菊非药用部位资源性化学成分特点及其潜在资源价值,并基于循环经济发展理念提出精细高值化、转化增效、粗放低值化及文旅融合特色化的菊资源多元化开发利用策略与途径,为提升菊资源利用效率,延伸菊资源经济产业链,推动碳达峰、碳中和目标实现提供研究思路和理论依据。

关键词：菊菊花资源专利布局非药用部位开发利用策略

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Non-invasive estimation of pulmonary hypertension and clinical deterioration risk in pediatric congenital heart disease:Development and validation of predictive tools

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Chinese Medical Journal 2024年第11期137卷 1384-1386页

作者： Ting Wang Dansha Zhou Yuqin Chen Suhua Kuang Yue Xing Qijian Yi Zhengxia Pan Weibin Xu Jiao Rao Yunqi Liu Guoliang Lu Ziying Lin Xiang Li Yi Xie Yulong Wu peng An Xiaoxiao Deng Jiayue He Jiayi Xie Chenxi Li Gang Geng daiyin Tian Enmei Liu Jingsi Huang Zhou Fu Jian Wang Department of Respiratory Chongqing Higher Institution Engineering Research Center of Children’s Medical Big Data Intelligent ApplicationNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China State Key Laboratory of Respiratory Diseases National Center for Respiratory MedicineGuangdong Key Laboratory of Vascular DiseasesNational Clinical Research Center for Respiratory DiseasesGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouGuangdong 510120China Department of Cardiac Surgery The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouGuangdong 510120China Department of Cardiovascular Medicine Children’s Hospital of Chongqing Medical University National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Thoracic and Cardiac Surgery Children’s Hospital of Chongqing Medical University National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Cardiac Center of Guangdong Women and Children Hospital Guangzhou GuangzhouGuangdong 511400China Department of Guangzhou Laboratory Guangzhou International Bio IslandGuangzhouGuangdong 510005China

To the Editor:Owing to the heterogeneity of congenital heart disease-associated pulmonary hypertension(CHDPH)disease and the development of the pulmonary vascular system in pediatric patients,the management of CHD-PH in children is signicantly different from that in adults.[1]Early identication and intervention of CHD-PH are of great signicance for disease management in children with CHD,and non-invasive,accurate clinical tools are urgently needed to predict PH risk in children with ***,the applicability of the current risk-scoring system to pediatric CHD-PH remains ***,there are presently no user-friendly,non-invasive online tools available for predicting CHD-PH,and there is a scarcity of related studies in Asian *** study aimed to develop and validate the prediction tools for estimating the risk of pulmonary hypertension and clinical deterioration in children with congenital heart disease.

关键词： pediatric congenital hypertension

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基于UPLC-Q-Orbitrap-MS对铁皮石斛水提物不同极性溶剂萃取物化学成分分析

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安徽中医药大学学报 2024年第4期43卷 92-99页

作者：李金淼解会群姚亮韩岚彭代银安徽中医药大学药学院安徽合肥230012 中药资源保护与开发研究所安徽合肥230012 安徽道地中药材品质提升协同创新中心安徽合肥230012 安徽中医药大学药学院现代中药安徽省重点实验室安徽合肥230012

目的建立超高效液相色谱串联—四极杆—静电场轨道阱质谱技术(ultra-performance liquid chromatography-linear ion trap quadrupole-Orbitrap-mass spectrometry,UPLC-Q-Orbitrap-MS)对铁皮石斛(Dendrobium officinale Kimura&Migo)水提物石油醚、乙酸乙酯、正丁醇3种萃取组分进行定性表征的方法。方法提取铁皮石斛水提物并依次用石油醚、乙酸乙酯、正丁醇萃取,旋蒸浓缩后,得到石油醚、乙酸乙酯、正丁醇萃取组分。样品经UPLC-Q-Orbitrap-MS分析,根据元素组成、分子量、质荷比、离子碎片等确定化合物信息并推导裂解规律,通过与文献、MzCloud、MzVault、PudChem、本地数据库比对确定鉴定结果。结果在正负离子模式下共鉴定出化合物62种,包括黄酮类成分20种,联苄类成分6种,羧酸及其衍生物6种,脂肪酸及其衍生物6种,酚类成分4种,氨基酸及其衍生物3种,糖类成分2种,生物碱类、苯丙素、蒽醌、萜类化合物各1种,其他类成分3种,还检测到8种含量较高、质谱信号较强的未知成分。其中水提石油醚萃取物中鉴定出化合物7种,乙酸乙酯萃取物中鉴定出化合物36种,正丁醇萃取物中鉴定出化合物48种。通过与文献比对,62种化合物中有7种化合物为首次从铁皮石斛中提取得到。结论该方法可快速有效分析铁皮石斛中多种化学成分,可为铁皮石斛质量控制及药效物质基础研究提供参考。

关键词：铁皮石斛超高效液相串联—四极杆—静电场轨道阱质谱技术化学成分定性分析

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霍山石斛对脾阴虚型慢性萎缩性胃炎大鼠免疫功能的影响

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安徽中医药大学学报 2024年第2期43卷 67-72页

作者：代玉亭陈佳永胡志华张思雨韩岚彭代银安徽中医药大学药学院安徽合肥230012 中药复方安徽省重点实验室安徽合肥230012 安徽道地中药材品质提升协同创新中心安徽合肥230012

目的探讨霍山石斛对脾阴虚型慢性萎缩性胃炎大鼠免疫功能的影响。方法将36只SD大鼠随机分为正常组,模型组,霍山石斛低、中、高剂量组,每组6只,通过灌服N-甲基-N-硝基-亚硝基胍复合温热药(附子、干姜、肉桂)及劳倦法建立脾阴虚型慢性萎... 详细信息

目的探讨霍山石斛对脾阴虚型慢性萎缩性胃炎大鼠免疫功能的影响。方法将36只SD大鼠随机分为正常组,模型组,霍山石斛低、中、高剂量组,每组6只,通过灌服N-甲基-N-硝基-亚硝基胍复合温热药(附子、干姜、肉桂)及劳倦法建立脾阴虚型慢性萎缩性胃炎大鼠模型。霍山石斛低、中、高剂量组大鼠分别按0.7、1.4、2.8 g/kg灌胃霍山石斛水悬液,正常组和模型组大鼠灌胃等容积生理盐水,持续灌胃21 d。比较各组大鼠的活动情况,体质量变化,脾脏指数和胸腺指数变化,脾脏组织形态学变化,外周血T淋巴细胞亚群、白细胞计数和分类,血清中免疫球蛋白A(immunoglobulin A,IgA)、免疫球蛋白M(immunoglobulin M,IgM)、免疫球蛋白G(immunoglobulin G,IgG),以及血清和胃黏膜组织中白细胞介素-2(interleukin-2,IL-2)、干扰素-γ(interferon-gamma,IFN-γ)、白细胞介素-4(interleukin-4,IL-4)、白细胞介素-10(interleukin-10,IL-10)水平。结果各给药组大鼠脾脏指数和胸腺指数均显著上升(P<0.05);脾脏组织病理状态改善;血清IgA、IgM、IgG水平显著上升(P<0.05);血清和胃黏膜组织IL-2、TNF-γ水平均有不同程度的升高(P<0.05),IL-4和IL-10水平均有不同程度下降(P<0.05)。此外,霍山石斛可提高大鼠外周血白细胞计数、淋巴细胞计数和中性粒细胞计数(P<0.05);能上调外周血中CD3+T淋巴细胞水平、CD4+T淋巴细胞水平、CD4+/CD8+,下调CD8+T淋巴细胞水平(P<0.05)。结论霍山石斛可提高脾阴虚型慢性萎缩性胃炎大鼠的免疫功能。

关键词：慢性萎缩性胃炎脾阴虚免疫功能霍山石斛

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TSC1 enables plastid development under dark conditions, contributing to rice adaptation to transplantation shock

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Journal of Integrative Plant Biology 2018年第2期60卷 112-129页

作者： Xiaoliang Shi Sunlu Chen Yu peng Yufeng Wang Jiugeng Chen Zhanghua Hu Baohe Wang Aihong Li daiyin Chao Yuhong Li Sheng Teng Laboratory of Photosynthesis and Environmental Biology CAS Center for Excellence in Molecular Plant Sciences Shanghai Institute of Plant Physiology and Ecology Chinese Academy of Science National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant Sciences Shanghai Institute of Plant Physiology and Ecology Chinese Academy of Sciences Institute of Virology and Biotechnology Zhejiang Academy of Agricultural Sciences Rice Breeding Center Lixiahe Agricultural Research Institute of Jiangsu Province

Since its domestication from wild rice thousands of years ago, rice has been cultivated largely through transplantation. During transplantation from the nursery to the paddy field, rice seedlings experience transplantation shock which affects their physiology and ***, the mechanisms underlying transplantation shock and rice adaptation to this shock are largely unknown. Here,we isolated a transplant-sensitive chloroplast-deficient（tsc_1）rice mutant that produces albino leaves after *** light from reaching the juvenile leaves and leaf primordia caused chloroplast deficiencies in transplanted tsc_1 seedlings. TSC_1 encodes a noncanonical adenosine triphosphate-binding cassette（ABC） transporter homologous to At NAP_（14） and is of cyanobacterial origin. We demonstrate that TSC_1 controls plastid development in rice under dark conditions, and functions independently of light ***, light rescued the tsc_1 mutant phenotype in a spectrum-independent manner. TSC_1 was upregulated following transplantation, and modulated the iron and copper levels, thereby regulating prolamellar body formation during the early P_4 stage of leaf development. Therefore, TSC_1 is indispensable for plastid development in the absence of light,and contributes to adaptation to transplantation *** study provides insight into the regulation of plastid development and establishes a framework for improving recovery from transplantation shock in rice.

关键词： TSC1 enables plastid development under dark conditions Figure contributing to rice adaptation to transplantation shock

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桃红四物汤对缺血性脑卒中损伤后微小RNA的影响

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安徽中医药大学学报 2024年第4期43卷 70-76页

作者：余超薛苏君张丽娟李雨朦李静静彭代银段贤春安徽中医药大学第一附属医院安徽合肥230031 安徽中医药大学药学院安徽合肥230012 新安医学教育部重点实验室安徽合肥230012

目的研究桃红四物汤(Taohong Siwu Decoction,THSWD)对缺血性脑卒中的微小RNA(microRNA,miRNA)表达谱的影响,探讨THSWD治疗缺血性脑卒中的分子机制。方法建立大脑中动脉闭塞(middle cerebral artery occlusion,MCAO)诱导的局灶性脑缺血大鼠模型,采用单细胞RNA测序技术检测THSWD治疗后MCAO大鼠miRNA表达谱。采用GO和KEGG富集分析方法分析miRNA作用于靶基因的功能。对表达差异显著的miRNA进行RT-qPCR实验验证。结果THSWD干预后,MCAO大鼠脑梗死区有13个miRNA表达发生变化,其中6个miRNA表达上调,7个miRNA表达下调。利用miRanda进行预测,确定了这13个miRNA的靶基因,构建了miRNA-mRNA网络,通过RT-qPCR验证了其中6个差异表达的miRNA(rno-miR-653-5p、rno-miR-216b-5p、rno-miR-3547、rno-miR-217-5p、rno-miR-758-3p和rno-miR-223-3p)。结论THSWD可以通过逆转某些miRNA的异常表达来治疗缺血性脑卒中。

关键词：缺血性脑卒中脑缺血微小RNA 桃红四物汤

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Regulative effect of Taohong Siwu decoction(桃红四物汤) on extracellular matrix of endometrium in drug-induced abortion

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Journal of Traditional Chinese Medicine 2021年第1期41卷 98-106页

作者： WANG Mengmeng GUO Dongdong HAN Lan peng.daiyin CHEN Weidong ZHANG Yanyan Anhui Province Key Laboratory of Chinese Medicinal Formula School of PharmacyAnhui University of Chinese MedicineHefei 230012China Key Laboratory of Xin'an Medicine Ministry of EducationSchool of PharmacyAnhui University of Chinese MedicineHefei 230012China

OBJECTIVE: To explore the effects of Taohong Siwu decoction(桃红四物汤, THSWD) on the extracellular matrix of endometrium in rats following drug-induced ***: Thirty-six pregnant female rats were administered mifepristone and misoprostol to induce abortion, and amounts of uterine bleeding were recorded. Pathological damage and collagen accumulation were detected by hematoxylin-eosin staining and Masson’s trichrome staining in uterus, respectively. Myeloperoxidase was evaluated by *** expression levels of fibronectin, laminin, matrix metalloproteinase 9(MMP-9), and tissue inhibitor of metalloproteinase 1(TIMP-1) were quantified using western ***: THSWD could promote endometrial protection in rats following drug-induced *** contents of cellulose and myeloperoxidase were significantly decreased in uterine tissue of THSWD-treated groups. Moreover, THSWD significantly decreased the expression levels of fibronectin, laminin, and TIMP-1. THSWD also significantly increased MMP-9 expression and the MMP-9/TIMP-1 ***: THSWD plays a critical role in endometrial protection by reducing extracellular matrix deposition and uterine fibrosis. These effects may have been achieved by increasing MMP-9, reducing TIMP-1, and/or altering the ratio of MMP-9/TIMP-1.

关键词： Abortion,induced extracellular matrix endometrium matrix metalloproteinase 9 tissue inhibitor of metalloproteinase-1 Taohong Siwu decoction

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The Partial Chloroplast Genome of <i>Hypericum monogynum</i>L. (Guttiferae)

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American Journal of Plant Sciences 2021年第5期12卷 707-710页

作者： Jing Wu Nianjun Yu daiyin peng Shihai Xing College of Pharmacy Anhui University of Chinese Medicine Hefei China Institute of Traditional Chinese Medicine Resources Protection and Development Anhui Academy of Chinese Medicine Hefei China Synergetic Innovation Center of Anhui Authentic Chinese Medicine Quality Improvement Hefei China Anhui Province Key Laboratory of Research & Development of Chinese Medicine Hefei China

Hypericum monogynum L. is an important medicinal and ornamental plant which belongs to the genus Hypericum in the Guttiferae family. The partial chloroplast genome sequence of H. monogynum has been presented in this study. The assembled partial chloroplast genome (cpDNA) was 120,005 bp in size, with an overall 36.96% GC content. It is 70 genes that are included in the chloroplast genome of Hypericum monogynum in this study, which are consisted of 33 protein-coding genes, 30 transfer RNA genes, as well as 7 ribosomal RNA genes. Phylogenetic analysis with the reported chloroplast genomes revealed that Hypericum monogynum is separated to other species in Guttiferae family, and it might well function as an external group of Guttiferae family.

关键词： Genus Hypericum Phylogenetic Analysis Genome Sequencing

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植物重金属镉积累调控机制及其应用研究进展

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植物生理学报 2024年第2期60卷 185-210页

作者：彭佳师王娅婷王梦琦卢玲丽汪鹏李柱李赛陈思颖孟栓顾天宇徐文忠晁振飞黄煜琪金崇伟晁代印陈彩艳吴龙华滕应赵方杰龚继明湖南科技大学生命科学与健康学院重金属污染土壤生态修复与安全利用湖南省高校重点实验室湖南湘潭411201 中国科学院分子植物科学卓越创新中心植物分子遗传国家重点实验室上海200032 浙江大学环境与资源学院教育部环境修复与生态健康重点实验室杭州310058 南京农业大学资源与环境科学学院作物遗传与种质创新国家重点实验室南京210095 中国科学院南京土壤研究所中国科学院土壤环境与污染修复重点实验室南京210008 中国科学院亚热带农业生态研究所中国科学院亚热带农业生态过程重点实验室长沙410125 湖南农业大学农学院长沙410128 中国科学院植物研究所北方资源植物重点实验室北京100093

镉(Cd)容易通过食物链对人体产生毒害,其引起的“痛痛病”是人类历史上重要的公共卫生事件。Cd是我国当前土壤中的主要无机污染物,“镉大米”等事件仍时有发生,严重威胁粮食安全和人体健康。植物作为初级生产者,是人体Cd暴露的的主要途... 详细信息

镉(Cd)容易通过食物链对人体产生毒害,其引起的“痛痛病”是人类历史上重要的公共卫生事件。Cd是我国当前土壤中的主要无机污染物,“镉大米”等事件仍时有发生,严重威胁粮食安全和人体健康。植物作为初级生产者,是人体Cd暴露的的主要途径。因此,阐释Cd向植物迁移、在植物体内的转运以及植物的Cd耐受机理,并依此指导低Cd作物的遗传改良和Cd污染环境的植物修复就具有重要的意义。本文综述了近10年来人们在植物Cd积累的调控机理、应对Cd污染的作物改良以及植物修复等方面的基础研究和应用成果,同时也探讨了该领域未来亟待解决的一些重要科学问题以及作物遗传改良设计的途径。

关键词：镉低镉作物育种植物修复重金属超积累修复型作物

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