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The In-Flight Realtime Trigger and Localization Software of GECAM

Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： Xiao-Yun Zhao Shao-Lin Xiong Xiang-Yang Wen Xin-Qiao Li Ce Cai Shuo Xiao Qi Luo Wen-Xi peng Dong-Ya Guo zheng-Hua An Ke Gong Jin-Yuan Liao Yan-Qiu Zhang Yue Huang Lu Li Xing Wen Fei Zhang Jing Duan Chen-Wei Wang Dong-Li Shi peng Zhang Qi-Bin Yi Chao-Yang Li Yan-Bing Xu Xiao-Hua Liang Ya-Qing Liu Da-Li Zhang Xi-Lei Sun Fan Zhang Gang Chen Huan-Yu Wang {3. Yang Xiao-Jing Liu Min Gao Mao-Shun Li Jin-Zhou Wang Xing Zhou Yi Zhao Wang-Chen Xue Chao zheng Jia-Cong Liu Xing-Bo Han Jin-Ling Qi Jia Huang Ke-Ke Zhang Can Chen Xiong-Tao Yang Dong-Jie Hou Yu-Sa Wang Rui Qiao Xiang Ma Xiao-Bo Li Ping Wang Xin-Ying Song Li-Ming Song Shi-Jie zheng Bing Li Hong-Mei Zhang Yue Zhu Wei Chen Jian-Jian He zhen Zhang Jin Hou Hong-Jun Wang Yan-Chao Hao Xiang-Yu Wang Zong-Yuan Yang Zhi-Long Wen Zhi Chang Yuan-Yuan Du Rui Gao Xiao-Fei Lan Yan-Guo Li Gang Li Xu-Fang Li Fang-Jun Lu Hong Lu Bin Meng Feng Shi Hui Wang Hui-zhen Wang Yu-peng Xu Jia-Wei Yang Xue-Juan Yang Shuang-Nan Zhang Chao-Yue Zhang Cheng-Mo Zhang Zhi-Cheng Tang Cheng Cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of chinese academy of sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation academy for Microsatellites of CAS Shanghai 201203China Changchun University of Science and Technology Changchun 130022China chinese academy of sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

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SRP54 Negatively Regulates IFN-Beta Production and Antiviral Response by Targeting RIG-I and MDA5

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Virologica Sinica 2021年第2期36卷 231-240页

作者： Dong-peng Wang Hong-Yan Zhang Bo-Wei Liao zhen Tong Zhi-sheng Xu Yan-Yi Wang Yan Yang Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China University of chinese academy of sciences Beijing 100049China

During virus infection,RIG-I-like receptors(RLRs)recognize viral RNAs and recruit the adaptor protein VISA to activate downstream signaling,leading to activation of transcription factors NF-κB and IRF3.which collaborate to induce type I interferons(IFNs).IFNs further induce expression of hundreds of IFN-stimulated genes(ISGs)that suppress viral replication and facilitate the adaptive immune *** production of IFNs is implicated in various immune *** we identified Signal Recognition Particle 54(SRP54)as a negative regulator of RLRs-induced antiviral *** of SRP54 inhibited RNA virus-triggered induction of IFN-b and increased viral replication,whereas knockdown of SRP54 had opposite ***,SRP54 interacted with both RIG-I and MDA5 and impaired their association with *** findings demonstrate that SRP54 acts as a negative regulator of RLRs-mediated innate immune response by disrupting the recruitment of VISA to RIG-I/MDA5.

关键词： TypeⅠinterferons(IFNs) SRP54 RLRs-induced signaling RIG-I/MDA5 and VISA interactions

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Improving winter wheat grain yield and water-/nitrogen-use efficiency by optimizing the micro-sprinkling irrigation amount and nitrogen application rate

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Journal of Integrative Agriculture 2021年第2期20卷 606-621页

作者： LI Jin-peng ZHANG zhen YAO Chun-sheng LIU Yang WANG Zhi-min FANG Bao-ting ZHANG Ying-hua College of Agronomy and Biotechnology China Agricultural UniversityBeijing 100193P.R.China School of Agronomy Anhui Agricultural UniversityHefei 230036P.R.China Wheat Research institute Henan Academy of Agricultural SciencesZhengzhou 450002P.R.China

Available irrigation resources are becoming increasingly scarce in the North china Plain (NCP),and nitrogen-use efficiency of crop production is also relatively ***,it is imperative to improve the water-use efficiency (WUE) and nitrogen fertilizer productivity on the ***,we conducted a two-year field experiment to explore the effects of different irrigation amounts (S60,60 mm;S90,90 mm;S120,120 mm;S150,150 mm) and nitrogen application rates (150,195 and 240 kg ha^(–1);denoted as N1,N2 and N3.respectively) under micro-sprinkling with water and nitrogen combined on the grain yield(GY),yield components,leaf area index (LAI),flag leaf chlorophyll content,dry matter accumulation (DM),WUE,and nitrogen partial factor productivity (NPFP).The results indicated that the GY and NPFP increased significantly with increasing irrigation amount,but there was no significant difference between S120 and S150;WUE significantly increased first but then decreased with increasing irrigation and S120 achieved the highest *** increase in nitrogen was beneficial to improving the GY and WUE in S60 and S90,while the excessive nitrogen application (N3. significantly reduced the GY and WUE in S120 and S150 compared with those in the N2 *** NPFP significantly decreased with increasing nitrogen rate under the same irrigation *** synchronous increase in spike number (SN) and 1 000-grain weight (TWG)was the main reason for the large increase in GY by micro-sprinkling with increasing irrigation,and the differences in SN and TGW between S120 and S150 were *** S60 and S90,the TGW increased with increasing nitrogen application,which enhanced the GY,while N2 achieved the highest TWG in S120 and *** the filling stage,the LAI increased with increasing irrigation,and greater amounts of irrigation significantly increased the chlorophyll content in the flag leaf,which was instrumental in increasing DM after anthesis and increasing the ***-sprinkling with in

关键词： micro-sprinkling irrigation winter wheat grain yield water and nitrogen utilization

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A Localization Method of High Energy Transients for All-sky Gamma-ray Monitor

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Research in Astronomy and Astrophysics 2024年第10期24卷 25-35页

作者： Yi Zhao Wangchen Xue Shaolin Xiong Qi Luo Yuanhao Wang Jiacong Liu Heng Yu Xiaoyun Zhao Yue Huang Jinyuan Liao Jianchao Sun Xiaobo Li Qibin Yi Ce Cai Shuo Xiao shenglun Xie Chao zheng Yanqiu Zhang Chenwei Wang Wenjun Tan Zhiwei Guo Chaoyang Li zhenghua An Gang Chen Yanqi Du Min Gao Ke Gong Dongya Guo Jiang He Jianjian He Bing Li Gang Li Xinqiao Li Jing Liang Xiaohua Liang Yaqing Liu Xiang Ma Rui Qiao Liming Song Xinying Song Xilei Sun Jin Wang Ping Wang Xiangyang Wen Hong Wu Yanbing Xu sheng Yang Dali Zhang Fan Zhang Hongmei Zhang peng Zhang Shu Zhang zhen Zhang Shijie zheng Keke Zhang Xingbo Han Haiyan Wu Hu Tai Hao Geng Gaopeng Lu Wei Xu Fanchao Lyu Hongbo Zhang Fangjun Lu Shuangnan Zhang Department of Astronomy Beijing Normal UniversityBeijing 100875China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of chinese academy of sciences Beijing 100049China School of Physics and Optoelectronics Xiangtan UniversityXiangtan 411105China College of Physics Hebei Normal UniversityShijiazhuang 050024China Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal UniversityGuiyang 550001China School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550001China institute of Astrophysics Central China Normal UniversityWuhan 430079China College of physics sciences Technology Hebei UniversityBaoding 071002China Physics and Space Science College China West Normal UniversityNanchong 637002China School of Computing and Artificial Intelligence Southwest Jiaotong UniversityChengdu 611756China College of Electronic and information Engineering Tongji UniversityShanghai 201804China Innovation academy for Microsatellites of chinese academy of sciences Shanghai 201304China National Space Science Center Chinese Academy of SciencesBeijing 100190China School of Earth and Space sciences University of Science and Technology of ChinaHefei 230026China Electronic Information School Wuhan UniversityWuhan 430072China Key Laboratory of Transportation Meteorology of china Meteorological Administration Nanjing Joint Institute for Atmospheric SciencesNanjing 210000China Key Laboratory of Middle Atmosphere and Global Environment Observation Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

Fast and reliable localization of high-energy transients is crucial for characterizing the burst properties and guiding the follow-up *** based on the relative counts of different detectors has been widely used for all-sky gamma-ray *** are two major methods for this count distribution localization:χ^(2)minimization method and the Bayesian *** we propose a modified Bayesian method that could take advantage of both the accuracy of the Bayesian method and the simplicity of the χ^(2)*** comprehensive simulations,we find that our Bayesian method with Poisson likelihood is generally more applicable for various bursts than the χ^(2)method,especially for weak *** further proposed a location-spectrum iteration approach based on the Bayesian inference,which could alleviate the problems caused by the spectral difference between the burst and location *** method is very suitable for scenarios with limited computation resources or timesensitive applications,such as in-flight localization software,and low-latency localization for rapidly follow-up observations.

关键词： methods:data analysis methods:analytical (stars:)gamma-ray burst:general

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“破溃点”——尸体腐败过程中腹腔自然破裂时刻的实验研究

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中国法医学杂志 2024年第1期39卷 68-74页

作者：赵兴春杨帆胡胜聂昊范佳佳彭真张更谦桂鹏钟增涛公安部鉴定中心北京100038 山西医科大学法医学院山西太原030001 南京农业大学生命科学学院江苏南京210095

目的本文聚焦腐败这一重要晚期尸体现象,以期找到更客观的晚期尸体现象关键事件或特征节点,为准确评估尸体腐败程度、进而推断死亡时间(PMI)提供有力依据。方法本研究通过对晚期尸体现象进行观测,对尸体腐败过程中肠道和尸坑土微生物菌... 详细信息

目的本文聚焦腐败这一重要晚期尸体现象,以期找到更客观的晚期尸体现象关键事件或特征节点,为准确评估尸体腐败程度、进而推断死亡时间(PMI)提供有力依据。方法本研究通过对晚期尸体现象进行观测,对尸体腐败过程中肠道和尸坑土微生物菌群结构变化,以及尸坑土理化性质的检测,从宏观和微观两个层面,分析尸体腐败过程中腹腔自然破裂这一关键事件发生的时刻前后变化。结果研究发现尸体腹腔自然破裂前后,腐败现象和相关微生物菌群结构以及环境理化性质三方面均有显著差异,且可观测性强,可以通过法医学观察、生物学和理化相关检测手段准确判断。本研究将这一关键事件发生时刻命名为“破溃点”。结论本文认为“破溃点”可以作为法医实践中尸体腐败程度评估的重要节点,也可以作为基于微生物菌群结构变化等表征构建PMI推断模型时的分界点,分段构建模型以提升PMI推断模型的准确度。

关键词：破溃晚期腐败微生物组死亡时间推断

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Single-cell transcriptomes reveal molecular specializations of neuronal cell types in the developing cerebellum

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Journal of Molecular Cell Biology 2019年第8期11卷 636-648页

作者： Jian peng Ai-li sheng Qi Xiao Libing Shen Xiang-Chun Ju Min Zhang Si-Ting He Chao Wu zhen-Ge Luo institute of Neuroscience State Key Laboratory of Neuroscience Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences Shanghai 200031 China University of chinese academy of sciences Beijing 100049 China ShanghaiTech University Shanghai 200031 China Co-innovation Center of Neuroregeneration Nantong University Nantong 226000 China

The cerebellum is critical for controlling motor and non-motor functions via cerebellar circuit that is composed of defined cell types, which approximately account for more than half of neurons in mammalsThe molecular mechanisms controlling developmental progression and maturation processes of various cerebellar cell types need systematic investigationHere, we analyzed transcriptome profiles of 21119 single cells of the postnatal mouse cerebellum and identified eight main cell clusters. Functional annotation of differentially expressed genes revealed trajectory hierarchies of granule cells (GCs) at various states and implied roles of mitochondrion and ATPases in the maturation of Purkinje cells (PCs), the sole output cells of the cerebellar cortexFurthermore, we analyzed gene expression patterns and co-expression networks of 28 ataxia risk genes, and found that most of them are related with biological process of mitochondrion and around half of them are enriched in PCs. Our results also suggested core transcription factors that are correlated with interneuron differentiation and characteristics for the expression of secretory proteins in glia cells, which may participate in neuronal modulationThus, this study presents a systematic landscape of cerebellar gene expression in defined cell types and a general gene expression framework for cerebellar development and dysfunction.

关键词： Single-cell transcriptomes molecular specializations neuronal cell

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Improvement of soil fertility and rice yield after long-term application of cow manure combined with inorganic fertilizers

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Journal of Integrative Agriculture 2023年第7期22卷 2221-2232页

作者： GAO peng ZHANG Tuo LEI Xing-yu CUI Xin-wei LU Yao-xiong FAN peng-fei LONG Shi-ping HUANG Jing GAO Ju-sheng ZHANG {3.-hua ZHANG Hui-min College of Resources Hunan Agricultural UniversityChangsha 410128P.R.China institute of Agro-environment and Ecology Hunan Academy of Agricultural SciencesChangsha 410125P.R.China College of Environmental Science and Engineering China West Normal UniversityNanchong 637002P.R.China institute of Nuclear Agriculture Science and Space Breeding Hunan Academy of Agricultural SciencesChangsha 410125P.R.China Qiyang Farmland Ecosystem National Observation and Research Station Institute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural SciencesQiyang 426182P.R.China

Fertilization is an effective technique to improve soil fertility and increase crop *** long-term effects of different fertilizers on soil considerably *** 3. consecutive years of different fertilization positioning experiments in a double cropping rice field of Qiyang Red Soil Experimental Station,seven different fertilization treatments including CK(no fertilization),NPK(nitrogen,phosphorus,and potassium fertilizer),M(cow manure),NPKM(nitrogen,phosphorus,and potassium with cow manure),NPM(nitrogen and phosphorus with cow manure),NKM(nitrogen and potassium with cow manure),and PKM(phosphorus and potassium with cow manure)were applied to study the effects on rice yield,soil fertility,and nutrient apparent balance in a paddy *** results showed that the annual average yields of rice in NPKM,NPM,NKM,PKM,M,NPK and CK treatments ranged from 6214 to 11562 kg *** under long-term organic and inorganic treatments(NPKM,NPM,NKM and PKM)were 22.58,15.3.,10.53.and 4.41%,respectively,greater than under the NPK *** organic carbon(SOC),total nitrogen(TN),available nitrogen(AN)and available potassium(AK)concentration with long-term organic and inorganic treatment(NPKM,NPM,NKM and PKM)were significantly higher than in inorganic fertilizer(NPK)*** total phosphorus(TP)and available phosphorus(AP)contentration with organic fertilizer combined with inorganic N and P fertilizer treatment(NPKM,NPM and PKM)were significantly higher than with inorganic fertilizer alone(NPK treatments).The average annual rice yield(11562 kg ha-1),SOC(20.88 g kg-1),TN(2.3. g kg-1),TP(0.95 g kg-1),TK(22.50 g kg-1)and AP(3..94 mg kg-1)concentrations were the highest in the NPKM *** soil AN concentration(152.40 mg kg-1)and AK contentration(151.00 mg kg-1)were the highest in the NKM treatment.N and P application led to a surplus of nitrogen and phosphorus in the soil,but NPKM treatment effectively reduced the surplus compared with other *** un

关键词： long-term fertilization rice yield soil fertility nutrient balance

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青海西金乌兰还东河中二叠世埃达克岩的发现及其意义

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沉积与特提斯地质 2004年第2期24卷 30-34页

作者：朱迎堂伊海生王强杨延兴郭通珍彭伟成都理工大学沉积地质研究所四川成都610059 中国科学院广州地球化学研究所广东广州510640 青海省地质调查院青海西宁810012

在西金乌兰金沙江缝合带西段还东河发现了中二叠世埃达克岩 ,其岩石类型主要为闪长岩。还东河埃达克岩与Ⅰ类埃达克岩化学成分相近 ,可能是俯冲洋壳熔融形成的产物。还东河埃达克岩的大地构造位置相当于西金乌兰金沙江缝合带西段西金... 详细信息

在西金乌兰金沙江缝合带西段还东河发现了中二叠世埃达克岩 ,其岩石类型主要为闪长岩。还东河埃达克岩与Ⅰ类埃达克岩化学成分相近 ,可能是俯冲洋壳熔融形成的产物。还东河埃达克岩的大地构造位置相当于西金乌兰金沙江缝合带西段西金乌兰段 ,进一步证明了西金乌兰大洋板片向南俯冲消减的重要事实。埃达克岩常与金、银、铜、钼等热液和斑岩矿床密切共生 ,西金乌兰金沙江缝合带东段具有丰富的铜、金等矿产资源 ,这一发现对在该带西段寻找该类矿产提供了一定的理论依据。

关键词：中二叠世埃达克岩西金乌兰青海

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定量血流分数和血流储备分数的诊断一致性和影响因素

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中国介入心脏病学杂志 2024年第9期32卷 481-488页

作者：张瑞涛谢鹏昕田振宇米琳周继升吴本真何立芸郭丽君北京大学第三医院心内科血管医学研究所血管稳态与重构全国重点实验室国家卫生健康委心血管分子生物学与调节肽重点实验室心血管受体研究北京市重点实验室北京100191

目的探讨血流储备分数(FFR)和定量血流分数(QFR)诊断一致性以及影响二者诊断一致性病变的特征。方法回顾分析2019年1月至2021年12月就诊于北京大学第三医院心内科冠状动脉造影狭窄3.%~70%并接受FFR检测的非急性心肌梗死患者。以FFR或QFR... 详细信息

目的探讨血流储备分数(FFR)和定量血流分数(QFR)诊断一致性以及影响二者诊断一致性病变的特征。方法回顾分析2019年1月至2021年12月就诊于北京大学第三医院心内科冠状动脉造影狭窄3.%~70%并接受FFR检测的非急性心肌梗死患者。以FFR或QFR≤0.80为阳性(+),>0.80为阴性(–),将患者分为:诊断一致组(FFR+/QFR+和FFR–/QFR–)、诊断不一致组(FFR+/QFR–和FFR–/QFR+),以FFR为金标准,分析QFR的诊断价值,比较各组之间临床特征及病变特征之间的差异。结果共纳入23.例患者,平均年龄(64.48±9.63.岁,男67.8%。QFR和FFR诊断一致性为184例(78.0%),Person相关系数为0.557(P1)。在FFR+患者中,诊断不一致组中最小管腔直径更大[(1.56±0.3.)mm比(1.3.±0.3.)mm,P=0.019]、病变长度更短[(21.3.±11.73.mm比(3..86±18.09)mm,P1]、冠状动脉造影衍生的微循环阻力指数(AMR)更高[(277.50±28.87)mmHg·s/m比(178.02±49.13.mmHg·s/m,P1]。通过二元Logistic回归分析提示AMR[OR0.93.95%CI0.88~0.99,P=0.03.]和病变长度[OR 1.27,95%CI 1.01~1.60,P=0.045]是诊断不一致独立预测因子。在FFR–组中,诊断不一致组的病变长度更长[(3..08±16.05)mm比(21.40±13.3.)mm,P=0.020],AMR[(169.66±24.01)mmHg·s/m比(265.95±44.78)mmHg·s/m,P1]和低密度脂蛋白胆固醇[1.57(1.10,1.97)mmol/L比2.15(1.79,2.74)mmol/L,P=0.03.]更低。二元Logistic回归分析未发现具有统计学意义变量。结论QFR和FFR具有较高的诊断一致性。在FFR+患者中,AMR和病变长度可能影响QFR和FFR的诊断一致性。

关键词：血流储备分数定量血流分数冠状动脉功能学冠状动脉造影衍生的微循环阻力指数

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Transcriptional activation function of hepatitis B virus Pre S1 protein in yeast

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Hepatobiliary & Pancreatic Diseases International 2003年第2期2卷 563-567页

作者： sheng-Xiang Xiao Xuan-Xian peng Yong-Lie Chu sheng-Bin Xiao Yan-Hong Wu {3.-Ping Cao Laboratory of Molecular Biology Institute of Dermatology Second Hospital Xi'an Jiaotong University Xi'an 710004 China. xiaosx@***

OBJECTIVE: To explore the feasibility of cloning of the hepatocyte receptor interacting with the Pre Slprotein of HBV by two-hybrid ***: Yeast expression plasmids encoding fusion proteins of full length or portions of Pre Sl ofHBV and DNA binding domain of yeast protein GAL4 were constructed and used to transform yeastreporter strain SFY526. Reporter gene product β-galactosidase activity was assayed as a measure oftranscriptional activation in yeast, Mammalian expression plasmid encoding fusion proteins of full lengthPre Sl and DNA binding domain of GAL4 was constructed and used to cotransfect hepatoma cell lineHuh-7 together with CAT reporter plasmid. Cell extracts were assayed for CAT activity by ***: The fusion proteins of full length Pre Sl protein and GAL4 DNA binding domain presentedtranscriptional activation function in yeast. The transcription activating sequence was localized to the 21 to47 amino acids of Pre Sl protein. Fusion proteins of full length Pre Sl and GAL4 DNA binding domaindid not show transcriptional activation function in mammalian ***: The transcription activating sequence of HBV Pre Sl protein in yeast overlaps thehepatocyte receptor binding site. The transcriptional activation function of HBV Pre Sl protein in yeastmay prevent researchers from using yeast two-hybrid system to clone HBV receptor interacting with Pre Slprotein. However, the Pre Sl protein does not show transcriptional activation function in mammaliancells. Mammalian two-hybrid system may be a practical method to clone the HBV hepatocyte receptorinteracting with Pre Sl protein.

关键词： HBV Pre S1 protein transcriptional activation yeast

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