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Modulation of d-orbital to realize enriched electronic cobalt sites in cobalt sulfide for enhanced hydrogen evolution in electrocatalytic water/seawater splitting

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Rare Metals 2024年第2期43卷 511-521页

作者： Jian-peng Sun Yu zheng Zi-sheng Zhang Xiang-Chao Meng Zi-zhen Li Key Laboratory of Marine Chemistry Theory and Technology(Ministry of Education) College of Chemistry and Chemical EngineeringOcean University of ChinaQingdao266100China Shanxi institute of Energy Taiyuan030600China Department of Chemical and Biological Engineering Faculty of EngineeringUniversity of OttawaOttawaONK1N6 N5Canada

Herein,a novel single-atomic Pt doping and interface-rich CoS/Co(OH)_(2)(Pt-CoS/Co(OH)_(2)/C)electrocatalyst has been successfully *** from precise regulation of d-orbital electronic structure modulation on Co site,Pt-CoS/Co(OH)_(2)/C exhibited remarkable HER activity and high stability for hydrogen evolution in splitting both water(73.mV@10 mA·cm^(−2)) and seawater(87 mV@10 mA·cm^(−2)).Notably,atomic Pt doping was introduced into CoS/Co(OH)_(2),which could produce local unbalanced Coulombic force and significantly increased the number of S vacancies,and then expose abundant Co ***,Co(OH)_(2) in Pt-CoS/Co(OH)_(2)/C could act as the adsorption sites for H_(2)O in hydrogen evolution reaction *** functional theory results also proved that atomic Pt doping,S vacancies and Co(OH)_(2) coupling could result in the formation of enriched electronic Co sites and optimize d_(z2) orbital electronic structure,and then realize the depth upward shift of d-band center and enhance the adsorption of H*on Co sites.

关键词： Electrocatalysts Hydrogen evolution reaction Pt-CoS/Co(OH)_(2) d-band center Electronic structure Water/seawater electrolysis

Host cyclophilin A facilitates SARS-CoV-2 infection by binding and stabilizing spike on virions

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Signal Transduction and Targeted Therapy 2024年第1期9卷 36-39页

作者： Xiangpeng sheng Fang Zhu Hong peng Fan Yang Yi Yang Cong Yang {3. Wang Wei Chen Deyin Guo Ronggui Hu State Key Laboratory of Molecular Biology Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghaiChina MOE Key Laboratory of Tropical Disease Control Centre for Infection and Immunity StudySchool of MedicineSun Yat-sen UniversityShenzhenChina ICU Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghaiChina

Dear Editor,The novel coronavirus SARS-CoV-2 rapidly evolutes to increase its infectivity and transmissibility,facilitates its immune escape,impairs vaccine efficacy,and currently causes repeated infections in human,which is mainly determined by the accumulated mutations in spike(S).1 Transmembrane S is a heavily glycosylated protein on the surface of the virion as homotrimer,responsible for binding to human angiotensin-converting enzyme 2(hACE2)receptor.2 While the architecture of S trimers has been well studied,how the stability of S is regulated by potential host factors remains unknown.

关键词： ACE2 vaccine infection

Lymph node-biomimetic scaffold boosts CAR-T therapy against solid tumor

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National Science Review 2024年第4期11卷 206-215页

作者： Ziyan Liao Jie Jiang Wei Wu Jiaqi Shi Yanfang Wang Yuejun Yao Tao sheng Feng Liu Wei Liu peng Zhao Feifei Lv Jie Sun Hongjun Li zhen Gu National Key Laboratory of Advanced Drug Delivery and Release Systems College of Pharmaceutical Sciences Zhejiang University Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang University Liangzhu Laboratory Zhejiang University Bone Marrow Transplantation Center of the First Affiliated Hospital and Department of Cell Biology Zhejiang University School of Medicine Department of Medical Oncology The First Affiliated Hospital School of Medicine Zhejiang University Department of Laboratory Medicine The First Affiliated Hospital Zhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated HospitalSchool of MedicineZhejiang University Jinhua institute of Zhejiang University MOE Key Laboratory of Macromolecular Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang University Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University

The limited infiltration and persistence of chimeric antigen receptor(CAR)-T cells is primarily responsible for their treatment deficits in solid tumors. Here, we present a three-dimensional scaffold, inspired by the physiological process of T-cell proliferation in lymph nodes. This scaffold gathers the function of loading,delivery, activation and expansion for CAR-T cells to enhance their therapeutic effects on solid tumors. This porous device is made from poly(lactic-co-glycolic acid) by a microfluidic technique with the modification of T-cell stimulatory signals, including anti-CD3. anti-CD28 antibodies, as well as cytokines. This scaffold fosters a 50-fold CAR-T cell expansion in vitro and a 15-fold cell expansion in vivo. Particularly, it maintains long-lasting expansion of CAR-T cells for up to 3. days in a cervical tumor model and significantly inhibits the tumor growth. This biomimetic delivery strategy provides a versatile platform of cell delivery and activation for CAR-T cells in treating solid tumors.

关键词： drug delivery cell therapy bioinspired biomaterials cancer immunotherapy

Magnetic-biased chiral molecules enabling highly oriented photovoltaic perovskites

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National Science Review 2024年第2期11卷 221-230页

作者： Jing Chen Caner Deger zhen-Huang Su Kai-Li Wang Guang-peng Zhu Jun-Jie Wu Bing-Chen He Chun-Hao Chen Tao Wang Xing-Yu Gao Ilhan Yavuz Yan-Hui Lou Zhao-Kui Wang Liang-sheng Liao institute of Functional Nano&Soft Materials(FUNSOM) Laboratory of Advanced Negative Carbon TechnologiesSoochow University Department of Physics Marmara University Shanghai Synchrotron Radiation Facility(SSRF) Shanghai Advanced Research InstituteChinese Academy of Sciences College of Energy Soochow Institute for Energy and Materials Innovations Soochow University Macao institute of Materials Science and Engineering Macau University of Science and Technology

The interaction between sites A, B and X with passivation molecules is restricted when the conventional passivation strategy is applied in perovskite（ABX3. photovoltaics. Fortunately, the revolving A-site presents an opportunity to strengthen this interaction by utilizing an external field. Herein, we propose a novel approach to achieving an ordered magnetic dipole moment, which is regulated by a magnetic field via the coupling effect between the chiral passivation molecule and the A-site（formamidine ion） in *** strategy can increase the molecular interaction energy by approximately four times and ensure a well-ordered molecular arrangement. The quality of the deposited perovskite film is significantly optimized with inhibited nonradiative recombination. It manages to reduce the open-circuit voltage loss of photovoltaic devices to 3.0 mV and increase the power conversion efficiency to 25.22%. This finding provides a new insight into the exploration of A-sites in perovskites and offers a novel route to improving the device performance of perovskite photovoltaics.

关键词： perovskite photovoltaics magnetic moment A-site regulation chiral molecules

Novel high-performance element in the electromagnetic finite-element method——node-edge element

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Journal of Systems Engineering and electronics 2008年第5期19卷 878-881页

作者： sheng xinqing peng {3. Center for Electromagnetic Simulation School of Information Science and Technology Beijing Inst. of Technology Beijing 100081 P. R. China

It is known in the computational electromagnetics （CEM） that the node element has a relative wellconditioned matrix, but suffers from the spurious solution problem; whereas the edge element has no spurious solutions, but usually produces an ill-conditioned matrix. Particularly, when the mesh is over dense, the iterative solution of the matrix equation from edge element converges very slowly. Based on the node element and edge element, a node-edge element is presented, which has no spurious solutions and better-conditioned matrix. Numerical experiments demonstrate that the proposed node-edge element is more efficient than now-widely used edge element.

关键词： node-edge element node element edge element matrix condition number.

Textual research of Wudu earthquake in 186 B.C. in Gansu Province, china and discussion on its causative structure

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Acta Seismologica Sinica(English Edition) 2007年第6期20卷 696-707页

作者：袁道阳雷中生何文贵熊振葛伟鹏刘兴旺刘百篪 Lanzhou institute of Seismology China Earthquake Administration Earthquake Administration of Jiangsu Province

On the basis of the textual research on the historical earthquake data and the field investigation of Wudu earthquake occurred in 186 B.C., we suggest that the earthquake parameters drawn from the present earthquake catalogs are not definite and amendments should be made. The heavily-damaged area of this earthquake should be located between Jugan township of Wudu County and Pingding township of Zhouqu County. Its epicenter should be in the vicinity of Lianghekou in Wudu County with a magnitude of about 7-7 1/4 and an intensity of about IX-X. The major axis direction of the heavily-damaged area should be in the WNW direction that is approximately consistent with the strike of the middle-east segment of Diebu-Bailongjiang active fault zone, and the origin time should match up to that of the latest paleoearthquake event [before （83.46） B.C.] obtained by the trench investigation. Certain seismic rupture evidences are still preserved on this fault segment. Therefore, we propose on the basis of comprehensive analysis that the causative structure of the M 7-7 1/4 Wudu earthquake in 186 B.C. should be in the middle-east segment of Diebu-Bailongjiang active fault zone.

关键词： Wudu earthquake in 186 B.C. textual research of historical earthquake causative structure Diebn-Bailongjiang fault zone

光照、水流和养殖密度对史氏鲟稚鱼摄食、行为和生长的影响

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水产学报 2004年第1期28卷 54-61页

作者：李大鹏庄平严安生王明学章龙珍华中农业大学水产学院中国水产科学研究院东海水产研究所中国水产科学研究院东海水产研究所湖北武汉 43.070 上海 200090 中国水产科学研究院长江水产研究所湖北荆州 43.000

研究了光照强度和周期,水流速度,养殖密度对史氏鲟摄食、生长和行为的影响。光照周期在一定的照度和时间范围内对史氏鲟稚鱼的摄食和生长没有显著影响。水流和养殖密度对史氏鲟的生长有着显著的影响。高水流速度和低养殖密度对史氏鲟的... 详细信息

研究了光照强度和周期,水流速度,养殖密度对史氏鲟摄食、生长和行为的影响。光照周期在一定的照度和时间范围内对史氏鲟稚鱼的摄食和生长没有显著影响。水流和养殖密度对史氏鲟的生长有着显著的影响。高水流速度和低养殖密度对史氏鲟的生长有着积极的影响,生长效率、特定生长率和日增重都随流速的增大和养殖密度的降低而增大,条件系数随密度的增大而减小,而净增重随密度的增大而增大,各密度组的史氏鲟稚鱼的生长离散没有加剧。在流速为0.06m·s-1和0.18m·s-1范围内,稚鱼的生长效率（GE）与流速（V）之间存在着显著的正相关关系,其关系式为GE=46.106+142.04V（r=0.5216）。特定生长率（SGR）与养殖密度（SD）之间存在着显著的负相关,其关系式为SGR=4.9728-0.4914SD（r=-0.6553.。3.环境因子对稚鱼的食欲未有明显影响,但饵料转化率会随养殖密度的增大和流速的降低而显著性增大。史氏鲟稚鱼在照度100～1100lx之间的趋光率为49.55％,无显著的趋光性;当亮区照度在13.00lx以上,椎鱼100％避光。处于全黑条件下的稚鱼的体色却普遍变浅,呈灰白色;而另两种光周期条件下的稚鱼体色深黑,全光照条件下的稚鱼体色与自然光周期下的一样。在试验流速范围内,水流刺激还将影响稚鱼的某些行为,在流水环境中稚鱼喜聚集和逆水游?

关键词：史氏鲟光照周期水流速度摄食行为生长

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新能源汽车管理与服务关键技术研究综述

中国公路学报 2024年第3期37卷 82-97页

作者：王震坡张普琛孙逢春张照生刘鹏北京理工大学机械与车辆学院北京100081 北京电动车辆协同创新中心北京100081

随着新能源汽车的推广应用,车辆规模爆发式增长的同时,在新能源汽车的产品端、运行端以及服务端出现了一系列问题:产品质量监管成效低、运行安全管控不精准、公共服务管理不全面。这些问题影响着新能源汽车的安全可靠运行,制约着新能源... 详细信息

随着新能源汽车的推广应用,车辆规模爆发式增长的同时,在新能源汽车的产品端、运行端以及服务端出现了一系列问题:产品质量监管成效低、运行安全管控不精准、公共服务管理不全面。这些问题影响着新能源汽车的安全可靠运行,制约着新能源汽车产业的发展,已经成为了行业的痛点。在汽车数字化的时代背景下,以大数据为核心,推动新能源汽车管理与服务关键技术的发展,是实现新能源汽车安全可靠高效应用、消除消费者安全焦虑、推动产业跨越式发展的必要支撑和保障。为了较为全面地综述该领域的技术水平和创新成果,从新能源汽车质量测评和溯源技术、新能源汽车安全运行管控和充电服务技术、新能源汽车行为分析辨识和碳核算技术3.面详细论述新能源汽车管理与服务关键技术的研究现状,并重点介绍了“运行大数据+”的新能源汽车“质量监管-运行管控-服务管理”技术体系,最后对目前新能源汽车管理与服务关键技术在产品质量监管、运行安全管控以及公共服务管理等方面存在的问题进行总结,对以大数据分析和挖掘为核心的新能源汽车“质量监测-运行管控-服务管理”技术进行展望。该综述可为新能源汽车管理与服务相关技术的进一步提高提供借鉴,也可为未来该领域技术的发展方向提供参考。

关键词：汽车工程新能源汽车综述管理服务质量测评安全监管

Skeletal myogenesis by human embryonic stem cells

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Cell Research 2006年第8期16卷 713-722页

作者： Jun Ke zheng~1 Yi Wang~1 Aditi Karandikar~1 Qian Wang~1 Hui Gai~1 Ai Lian Liu~1 Chao peng~1 Hui zhen {3.~(1,2) ~1Center for Developmental Biology,Xinhua Hospital,School of Medicine,Shanghai Jiao Tong University,1665 Kong Jiang Road,Shanghai 200092,china:~2Laboratory of Stem Cell Biology,institute of Biochemisny and Cell Biology,Shanghai institutes of Biological sciences,chinese academy of sciences,Shanghai 20003.,china CenterforDevelopmentalBiology XinhuaHospitalSchoolofMedicineShanghaiJiaoTongUniversity1665KongJiangRoadShanghai200092China LaboratoryofStemCellBiology InstituteofBiochemistryandCellBiology

We have examined the myogenic potential of human embryonic stem(hES)cells in a xeno-transplantation *** we show that precursors differentiated from hES cells can undergo myogenesis in an adult environmentand give rise to a range of cell types in the myogenic *** study provides direct evidences that hES cells canregenerate both muscle and satellite cells in viro and are another promising cell type for treating muscle degenerativedisorders in addition to other myogenic cell types.

关键词： Skeletal myogenesis embryonic stem cell differentiation