检索结果-南通市图书馆

MC-ICP-MS高阻放大器校正偏移对同位素测试的影响——以汞同位素为例

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

矿物岩石地球化学通报 2024年第1期43卷 140-150页

作者：李鹏飞郑旺孟旭男张立欣孙若愚陈玖斌天津大学地球系统科学学院表层地球系统科学研究院天津300072

增益(Gain)校正有助于消除MC-ICP-MS不同高阻放大器之间的阻值差异,进而提高同位素分析的精度和准确度,但有关Gain的偏移和校正频率对同位素测试的影响和作用原理还缺乏系统认识。本研究结合本实验室Neptune Plus MC-ICP-MS的Gain校正数... 详细信息

增益(Gain)校正有助于消除MC-ICP-MS不同高阻放大器之间的阻值差异,进而提高同位素分析的精度和准确度,但有关Gain的偏移和校正频率对同位素测试的影响和作用原理还缺乏系统认识。本研究结合本实验室Neptune Plus MC-ICP-MS的Gain校正数据,以实际测试的汞同位素数据为例,评估了放大器Gain校正系数偏移对同位素测试的影响。结果显示,当测试标样和样品的校正系数偏移幅度一致时,汞同位素测试结果基本无变化;当偏移幅度存在明显差异且单一放大器校正系数的相对偏移幅度超过–0.070‰~0.058‰时,汞同位素的测试结果大于分析误差。Gain校正系数单日的相对变化幅度(–0.028‰~0.028‰)可保证汞同位素测试结果小于分析误差,但长期的偏移却会导致汞同位素变化远超分析误差。此外,仪器的硬件、温度和真空度等也是Gain校正系数变化的重要影响因素,因此建议定期维护仪器,并每日进行Gain校正,以保证测试结果的稳定和准确。

关键词：多接收电感耦合等离子体质谱仪高阻放大器放大器校正汞同位素

AGV Scheduling Optimization of Automated Port Based on Disruption Management

在线全文

学校读者我要写书评

暂无评论

Journal of Transportation Technologies 2024年第3期14卷 423-444页

作者： Ching-Kuei Kao Qi-Er Ke King-Zoo Tang peng-Jung lin Key Laboratory of LNG Industry Chain Fujian University of Technology Fuzhou China Department of Logistics Management Fujian University of Technology Fuzhou China Department of Information Management Taiwan Chung Cheng University Chiayi Metaverse and New Media College Yango University Fuzhou China

The recent rapid development of China’s foreign trade has led to the significant increase in waterway transportation and automated container ports. Automated terminals can significantly improve the loading and unloading efficiency of container terminals. These terminals can also increase the port’s transportation volume while ensuring the quality of cargo loading and unloading, which has become an inevitable trend in the future development of ports. However, the continuous growth of the port’s transportation volume has increased the horizontal transportation pressure on the automated terminal, and the problems of route conflicts and road locks faced by automated guided vehicles (AGV) have become increasingly prominent. Accordingly, this work takes Xiamen Yuanhai automated container terminal as an example. This work focuses on analyzing the interference problem of path conflict in its horizontal transportation AGV scheduling. Results show that path conflict, the most prominent interference factor, will cause AGV scheduling to be unable to execute the original plan. Consequently, the disruption management was used to establish a disturbance recovery model, and the Dijkstra algorithm for combining with time windows is adopted to plan a conflict-free path. Based on the comparison with the rescheduling method, the research obtains that the deviation of the transportation path and the deviation degree of the transportation path under the disruption management method are much lower than those of the rescheduling method. The transportation path deviation degree of the disruption management method is only 5.56%. Meanwhile, the deviation degree of the transportation path under the rescheduling method is 44.44%.

关键词： Automated Port Disruption Management Automated Guided Vehicle Scheduling Dijkstra Algorithm

高龄非瓣膜性心房颤动患者遗传多态性与利伐沙班出血事件风险的相关性

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华老年心脑血管病杂志 2024年第7期26卷 755-758页

作者：李鹏梁存禹丁欢欢王娟新疆医科大学第五附属医院心内科乌鲁木齐830011

目的探讨高龄非瓣膜性心房颤动患者遗传多态性与利伐沙班出血事件风险的相关性。方法选取2019年6月至2022年6月于新疆医科大学第五附属医院心内科就诊的老年非瓣膜性心房颤动患者180例,所有患者均服用利伐沙班,随访1年,最终纳入167例... 详细信息

目的探讨高龄非瓣膜性心房颤动患者遗传多态性与利伐沙班出血事件风险的相关性。方法选取2019年6月至2022年6月于新疆医科大学第五附属医院心内科就诊的老年非瓣膜性心房颤动患者180例,所有患者均服用利伐沙班,随访1年,最终纳入167例,根据患者是否发生出血事件分为出血组31例和对照组136例。比较2组患者临床资料和遗传多态性,采用多因素logistic回归分析遗传多态性与高龄非瓣膜性心房颤动患者服用利伐沙班发生出血事件的相关性。结果出血组细胞色素氧化酶2C9(CYP2C9)*1、CYP2C9*3、维生素K环氧化物还原酶复合体1(VKORC1)-GG频率高于对照组,CYP2C9*2、VKORC1-AA、VKORC1-AG频率低于对照组(P<0.01)。多因素logistic回归分析显示,CYP2C9*1、CYP2C9*3、VKORC1-GG是高龄非瓣膜性心房颤动患者服用利伐沙班发生出血事件的独立危险因素(OR=1.880,95%CI:1.126~1.997,P=0.030;OR=1.432,95%CI:1.044~1.964,P=0.026;OR=2.176,95%CI:1.173~4.037,P=0.014),CYP2C9*2、VKORC1-AA、VKORC1-AG是高龄非瓣膜性心房颤动患者服用利伐沙班发生出血事件的保护因素。结论 CYP2C9和VKORC1遗传基因的多态性与高龄非瓣膜性心房颤动患者服用利伐沙班发生出血事件显著相关,其中CYP2C9*1、CYP2C9*3、VKORC1-GG基因型是独立危险因素,CYP2C9*2、VKORC1-AA、VKORC1-AG基因型则是保护因素。

关键词：心房颤动基因型利伐沙班出血 CYP2C9基因多态性 VKORC1基因多态性

Prognostic value of neutrophil/lymphocyte,platelet/lymphocyte,lymphocyte/monocyte ratios and Glasgow prognostic score in osteosarcoma:A meta-analysis

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第7期10卷 2194-2205页

作者： li-peng peng Jie li Xian-Feng li Department of Orthopedic The Second People's Hospital of YibinYibin 644000Sichuan ProvinceChina

BACKGROUND Some studies investigated the prognostic role of several blood biomarkers,including the neutrophil/lymphocyte ratio(NLR),platelet/lymphocyte ratio(PLR),lymphocyte/monocyte ratio(LMR)and Glasgow prognostic score(GPS),in osteosarcoma,but their results were inconsistent with each *** To identify the prognostic value of NLR,PLR,LMR and GPS in osteosarcoma patients through reviewing relevant *** The PubMed,EMBASE,Web of Science and CNKI databases were searched up to October 2,*** primary and second outcomes were overall survival(OS)and disease-free survival(DFS),*** hazard ratios(HRs)with 95%confidence intervals(CIs)were combined to assess the association between these indicators and prognosis of osteosarcoma *** A total of 13 studies involving 2087 patients were eventually *** pooled results demonstrated that higher NLR and GPS were significantly associated with poorer OS(HR=1.88,95%CI:1.38-2.55,P<0.001;HR=2.19,95%CI:1.64-2.94,P<0.001)and DFS(HR=1.67,95%CI:1.37-2.04,P<0.001;HR=2.50,95%CI:1.39-4.48,P<0.001).However,no significant relationship of PLR and LMR and OS(P=0.085;P=0.338)and DFS(P=0.396;P=0.124)was *** Higher NLR and GPS were related with worse prognosis and might serve as novel prognostic indicators for osteosarcoma patients.

关键词： Neutrophil/lymphocyte Platelet/lymphocyte Lymphocyte/monocyte ratios Glasgow prognostic score Osteosarcoma Prognosis Meta-analysis

Study on the Mechanism of Glutamine Promoting the Synthesis of Colonic Mucin and Maintaining the Stability of Intestinal Microbiota in Septic Mice

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Yanyan Pan Gang Yang Dan Wu Yan Wei Shijun Fan lin Xia Qian Chen Qianying Huang Yongling Lu Xi peng Clinical Medical Research Center， Southwest Hospital， Third Military Medical University (Army Medical University) Burn Department， Ningbo No.2 Hospital nstitute of Burn Research， State Key Laboratory of Trauma and Chemical Poisoning， Southwest Hospital， Third Military Medical University (Army Medical University)

Colonic mucus and gut microbiota closely linked through mutual regulatory effect. While their alterations during sepsis and whether glutamine can maintain the colonic mucus barrier and gut microbiota stability are unclear. Cecal ligation and puncture-induced sepsis in mice was utilized to observe changes in colonic mucus， gut microbiota， and their interaction with glutamine intervention. Our findings indicated that glutamine mitigated sepsis-induced intestinal damage and restores colonic mucus barrier function by augmenting mucin synthesis. Further analysis revealed that goblet cells were under oxidative stress after sepsis， resulting in anterior gradient-2 (AGR2)， the key mucin-modifying enzyme， being dissynthesized， and inhibiting mucin2 (MUC2) maturation. glutamine could ameliorates this situation by promoting the key enzyme glucose-6-phosphate dehydrogenase (G6PD) glycosylation in the pentose phosphate pathway， increasing the reduced nicotinamide adenine dinucleotide phosphate (NADPH) synthesis， reducing endoplasmic reticulum stress， and accelerating AGR2 synthesis and MUC2 maturation. Additionally， glutamine aided in maintaining gut microbiota stability during sepsis， up-regulating mucin-associated bacteria such as Akkermansia and Alistipes. These bacteria， intimately linked to mucin synthesis and degradation， may impact intestinal mucus stability. In conclusion， glutamine can maintain goblet cell redox balance， promotes AGR2 synthesis and MUC2 maturation， shields the mucus barrier， and potentially maintains gut microbiota stability by regulating the interaction between bacteria and mucus， thus alleviating sepsis-induced intestinal damage.

关键词：

Identification of SSR markers linked to the abscission of cotton boll traits and mining germplasm in Cotton

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Cotton Research 2024年第2期7卷 177-187页

作者： SHUI Guangling liN Hairong MA Xiaomei ZHU Bo HAN peng AINI Nurimanguli GUO Chunping WU Yuanlong PAN Zhenyuan YOU Chunyuan SONG Guoli NIE Xinhui Key Laboratory of Oasis Ecology Agricultural of Xinjiang Bingtuan Agricultural CollegeShihezi UniversityShiheziXinjiang 832003China Cotton Institute Xinjiang Academy of Agriculture and Reclamation ScienceShiheziXinjiang 832000China Agricultural Science Research Institute of the 5th Division of Xinjiang Production and Construction Corps ShuangheXinjiang 833408China Modern Agricultural College Kashi UniversityKashiXinjiang 844000China National Key Laboratory of Crop Genetic Improvement College of Plant Sciences&TechnologyHuazhong Agricultural UniversityWuhanHubei 430070China National Key Laboratory of Cotton Bio‑Breeding and Integrated Utilization Institute of Cotton ResearchChinese Academy of Agricultural SciencesAnyangHenan 455000China

Background Cotton is an economically important *** is crucial to find an effective method to improve cotton yield,and one approach is to decrease the abscission of cotton bolls and ***,the lack of knowledge of the genetic and molecular mechanisms underlying cotton boll abscission traits has hindered genetic *** Pearson’s correlation analysis revealed a significant positive correlation between boll abscission rates 1(AR1)and boll abscission rates 2(AR2).A genome-wide association study was conducted on 145 loci that exhibited high polymorphism and were uniformly distributed across 26 chromosomes(pair).The study revealed 18,46,and 62 markers that were significantly associated with boll abscission,fiber quality,and yield traits(Plity *** of the marker loci identified in this study had been previously *** on phenotypic effects,six typical cultivars with elite alleles related to cotton boll abscission,fiber quality,and yield traits were *** cultivars hold great promise for widespread utilization in breeding *** These results lay the foundation for understanding the molecular regulatory mechanism of cotton boll abscission and provide data for the future improvement of cotton breeding.

关键词： SSR Genome wide association studies Abscission Favorable alleles Cotton Genetic improvement

在线全文

学校读者我要写书评

暂无评论

安徽省夜光时空分布和变化特征分析

黑龙江工程学院学报 2024年第1期38卷 38-45页

作者：崔阳彭俊潘志成姚欣滁州学院地理信息与旅游学院安徽滁州239000

夜间灯光影像能够反映地表夜间灯光亮度,从而在一定程度上反映人类活动强度,长时间序列的夜间灯光数据对于经济发展研究具有重要参考价值。以安徽省为研究区,基于时间序列为2012—2020年的NPP-VIIRS夜光遥感影像,利用GIS空间分析、标准... 详细信息

夜间灯光影像能够反映地表夜间灯光亮度,从而在一定程度上反映人类活动强度,长时间序列的夜间灯光数据对于经济发展研究具有重要参考价值。以安徽省为研究区,基于时间序列为2012—2020年的NPP-VIIRS夜光遥感影像,利用GIS空间分析、标准差椭圆和重心迁移轨迹等方法,分析安徽省夜光时空分布和变化特征,并且从时间和空间尺度上研究夜光与GDP的关系。结果表明:安徽省夜光值在时间序列上呈现“先缓慢上升后快速上升”的变化趋势,低光区、中光区和高光区占比不断增加,无光区占比不断减少。安徽省夜光亮度在空间上呈现由中部向南北递减的变化趋势,高光增长区主要分布在皖中地区,低光增长区主要分布在皖北地区,无光区大部分处于皖南地区。安徽省夜光重心均在合肥市,整体呈现向西南方向迁移,且夜光与GDP在时空变化上呈高度正相关。

关键词：安徽省夜光遥感 NPP-VIIRS GIS空间分析

联合检测IL-5、IL-17A、IFN-α诊断慢性阻塞性肺疾病患者急性加重预警诊断模型的建立及临床应用评价

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

中华检验医学杂志 2024年第7期47卷 770-778页

作者：李蕊马锡慧孙玉洁郭宗伟彭聪孔祥瑞韩永张效云肖漓河北北方学院研究生学院张家口075000 解放军总医院第八医学中心、呼吸与危重症医学部研究所、北京市器官移植与免疫调节重点实验室北京100091

目的:建立应用于慢性阻塞性肺疾病(COPD)患者急性加重(AECOPD)的预警诊断模型,为临床提供简便、快速、准确的辅助诊断依据。方法:方法学建立与验证。构建受试者样本库,选取2021年9月10日至2023年7月25日就诊于解放军总医院第八医学中心... 详细信息

目的:建立应用于慢性阻塞性肺疾病(COPD)患者急性加重(AECOPD)的预警诊断模型,为临床提供简便、快速、准确的辅助诊断依据。方法:方法学建立与验证。构建受试者样本库,选取2021年9月10日至2023年7月25日就诊于解放军总医院第八医学中心的COPD患者172例。其中102例为模型建立队列,有稳定期COPD(SCOPD)组49例(男性42例,女性7例),年龄(69.71±11.16)岁、AECOPD组53例(男性49例,女性4例),年龄(72.60±10.19)岁;其余70例为模型验证队列,有SCOPD组35例(男性28例,女性7例),年龄(69.97±10.40)岁、AECOPD组35例(男性33例,女性2例),年龄(71.43±9.67)岁。空腹采集外周血样本,采用流式细胞术检测白细胞介素(IL)-1β、IL-4、IL-5、IL-6、IL-10、IL-17A、干扰素(IFN)-α和肿瘤坏死因子-α(TNF-α)表达水平,通过Mann-Whitney U检验进行差异分析。采用二元logistic回归分析筛选与急性加重期慢阻肺患者的相关危险因素。通过受试者工作特征(ROC)曲线评价模型的诊断效力。结果:模型建立队列中SCOPD组的IL-5[1.64(0.60,2.86)pg/ml]、IL-17A[1.42(0.88,2.29)pg/ml]、IFN-α[0.91(0.59,1.81)pg/ml]低于AECOPD组患者血浆中IL-5[4.68(2.34,9.40)pg/ml,Z=-5.362,P<0.001]、IL-17A[2.33(1.59,4.62)pg/ml,Z=-4.217,P<0.001]、IFN-α[2.83(0.91,3.75)pg/ml,Z=-3.913,P<0.01]水平,SCOPD和AECOPD组间二元logistic回归分析结果显示,IL-5、IL-17A、IFN-α是COPD患者急性加重的独立危险因素(P<0.05),且回归方程为Y=-2.861+0.364×IL-5+0.385×IL-17A+0.445×IFN-α,三者联合检测时曲线下面积(AUC)值可达0.866(P<0.001)。模型验证队列中SCOPD及AECOPD组人群相比,IL-5、IL-17A、IFN-α联合检测AUC为0.858(P<0.001),Kappa值为0.773(P<0.05)。结论:联合检测IL-5、IL-17A、IFN-α对急性加重期COPD患者具有较高的诊断效能,且该联合诊断模型性能可靠、与临床诊断的一致性较好、可行性高,为急性加重期COPD的临床诊断提供了新的潜在工具,具有进一步探索优化及推广应用的价值。

关键词：流式细胞术慢性阻塞性肺疾病急性加重生物标志物诊断

社会工作介入突发公共卫生危机事件的路径探究

在线全文

学校读者我要写书评

暂无评论

大理大学学报 2024年第1期9卷 46-52页

作者：古瑶彭华民郭建宏南京大学社会学院南京210000

探讨社会工作介入突发公共卫生危机事件的路径,对于推动各方力量参与到国家应急救援体系中具有重要意义。基于危机干预理论和生态系统理论,对J省社会工作协会工作人员及各方协调人员进行深度访谈。研究发现,J省社会工作协会调动各方资源... 详细信息

探讨社会工作介入突发公共卫生危机事件的路径,对于推动各方力量参与到国家应急救援体系中具有重要意义。基于危机干预理论和生态系统理论,对J省社会工作协会工作人员及各方协调人员进行深度访谈。研究发现,J省社会工作协会调动各方资源,协助国家共同抗击疫情,其组织方式和行动模式高效且实际,但社会工作介入路径尚存不足,需从微观、中观和宏观角度出发,针对存在的问题进一步完善和改进。

关键词：公共卫生危机社会工作介入路径

维普期刊数据库博看期刊