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Bone biomaterials and interactions with stem cells

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Bone Research 2017年第4期5卷 253-285页

作者： Chengde Gao shuping peng Pei Feng Cijun Shuai State Key Laboratory of High Performance Complex Manufacturing College of Mechanical and Electrical EngineeringCentral South UniversityChangshaChina The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health Xiangya HospitalCentral South UniversityChangshaChina The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Cancer Research InstituteCentral South UniversityChangshaChina Jiangxi University of Science and Technology GanzhouChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceXiangya HospitalCentral South UniversityChangshaChina

Bone biomaterials play a vital role in bone repair by providing the necessary substrate for cell adhesion, proliferation, and differentiation and by modulating cell activity and function. In past decades, extensive efforts have been devoted to developing bone biomaterials with a focus on the following issues：（1） developing ideal biomaterials with a combination of suitable biological and mechanical properties; （2） constructing a cell microenvironment with pores ranging in size from nanoscale to submicro- and microscale; and （3） inducing the oriented differentiation of stem cells for artificial-to-biological transformation. Here we present a comprehensive review of the state of the art of bone biomaterials and their interactions with stem cells. Typical bone biomaterials that have been developed, including bioactive ceramics, biodegradable polymers, and biodegradable metals, are reviewed, with an emphasis on their characteristics and applications. The necessary porous structure of bone biomaterials for the cell microenvironment is discussed, along with the corresponding fabrication methods. Additionally, the promising seed stem cells for bone repair are summarized, and their interaction mechanisms with bone biomaterials are discussed in detail. Special attention has been paid to the signaling pathways involved in the focal adhesion and osteogenic differentiation of stem cells on bone biomaterials. Finally, achievements regarding bone biomaterials are summarized, and future research directions are proposed.

关键词： Bone biomaterials and interactions with stem cells

Nano-SiC reinforced Zn biocomposites prepared via laser melting:Microstructure,mechanical properties and biodegradability

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Journal of Materials Science & Technology 2019年第11期35卷 2608-2617页

作者： Chengde Gao Meng Yao Cijun Shuai shuping peng Youwen Deng State Key Laboratory of High Performance Complex Manufacturing College of Mechanical and Electrical EngineeringCentral South UniversityChangsha 410083China Jiangxi University of Science and Technology Ganzhou 341000China Shenzhen Institute of Information Technology Shenzhen 518172China NHC Key Laboratory of Carcinogenesis and The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Xiangya HospitalCentral South UniversityChangsha 410013China Cancer Research Institute School of Basic Medical SciencesCentral South UniversityChangsha 410011China Department of Emergency The Second Xiangya Hospital of Central South UniversityChangsha 410011China

Zn has been regarded as new kind of potential implant biomaterials due to the desirable biodegradability and good biocompatibility,but the low strength and ductility limit its application in bone *** the present study,nano-SiC was incorporated into Zn matrix via laser melting,aiming to improve the mechanical *** microstructure analysis showed that nano-SiC distributed along Zn grain *** the laser rapid solidification,nano-SiC particles acted as the sites for heterogeneous nucleation,which resulted in the reduction of Zn grain size from 250μm to 15μm with 2 wt%SiC(Zn-2 SiC).Meanwhile,nano-SiC acted as a reinforcer by virtue of Orowan strengthening and dispersion *** a consequence,the nanocomposites showed maximal compressive yield strength(121.8±5.3 MPa)and high microhardness(72.24±3.01 HV),which were increased by 441%and 78%,respectively,compared with pure ***,fracture analysis indicated a more ductile fracture of the nanocomposites after the incorporation of nano-SiC In addition,the nanocomposites presented favorable biocompatibility and accelerated degradation caused by intergranular *** findings suggested that the nano-SiC reinforced Zn biocomposites may be the potential candidates for orthopedic implants.

关键词： Zn Nano-SiC Biocomposites Laser melting Mechanical properties

Magnetostrictive alloys:Promising materials for biomedical applications

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Bioactive Materials 2022年第2期7卷 177-195页

作者： Chengde Gao Zihao Zeng shuping peng Cijun Shuai State Key Laboratory of High Performance Complex Manufacturing College of Mechanical and Electrical EngineeringCentral South UniversityChangsha410083China NHC Key Laboratory of Carcinogenesis The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of EducationSchool of Basic Medical ScienceCentral South UniversityChangsha410078HunanChina School of Energy and Machinery Engineering Jiangxi University of Science and TechnologyNanchang330013China Institute of Bioadditive Manufacturing Jiangxi University of Science and TechnologyNanchang330013China Shenzhen Institute of Information Technology Shenzhen518172China

Magnetostrictive alloys have attracted increasing attention in biomedical applications because of the ability to generate reversible deformation in the presence of external magnetic *** review focuses on the advances in magnetostrictive alloys and their biomedical *** theories of magnetostriction are systematically *** different types of magnetostrictive alloys and their preparation methods are also reviewed in *** magnetostrictive strains and phase compositions of typical magnetostrictive alloys,including iron based,rare-earth based and ferrite materials,are ***,a variety of approaches to preparing rods,blocks and films of magnetostriction materials,as well as the corresponding methods and setups for magnetostriction measurement,are summarized and ***,the interactions between magnetostrictive alloys and cells are analyzed and emphasis is placed on the transduction and transformation process of mechanochemical signals induced by *** latest applications of magnetostrictive alloys in remote microactuators,magnetic field sensors,wireless implantable devices and biodegradable implants are also ***,future research directions of magnetostrictive alloys are prospected with focus on their potential applications in remote cell actuation and bone repair.

关键词： Magnetostriction alloys Magnetostriction theories Preparation techniques Measurement methods Biomedical applications

In-situ deposition of apatite layer to protect Mg-based composite fabricated via laser additive manufacturing

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Journal of Magnesium and Alloys 2023年第2期11卷 629-640页

作者： Youwen Yang Changfu Lu Lida Shen Zhenyu Zhao shuping peng Cijun Shuai Institute of Bioadditive Manufacturing Jiangxi University of Science and TechnologyNanchang 330013China Jiangsu Key Laboratory of Precision and Micro-Manufacturing Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China Shenzhen Institute of Information Technology Shenzhen 518172China NHC Key Laboratory of Carcinogenesis School of basic Medical ScienceCentral South UniversityChangshaHunan 410013China School of energy and machinery engineering Jiangxi University of Science and TechnologyNanchang 330013China State Key Laboratory of High Performance Complex Manufacturing Central South UniversityChangsha 410083China

Biodegradable magnesium(Mg) and its alloy show huge potential as temporary bone substitute due to the favorable biocompatibility and mechanical compatibility. However, one issue deserves attention is the too fast degradation. In this work, mesoporous bioglass(MBG)with high pore volume(0.59 cc/g) and huge specific surface area(110.78 m^(2)/g) was synthesized using improved sol-gel method, and introduced into Mg-based composite via laser additive manufacturing. Immersion tests showed that the incorporated MBG served as powerful adsorption sites, which promoted the in-situ deposition of apatite by successively adsorbing Ca2+and HPO42-. Such dense apatite film acted as an efficient protection layer and enhanced the corrosion resistance of Mg matrix, which was proved by the electrochemical impedance spectroscopy measurements. Thereby, Mg based composite showed a significantly decreased degradation rate of 0.31 mm/year. Furthermore,MBG also improved the mechanical properties as well as cell behavior. This work highlighted the advantages of MBG in the fabrication of Mg-based implant with enhanced overall performance for orthopedic application.

关键词： Laser addictive manufacture Mg-based composite Mesoporous bioglass In-situ deposition Degradation behavior

Dual alloying improves the corrosion resistance of biodegradable Mg alloys prepared by selective laser melting

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Journal of Magnesium and Alloys 2021年第1期9卷 305-316页

作者： Chengde Gao Sheng Li Long Liu Shizhen Bin Youwen Yang shuping peng Cijun Shuai State Key Laboratory of High Performance Complex Manufacturing College of Mechanical and Electrical EngineeringCentral South UniversityChangsha 410083China Jiangxi University of Science and Technology Ganzhou 341000China Department of Oncology Third Xiangya Hospital of Central South UniversityChangsha 410013China NHC Key Laboratory of Carcinogenesis and The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Xiangya HospitalCentral South UniversityChangshaHunan China

Mg alloys have been regarded as revolutionary metallic biomaterials for biodegradable bone implants,but their applications are mainly blocked by the too rapid degradation in physiological *** study explores the dual alloying effects of Mn and/or Sn on the performance of Mg alloys prepared by selective laser *** observed microstructure indicated remarkable refinement of both the grains and intermetallic phases in the Mn-and/or Sn-containing alloys during the rapid solidification ***,approximately a half decrease in corrosion rate was observed for AZ61-0.4Mn-0.8Sn alloy with respect to AZ61 *** improved corrosion behavior was primarily due to the enhanced protective effects of surface layers,in which Mn-and/or Sn-rich phases acted as a helpful barrier against medium penetration and thereby alleviated the current exchange with the *** addition,the solute Mn and/or Sn positively shifted the corrosion potential,which also brought about a better corrosion ***,the strength and hardness of the alloys were also effectively improved and comparable to those of cortical *** could be ascribed to the dissolved Mn and/or Sn atoms and the finely dispersed intermetallic phases,which might cause lattice distortion and precipitation ***,the Mn-and/or Sn-containing alloys showed good cytocompatibility as indicated by the normal morphology and increased viability of MG-63 *** findings suggest that the developed AZ61-Mn-Sn alloy is a promising candidate for biodegradable bone implants.

关键词： Dual alloying Mg alloys Selective laser melting Corrosion resistance Cytocompatibility

A bifunctional bone scaffold combines osteogenesis and antibacterial activity via in situ grown hydroxyapatite and silver nanoparticles

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Bio-Design and Manufacturing 2021年第3期4卷 452-468页

作者： Youwen Yang Yun Cheng Fang Deng Lida Shen Zhenyu Zhao shuping peng Cijun Shuai Institute of Bioadditive Manufacturing Jiangxi University of Science and TechnologyNanchang 330013China Jiangsu Key Laboratory of Precision and Micro-Manufacturing Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China Shenzhen Institute of Information Technology Shenzhen 518172China NHC Key Laboratory of Carcinogenesis School of Basic Medical ScienceCentral South UniversityChangsha 410013China School of Energy and Machinery Engineering Jiangxi University of Science and TechnologyNanchang 330013China State Key Laboratory of High Performance Complex Manufacturing Central South UniversityChangsha 410083China

Hydroxyapatite(HA)nanoparticles and silver(Ag)nanoparticles are expected to enable desirable bioactivity and antibac-terial properties on biopolymer ***,interfacial adhesion between HA/Ag and the biopolymer is poor due to the large physicochemical differences between these *** this study,poly L-lactic acid(PLLA)powder was first surface-modified with bioactive polydopamine(PDA)in an alkaline ***,HA and Ag nanoparticles were grown in situ on the PDA-coated PLLA powder,which was then adhered to the porous bone scaffold using a selective laser-sintering *** showed that HA and Ag nanoparticles were homogenously distributed in the matrix,with enhanced mechanical *** body fluid bioactivity tests showed that the in situ grown HA-endowed scaffold shows excellent *** vitro tests confirmed that the scaffold exhibits favorable biocompatibility with human umbilical cord mesenchymal stem cells,as well as strong antibacterial activity against Gram-negative Escherichia ***,in vivo assays indicated that the scaffold promoted bone generation,with a new bone area fraction of 71.8%after 8 weeks’implantation,without inflammation.

关键词： Bone scaffold In situ growth Hydroxyapatite Antibacterial properties Surface modification

Laser additive manufacturing of zinc:formation quality,texture,and cell behavior

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Bio-Design and Manufacturing 2023年第2期6卷 103-120页

作者： Mingli Yang Liuyimei Yang shuping peng Fang Deng Yageng Li Youwen Yang Cijun Shuai Institute of Additive Manufacturing Jiangxi University of Science and TechnologyNanchang 330013China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou 341119China The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Central South UniversityChangsha 410078China NHC Key Laboratory of Carcinogenesis School of Basic Medical ScienceCentral South UniversityChangsha 410013China Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Key Laboratory of Construction Hydraulic Robots of Anhui Higher Education Institutes Tongling UniversityTongling 244061China State Key Laboratory of High Performance Complex Manufacturing Central South UniversityChangsha 410083China

Laser powder bed fusion(LPBF)makes it possible for biodegradable zinc(Zn)to be used to produce customized orthopedic *** this research,we investigate the impact of laser power and scanning speed on the development of surface quality,relative densification,and texture during LPBF of Zn *** laser power was able to decrease melt viscosity and surface tension,which improved the metallurgical bonding between adjacent *** and twisted tracks also became continuous and *** speed could controlmolten-pool temperature to restrain grain natural orientation,achieving various crystal orientations and a weakened ***,it further avoided the thermal expansion and contraction caused by excessive energy storage and accumulation in the matrix,thus reducing the generation of high-dislocation *** a result,by selecting a reasonable laser power and scanning speed,the LPBF parts exhibited a flat surface morphology and a high density over 99.5%.Their average hardness,mechanical strength,and elongation reached 50.2 HV,127.8 MPa,and 7.6%,***,the parts displayed a moderate degradation rate and excellent osteogenic *** these results provide a basis for selecting process parameters to optimize the comprehensive properties of LPBF-processed Zn parts for biodegradable applications.

关键词： Zn implants Additive manufacturing Laser powder bed fusion Formation quality Texture Osteogenic properties

Software-Defined Optical Data Centre Networks

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China Communications 2015年第8期12卷 1-9页

作者： peng shuping GUO Bingli SHU Yi George Zervas Reza Nejabati Dimitra Simeonidou High Performance Networks Group University of Bristol

Based on the analysis of data centre(DC) traffic pattern, we introduced a holistic software-defined optical DC solution. Architecture-on-Demand based hybrid optical switched(OPS/OCS) data centre network(DCN) fabric is introduced, which is able to realise different inter-and intra-cluster configurations and dynamically support diverse traffic in the DC. The optical DCN is controlled and managed by a software-defined networking(SDN) enabled control plane to achieve high programmability. Moreover, virtual data centre(VDC) composition is developed as an application of such softwaredefined optical DC to create VDC slices for different tenants.

关键词： optical data centre (DC) software-defined networking (SDN) virtual data centre(VDC) virtualisation

Accelerated degradation of HAP/PLLA bone scaffold by PGA blending facilitates bioactivity and osteoconductivity

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Bioactive Materials 2021年第2期6卷 490-502页

作者： Cijun Shuai Wenjing Yang Pei Feng shuping peng Hao Pan State Key Laboratory of High Performance Complex Manufacturing College of Mechanical and Electrical EngineeringCentral South UniversityChangsha410083China Institute of Bioadditive Manufacturing Jiangxi University of Science and TechnologyNanchang330013China Shenzhen Institute of Information Technology Shenzhen518172China NHC Key Laboratory of Carcinogenesis School of Basic Medical ScienceCentral South UniversityChangshaHunan410013China School of Energy and Machinery Engineering Jiangxi University of Science and TechnologyNanchang330013China Department of Periodontics&Oral Mucosal Section Xiangya Stomatological HospitalCentral South UniversityChangsha410013China

The incorporation of hydroxyapatite(HAP)into poly-L-lactic acid(PLLA)matrix serving as bone scaffold is expected to exhibit bioactivity and osteoconductivity to those of the living *** too low degradation rate of HAP/PLLA scaffold hinders the activity because the embedded HAP in the PLLA matrix is difficult to contact and exchange ions with body *** this study,biodegradable polymer poly(glycolic acid)(PGA)was blended into the HAP/PLLA scaffold fabricated by laser 3D printing to accelerate the *** results indicated that the incorporation of PGA enhanced the degradation rate of scaffold as indicated by the weight loss increasing from 3.3%to 25.0%after immersion for 28 days,owing to the degradation of high hydrophilic PGA and the subsequent accelerated hydrolysis of PLLA ***,a lot of pores produced by the degradation of the scaffold promoted the exposure of HAP from the matrix,which not only activated the deposition of bone like apatite on scaffold but also accelerated apatite *** tests exhibited a good osteoblast adhesion,spreading and proliferation,suggesting the scaffold provided a suitable environment for cell ***,the scaffold displayed excellent bone defect repair capacity with the formation of abundant new bone tissue and blood vessel tissue,and both ends of defect region were bridged after 8 weeks of implantation.

关键词： PGA HAP/PLLA Scaffold Degradation Bone regeneration