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老年脑梗患者的康复护理及延续护理效果研究

智慧健康 2022年第32期8卷 230-234页

作者：罗娟娟郝环蓝惠兰彭迳英广东省人民医院珠海医院/珠海市金湾中心医院内科广东珠海519015

目的对老年脑梗患者的康复护理以及延续护理效果展开研究。方法选取本院2019年8月-2021年8月收治的100例老年脑梗患者为研究对象,采取随机平均法分为两组,各50例。对照组患者住院期间接受常规康复护理干预,并在对照组患者出院后对患者... 详细信息

目的对老年脑梗患者的康复护理以及延续护理效果展开研究。方法选取本院2019年8月-2021年8月收治的100例老年脑梗患者为研究对象,采取随机平均法分为两组,各50例。对照组患者住院期间接受常规康复护理干预,并在对照组患者出院后对患者展开常规随访,观察组在住院期间接受常规康复护理,患者出院后对患者展开延续护理,对两组护理效果展开对比观察。结果对比发现观察组患者护理后NIHSS、SAS与SDS评分更低,角色功能及生活自理能力评分更高,观察组患者护理后神经功能恢复更好、生活质量更高,心理状态更稳定。结论对老年脑梗患者实施康复训练与延续护理能够有效提升患者生活水平、改善患者精神状态、促进患者病后神经功能的恢复,延续护理在老年脑梗护理中的应用值得推广。

关键词：老年脑梗康复护理延续护理护理效果生活自理能力生活质量

应重视冠脉介入围术期水化预防对比剂急性肾损伤个性化方案

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实用医学杂志 2020年第7期36卷 849-853页

作者：陈竹君魏水生杨辉剑刘勇彭迳英丘伟燕郭照东应明广东省冠心病预防重点实验室心内科广东省心血管研究所广东省人民医院心内科广东医学科学院广州510100

随着介入技术的全面普及,对比剂使用量也呈迅猛增长趋势,对比剂相关急性肾损伤(CA-AKI)的防治将面临严峻挑战。从病理生理机制上分析,对比剂相关急性肾损伤主要包括以下直接和间接肾损伤及血流动力学障碍。首先,在血管内暴露对比剂会导... 详细信息

随着介入技术的全面普及,对比剂使用量也呈迅猛增长趋势,对比剂相关急性肾损伤(CA-AKI)的防治将面临严峻挑战。从病理生理机制上分析,对比剂相关急性肾损伤主要包括以下直接和间接肾损伤及血流动力学障碍。首先,在血管内暴露对比剂会导致短暂的全身血管舒张,导致肾血管床的强烈收缩。肾髓质外血管收缩有较低的基线氧张力,导致氧供需不匹配及肾小管缺血性损伤。第二,对对比剂引起的肾小管上皮细胞有直接毒性作用。再次,对比剂的使用导致活性氧(ROS)的产生,这将加速肾小管细胞损伤。但新近研究表明,未经过精准评估的过量水化策略不但不能有效降低CA-AKI发生率,还会导致严重不良事件发生风险增加。基于以上前景,探索个体化、高效、低成本、易推广的个体化水化治疗方案具有重大临床意义。

关键词：对比剂相关急性肾损伤水化方案个体化

睫状视网膜动脉与视网膜中央动脉阻塞患者中心视力损害的相关性分析

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实用临床医药杂志 2017年第7期21卷 102-104页

作者：彭晶莹张军军蒋小爽李锐锋李玲四川大学华西医院眼科四川成都614000 武警重庆总队医院眼科重庆400061

目的探讨睫状视网膜动脉与视网膜中央动脉阻塞(CRAO)中心视力损害的相关性。方法选取CRAO患者32例(32只眼),回顾性分析所有患者的中心视力与荧光素眼底血管造影(FFA)检查结果,探讨睫状视网膜动脉与中心视力损害程度的相关性。结果 32只... 详细信息

目的探讨睫状视网膜动脉与视网膜中央动脉阻塞(CRAO)中心视力损害的相关性。方法选取CRAO患者32例(32只眼),回顾性分析所有患者的中心视力与荧光素眼底血管造影(FFA)检查结果,探讨睫状视网膜动脉与中心视力损害程度的相关性。结果 32只患眼中,11只眼有睫状视网膜动脉。中心视力检查结果显示,在32只眼中,轻度、中度及重度视力损害分别为10、9和13只眼。有睫状视网膜动脉的CRAO患者和无睫状视网膜动脉的CRAO患者各个程度的中心视力损害比较均有显著差异(P<0.05),且睫状视网膜动脉同CRAO患者患眼的中心视力损害程度具有显著相关性。结论 34.4%的CRAO患者存在睫状视网膜动脉,且睫状视网膜动脉同CRAO患者的中心视力损害程度具有显著相关性。

关键词：睫状视网膜动脉视网膜中央动脉阻塞中心视力相关性

Life cycle assessment of HFC-134a production by calcium carbide acetylene route in China

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Chinese Journal of Chemical Engineering 2022年第2期35卷 236-244页

作者： Suisui Zhang jingying Li Yan Nie Luyao Qiang Boyang Bai Zhiwei peng Xiaoxun Ma School of Chemical Engineering Northwest UniversityXi’an 710069China Chemical Engineering Research Center of the Ministry of Education(MOE)for Advanced Use Technology of Shanbei Energy Xi’an 710069China Shaanxi Research Center of Engineering Technology for Clean Coal Conversion Xi’an 710069China Collaborative Innovation Center for Development of Energy and Chemical Industry in Northern Shaanxi Xi’an 710069China International Scientific and Technological Cooperation Base of the Ministry of Science and Technology(MOST)for Clean Utilization of Hydrocarbon Resources Xi’an 710069China

HFC-134a is a widely used environment-friendly *** present,China is the largest producer of HFC-134a in the *** production of HFC-134a in China mainly adopts the calcium carbide acetylene ***,the production route has high resource and energy consumption and large waste emission,and few of the studies addressed on the environmental performance of its production *** study quantified the environmental performance of HFC-134a production by calcium carbide route via carrying out a life cycle assessment(LCA)using the CML 2001 *** uncertainty analysis by Monte-Carlo simulation was also carried *** results showed that electricity had the most impact on the environment,followed by steam,hydrogen fluoride and chlorine,and the impact of direct CO_(2) emissions in calcium carbide production stage on the global warming effect also could not be ***,the clean energy(e.g.,wind,solar,biomass,and natural gas)was used to replace coal-based electricity and coal-fired steam in this study,showing considerable environmental *** the same time,the use of advanced production technologies could also improve environmental benefits,and the environmental impact of the global warming category could be reduced by 4.1%via using CO_(2) capture and purification *** Chinese database of HFC-134a production established in this study provides convenience for the relevant study of *** the production of HFC-134a,this study helps to better identify the specific environmental hotspots and proposes useful ways to improve the environmental benefits.

关键词： HFC-134a Calcium carbide Life cycle assessment Environmental impact Carbon capture

Applications of magnesium alloys for aerospace:A review

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Journal of Magnesium and Alloys 2023年第10期11卷 3609-3619页

作者： jingying Bai Yan Yang Chen Wen Jing Chen Gang Zhou Bin Jiang Xiaodong peng Fusheng Pan School of Material Science and Engineering Chongqing UniversityChongqing 400044China Beijing Spacecrafts Manufacturing Co. LtdChina Academy of Space TechnologyBeijing 100094China

With the increasingly excellent performance of magnesium alloy materials, magnesium alloys are increasingly widely used under the urgent need for weight reduction in aerospace applications. However, due to the severe aviation environment, the strength, corrosion resistance and electrical conductivity of magnesium alloy materials need to be further improved. Many scholars are committed to studying higher comprehensive mechanical properties. Besides, they have studied surface treatment processes with space application characteristics, such as high emissivity oxidation and high anti-corrosion electroplating. To further improve the safety and reliability of magnesium alloys and expand their applications, this paper discusses several kinds of magnesium alloys and summarizes their research progress. The whole manuscript should be revised by an expert who has more experience on English writing. At the same time, the surface treatments of magnesium alloy materials for aerospace are analyzed. Besides, the application of magnesium alloy in aerospace field is summarized. With the in-depth research of many scholars, the improvement of material properties and the development of surface protection and functional technology, it is believed that magnesium alloys will be used in more and more aerospace applications and make more contributions to the aerospace field.

关键词： Magnesium alloy Aerospace Application Review Surface treatment

Graphitic Carbon Quantum Dots Modified Nickel Cobalt Sulfide as Cathode Materials for Alkaline Aqueous Batteries

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Nano-Micro Letters 2020年第2期12卷 1-18页

作者： Yirong Zhu jingying Li Xiaoru Yun Ganggang Zhao peng Ge Guoqiang Zou Yong Liu Hongshuai Hou Xiaobo Ji College of Metallurgy and Material Engineering Hunan University of TechnologyZhuzhou 412007People’s Republic of China College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083People’s Republic of China State Key Lab of Powder Metallurgy Central South UniversityChangsha 410083People’s Republic of China

Carbon quantum dots(CQDs)as a new class of emerging materials have gradually drawn researchers’concern in recent *** this work,the graphitic CQDs are prepared through a scalable approach,achieving a high yield with more than 50%.The obtained CQDs are further used as structure-directing and conductive agents to synthesize novel N,S-CQDs/NiCo2S4 composite cathode materials,manifesting the enhanced electrochemical properties resulted from the synergistic effect of highly conductive N,S-codoped CQDs offering fast electronic transport and unique micro-/nanostructured NiCo2S4 microspheres with Faradaic redox characteristic contributing large ***,the nitrogen-doped reduced graphene oxide(N-rGO)/Fe2O3 composite anode materials exhibit ultrahigh specific capacity as well as significantly improved rate property and cycle performance originating from the high-capacity prism-like Fe2O3 hexahedrons tightly wrapped by highly conductive N-rGO.A novel alkaline aqueous battery assembled by these materials displays a specific energy(50.2 Wh kg^−1),ultrahigh specific power(9.7 kW kg^−1)and excellent cycling performance with 91.5%of capacity retention at 3 A g^−1 for 5000 *** present research offers a valuable guidance for the exploitation of advanced energy storage devices by the rational design and selection of battery/capacitive composite materials.

关键词： Energy storage Alkaline aqueous batteries Carbon quantum dot Nickel cobalt sulfide

A stepwise-responsive editor integrated with three copper ions for the treatment of oral squamous cell carcinoma

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Nano Research 2024年第6期17卷 5424-5434页

作者： Jinna Ren jingying Hu Fan Dong Yan Xu Yang peng Yuping Qian Guanmeng Zhang Min Wang Yuguang Wang Department of Prosthodontics Hospital of StomatologyJilin UniversityChangchun 130021China Department of General Dentistry II Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China Center of Digital Dentistry Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China Department of Nursing Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China The VIP Department School and Hospital of StomatologyChina Medical UniversityLiaoning Provincial Key Laboratory of Oral DiseasesShenyang 110002China

Cuprotosis,a new type of cell death,provides great opportunities for the treatment of oral squamous cell carcinoma,as nanocarriers of copper ions can induce cuprotosis and immunogenic ***,we studied an editor that enables production of a nanoparticle“storm”in oral squamous cell carcinoma,maximizing the toxic effect of these particles and reprogramming the tumor microenvironment;as a result,T cells and natural killer(NK)cells can infiltrate the tumor microenvironment to activate an antitumor immune *** this basis,the editor can be combined with optical therapy to improve patient *** this study,the metal ratio was regulated in response to the nanocarrier of acid response ***,in the presence of a specific copper ion content,the nanocarrier could change the permeability of the tumor cell *** on these results,the nanoparticles were cracked in an acidic environment and then released copper ***,the nanoparticles contributed to cuprotosis and immunogenic *** addition,the editor could inhibit murine oral cancer 1(MOC1)tumors in C57BL/6 without *** rate of tumor growth inhibition was as high as approximately 80%.This strategy provides a new idea for ***,it can improve the interaction between immunotherapy and the copper-induced death of oral squamous cell *** all,this study will provide a new opportunity for the effective treatment of oral squamous cell carcinoma.

关键词： cuprotosis immunogenic death photothermal therapy tumor microenvironment immunotherapy

Characterization of precipitation in the background of atmospheric pollutants reduction in Guilin: Temporal variation and source apportionment

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Journal of Environmental Sciences 2020年第12期32卷 1-13页

作者： Ling Li Hong Li Liang peng Yongshan Li Yi Zhou Fahe Chai Zhaoyu Mo Zhiming Chen jingying Mao Wenxing Wang State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China College of Chemistry and Chemical Engineering Southwest Petroleum UniversityChengdu 610500China Guilin Environmental Monitoring Center Station Guilin 541002China Scientific Research Academy of Guangxi Environmental Protection Nanning 530022China Institute of Environmental and Climate Research Jinan UniversityGuangzhou 511443China Environmental Research Institute Shandong UniversityQingdao 266237China

Rainfall samples were collected from three observation sites in Guilin from 2013 to 2017, and the chemical composition characteristics of precipitation and the contribution made by different ion sources were analyzed when atmospheric pollutants levels were reduced. The results showed that acid gas emissions and atmospheric pollutant concentrations continued to decline during the study period. However, the change in the volume-weighted mean p H at the three sites suggested that acid rain pollution was not alleviated and began to deteriorate after 2015. The continuing downward trend for alkaline neutralizing ions(Ca^(2+), NH_4^+) in precipitation indicated that the reduction in alkaline neutralizing substances in the atmosphere was an important factor that led to the deterioration in acid rain across Guilin. The principal component analysis and spearman correlation analysis indicated five sources of ions in precipitation. Quantitative assessment of these five sources indicated that fossil fuel combustion contributed the most ions concentration in precipitation at the three sites, followed by agriculture, terrestrial(crustal) sources, marine sources, and biomass burning. Long-distance airflow might affect the acidity, the electrical conductivity(EC), and ion concentrations in precipitation across Guilin. The airflow trajectory from the west and southeast directions corresponded to higher acidity and ion concentrations. According to the current air pollution control strategy planned by Guilin, reducing atmospheric coarse particles and NH_3 at the same time may potentially lead to further deteriorations in acid rain contents. Therefore, Guilin needs to develop more reasonable pollution prevention measures that synergistically control atmospheric pollutants and acid rain pollution.

关键词： Precipitation chemistry Characterization Source contributions Synergistic control Guilin

Molecular characterization,expression patterns,and subcellular localization of a classical and a novel nonclassical MHC class Iαmolecules from Japanese eel Anguilla japonica

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Aquaculture and Fisheries 2023年第2期8卷 108-123页

作者： Jianjun Feng Xinwei peng peng Lin Yilei Wang Ziping Zhang Yuankai Xu pengyun Chen jingying Wu Engineer Research Center of Eel Modern Industry Technology Ministry of EducationXiamen361021China College of Fisheries Jimei UniversityXiamen361021China College of Animal Science Fujian Agriculture and Forestry UniversityFuzhou350002China Ningbo Institute of Oceanography Ningbo315832China

Major histocompatibility complex(MHC)molecules play a critical role in the immune response of vertebrate animals by presenting foreign antigens to T *** this study,we first cloned and identified a classical and a novel nonclassical MHC Iαmolecules from Japanese eel(Anguilla japonica),named as AjMHC I-UBA and AjMHC I-L,*** full-length cDNA of AjMHC I-UBA contains an open reading frame(ORF)of 1047 bp encoding a predicted protein of 348 amino acids,while AjMHC I-L 1089 bp encodes 362 amino *** multiple alignment of the amino acid sequence showed that AjMHC I-UBA and AjMHC I-L consist of an N-terminal MHC I superfamily domain withinα1 andα2 helices,an IgC-MHC Iα3 domain,and a transmembrane region close to the C-terminal,which are similar to other fish and mammal *** polymorphism analysis showed that eight different major alleles of AjMHC I-UBA,named as AjMHC I-UBA*0101~1001,were identified from six Japanese eel ***,a distinguishing signature of the nonclassical L-lineage genes specific motif“HINMTL”,including an N-glycosylation site(NXS/T),was present in theα3 domain of AjMHC I-L *** the predicted three-dimensional structures of AjMHC I-UBA and AjMHC I-L are similar to that of human MHC Iα,phylogenetic analysis showed that these two protein molecules belong to classical MHC I UBA gene of U-lineage and nonclassical MHC I gene of L-lineage,*** real-time polymerase chain reaction(qRT-PCR)analysis revealed that the highest expression of AjMHC I-UBA and AjMHC I-L was found in the intestine and the expression level of AjMHC I-UBA in all of the examined tissues was significantly higher than that of AjMHC *** expressions of AjMHC I-UBA and AjMHC I-L in liver,kidney and spleen were significantly induced following injection with the viral mimic poly I:C,LPS,and Aeromonas hydrophila *** vitro,the AjMHC I-UBA and AjMHC I-L transcripts of Japanese eel liver cells were si

关键词： Anguilla japonica MHC Iα mRNA expression Subcelluar localization