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Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： Yan Li peng hao Hongmei Duan Fei hao Wen Zhao Yudan Gao Zhaoyang Yang Kwok-Fai So Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

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供应链韧性研究进展及其测度方法研究

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南宁师范大学学报（自然科学版） 2025年第1期42卷 48-58页

作者：马小雅徐浩彭俊豪南宁师范大学物流管理与工程学院广西南宁530100

通过文献计量和知识图谱方法,以“供应链韧性”为主题,分别从Web of Science和CNKI数据库中筛选出相关度较高的期刊文献,以“供应链韧性”测度为主题,从Web of Science数据库中筛选相关度较高的期刊文献。通过分析2010年以来国内外相关... 详细信息

通过文献计量和知识图谱方法,以“供应链韧性”为主题,分别从Web of Science和CNKI数据库中筛选出相关度较高的期刊文献,以“供应链韧性”测度为主题,从Web of Science数据库中筛选相关度较高的期刊文献。通过分析2010年以来国内外相关研究,探讨供应链韧性的热点问题、核心领域以及测度方法。研究发现:供应链韧性的热点问题主要聚焦供应链韧性的特性、测度方法、评价指标和影响因素,供应链韧性研究的核心领域则在供应链韧性特性研究、供应链韧性的优化设计以及供应链风险管理;供应链韧性测度的研究热点聚焦供应链韧性测度方法、指标体系、影响因素和供应链特性方面;供应链韧性及其测度的研究均呈现明显的时期特征。通过对测度方法的深入研究分析发现:供应链韧性测度方法包括定性分析、定量分析和综合评价分析,常用的综合评价法涵盖主观和客观权重法,旨在全面评估供应链的抵抗、恢复和适应能力。最后从供应链韧性理论深化和整合方向、供应链韧性测度指标体系构建和方法创新等方面对未来的研究方向进行探讨,以期对后续研究提供一定的指导。

关键词：供应链韧性测度方法评价指标影响因素文献计量知识图谱

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Photocatalytic reduction of CO2 over Sm-doped TiO2 nanoparticles

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Journal of Rare Earths 2020年第12期38卷 1297-1304页

作者： hao peng Ruitang Guo He Lin School of Mechanical and Power Engineering Shanghai Jiaotong UniversityShanghai 200240China College of Energy and Mechanical Engineering Shanghai University of Electric PowerShanghai 200090China Shanghai Engineering Research Center of Power Generation Environment Protection Shanghai 200090China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China

Highly efficient photocatalytic reduction of CO2 is essential for solving the greenhouse effect and energy *** this paper,the Sm-TiO2 nanocomposites were successfully prepared via sol-gel *** CO2 photoreduction activities of synthesized samples were tested under irradiation for 6 h and the results indicate that the 0.5% Sm-TiO2 catalyst has superior performance and *** CO and CH4 yields of0.5% Sm-TiO2 catalyst are 55.47 and 3.82 μmol/g·cat respectively,which are 5.02 and 2.67 times the yield of *** possible mechanism of Sm doped TiO2 was investigated through comprehensive characterization and photoetectrochemical analysis,After the Sm doping,the photo-generated electrons in TiO2 could migrate to Sm 4 f,and some of them can be captured by reducing Sm3+ o Sm2+,which can lower the recombination rate of electron and hole ***,the enhanced photocatalytic performance could be ascribed to large specific surface area,fast separation rate of electron-hole pairs and high visible light *** report provides some meaningful attempts in researching the CO2 photocatalytic reduction.

关键词： Photocatalyst Sm-TiO2 CO2 reduction Electron-hole pairs Rare earths

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Monitoring of renal ischemia reperfusion injury in rabbits by ultrasonic contrast and its relationship with expression of VEGF in renal tissue

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Asian Pacific Journal of Tropical Medicine 2016年第2期9卷 186-190页

作者： peng hao Department of Ultrasound Huai'an First People's Hospital Nanjing Medical University

Objective: To evaluate the renal ischemia reperfusion injury(IRI) in rabbits using the ultrasonic contrast technique and discuss the clinical value of ultrasonic contrast technique in the diagnosis of renal IRI by comparing the time-intensity curve of renal cortex and the expression of vascular endothelial growth factor(VEGF) of renal tissue. Methods: Twenty 3-month-old New Zealand rabbits were randomly divided into 4 groups, namely Ctrl group, IRI-12 h, IRI-24 h and IRI-48 h groups. The two dimensional gray-scale ultrasonography was employed to determine and mark the position of rabbit kidney. Rabbits were given the intraperitoneal anesthesia with 20% urethane with the dosage of 5 m L/kg. The aseptic operation was performed after the local skin disinfection in the area of both kidneys. The right kidney of animals in the control group was excised without any treatment for the left kidney. After excising the right kidney of animals in groups of IRI-12 h, IRI-24 h and IRI-48 h, the aneurysm clip was used to clip the renal pedicle vessel of left kidney, in order to simulate the ischemia. Because of the tissue ischemia, it could be seen that the color of kidney was changed from bright red to dark red, which indicated the successful modeling of ischemia. The aneurysm clip was released after one hour of maintaining the ischemia. Then the kidney turned out to be bright red from dark red, which indicated that the reperfusion was completed. Taking this moment as the time of ischemia reperfusion, the wound was stitched up. A total of 12, 24 and 36 h after the operation, the two-dimensional and color Doppler flow imaging and ultrasonic contrast were employed for the examination. The dynamic changes of ultrasonic contrast were recorded. The quantitative analysis software(Qontra Xt) was adopted to analyze the time-intensity curve of echo at different positions of renal cortex. After the ultrasonic contrast testing, rabbits were put to death. The renal cortex tissue was isolated

关键词： Ischemia reperfusion injury Kidney Ultrasonic contrast VEGF

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Spatial-temporal dynamics of alpine grassland coverage and its response to climate warming in *** Nature Preserve during 2000-2019

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Journal of Mountain Science 2022年第8期19卷 2297-2311页

作者： MA Fei peng Pei-hao College of Earth Sciences Chengdu University of TechnologyChengdu 610059China

The Qinghai-Tibet Plateau(QTP)has the largest and highest alpine grassland ecosystem in the world,which is considered to be the most sensitive and vulnerable ecosystem to climate *** dynamic changes and driving mechanism have always been widely *** Qomolangma National Nature Preserve(QNNP),with the largest altitude difference in the world,was selected as the study area to analyse the spatial-temporal dynamics of grassland coverage and the different characteristics of elevation gradients at the southern slope(SS)and northern slope(NS)with MODIS MOD13Q1 NDVI and MOD11A2 land surface temperature data from 2000to 2019 using the Mann-Kendall trend test and Theil-Sen slope ***,the response mechanism of grassland coverage to climate warming is *** results revealed that from 2000 to 2019,the grassland coverage change in the study area is mainly *** increased area proportion of grassland coverage on the southern slope is significantly higher than that on the northern slope,and the decreased area proportion of grassland coverage on the northern slope is significantly greater than that on the southern *** change characteristics of grassland coverage in the QNNP exhibit an obvious elevation gradient;the higher the elevation,the greater the increased area proportion of grassland coverage,particularly on the *** land surface temperature can be used as a proxy for analysing the temporal and spatial variation trends of air temperature in the *** the increase of the altitude,the land surface temperature rise rate on both the southern slope and northern slope exhibited an increasing trend,and the sensitivity of grassland coverage to temperature rise was higher on the northern *** water condition was the decisive factor for the horizontal and vertical spatial heterogeneity of the dynamic change of grassland coverage,and the melting of glaciers and thawing of permafrost were important sources of water for grassland gro

关键词： Alpine grassland Global warming Vegetation dynamic Elevation gradient Qomolangma

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Smooth interpolation on homogeneous matrix groups for computer animation

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第7期7卷 1168-1177页

作者： LI Jun hao peng-wei Center for Information Science Peking University Beijing 100081 China Department of Computer Science Queen Mary University of London London E1 4NS UK

Homogeneous matrices are widely used to represent geometric transformations in computer graphics, with interpo- lation between those matrices being of high interest for computer animation. Many approaches have been proposed to address this problem, including computing matrix curves from curves in Euclidean space by registration, representing one-parameter curves on manifold by rational representations, changing subdivisional methods generating curves in Euclidean space to corresponding methods working for matrix curve generation, and variational methods. In this paper, we propose a scheme to generate rational one-parameter matrix curves based on exponential map for interpolation, and demonstrate how to obtain higher smoothness from existing curves. We also give an iterative technique for rapid computing of these curves. We take the computation as solving an ordinary differential equation on manifold numerically by a generalized Euler method. Furthermore, we give this algorithm’s bound of the error and prove that the bound is proportional to the shift length when the shift length is sufficiently small. Compared to direct computation of the matrix functions, our Euler solution is faster.

关键词： Computer animation Spline and piecewise polynomial approximation

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Numerical Analysis on Solidification Behavior of Graphene Nanoplatelet Based Nanofluid in Cold Storage Cavity

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Journal of Thermal Science 2022年第4期31卷 1180-1193页

作者： CHEN Chen FENG Shiyu peng hao peng Xiaotian LIU Weihua College ofAerospace Engineering Nanjing University ofAeronautics and Astronautics Nanjing 210016China Institute of Thermal Engineering Shanghai Maritime UniversityShanghai 201306China

Addition of graphene nanoplatelet(GNP)into water is a promising method for improving cold storage system performance,and its application requires comprehensive understanding of solidification behavior of GNP-water *** the present study,the influences of GNP mass concentration,cold storage cavity size and shape on solid-liquid interface evolution,temperature distribution,streamline profile as well as solidification rate are numerically *** enthalpy-porosity technique is adopted to track solid-liquid *** results show that the enhancement effect of GNPs on solidification is mainly reflected in the final stage in which heat conduction is predominant;the solidification occurs at the bottom of cavity in the early stage,and the solid-liquid interface is similar to the shape of cavity itself and then tends to be circular in the middle and final stages respectively;the reduction degree of solidification time reaches 30.1%at GNP mass concentration of 1.2 wt%under present simulation conditions;decreasing cavity size and adopting triangular cavity are beneficial for promoting the solidification,but they will suppress the enhancement effect of GNPs on solidification.

关键词： cavity shape graphene nanofluid phase change material solidification

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Comparative evaluation of three machine learning algorithms on improving orbit prediction accuracy

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Astrodynamics 2019年第4期3卷 325-343页

作者： hao peng Xiaoli Bai Department of Mechanical and Aerospace Engineering RutgersThe State University of New JerseyPiscatawayNJ 08854USA

In this paper,the recently developed machine learning(ML)approach to improve orbit prediction accuracy is systematically investigated using three ML algorithms,including support vector machine(SVM),artificial neural network(ANN),and Gaussian processes(GPs).In a simulation environment consisting of orbit propagation,measurement,estimation,and prediction processes,totally 12 resident space objects(RSOs)in solar-synchronous orbit(SSO),low Earth orbit(LEO),and medium Earth orbit(MEO)are simulated to compare the performance of three ML *** results in this paper show that ANN usually has the best approximation capability but is easiest to overfit data;SVM is the least likely to overfit but the performance usually cannot surpass ANN and ***,the ML approach with all the three algorithms is observed to be robust with respect to the measurement noise.

关键词： resident space objects(RSOs) orbit prediction machine learning(ML) support vector regression artificial neural network(ANN) Gaussian processes(GPs)

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The BP Neural Network’s GA Optimization and Its Realization on MATLAB

The BP Neural Network’s GA Optimization and Its Realization...

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第25届中国控制与决策会议

作者： peng hao-yue School of Management Science and Engineering Shanxi University of Finance and Economics

ISBN: (纸本)9781467355339

Based on the analysis of The BP Neural Network’s structrue and drawbacks, the article uses the Genetic Algorithms to optimize initial weights and thresholds. It still uses function simulation to compare these two neural networks based on the MATLAB. The results show that GA-BP neural networks can reduce the function time and make it more scientific.

关键词： Back-Propagation Genetic Algorithms optimization MATLAB

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The effect of electric charge on the mechanical properties of graphene

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Science China(Physics,Mechanics & Astronomy) 2013年第6期56卷 1148-1156页

作者： hao peng GAO YuanWen ZHOU YouHe Key Laboratory of Mechanics on Disaster and Environment in Western China The Ministry of Education of Chinaand Department of Mechanics and Engineering SciencesCollege of Civil Engineering and MechanicsLanzhou University

The effect of electric charge on the mechanical properties of graphene under tensile loading is investigated by using molecular dynamics method.A modified atomistic moment method based on the classical electrostatics theory is proposed to obtain the distribution of extra charges induced by an external electric field and net electric charges stored in *** electrostatic interactions between charged atoms are calculated using the coulomb *** results show that the Young's modulus and the critical fracture stress under uniaxial tension decrease with the increase of electric potential and net charges on *** failure of graphene induced by electric charges is found to be controlled by charge *** results indicate that the carbon-carbon bonds at the edge of graphene will break first.

关键词： charge distribution fracture mechanism electric charge mechanics

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