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Real-world effectiveness and safety of Janus kinase 1 inhibitors for the treatment of moderate-to-severe atopic dermatitis:a single-center,prospective study in China

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Frontiers of Medicine 2024年第4期18卷 752-756页

作者： Yihui Chen Qiaozhi Cao cong peng Bingjing Zhou Yu Jiang Xiang Chen Jie Li Department of Dermatology Xiangya HospitalCentral South UniversityChangsha410008China Hunan Key Laboratory of Skin Cancer and Psoriasis Xiangya HospitalCentral South UniversityChangsha410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha410008China Furong Laboratory Changsha410008China

Dear Editor,Upadacitinib and abrocitiniboareselective,smallmolecule Janus kinase 1(JAK1)inhibitors approved in China for the treatment of moderate-to-severe atopic dermatitis(AD)[1].The favorable efficacy and tolerable safety of upadacitinib and abrocitinib have been determined in several clinical trials[2-5].However,realworld data,especially in Asian populations,are ***,we conducted a prospective,24-week,real-life observational study to assess the effectiveness and safety of abrocitinib and upadacitinib for the treatment of moderate-to-severe AD in a Chinese patient *** patients with moderate-to-severe AD(IGA score 3-4)in the Department of Dermatology.

关键词： dermatitis prospective treatment

Enhanced cyclic stability of partially disordered spinel cathodes through direct fluorination with gaseous fluorine

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Rare Metals 2024年第4期43卷 1635-1646页

作者： Yong-Nian Ma Ling-Chen Kong Shao-Shan Chen Yong Wang Li-Dong Sun cong peng Meng-Meng Qin Yu Li Wei Feng Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and EngineeringTianjin UniversityTianjin300072China Institute of Advanced Technology and Equipment Beijing University of Chemical TechnologyBeijing100029China

Spinel-type cathodes are considered an optimal substitute for conventional layered oxide cathodes owing to their use of inexpensive and earth-abundant manganese as the redox-active ***,the introduction of cation disorder can effectively suppress the detrimental two-phase reaction to realize high capacities in a wide voltage ***,the continuous capacity decay during cycles has hindered the widespread application of these cathode *** fluorides exhibit excellent electrochemical stability at high voltage;therefore,in this study,the direct F2 gas reaction with a partially disordered spinel cathode(Li_(1.6)Mn_(1.6)O_(3.7)F_(0.3,)LMOF1.6)was initially applied to investigate the impacts of fluorination on the surface structure and electrochemical *** inorganic fluorinated layer,mainly containing LiF,was distributed uniformly on the surface of LMOF1.6nanoparticles after fluorination for an appropriate time without the turbulence caused by the valency of manganese cation,which improved the capacity retention and rate capability by the suppression of structural damage,parasitic reaction,and cation *** LMOF1.6cathode fluorinated for 0.5 h exhibited a capacity of283.6 mAh·g^(-1)at 50 mA·g^(-1)and an enhanced capacity retention of 29.6%after 50 cycles in the voltage range of1.5-4.8 V,as compared to the pristine LMOF1.6 with only27.9%capacity retention.

关键词： Spinel-type cathodes Direct fluorination Capacity retention ability High rate capability

Designing mesostructured iron (Ⅱ) fluorides with a stable in situ polymer electrolyte interface for high-energy-density lithium-ion batteries

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eScience 2024年第1期4卷 132-142页

作者： Lidong Sun Yong Wang Lingchen Kong Shaoshan Chen cong peng Jiahui Zheng Yu Li Wei Feng School of Materials Science and Engineering Tianjin UniversityTianjin 300072PR China Key Laboratory of Advanced Ceramics and Machining Technology Ministry of Education Tianjin 300072PR China

As high-energy cathode materials,conversion-type metal fluorides provide a prospective pathway for developing next-generation lithium-ion ***,they suffer from severe performance decay owing to continuous structural destruction and active material dissolution upon cycling,which worsen at elevated ***,we design a novel FeF2 cathode with in situ polymerized solid-state electrolyte systems to enhance the cycling ability of metal fluorides at 60 *** FeF2 with a mesoporous structure(meso-FeF2)improves Liþdiffusion and relieves the volume change that typically occurs during the alternating conversion *** structural stability of the meso-FeF2 cathode is strengthened by an in situ polymerized solid-state electrolyte,which prevents the pulverization and ion dissolution that are inevitable for conventional liquid *** the double action of this in situ polymerized solid-state electrolyte and the meso-FeF2's mesoporous structure,the active material maintains an intact SEI layer and part of the mesoporous structure after long charge–discharge cycling,showing excellent cycling stability at high temperatures.

关键词： Iron fluorides Lithium-ion batteries In situ polymer electrolyte Mesoporous structure

CD147 Facilitates the Pathogenesis of Psoriasis through Glycolysis and H3K9me3 Modification in Keratinocytes

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Research 2024年第1期2023卷 509-523页

作者： Chao Chen Xiaoqing Yi Panpan Liu Jie Li Bei Yan Detian Zhang Lei Zhu Pian Yu Lei Li Jiaxiong Zhang Yehong Kuang Shuang Zhao Wu Zhu cong peng Xiang Chen Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunanChina National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology ChangshaHunanChina Furong Laboratory ChangshaHunanChina Hunan Key Laboratory of Skin Cancer and Psoriasis Hunan Engineering Research Center of Skin Health and DiseaseXiangya HospitalCentral South UniversityChangshaHunanChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunanChina

Psoriasis is a chronic inflammatory skin disease featuring rapid proliferation of epidermal *** elevated glycolysis flux has been reported in psoriasis,the molecular mechanisms underlying its pathogenesis remain *** investigated the role of the integral membrane protein CD147 in psoriasis pathogenesis,observing its high expression in psoriatic skin lesions of humans and imiquimod(IMQ)-induced mouse *** mouse models,genomic deletion of epidermal CD147 markedly attenuated IMQ-induced psoriatic *** found that CD147 interacted with glucose transporter 1(Glut1).Depletion of CD147 in the epidermis blocked glucose uptake and glycolysis in vitro and in *** CD147-knockout mice and keratinocytes,oxidative phosphorylation was increased in the epidermis,indicating CD147's pivotal role in glycolysis reprogramming during pathogenesis of *** non-targeted and targeted metabolic techniques,we found that epidermal deletion of CD147 significantly increased the production of carnitine and α-ketoglutaric acid(α-KG).

关键词： CD147 pathogenesis markedly

Development and Evaluation of a Promising Biomarker for Diagnosis of Latent and Active Tuberculosis Infection

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Infectious Diseases & Immunity 2024年第1期4卷 10-24页

作者： cong peng Fan Jiang Yinping Liu Yong Xue peng Cheng Jie Wang Liang Wang Wenping Gong Hebei North University Zhangjiakou 075000Hebei ProvinceChina Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and Treatment Senior Department of TuberculosisEighth Medical Center of PLA General HospitalBeijing 100091China Department of Geriatrics Eighth Medical Center of PLA General HospitalBeijing 100091China Section of Health No.94804 Unit of the Chinese People's Liberation ArmyShanghai 200434China

Background:Diagnosing latent tuberculosis(TB)infection(LTBI)and active TB(ATB)is crucial for preventing disease progression and ***,current diagnostic tests have limitations in terms of accuracy and sensitivity,making it challenging to diagnose these different infection ***,this study intends to develop a promising biomarker for LTBI and ATB diagnosis to overcome the limitations of the current diagnostic ***:We developed a novelmultiepitope-based diagnostic biomarker(MEBDB)fromLTBI region of differentiation antigens using bioinformatics and *** responses induced byMEBDM were detected using enzyme-linked immunosorbent spot and cytometric bead *** study was conducted from April 2022 to December 2022 in the SeniorDepartment of Tuberculosis at the 8thMedical Center of PLA General Hospital,*** samples were collected from participants with ATB,individuals with LTBI,and healthy controls(HCs).The diagnostic efficacy of MEBDB was evaluated using receiver operating characteristic ***:A novel MEBDB,designated as CP19128P,was ***19128P comprises 19 helper T lymphocyte epitopes,12 cytotoxic T lymphocyte epitopes,and 8 B-cell *** silico simulations demonstrated that CP19128P possesses strong affinity for Toll-like receptors and elicits robust innate and adaptive immune ***19128P generated significantly higher levels of tumor necrosis factor(TNF-α),interleukin 4(IL-4),and IL-10 in ATB patients(n=7)and LTBI(n=8)individuals compared with HCs(n=62)(P<0.001).Moreover,CP19128P-induced specific cytokines could be used to discriminate LTBI and ATB from healthy subjects with high sensitivity and *** IL-2 with IL-4 or TNF-α could differentiate LTBI from HCs(the area under the receiver operating characteristic curve[AUC],0.976[95% confidence interval[CI],0.934-1.000]or 0.986[0.956-1.000]),whereas combining IL-4 with IL-17A or TNF-α could differentiate ATB from

关键词： Tuberculosis Latent tuberculosis infection Active tuberculosis Multiepitope-based diagnostic biomarker Bioinformatics:Immunoinformatics

胃肠道解痉药匹维溴铵对表皮葡萄球菌的体外和体内抗菌活性研究

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中国感染控制杂志 2024年第9期23卷 1077-1083页

作者：彭程彭聪侯正利湖南师范大学附属长沙医院检验科湖南长沙410006 长沙市第四医院检验科湖南长沙410006

目的研究匹维溴铵(PVB)对表皮葡萄球菌(表葡)的体外和体内抗菌活性。方法收集长沙市某医院2022年1-12月住院患者血液分离的表葡。采用微量肉汤稀释试验和纸片扩散法检测表葡对PVB的敏感性,通过时间-杀菌曲线检测PVB抗菌效果的时间和浓... 详细信息

目的研究匹维溴铵(PVB)对表皮葡萄球菌(表葡)的体外和体内抗菌活性。方法收集长沙市某医院2022年1-12月住院患者血液分离的表葡。采用微量肉汤稀释试验和纸片扩散法检测表葡对PVB的敏感性,通过时间-杀菌曲线检测PVB抗菌效果的时间和浓度依赖性,透射电镜观察PVB处理后细菌的超微结构改变,结晶紫染色试验检测PVB对表葡生物膜的抑制和清除效果,采用棋盘稀释法研究PVB与抗菌药物的联合抗菌效果。构建皮肤脓肿感染模型,检测PVB的体内抗菌活性。结果药敏试验结果显示,PVB对表葡标准菌株RP62A、ATCC 12228的最低抑菌浓度(MIC)、最低杀菌浓度(MBC)均分别为8、16μg/mL;对表葡临床菌株的MIC、MBC分别为4~8μg/mL、8~16μg/mL。纸片扩散法结果显示,与未加药的对照组(0.60±0)cm相比,0.2 mg PVB出现明显抑菌圈[(2.26±0.09)cm;t=45.34,P<0.001],且抑菌圈直径随着PVB药量增加而增大。时间-杀菌曲线结果提示,PVB具有杀菌活性,且随着药物浓度和作用时间的增加而增强。透射电镜观察发现PVB可明显破坏表葡的正常结构,导致细菌水肿和裂解。此外,1×MIC的PVB还可显著抑制表葡生物膜的形成,使其生物膜的形成量(A 570 nm)从(2.30±0.18)减少到(0.47±0.11;t=14.85,P<0.001)。同时,1×MIC的PVB还可有效破坏已形成的生物膜,使生物膜的量从(2.64±0.10)减少到(1.77±0.30;t=4.76,P=0.009)。PVB与阿米卡星和庆大霉素联用具有协同抗菌活性,其协同抑菌指数分别为0.50、0.31。动物模型发现10 mg/kg体重的PVB可使脓肿面积从(68.83±10.68)mm 2减少到(35.50±10.58)mm 2(t=6.52,P<0.001),且使脓肿中的活菌量从(6.11±0.55)lg(CFU/脓肿)减少到(3.60±0.34)lg(CFU/脓肿)(t=3.08,P=0.014)。苏木精-伊红染色发现PVB用药组皮肤脓肿中的炎性细胞浸润相比对照组明显减少,趋于正常。结论PVB对表葡具有明显的体外和体内抗菌活性,有望成为表葡相关感染的替代治疗途径。

关键词：匹维溴铵药物重利用表皮葡萄球菌生物膜脓肿感染模型抗菌活性

新媒体下高职院校学生就业与创业能力的培养对策

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湖北开放职业学院学报 2024年第3期37卷 19-21页

作者：彭聪广州城建职业学院广东广州510925

在大众创业、万众创新响应下,职业院校掀起创业热潮,为学生就业创业提供新的思路,也促进学生就业创业技能的提升。但同时,新媒体引发的就业环境的变化,也容易使学生出现浮躁的就业心理,增加学校就业创业指导的难度。对此,本文具体分析... 详细信息

在大众创业、万众创新响应下,职业院校掀起创业热潮,为学生就业创业提供新的思路,也促进学生就业创业技能的提升。但同时,新媒体引发的就业环境的变化,也容易使学生出现浮躁的就业心理,增加学校就业创业指导的难度。对此,本文具体分析新媒体下就业创业指导工作面临的机遇和挑战,积极探索改进的路径,并在实践层面提出具体的实践策略,以期提升学生就业与创业能力,促使学生成功地就业与创业。

关键词：新媒体就业与创业人才培养

面向数字经济的新商科人才数字化能力培养模式探索与实践——以物流管理专业为例

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物流科技 2024年第8期47卷 179-181页

作者：彭聪重庆对外经贸学院跨境商务学院重庆401520

文章分析了数字经济背景下应用型本科院校物流管理专业推进商科人才数字化能力提升的必要性,构建了以数据思维启迪为基础、以业务技能训练为重点、以创新型应用实践为延伸的数字化能力培养模式,并在此过程中采取理论与实践相衔接提升学... 详细信息

文章分析了数字经济背景下应用型本科院校物流管理专业推进商科人才数字化能力提升的必要性,构建了以数据思维启迪为基础、以业务技能训练为重点、以创新型应用实践为延伸的数字化能力培养模式,并在此过程中采取理论与实践相衔接提升学生数据思维、线上与线下相混合淬炼学生业务技能、校内与校外产教研合作打造学生应用创新能力的方法,以实现物流管理专业人才培养与企业数字化转型下的人才需求相契合,旨在推动人才培养质量的不断提升。

关键词：数字经济数字化能力培养模式

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饮水安全工程输配水管道施工技术探讨

湖南水利水电 2024年第1期 21-23页

作者：彭聪娄底市水利水电工程建设有限责任公司湖南娄底417000

随着社会经济的快速发展,人们对饮水安全的重视程度在不断增加,而饮水工程的质量直接影响了人们的饮水安全。采取有效的施工方式来提升饮水工程的施工质量是保障人们饮水安全的关键,文章以某公司南区、北区供水分离移交项目为例对输配... 详细信息

随着社会经济的快速发展,人们对饮水安全的重视程度在不断增加,而饮水工程的质量直接影响了人们的饮水安全。采取有效的施工方式来提升饮水工程的施工质量是保障人们饮水安全的关键,文章以某公司南区、北区供水分离移交项目为例对输配水管道施工技术在饮水安全工程中的应用进行说明。

关键词：饮水安全工程输配水管道施工