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Beamline design for multipurpose muon beams at CSNS EMuS

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Nuclear Science and Techniques 2024年第5期35卷 1-12页

作者： Yang Hong Ying-peng Song Lu-Ping Zhou Jing-Yu tang Zhi-Hao Zhou Nikolaos Vassilopoulos Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China University of chinese academy of sciences Beijing 100049China Radiotherapy Physics and Technology Center Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China Xi’an Jiaotong University Health Science Center Xi’an 710049China Department of Radiation Oncology First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710049China school of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China

A new muon beam facility,called the Experimental Muon Source(EMuS),was proposed for construction at the China Spallation Neutron Source(CSNS).The design of the complex muon beamlines for the EMuS baseline scheme,which is based on superconducting solenoids,superferric dipoles and room-temperature magnets,is presented *** muon beams,including surface muons,decay muons and low energy muons,have been developed for multipurpose *** optics design and simulation results of the trunk beamline and branch beamlines are *** a proton beam power of 25.kW at a standalone target station that consists of a conical graphite target and high-field superconducting solenoids,the muon beam intensity in the trunk beamline varies from 10^(7)/s for surface muons to 10^(10)/s for high-momentum decay *** at the endstations,these values vary from 10^(5./s for surface muons to 10^(8)/s for decay muons.

关键词： Surface muons Decay muons Muon beamline Superconducting solenoids Multi-channel electrostatic separator

fMRI time series analysis based on stationary wavelet and spectrum analysis

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Progress in Natural Science:Materials International 2006年第11期16卷 1171-1176页

作者： ZHI Lianhe~ 1,2,3 , ZHAO Xia~4, SHAN Baoci~1**, peng Silong~5. YAN Qiang~1, YUAN Xiuli~1 and tang Xiaowei~ 1,6 (1. Key Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, chinese academy of sciences, {5. 100049, China 2. graduate school of chinese academy of sciences, {5. 100049, China 3. Department of Physics, Zhoukou Normal University, Zhoukou 466100, China 4. Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas 78229, USA 5. National ASIC Design and Engineering Center, Institute of Automation, chinese academy of sciences, {5. 100049, China 6. Department of Physics, Zhejiang University, Hangzhou 310027, China) Key Laboratory of Nuclear Analysis Techniques Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China

The low signal to noise ratio (SNR) of functional MRI (fMRI) prefers more sensitive data analysis methods. Based on stationary wavelet transform and spectrum analysis, a new method with high detective sensitivity was developed for analyzing fMRI time series, which does not require any prior assumption of the characteristics of noises. In the proposed method, every component of fMRI time series in the different time-frequency scales of stationary wavelet transform was discerned by the spectrum analysis, then the components from noises were removed using the stationary wavelet transform, finally the components of real brain activation were detected by cross-correlation analysis. The results obtained from both simulated and in vivo visual experiments illustrated that the proposed method has much higher sensitivity than the traditional cross-correlation method.

关键词： fMRI stationary wavelet transform spectrum analysis data analysis.

HiFAST:An HIdata calibration and imaging pipeline for FAST

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 182-199页

作者： Yingjie Jing Jie Wang Chen Xu Ziming Liu Qingze Chen Tiantian Liang Jinlong Xu Yixian Cao Jing Wang Huijie Hu Chuan-peng Zhang Qi Guo Liang Gao Mei Ai Hengqian Gan Xuyang Gao Jinlin Han Ligang Hou Zhipeng Hou peng Jiang Xu Kong Fujia Li Zerui Liu Li Shao Hengxing Pan Jun Pan Lei Qian Jinghai Sun Ningyu tang Qingliang Yang Bo Zhang Zhiyu Zhang Ming Zhu National Astronomical Observatories Chinese Academy of SciencesBeijing 100012China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 02206China school of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Guizhou Radio Astronomical Observatory Guizhou UniversityGuiyang 55000China Max Planck Institute for Extraterrestrial Physics Garching 85748Germany Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Institute of Computational Cosmology Department of PhysicsUniversity of DurhamDurham DHI 3LEUK CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Deep Space Exploration Laboratory/Department of Astronomy University of Science and Technology of ChinaHefei 230026China school of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Astrophysics Department of PhysicsUniversity of OxfordOxford OX/3RHUK College of Earth sciences Guilin University of TechnologyGuilin 541004China Department of Physics Anhui Normal UniversityWuhu 241002China school of Astronomy and Space Science Nanjing UniversityNanjing 210023China Key Laboratory of Modern Astronomy and Astrophysics Nanjing UniversityNanjing 20023China

The Five-hundred-meter Aperture Spherical radio Telescope(FAST)has the largest aperture and a 19-beam L-band receiver,making it powerful for investigating the neutral hydrogen atomic gas(HI)in the *** present HiFAST(https://***),a dedicated,modular,and self-contained calibration and imaging pipeline for processing the H?data of *** pipeline consists of frequency-dependent noise diode calibration,baseline fitting,standing wave removal using an FFT-based method,flux density calibration,stray radiation correction,and gridding to produce data *** modules can be combined as needed to process the data from most FAST observation modes:tracking,drift scanning,On-The-Fly mapping,and most of their *** HiFAST,the root-mean-square(RMS)noises of the calibrated spectra from all 19 beams were only slightly(~5.)higher than the theoretical *** results for the extended source M33 and the point sources are consistent with the results from *** moment maps(0,1 and 2)of M33 agree well with the results from the Arecibo Galaxy Environment Survey(AGES)with a fractional difference of less than 10%.For a common sample of 221 sources with signal-to-noise ratio S/N>10 from the Arecibo Legacy Fast ALFA(ALFALFA)survey,the mean value of fractional difference in the integrated flux density,Sint,between the two datasets is approximately 0.005.,with a dispersion of 15.4%.Further checks on the integrated flux density of 23 sources with seven observations indicate that the variance in the flux density of the source with luminous objects(Sint>2.5.Jy km s-1)is less than 5..Our tests suggest that the FAST telescope,with the efficient,precise,and user-friendly pipeline HiFAST,will yield numerous significant scientific findings in the investigation of the H?in the universe.

关键词： fractional luminous correction

Study of proton resonances in ^(18)Ne via resonant elastic scattering of ^(17)F+p and its astrophysical implication

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Science China(Physics,Mechanics & Astronomy) 2011年第S1期54卷 32-36页

作者： HE JianJun1, HU Jun1,2, XU ShiWei1, CHEN ZhiQiang1, ZHANG XueYing1, WANG JianSong1, YU XiangQing1, ZHANG LiYong1,2, LI Long1,2, YANG YanYun1,2, MA peng1,2, ZHANG XueHeng1, HU ZhengGuo1, GUO ZhongYan1, XU Xing1,2, YUAN XiaoHua1, LU Wan1,2, YU YuHong1, ZANG YongDong1,2, tang ShuWen1,2, YE RuiPing1,2, CHEN JinDa1,2, JIN ShiLun1,2, DU ChengMing1,2, WANG ShiTao1,2, MA JunBing1,2, LIU LongXiang1,2, BAI Zhen1,2, LEI XiangGuo1, SUN ZhiYu1, ZHANG YuHu1, ZHOU XiaoHong1, XU HuShan1, SU Jun3, LI ErTao3, WANG HongWei4, TIAN WenDong4 & LI XiangQing5.1 Institute of Modern Physics (IMP), chinese academy of sciences, Lanzhou 730000, China 2 {5. University of chinese academy of sciences, beijing 100049, China 3 China Institute of Atomic Energy (CIAE), beijing 102413, China 4 Shanghai Institute of Applied Physics (SINAP), chinese academy of sciences, Shanghai 201800, China 5.school of Physics and State Key Laboratory of Nuclear Physics and Technology, Peking University, beijing 100871, China Institute of Modern Physics (IMP) Chinese Academy of Sciences Lanzhou China graduate University of chinese academy of sciences Beijing China China Institute of Atomic Energy (CIAE) Beijing China Shanghai Institute of Applied Physics (SINAP) Chinese Academy of Sciences Shanghai China school of Physics and State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China

The proton resonant properties in 18Ne, which determine the reaction rate of the key stellar 14O(α,p)17F reaction, have been studied by using a technique of proton resonant elastic scattering of 17F+p. A 4.22 MeV/nucleon 17F radioactive ion (RI) beam was produced via a projectile-fragmentation reaction, and separated by a Radioactive Ion Beam Line in Lanzhou (RIBLL). By bombarding a thick (CH2)n target, the energy spectra of the recoiled protons were measured by two ΔE-E silicon telescopes at the center-of-mass scattering angles of θc.m.≈175.±5., θc.m.≈15.°±8°, respectively. Several proton resonances in 18Ne were ob served clearly. A further R-matrix analysis of the experimental data is under way to determine the resonant parameters. The present work reports the preliminary results briefly.

关键词： resonant reaction reaction rate explosive burning accreting binary systems

HiFAST:An H?data calibration and imaging pipeline for FAST

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Science China(Physics,Mechanics & Astronomy) 2024年第5期Mechanics & Astronomy) .卷 186-203页

作者： Yingjie Jing Jie Wang Chen Xu Ziming Liu Qingze Chen Tiantian Liang Jinlong Xu Yixian Cao Jing Wang Huijie Hu Chuan-peng Zhang Qi Guo Liang Gao Mei Ai Hengqian Gan Xuyang Gao Jinlin Han Ligang Hou Zhipeng Hou peng Jiang Xu Kong Fujia Li Zerui Liu Li Shao Hengxing Pan Jun Pan Lei Qian Jinghai Sun Ningyu tang Qingliang Yang Bo Zhang Zhiyu Zhang Ming Zhu National Astronomical Observatories Chinese Academy of Sciences Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University school of Astronomy and Space Science University of Chinese Academy of Sciences Guizhou Radio Astronomical Observatory Guizhou University Max Planck Institute for Extraterrestrial Physics Kavli Institute for Astronomy and Astrophysics Peking University Institute of Computational Cosmology Department of PhysicsUniversity of Durham CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of Sciences Deep Space Exploration Laboratory/Department of Astronomy University of Science and Technology of China school of Astronomy and Space Science University of Science and Technology of China Astrophysics Department of PhysicsUniversity of Oxford College of Earth sciences Guilin University of Technology Department of Physics Anhui Normal University school of Astronomy and Space Science Nanjing University Key Laboratory of Modern Astronomy and Astrophysics Nanjing University

The Five-hundred-meter Aperture Spherical radio Telescope（FAST） has the largest aperture and a 19-beam L-band receiver,making it powerful for investigating the neutral hydrogen atomic gas（H?） in the *** present HiFAST（https://***）,a dedicated,modular,and self-contained calibration and imaging pipeline for processing the H?data of *** pipeline consists of frequency-dependent noise diode calibration,baseline fitting,standing wave removal using an FFT-based method,flux density calibration,stray radiation correction,and gridding to produce data *** modules can be combined as needed to process the data from most FAST observation modes:tracking,drift scanning,On-The-Fly mapping,and most of their *** HiFAST,the root-mean-square（RMS） noises of the calibrated spectra from all 19 beams were only slightly（～5.） higher than the theoretical *** results for the extended source M33 and the point sources are consistent with the results from *** moment maps（0,1 and 2） of M33 agree well with the results from the Arecibo Galaxy Environment Survey（AGES） with a fractional difference of less than 10%.For a common sample of 221 sources with signal-to-noise ratio S/N>10 from the Arecibo Legacy Fast ALFA（ALFALFA） survey,the mean value of fractional difference in the integrated flux density,Sint,between the two datasets is approximately 0.005.,with a dispersion of 15.4%.Further checks on the integrated flux density of 23 sources with seven observations indicate that the variance in the flux density of the source with luminous objects(Sint>2.5.Jy km s-1) is less than 5..Our tests suggest that the FAST telescope,with the efficient,precise,and user-friendly pipeline HiFAST,will yield numerous significant scientific findings in the investigation of the H? in the universe.

关键词：

Intracellular pharmacokinetic study of zidovudine and its phosphorylated metabolites

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Acta Pharmaceutica Sinica B 2016年第2期6卷 158-162页

作者： Lingli Mu Rui Zhou Fang tang Xingling Liu Sanwang Li Feifan Xie Xiang Xie Jie peng peng Yu Medical College Hunan Normal University school of Pharmaceutical sciences Central South University

Zidovudine (AZT), the first drug approved by the US Food and Drug Administration for the treatment of human immunodeficiency virus (HIV) infection, is metabolized in the host cells to 5.-AZT triphosphate (AZT-TP) which inhibits HIV reverse transcriptase. As the pharmacokinetics of AZT and its phosphorylated metabolites in human peripheral blood mononuclear cells (hPBMCs) is limited, the aim of this study was to determine the pharmacokinetic parameters of AZT and its phosphorylated metabolites in hPBMCs from 12 healthy chinese male subjects after a single oral dose of 600 mg of AZT. Blood samples were collected prior to drug administration, then at 0.5. 1, 1.5. 2, 2.5. 3, 3.5. 4, 5. 6, 8 and 10 h after drug administration. Mononuclear cells collected by Ficoll-Hypaque density gradient centrifugation were used for determination of AZT and metabolites [AZT monophosphate (AZT-MP), AZT diphosphate (AZT-DP) and AZT-TP] and the plasma was used to evaluate the pharmacokinetics of AZT. Plasma concentration of AZT peaked within 0.5.3 h and intracellular concentrations of AZT, AZT-MP, AZT-DP and AZT-TP peaked within 1.083, 1.5.0, 1.417 and 1.5.3 h, respectively. AZT in plasma was eliminated rapidly with t(1/2) of 2.022 h, and AZT-MP, AZT-DP and AZT-TP were eliminated with t(1/2) of 13.428, 8.285.and 4.240 h, respectively. The plasma concentration of the phosphorylated metabolites was not quantifiable. (C) 2016 chinese Pharmaceutical Association and Institute of Materia Medica, chinese academy of Medical sciences. Production and hosting by Elsevier B.V.

关键词： LC-MS/MS Zidovudine Metabolites Phosphates hPBMCs hPBMCs Pharmacokinetics Intracellular killed

Selective fluorination on donor and acceptor for management of efficiency and energy loss in non-fullerene organic photovoltaics

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Science China Chemistry 2023年第4期66卷 1190-1200页

作者： You Chen peng Lei Yanfang Geng Ting Meng Xiangyu Li Qingdao Zeng Qing Guo Ailing tang Yufei Zhong Erjun Zhou CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Henan Institute of Advanced Technology Zhengzhou UniversityZhengzhou 450003China school of Materials Science and Engineering Ningbo Tech UniversityNingbo 315100China

Although fluorination has been proved effective to modulate optoelectronic properties and film morphology,knowledge of managing power conversion efficiency(PCE)and energy loss(Eloss)of organic photovoltaics(OPVs)by selective fluorination on the donor and/or acceptor is *** we designed and synthesized three 1,2,3-benzotriazole(BTA)-based linear polymers(PE45.PE46 and PE47)with different numbers of fluorine atom substitution on the conjugated phenyl side *** classic non-fullerene acceptors(NFAs)Y5.without fluorination)and Y6(with fluorination)were utilized to manage the device efficiency and energy *** results revealed that increasing fluorine substitutions on polymer donor improved the OPV efficiencies when the fluorinated Y6 was used as the acceptor,whereas decreased the PCEs when the non-fluorinated Y5.was used as the *** energy loss declined with the growing fluorine substitutions on polymer donor,and Y5.systems gave the lower values in comparison with the corresponding Y6 *** turns out that PE47:Y6 achieved the highest PCE of 15.5.%with an open-circuit voltage(VOC)of 0.84 V(Eloss=0.5. e V)due to the highest and balanced hole/electron mobilities,suppressed bimolecular recombination and fibril network morphology,which is the highest value in the BTA-based ***,PE47:Y5.attained an ultralow non-radiative energy loss of 0.15.e V,which is one of the lowest values among the reported *** work could not only give a direct path on how to manage the efficiency and energy loss by selective fluorination on donor and acceptor,but also show a deep understanding on charge generation,transport and collection induced by selective fluorination.

关键词： fluorination D-π-A polymer non-fullerene acceptor energy loss organic solar cells

Charge‑Transfer Resonance and Electromagnetic Enhancement Synergistically Enabling MXenes with Excellent SERS Sensitivity for SARS‑CoV‑2 S Protein Detection

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Nano-Micro Letters 2021年第3期13卷 177-193页

作者： Yusi peng Chenglong Lin Li Long Tanemura Masaki Mao tang Lili Yang Jianjun Liu Zhengren Huang Zhiyuan Li Xiaoying Luo John RLombardi Yong Yang State Key Laboratory of High‑Performance Ceramics and Superfine Microstructures Shanghai Institute of CeramicsChinese Academy of Sciences1295 Dingxi RoadShanghai 200050People’s Republic of China graduate school of the chinese academy of sciences No.19(A)Yuquan RoadBeijing 100049People’s Republic of China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049People’s Republic of China school of Physics and Optoelectronics South China University of TechnologyGuangzhou 510641People’s Republic of China Department of Frontier Materials Nagoya Institute of TechnologyNagoya 466‑8555Japan State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteRenji HospitalShanghai Jiaotong University School of MedicineShanghai 200032People’s Republic of China City College CUNYNew YorkNYUSA

The outbreak of coronavirus disease 2019 has seriously threatened human *** and sensitively detecting SARSCoV-2 viruses can help control the spread of ***,it is an arduous challenge to apply semiconductor-based substrates for virus SERS detection due to their poor ***,it is worthwhile to search novel semiconductor-based substrates with excellent SERS *** we report,for the first time,Nb2C and Ta2C MXenes exhibit a remarkable SERS enhancement,which is synergistically enabled by the charge transfer resonance enhancement and electromagnetic *** SERS sensitivity is optimized to 3.0×10^6 and 1.4×10^6 under the optimal resonance excitation wavelength of 5.2 ***,remarkable SERS sensitivity endows Ta2C MXenes with capability to sensitively detect and accurately identify the SARS-CoV-2 spike ***,its detection limit is as low as 5.10^−9 M,which is beneficial to achieve real-time monitoring and early warning of novel *** research not only provides helpful theoretical guidance for exploring other novel SERS-active semiconductor-based materials but also provides a potential candidate for the practical applications of SERS technology.

关键词： Nb2C and Ta2C MXenes SERS sensitivity PICT resonance SARS-CoV-2 S protein

A machine learning-based algorithm used to estimate the physiological elongation of ocular axial length in myopic children

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Eye and Vision 2020年第1期7卷 485-496页

作者： Tao tang Zekuan Yu Qiong Xu Zisu peng Yuzhuo Fan Kai Wang Qiushi Ren Jia Qu Mingwei Zhao Department of Ophthalmology&Clinical Centre of Optometry Peking University People’s HospitalBeijing 100044China College of Optometry Peking University Health Science CenterBeijingChina Eye Disease and Optometry Institute Peking University People’s HospitalBeijingChina beijing Key Laboratory of the Diagnosis and Therapy of Retinal and Choroid Diseases BeijingChina academy for Engineering&Technology Fudan UniversityShanghaiChina Department of Biomedical Engineering College of EngineeringPeking UniversityBeijing 100871China school of Ophthalmology and Optometry and Eye Hospital Wenzhou Medical UniversityWenzhouZhejiangChina

Background:Axial myopia is the most common type of ***,due to the high incidence of myopia in chinese children,few studies estimating the physiological elongation of the ocular axial length(AL),which does not cause myopia progression and differs from the non-physiological elongation of AL,have been *** purpose of our study was to construct a machine learning(ML)-based model for estimating the physiological elongation of AL in a sample of chinese school-aged myopic ***:In total,1011 myopic children aged 6 to 18 years participated in this ***-sectional datasets were used to optimize the ML *** input variables included age,sex,central corneal thickness(CCT),spherical equivalent refractive error(SER),mean K reading(K-mean),and white-to-white corneal diameter(WTW).The output variable was AL.A 5.fold cross-validation scheme was used to randomly divide all data into 5.groups,including 4 groups used as training data and one group used as validation *** types of ML algorithms were implemented in our *** best-performing algorithm was applied to predict AL,and estimates of the physiological elongation of AL were obtained as the partial derivatives of AL_(predicted)-age curves based on an unchanged SER value with increasing ***:Among the six algorithms,the robust linear regression model was the best model for predicting AL,with a R^(2) value of 0.87 and relatively minimal averaged errors between the predicted AL and true *** on the partial derivatives of the AL_(predicted)-age curves,the estimated physiological AL elongation varied from 0.010 to 0.116 mm/year in male subjects and 0.003 to 0.110 mm/year in female subjects and was influenced by age,SER and *** to the model,the physiological elongation of AL linearly decreased with increasing age and was negatively correlated with the SER and the ***:The physiological elongation of the AL is rarely recorded in clinical data in

关键词： Myopia Myopia progression Machine learning Ocular axial length Physiological elongation Orthokeratology