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氯化高锡催化合成乙酸环己酯

中国实用医药 2006年第9期1卷 27-28页

作者：彭彩云刘平安王福东盛文兵湖南中医药大学药学院有机药化教研室湖南长沙410208

目的高效率合成乙酸环己酯。方法以乙酸与环己醇为原料,氯化高锡为催化剂合成乙酸环己酯。结果在优化反应条件下,酯的收率最高达94.6%。最佳反应条件是:醇酸摩尔比是0.7:1,催化剂用量为乙酸质量的5%,反应时间是1.5小时。结论实验表明催... 详细信息

目的高效率合成乙酸环己酯。方法以乙酸与环己醇为原料,氯化高锡为催化剂合成乙酸环己酯。结果在优化反应条件下,酯的收率最高达94.6%。最佳反应条件是:醇酸摩尔比是0.7:1,催化剂用量为乙酸质量的5%,反应时间是1.5小时。结论实验表明催化剂催化性能好,具有稳定性高,反应条件温和,后处理简单,无环境污染,能重复使用的特点。

关键词：氯化高锡乙酸环己酯催化合成

Mechanism,condition and characteristics for the formation of the network structure in Zr-Al-Ni-Cu bulk metallic glasses

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Science China(Physics,Mechanics & Astronomy) 2015年第6期58卷 103-108页

作者： AN WeiKe DING DaWei cai AnHui ZHOU GuoJun LUO yun LI JiangHong peng YongYi College of Mechanical Engineering Hunan Institute of Science and Technology Institute of Physics Chinese Academy of Sciences State Key Laboratory of Powder Metallurgy Central South University School of Physics and Electronics Central South University

Mechanism,condition and characteristics for the formation of the network structure in a group of Zr-Al-Ni-Cu bulk metallic glasses(BMGs) were *** results show that the constituent segregation and/or the symplastic growth would be the mechanisms for the formation of the cell structure in the present Zr-Al-Ni-Cu *** cell structure can be easily obtained for the glass forming alloys whose compositions locate nearby the eutectic *** shorter the distance is from the eutectic point,the larger the cell and the thicker the cell wall of the network structure will *** present investigation would provide useful information for the development of the BMG with the network structure.

关键词： Zr-Al-Ni-Cu bulk metallic glass network structure mechanism characteristics

An Improved Practical Byzantine Fault-Tolerant Algorithm Based on XGBoost Grouping for Consortium Chains

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Computers, Materials & Continua 2025年第1期82卷 1295-1311页

作者： Xiaowei Wang Haiyang Zhang Jiasheng Zhang Yingkai Ge Kexin Cui Zifu peng Zhengyi Li Lihua Wang College of Electronic and Information Engineering Shandong University of Science and TechnologyQingdao266590China

In response to the challenges presented by the unreliable identity of the master node,high communication overhead,and limited network support size within the Practical Byzantine Fault-Tolerant(PBFT)algorithm for consortium chains,we propose an improved PBFT algorithm based on XGBoost grouping called XG-PBFT in this ***-PBFT constructs a dataset by training important parameters that affect node performance,which are used as classification indexes for *** XGBoost algorithm then is employed to train the dataset,and nodes joining the system will be grouped according to the trained grouping *** them,the nodes with higher parameter indexes will be assigned to the consensus group to participate in the consensus,and the rest of the nodes will be assigned to the general group to receive the consensus *** order to reduce the resource waste of the system,XG-PBFT optimizes the consensus protocol for the problem of high complexity of PBFT ***,we evaluate the performance of *** experimental results show that XG-PBFT can significantly improve the performance of throughput,consensus delay and communication complexity compared to the original PBFT algorithm,and the performance enhancement is significant compared to other algorithms in the case of a larger number of *** results demonstrate that the XG-PBFT algorithm is more suitable for large-scale consortium chains.

关键词： Consortium chain PBFT grouping reputation XGBoost

Targeting capabilities of engineered extracellular vesicles for the treatment of neurological diseases

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Neural Regeneration Research 2025年第11期20卷 3076-3094页

作者： Xinyu Yang Xiangyu Gao Xiaofan Jiang Kangyi Yue peng Luo Department of Neurosurgery Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina

Recent advances in research on extracellular vesicles have significantly enhanced their potential as therapeutic agents for neurological *** to their therapeutic properties and ability to cross the blood–brain barrier,extracellular vesicles are recognized as promising drug delivery vehicles for various neurological conditions,including ischemic stroke,traumatic brain injury,neurodegenerative diseases,glioma,and ***,the clinical application of natural extracellular vesicles is hindered by their limited targeting ability and short clearance from the *** address these limitations,multiple engineering strategies have been developed to enhance the targeting capabilities of extracellular vesicles,thereby enabling the delivery of therapeutic contents to specific tissues or ***,this review aims to highlight the latest advancements in natural and targeting-engineered extracellular vesicles,exploring their applications in treating traumatic brain injury,ischemic stroke,Parkinson's disease,Alzheimer's disease,amyotrophic lateral sclerosis,glioma,and ***,we summarized recent clinical trials involving extracellular vesicles and discussed the challenges and future prospects of using targeting-engineered extracellular vesicles for drug delivery in treating neurological *** review offers new insights for developing highly targeted therapies in this field.

关键词： Alzheimer's disease amyotrophic lateral sclerosis engineered extracellular vesicles glioma ischemic stroke neurological diseases Parkinson's disease psychosis targeted drug delivery traumatic brain injury

PBL教学法在中医药独立学院化学实验教学中的实践与体会

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中医药导报 2014年第6期20卷 151-153页

作者：彭彩云盛文兵傅榕赓刘向前湖南中医药大学药学院湖南长沙410208

目的:探索在中医药独立学院的化学实验教学中引入PBL教学的运行模式与意义。方法:通过问题提出、场景设计、案例编制、具体实施、反馈评价实施PBL教学模式。结果:摸索了PBL教学模在独立学院化学实验中的运行方式与评价方案。结论:PBL教... 详细信息

目的:探索在中医药独立学院的化学实验教学中引入PBL教学的运行模式与意义。方法:通过问题提出、场景设计、案例编制、具体实施、反馈评价实施PBL教学模式。结果:摸索了PBL教学模在独立学院化学实验中的运行方式与评价方案。结论:PBL教学模式在独立学院化学实验中能有效提高学生分析解决问题能力,对应型医药人才培养具有重要作用。

关键词：中医药独立学院化学实验教学 PBL教学法

Ternary Ag/Ag3PO_(4)/MIL-125-NH2 Z-scheme heterojunction for boosted photocatalytic Cr(Ⅵ)cleanup under visible light

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Chinese Chemical Letters 2020年第10期31卷 2645-2650页

作者： yun-cai Zhou peng Wang Huifen Fu Chen Zhao Chong-Chen Wang Beijing Key Laboratory of Functional Materials for Building Structure and Environment Remediation Beijing University of Civil Engineering and ArchitectureBeijing 100044China

The binary Ag3 P04/MIL-125-NH2(AMN-X)composites were synthesized through ion exchange-solution method,and the ternary Ag/Ag3 PO_(4)/MIL-125-NH2(AAMN-X)Z-scheme heterojunctions were prepared via the photo chemical reduction deposition *** photocatalytic hexavalent chromium(Cr(VI))sequestration over AMN-X and AAMN-X were investigated under visible ***-120 accomplished superior reduction performance due to that Ag nanoparticles(NPs)act as electrons transfer bridge to enhance the separation efficiency of photogenerated e-h+pairs,in which the reaction rates(***)were 2.77 and 124.2 fold higher than those of individual MIL-125-NH2 and Ag3 PO_(4),*** influences of different pH values,small organic acids and coexisting ions on the photocatalytic perfo rmance of AAMN-120 were also *** addition,the AAMN-120 heterojunction expressed great reusability and stability in cycling *** mechanism of photocatalytic Cr(VI)was investigated and verified through photoluminescence(PL),electrochemistry,electron spin resonance(ESR),active species capture,and Pt element deposition experiments.

关键词： MIL-125-NH2 Ag/Ag3PO4 Hexavalent chromium Z-scheme heterojunction Photocatalysis

中药学专业《药物合成反应》课程学生学习评价体系的建立

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中医药导报 2015年第17期21卷 113-114页

作者：彭彩云蔡雄刘强刘文彬傅榕赓盛文兵李鑫湖南中医药大学中医诊断研究所湖南长沙410007 中医诊断学湖南省重点实验室湖南长沙410007 湖南中医药大学药学院湖南长沙410208

介绍了建立中药学专业《药物合成反应》课程学生学习评价体系的方法和实践体会。评价体系的主要内容是根据专业特点、课程性质和特点,采用随堂考试和随机提问、查文献写综述与闭卷笔试3者相组合的模式评价学生成绩。认为该评价体系不仅... 详细信息

介绍了建立中药学专业《药物合成反应》课程学生学习评价体系的方法和实践体会。评价体系的主要内容是根据专业特点、课程性质和特点,采用随堂考试和随机提问、查文献写综述与闭卷笔试3者相组合的模式评价学生成绩。认为该评价体系不仅调动了学生学习的能动性与兴趣和科技论文写作能力,也提高了药物合成反应课程的教学质量。

关键词：中药学专业药物合成反应学习评价体系教学质量

Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

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Science China Chemistry 2025年第1期68卷 360-368页

作者： Zheng Liu Changyu Zhang Zipeng Li Wanying Ma Jia Liu Xiang Xia Ning Xu Wen Sun Jianjun Du Jiangli Fan Xiaojun peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

关键词： NIR fluorescent probe ER viscosity hepatic fibrosis gender difference estrogen

Physics based circuit compatible model for hybrid antiferroelectric random access memory

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Science China(Information Sciences) 2025年第1期68卷 396-397页

作者： Qiuxia WU Yue peng Wenwu XIAO Wenxuan MA Shuo ZHANG Litao SUN Chunfu ZHANG Xiaohua MA Yue HAO School of Microelectronics Xidian University Xi'an Uni IC Semiconductors

Since the discovery of HfO2-based ferroelectric （FE） materials in 2011,considerable advancements have been made in material preparation,mechanism research,and device realization [1].Consequently,these materials are now regarded as leading candidates for embedded non-volatile memory（eNVM）.Beyond eNVM applications,recent studies have demonstrated that memory devices with antiferroelectric（AFE） films can achieve high response speeds,low latency,and reduced power consumption while maintaining excellent endurance characteristics [2,3].Additionally,the typical double hysteresis loops and multiple non-overlapping polarization current peaks of AFE films offer a novel approach to designing multistate ***,in order to further promote the application of high storage density AFE,an AFRAM electronic design automation （EDA） model must be developed,and it has yet to be proposed.

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