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Acta Oceanologica Sinica 2024年第2期43卷 111-119页

作者： Muralidhar Kocherla Durbar Ray Manavalan Satyanarayanan Hilda Joao Virsen Gaikwad pb ramamurty CSIR-National Institute of Oceanography Dona Paula 403004GoaIndia CSIR-National Geophysical Research Institute Uppal RoadHyderabad 500007India

The tephra layers in multiple sediment cores from the offshore region of the Mahanadi basin in the northern Bay of Bengal were investigated for possible volcanic sources. The glass shards from those tephra layers were studied for size distribution, texture, and elemental geochemistry to establish chronostratigraphic markers for regional and global Quaternary correlation. The textural features of fine-grained(silty) volcanic glasses suggest the distal source of these tephra deposits. Major element composition with elevated SiO_(2) contents ranging between75%–76% and dominance of K_(2)O(> 4.5%) over CaO(< 0.9%) suggest ashes have originated from siliceous rhyolitic melts, similar to the petrographic composition of tephra from the Toba volcano. The bulk trace element compositions of the same glass shards were comparable with those reported in the youngest Toba tephra reported elsewhere. Likewise, the LREE-dominated chondrite normalized REE profiles of tephra from the Mahanadi basin closely resemble the characteristic REE patterns in Toba ash from other parts of the Indian Ocean and thus confirmed the contribution of the youngest Toba super-eruption for this ash layers.

关键词： Mahanadi basin Bay of Bengal volcanic glass glass morphology glass-chemistry

Pre-operative visceral adipose tissue radiodensity is a potentially novel prognostic biomarker for early endoscopic post-operative recurrence in Crohn’s disease

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 740-750页

作者： Phillip Gu Shishir Dube Norman Gellada So Yung Choi Susan Win Yoo Jin Lee Shaohong Yang Talin Haritunians Gil Y Melmed Eric A Vasiliauskas Niru Bonthala Gaurav Syal Andres J Yarur David Ziring Shervin Rabizadeh Phillip Fleshner Cindy Kallman Suzanne Devkota Stephan R Targan Dalin Li Dermot pb McGovern Department of Medicine Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Imaging Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Biostatistics Shared Resource Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Internal Medicine Keimyung University School of MedicineDaegu 42601South Korea Department of Medicine University of California at Los AngelesLos AngelesCA 90095United States Department of Medicine University of California at San DiegoSan DiegoCA 92093United States Department of Pediatrics Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Surgery Cedars-Sinai Medical CenterLos AngelesCA 90048United States

BACKGROUND Evidence suggests inflammatory mesenteric fat is involved in post-operative recurrence(POR)of Crohn’s disease(CD).However,its prognostic value is INTRODUCTION Crohn’s disease(CD)is a debilitating chronic immune-mediated inflammatory disease(IMID)of the gastrointestinal tract that is increasing in incidence and prevalence globally[1].CD patients often undergo surgery for disease-related complic-ations and/or medically refractory ***,surgery is not curative,and many patients develop post-operative recurrence(POR)of CD with a significant proportion eventually requiring additional *** advances in early detection and therapeutics,the contemporary 10-year risk of surgery has improved from 50%to 26%,but the risk of recurrent surgery has remained unchanged at 30%,suggesting a need to improve post-operative management strategies[2].Presently,there are two accepted strategies to mitigate POR,but each have potential ***,patients start early post-operative pharmacologic prophylaxis within 4-6 wk after *** strategy can potentially overtreat a subset of patient who may not develop long-term disease recurrence off ***,these patients are at risk of medication-related adverse events and the direct and indirect costs associated with therapy with little or no benefit[3].The second strategy is performing early colonoscopy within 6-12 months after surgery and escalating therapy based on FOOTNOTES Author contributions:Gu P is the guarantor of the article and was involved in concept and design,data collection,statistical analysis,drafting of manuscript,and final approval of manuscript;Dube S and Choi SY were involved in statistical analysis,drafting of the manuscript,and final approval of manuscript;Gellada N,Win S,Lee YJ and Yang S were involved in the data collection,drafting of the manuscript,and final approval of manuscript;Haritunians T and Li D were involved in data analysis and interpretation,drafting

关键词： Crohn’s disease Surgery Visceral adipose tissue Mesenteric adipose tissue Creeping fat Computed tomography

ABSOLUTE STABLE HOMOTOPY FINITE ELEMENT METHODS FOR CIRCULAR ARCH PROBLEM AND ASYMPTOTIC EXACTNESS POSTERIORI ERROR ESTIMATE

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Journal of Computational Mathematics 2002年第6期20卷 653-672页

作者： Feng, MF Ming, pb Yang, RK Sichuan Univ Dept Math Chengdu 610064 Peoples R China

In this paper, HFEM is proposed to investigate the circular arch problem. Optimal error estimates are derived, some superconvergence results are established, and an asymptotic exactness posteriori error estimator is presented. In contrast with the classical displacement variational method, the optimal convergence rate for displacement is uniform to the small parameter. In contrast with classical mixed finite element methods, our results are free of the strict restriction on h(the mesh size) which is preserved by all the previous papers. Furtheremore we introduce an asymptotic exactness posteriori error estimator based on a global superconvergence result which is discovered in this kind of problem for the first time.

关键词： HFEM arch superconvergence asymptotic exactness posteriori error estimator

Past, present and future of fuel cells

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电池 2002年第3期32卷 130-132页

作者： A.C.C.Tseung(School of Chemical and Life Sciences,University of Greenwich,London SE18 6pb,UK) School of Chemical and Life Sciences University of Greenwich 英国

Though the fuel cell was invented by Grove in 1839,there are no commercially viable products at *** development of fuel cells can be conveniently divided into three phases exploratory phase(1839-1967).The main emphasis of the work is to increase the area of the three phase interface at the *** problem was solved by Bacon who invented the dual porosity,biporous nickel *** demonstrated the first H 2/O 2 fuel cell(180℃,20atm).This cell was later improved and scaled up to power the Apollo lunar ***,the cost is too high for civilian applications and we come to the development phase (1967-2001).The main emphasis has been on the use of Teflon bonded electrodes and novel catalysts(PtRu,Pt/WO 3 and Pt Ru/WO 3 anode catalyst for the anodic oxidation of impure H 2 and *** addition,the recent discovery of gadolinium doped ceria has reduced the operating temperature of solid oxide electrolytes to ～500℃ instead of 1?000℃.From 2001 onwards,we may be entering the breakthrough phase where the most favourable candidates are direct methanol vapor fuel cells and solid oxide electrolyte fuel *** the former case,there is a need to reduce the cross over of methanol to the cathode compartment and the development of air cathode catalyst which are less affected by methanol and in the latter case,there is a need to improve the activity of the anode and cathode catalysts.

关键词：燃料电池电催化反应电解液电极

Malignant gastrointestinal melanomas of unknown origin: Should it be considered primary?

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World Journal of Gastroenterology 2007年第29期13卷 4027-4029页

作者： A Manouras M Genetzakis E Lagoudianakis H Markogiannakis A Papadima G Kafiri K Filis pb Kekis V Katergiannakis First Department of Propaedeutic Surgery Hippocrateion Hospital University of Athens Athens Medical School Athens Greece

We read with interest the article entitled： ‘Jejuno-jejunal invagination due to intestinal melanoma’ by Resta , et al. They reported a rare clinical case of a young woman with a bleeding jejunal melanoma, whose early clinical presentation was an intestinal invagination. The article is also referred to the rarity of gastrointestinal melanomas as well as their possible primary nature.

关键词： Primary gastrointestinal melanomas Unknown origin

Genetic associations with adverse events from anti-tumor necrosis factor therapy in inflammatory bowel disease patients

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World Journal of Gastroenterology 2017年第40期23卷 7265-7273页

作者： Daniel Lew Soon Man Yoon Xiaofei Yan Lori Robbins Talin Haritunians Zhenqiu Liu Dalin Li Dermot pb McGovern Department of Medicine Cedars-Sinai Medical Center F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute Cedars-Sinai Medical Center Department of Gastroenterology Cedars-Sinai Medical Center

AIM To study the type and frequency of adverse events associated with anti-tumor necrosis factor(TNF)therapy and evaluate for any serologic and genetic *** This study was a retrospective review of patients attending the inflammatory bowel disease(IBD) centers at Cedars-Sinai IBD Center from 2005-2016. Adverse events were identified via chart review. IBD serologies were measured by ELISA. DNA samples were genotyped at Cedars-Sinai using Illumina Infinium Immunochipv1 array per manufacturer's protocol. SNPs underwent methodological review and were evaluated using several SNP statistic parameters to ensure optimal allele-calling. Standard and rigorous QC criteria were applied to the genetic data, which was generated using immunochip. Genetic association was assessed by logistic regression after correcting for population *** Altogether we identified 1258 IBD subjects exposed to anti-TNF agents in whom Immunochip data were available. 269/1258 patients(21%) were found to have adverse events to an anti-TNF-α agent that required the therapy to be discontinued. 25% of women compared to 17% of men experienced an adverse event. All adverse events resolved after discontinuing the antiTNF agent. In total: n = 66(5%) infusion reactions; n = 49(4%) allergic/serum sickness reactions; n = 19(1.5%) lupus-like reactions, n = 52(4%) rash, n = 18(1.4%) infections. In Crohn's disease, Ig A ASCA(P = 0.04) and Ig G-ASCA(P = 0.02) levels were also lower in patients with any adverse events, and anti-I2 level in ulcerative colitis was significantly associated with infusion reactions(P = 0.008). The logistic regression/human annotation and network analyses performed on the Immunochip data implicated the following five signaling pathways: JAK-STAT(Janus Kinase-signal transducer and activator of transcription), measles, IBD, cytokine-cytokine receptor interaction, and toxoplasmosis for any adverse event. CONCLUSION Our study shows 1 in 5 IBD patients experience an

关键词： Genetic associations Inflammatory bowel disease Anti-tumor necrosis factor Adverse events

清醒狗与开胸麻醉狗心肌顿抑氧自由基作用的研究

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中国病理生理杂志 1995年第2期11卷 143-147页

作者：李小鹰 McCay pb 解放军总医院

本实验应用自旋捕捉剂ＰＢＮ证实了开胸麻醉狗与清醒狗心肌顿抑模型的主要区别。冠状动脉阻闭１５ｍｉｎ后再灌注头３小时ＰＢＮ加合物释放总量开胸麻醉狗明显高于清醒狗（约为５倍），而且心肌顿抑的恢复开胸狗明显差于清醒狗。这种区... 详细信息

本实验应用自旋捕捉剂ＰＢＮ证实了开胸麻醉狗与清醒狗心肌顿抑模型的主要区别。冠状动脉阻闭１５ｍｉｎ后再灌注头３小时ＰＢＮ加合物释放总量开胸麻醉狗明显高于清醒狗（约为５倍），而且心肌顿抑的恢复开胸狗明显差于清醒狗。这种区别的主要原因推测是开胸创伤本身以及肾上腺素能神经过度兴奋引起，从而提示在心肌顿抑氧自由基产生的研究中应用清醒动物模型的重要性。

关键词：狗氧自由基心肌顿抑心肌缺血

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泰国和东南亚国家中的凝血疾病

国际输血及血液学杂志 1989年第2期12卷 101-102页

作者： Isarangkura pb 邓承祺 Mahidol大学泰国曼谷

遗传性凝血疾病(HCD) 东南亚国家HCD的流行情况或多或少类似于西方国家。1977-1979年泰国对血友病流行作了全国性调查,结果为1/1.3-2万。多数为血友病甲、乙,血管性假血友病和遗传性血小板机能障碍。血友病甲、乙、丙的发病率分别为84%,... 详细信息

遗传性凝血疾病(HCD) 东南亚国家HCD的流行情况或多或少类似于西方国家。1977-1979年泰国对血友病流行作了全国性调查,结果为1/1.3-2万。多数为血友病甲、乙,血管性假血友病和遗传性血小板机能障碍。血友病甲、乙、丙的发病率分别为84%,12%和4%。血管性假血友病与血友病的比例的1∶6。遗传性因子Ⅰ、Ⅱ、Ⅴ、Ⅶ、Ⅻ、Ⅷ也已有少数病例报道。泰国对HCD治疗使用最多的血液成分是FFP、冰冻冷沉淀和FDP(新鲜冻干血浆)。目前全国甚至乡村医院都广泛使用FDP替代FFP作为治疗血液凝固性疾病、补充血浆蛋白、扩张血浆和急性失血及登革出血热伴低血容量性休克时替代血容量。获得性凝血疾病 1.感染引起出血的感染有登革出血热、疟疾、细菌性败血症、原虫和病毒感染、急性暴发性肝炎

关键词：凝血获得性 FDP 血小板机能障碍东南亚国家血液成分冷沉淀血液凝固疾病泰国