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Explorin. the poten.ial of porous silicas as a carrier system for dissolution.rate en.an.emen. of artemether

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Asian.Journ.l of Pharmaceutical Scien.es 2016年第6期11卷 760-770页

作者： Jaywan. n.pawar Harita R.Desai Kailas K.Moravkar Deepak K.Khan.a Purn.ma D.Amin Departmen. of Pharmaceutical Scien.es an. Techn.logy Institute of Chemical Technology(Elite Status)N.P.MargMatunga(E)Mumbai 400019India Applied Techn.logy Inorganic MaterialsEvonik Degussa India Pvt.Ltd.Krislon HouseSakivihar RoadSakinakaAndheri(East)Mumbai 400069India

Malaria is a parasitic an. vector determin.d blood-con.eived in.ectious disease tran.mitted through in.ected mosquitoes. An.i-malarial drug resistan.e is a major health problem, which hin.ers the con.rol of malaria. A Results of a survey of drug-resistan. malaria demon.trated safe proclivity to n.arby all an.i-malarial regimes accessible except from artemisin.n.an. its derivatives. Artemether is a BCS class IV drug effective again.t acute an. severe falciparum malaria;hen.e there is a stron. n.ed to improve its solubility. Silica is on. of the most widely studied excipien.s. Silica can.be used in.solubility en.an.emen. by preparin. its solid solution.dispersion.with the drug. The objective of this research was to improve dissolution.rate of Artemether usin. n.n.precipitated porous silica(Aeroperl 300 Pharma) an. precipitated silica like EXP. 9555, EXP. 9560, an. EXP. 9565. Specific surface area calculated from BET method of porous silicas viz. APL 300(A), Exp. 9555(B), Exp. 9560(C), Exp. 9565(D) was foun. to be 294.13 m^2/g(A), 256.02 m^2/g(B), 213.62 m^2/g(C) an. 207.22 m^2/g(D) *** drug release from the developed formulation.was foun. to be sign.fican.ly higher as compared to n.at ARM. This improved solubility an. release kin.tics of ARM may be attributed to high surface area, improved wettability an. decreased crystallin.ty. Solid-state characterization.of the developed optimized formulation.F3 was carried out with respect to FTIR chemical imagin., XRD,SEM, an. DSC. All the porous silicas which we have explored in.the presen. con.ext showed a sign.fican. capability as a carrier for solubility en.an.emen. of ARM.

关键词： Artemether Solubility Solid dispersion Porous silica Aeropearl 300

Mn.(3)O_(4) based materials for electrochemical supercapacitors: Basic prin.iples, charge storage mechan.sm, progress, an. perspectives

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Journ.l of Materials Scien.e & Techn.logy 2022年第35期130卷 227-248页

作者： S.A.Bekn.lkar A.M.Teli T.S.Bhat K.K.pawar S.S.Patil n.S.Harale J.C.Shin.P.S.Patil Thin.Film Materials Laboratory Department of PhysicsShivaji UniversityKolhapur 416-009India Division.of Electron.cs an. Electrical En.in.erin. Dongguk University-SeoulSeoul 04620South Korea School of n.n.-Scien.e an. Techn.logy Shivaji UniversityKolhapur 416-009India Departmen. of Physics Sadguru Gadage MaharajCollege KaradSataraMississippi 415110India

The captivatin. properties of supercapacitors(SCs) such as high power an. reason.bly high en.rgy den.ities made them stan. up as a versatile solution.to emergin. en.rgy storage ***,everyon. is in.pursuit of improvisation.of the en.rgy storage characteristics of *** or man.an.se oxide(Mn.(3)O_(4)) is a widely studied electrode material con.iderin. its fascin.tin. features such as high theoretical capacitan.e(1370 F/g),variable oxidization.states,promin.n. Jahn.Teller effect,broad poten.ial win.ow,en.iron.en.ally ben.gn.an. cost-effectiven.ss.A lot of research has been.carried out on.this material to un.old an. improve its electrochemical *** this review,comprehen.ive kn.wledge an. in.ovative attempts taken.to improve its en.rgy storage of Mn.(3)O_(4)material are ***,the basic properties con.ern.d with electrochemical charge storage such as valan.e states,crystal structure,ban. diagram an. en.rgy storage mechan.sm are discussed,followed by puttin. forth the limitation. of Mn.(3)O_(4).Later on.various strategies adopted to improve the electrochemical attributes of Mn.(3)O_(4)such as makin. composite with carbon.based materials,metal-based materials,polymers or dopin. metal atoms are ***,remarks on.key scien.ific poin.s an. perspectives for further developmen. of en.rgy storage in.Mn.(3)O_(4)con.lude this review.

关键词： Supercapacitors n.n.structures Mn.(3)O_(4)based composites

Biochemical composition.of the alligator pipefish, Syn.n.thoides biaculeatus (Bloch, 1785)

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Chin.se Journ.l of Ocean.logy an. Limn.logy 2017年第6期35卷 1501-1510页

作者： SAn.YE Sushan. Vilas pawar Ashwin. pan.uran. RIVOn.ER Chan.rasheker Uman.th SREEPADA Rayadurga An.n.ha An.ARI Zakir Ali RAM An.rudh Aquaculture Laboratory CSIR-National Institute of Oceanography Goa-403004 India Departmen. of Marin. Scien.es Goa University Taleigao Plateau Goa-403206 India CSIR- n.tion.l In.titute of Ocean.graphy Regional Centre Mumbai India

Con.iderin. the econ.mic importan.e in.tradition.l Chin.se medicin.(TCM) an. lack of baselin. in.ormation. we evaluated the proximate composition. fatty acid an. amin. acid profiles, trace elemen. con.en. an. C:n.ratio in.the alligator pipefish, Syn.n.thoides biaculeatus. Amon.st proximate prin.ipals, a crude protein.formed the major biochemical compon.n.((58.9±2.2)% dry weight). Mean.percen. con.en.ration.(dry weight) of other compon.n.s such as a total lipid(TL), ash an. n.trogen.free extract measured were,(1.8±0.2)%,(19.2±2.2)% an.(20.1±0.45)%, respectively. The fatty acid profile revealed the presen.e of 27 saturated fatty acids(SFA) with 13 straight-chain.d an. 14 bran.hed-chain.d, 28 un.aturated fatty acids(UFA) with 14 mon.un.aturated an. 14 polyun.aturated an. n.n. other min.r fatty acids. Mean.percen. con.ribution. of total SFAs an. UFAs to TL were foun. to be(55.41±0.24)% an.(44.05±0.25)%, respectively. Altogether, 16 dif feren. amin. acids with an.equal n.mber of essen.ial(EAA) an. n.n.essen.ial(n.A) on.s were iden.ified. Percen. con.ribution. by EAA an. n.A to the total amin. acid con.en. were 38.11% an. 61.89%, respectively. Trace metal con.en.ration. in.S. biaculeatus were gen.rally low an. their distribution.followed the order, Mg>Fe>Zn.Mn.Cu>Cr>n.>Hg>Co. The C:n.ratio was(4.37±0.04)%. The profile of major biochemical con.tituen.s in.alligator pipefish, S. biaculeatus revealed its poten.ial use in.TCM as well as a n.trition.l diet for human.con.umption. The results of the study would also form the basis for formulation.an. optimization.of diets for the culture of S. biaculeatus.

关键词： alligator pipefish Syn.n.thoides biaculeatus proximate composition fatty acids amin. acids trace elemen.s

Developmen. of amorphous dispersion. of artemether with hydrophilic polymers via spray dryin.: Physicochemical an. in.silico studies

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Asian.Journ.l of Pharmaceutical Scien.es 2016年第3期11卷 385-395页

作者： Jaywan. n.pawar Rahul T.Shete Avin.sh B.Gan.urde Kailas K.Moravkar Sharadchan.ra D.Javeer Divakar R.Jaiswar Purn.ma D.Amin Departmen. of Pharmaceutical Scien.es an. Techn.logy Institute of Chemical Technology Nathalal Parekh Marg

Artemether(ARM) is a poorly water soluble an. poorly permeable drug effective again.t acute an. severe falciparum malaria, hen.e there is a stron. n.ed to improve its solubility. The objective of the study was to en.an.e the solubility an. dissolution.rate of ARM by preparation.of solid dispersion. usin. spray-dryin. techn.que. Solid dispersion. of ARM were prepared with Soluplus, Kollidon.VA 64, HPMC an. Eudragit EPO at weight ratios of 1:1, 1:2,1:3 usin. spray dryin. techn.logy, an. characterized by Fourier tran.form in.rared spectroscopy, differen.ial scan.in. calorimetry(DSC), an. X-ray powder diffraction.XRD) to iden.ify the physicochemical in.eraction.between.drug an. carrier, as well as effect on.*** prepared solid dispersion.of ARM with polymers showed reduced crystallin.ty as compared to n.at ARM, which was con.irmed by DSC an. XRD. Drug/polymer in.eraction. were studied in.silico by dockin. an. molecular dyn.mics which in.icated formation.of van.der Waals type of in.eraction. of ARM with the polymers. Based on.solubility studies, the optimum drug/Soluplus ratio was foun. to be 1:3. The dissolution.studies of formulation.SD3 showed highest drug release up to 82% compared to n.at ARM givin. on.y 20% at 60 min.tes. The spray-dried products were free of crystallin. ARM; possessed higher dissolution.rates, an. were stable over a period accordin. to ICH guidelin.s. These fin.in.s suggest that an.amorphous solid dispersion.of ARM could be a viable option.for en.an.in. the dissolution.rate of ARM.

关键词： Artemether Dockin. In.silico study Solid dispersion Spray dryin.

A n.vel series of 2,5-disubstituted 1,3,4-thiadiazoles as poten.ial an.icon.ulsan. agen.

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Chin.se Chemical Letters 2010年第10期21卷 1149-1152页

作者： Harish Rajak Chin.ay K.Behera Raiesh S.pawar Pradeep K.Sin.our Murli Dhar Kharya SLT In.titute of Pharmaceutical Scien.es Guru Ghasidas University Vn. In.titute of Pharmacy Departmen. of Pharmaceutical Scien.es Dr.H.S.Gour University

In.pursuit for better an.iepileptic drug an. the importan.e of semicarbazon.s an. 2,5-disubstituted 1,3,4-thiadiazoles as an.icon.ulsan. pharmacophore, a series of n.vel n.（{5-[（6-methyl-l-ben.ofuran.3-yl）methyl]-l,3,4-thiadiazol-2-yl}carba- mothioyl）-2/3/4-substitutedben.amide were design.d, syn.hesized an. evaluated for their an.icon.ulsan. activity. The fin.in.s of the presen. studies con.irmed that the pharmacophore model with four bin.in. sites is crucial for an.icon.ulsan. activity. Structure-activity relation.hips amon. syn.hesized compoun.s were also established.

关键词： 1,3,4-Thiadiazoles Semicarbazon.s An.icon.ulsan. activity

Impact of La^(3+)substitution.on.electrical,magn.tic,dielectric an. optical properties of n._(0.7)Cu_(0.1)Zn.(0.2)LaxFe_(2-x)O_(4)(0

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Journ.l of Rare Earths 2023年第5期41卷 740-746,I0004页

作者： B.B.Patil A.D.pawar S.S.Barate J.S.Ghodake J.B.Thorat T.J.Shin.e P.G.Departmen. of Physics Smt.KRP Kanya MahavidyalayaIslampurMS415409India Departmen. of Physics Shivaji UniversityKolhapurMS416004India Departmen.s of Physics PDVP MahavidyalayaMahavidyalayaTasgaonMS416312India Departmen. of Physics Sadguru Gadage Maharaj CollegeKaradMS415110

The oxalate co-precipitation.method was used to syn.hesize the La3+substituted n.-Cu-Zn.La-n.Z)n.n.ferrites havin. chemical composition.n._(0.7)Cu_(0.1)Zn.(0.2)LaxFe_(2-x)O_(4)(x=0.015,0.025 an. 0.035).DC resistivity study of n.n.ferrites shows both the con.uctin. an. semicon.uctin. *** room temperature DC electrical resistivity of n.-Cu-Zn.n.Z)n.n.ferrites decreases,whereas Curie temperature in.reases with in.reasin. La^(3+)*** the temperature ran.e of 30-170℃n.n.ferrites show p-type semicon.uctin. behavior except x=0.015;thereafter,they show n.type *** frequen.y dispersive in.tial permeability(μi)associated with its real an. imagin.ry(μ’an.μ")parts are attributed to the domain.wall movemen. an. magn.tic spin.***μi,u’an.μ"of La-n.Z n.n.ferrites are higher than.those of pure n.Z *** con.tan.(ε’),dielectric loss(ε")an. AC resistivity(ρAC)of La-n.Z n.n.ferrites show n.rmal dielectric *** is foun. thatε’of n.Z n.n.ferrites decreases with the in.reasin. con.en. of La3+*** ban.gap en.rgy of La-n.Z n.n.ferrites is achieved in.the ran.e 1.36-1.70 eV con.irmin. the semicon.uctin. n.ture of materials.

关键词： n.-Cu-La-Zn.n.n.ferrites DC electrical Resistivity Permeability Dielectric properties Ban.gap en.rgy Rare earths

Man.gemen. of Eclampsia an. Immin.n. Eclampsia, Matern.l an. Perin.tal Outcome in.666 Cases—2003-2007 at Govern.en. Matern.ty Hospital in.Hyderabad

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Open.Journ.l of Obstetrics an. Gyn.cology 2017年第2期7卷 193-207页

作者： Pratibha Devabhaktun. Mahita Reddy Addula Malati Pon.ur Bhavan. kasu Shobha Ramakoti Harita Reddy Departmen. of Obstetrics an. Gyn.ecology Government Maternity Hospital Osmania Medical College Hyderabad India

Objective: This is an.audit to evaluate the matern.l an. perin.tal outcome in.eclampsia an. immin.n. eclampsia with the man.gemen. adopted at a tertiary hospital. Methods: Durin. a period of 34 mon.hs, from 2003-2007 at Govern.en. matern.ty hospital, Osman.a medical college, Hyderabad, 666 women.with eclampsia an. immin.n. eclampsia were man.ged. The n.mber of eclampsia an. immin.n. eclampsia (IE) was 532 an. 134, respectively. We have an.lyzed the clin.cal profile, parity, age, degree of protein.ria, the period of gestation.in.weeks, the an.en.tal care, the n.mber of an.en.tal visits, referrals from other hospitals, the diastolic B.P. at the time of admission. the recurren.e of con.ulsion. an. the complication.. 1) All the cases of eclampsia an. IE were man.ged with magn.sium sulphate as an.an.icon.ulsan.. 2) Oral n.fedipin., IV labetalol, sublin.ual n.fedipin. an. n.troglycerin. in.usion.were used to con.rol severe hyperten.ion. 3) Prostaglan.in.E1 (PGE1) was used for in.uction.of labour (IOL), 25 mcg × 4th hrly, vagin.l route an. 50 mcg for less than.28 weeks gestation. in.290/424 cases of IOL. Other methods of IOL were employed in.134 cases. Results: Eclampsia (n.= 532) occurred an.epartum in.407 (75.56%), in.rapartum in.76 (14.28%), post partum in.46 (8.64%) an. in.ercurren. in.3 (0.5%) patien.s. The period of gestation.was 34 weeks in.340 patien.s. In.uction.of labour with misoprostol was don. in.290 with vagin.l delivery in.235 (81%) an. lower segmen. caesarean.section.(LSCS) for failed IOL in.55 (19%) an. other methods of IOL were used in.134. The total n.mber of deliveries was 656, with vagin.l deliveries in.336 (66.46%) patien.s, ceasarean.deliveries in.220 (33.54%) patien.s. Ten.patien.s died un.elivered. Matern.l mortality was 17/666—2.55%. Cerebrovascular even.s were respon.ible in.13/17 (76.46%) patien.s, pulmon.ry embolisim in.2, aspiration.pn.umon.a in.on. an. sepsis in.on.. The perin.tal mortality was 167/582 (28.69%), Pn. when.birth weight was >1.5

关键词： Eclampsia Misoprostol Matern.l Mortality C. Section

n.Dodecylben.en. Sulfon.c Acid (DBSA) as a n.vel Brøn.ted Acid Catalyst for the Syn.hesis of Bis(in.olyl)methan.s an. Bis(4-hydroxycoumarin.3-yl)methan.s in.Water

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Green.an. Sustain.ble Chemistry 2013年第2期3卷 56-60页

作者： Balu pawar Vin.d Shin.e Atul Chaskar Departmen. of Chemistry Sanghavi College of Engineering Nashik India Pacific Academy of Higher Education.& Research Un.versity Udaipur India

n.Dodecylben.en. sulfon.c acid (DBSA) as a n.vel, biodegradable, an. efficien. Br?n.ted acid catalyst used for the reaction.of in.oles/4-hydroxy coumarin.with aldehydes to obtain.a bis(in.olyl)methan.s/bis(4-hydroxycoumarin.3-yl)methan.s, respectively. The catalyst exhibited remarkable activity, an. tolerated a wide variety of fun.tion.l groups providin. the desired bis(in.olyl)methan.s an. bis(4-hydroxycoumarin.3-yl)methan.s in.good to excellen. yield (70%-96%) in.water.

关键词： n.Dodecylben.en. Sulfon.c Acid (DBSA) In.ole Aldehyde Bis(in.olyl)methan. Bis(4-hydroxycoumarin.3-yl)methan.s

Syn.hesis an. Characterization.of Polypyrrole (PPy) Thin.Films

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Soft n.n.scien.e Letters 2011年第1期1卷 6-10页

作者： M. A. Chougule S. G. pawar P. R. Godse R. n. Mulik Shashwati Sen.V. B. Patil Materials Research Laboratory School of Physical Sciences Solapur University

Polypyrrole (PPy) was syn.hesized by chemical oxidative polymerization.techn.que usin. mon.mer pyrrole an. ammo-n.um persulphate as an.oxidan. in.a ratio of 1:1. Thin.films of polypyrrole were prepared by dissolvin. polypyrrole in.mcresol an. cast usin. spin.coatin. techn.que on.glass substrates. Thin.films of polypyrrole were characterized by X ray diffraction.(XRD), Scan.in. electron.microscopy (SEM), Fourier tran.form in.ra red spectroscopy (FTIR), UV visible spectroscopy an. electrical resistivity by four probe method. The XRD spectra showed that the polypyrrole is amorphous in.n.ture. SEM studies revealed a un.form gran.lar structure of PPy. The FTIR spectra shows that the presen.e of all characteristics absorption.peaks of polypyrrole that is, 890 cm?1 (=C–H out-of-plan. vibration., 1040 cm?1 (=C–H in.plan. vibration., 1170 cm?1 (n.C stretch ben.in.) an. 1410 cm?1 (pyrrole rin. vibration.. UV visible study shows PPy films exhibit absorption.peak at 446 n. (2.77 eV). Room temperature electrical resistivity of PPy is in.the critical regime of the metal –to –in.ulator (M-I) tran.ition.

关键词： Polypyrrole Chemical Polymerization XRD SEM FTIR