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麻醉专科培训项目中丙泊酚滥用的调查研究

麻醉与镇痛 2008年第5期4卷 89-94页

作者： paul e. Wischmeyer Bradley R. Johnson Joel e. Wilson Colleen Dingmann Heidi M. Bachman evan Roller Zung Vu Tran Thomas K. Henthorn 谢鹏(译) 喻田(校) Department of Anesthesiology University of Colorado Denver Colorado Department of Chemistry Valparaiso University Valparaiso Indiana Department of Biostatistics University of Colorado Denver Colorado 不详

背景尽管传统观点并不认为丙泊酚是一种可以滥用的药物，但亚麻醉剂量的丙泊酚有潜在的滥用可能。我们通过本项调查研究来评估麻醉专科丙泊酚滥用的发生率及其转归。方法调查内容以电子邮件方式，发送到美国126个麻醉专科培训项目。结... 详细信息

背景尽管传统观点并不认为丙泊酚是一种可以滥用的药物，但亚麻醉剂量的丙泊酚有潜在的滥用可能。我们通过本项调查研究来评估麻醉专科丙泊酚滥用的发生率及其转归。方法调查内容以电子邮件方式，发送到美国126个麻醉专科培训项目。结果此项调查的回复率为100％。在过去的10年中，18％的科室报告存在一起或多起丙泊酚滥用或挪用。本研究显示，最近10年，麻醉实施者中丙泊酚滥用的发生率为10／10000，比前次调研的结果增加5倍（P=0．005）。在上报的25个滥用丙泊酚的个案中，有7人死于丙泊酚滥用（占28％），其中6人是住院医生。约有71％的科室没有对丙泊酚建立起类似阿片类药物管理的监督系统。在滥用发生期间，科室没有对丙泊酚进行监控（如药品清点），与滥用发生率之间存在一定的关联（P=0．048）。结论在过去10年中，麻醉专科培训项目中丙泊酚滥用的发生率似乎呈增长趋势，多数死亡病例发生在住院医师身上。许多科室没有对丙泊酚进行药品清点和监控。令人担忧的是，所有报道有丙泊酚滥用致死的科室都没有对丙泊酚进行药品清点。

关键词：亚麻醉剂量培训项目丙泊酚专科药物管理发生率电子邮件住院医生

energy Driven by Internet of Things Analytics and Artificial Intelligence

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Journal of energy and Power engineering 2022年第1期16卷 24-31页

作者： Bahman Zohuri paul e.Bowen Akansha Agarwal Dinesh Kumar Masoud Moghaddam Ageno School of Business Business Analytics SchoolGolden Gate UniversitySan FranciscoCalifornia 94105USA California Polytechnic State University San Luis Obispo MBA 1996San Luis ObispoCalifornia 93401USA *** Chief Executive OfficerSan Francisco BayCalifornia 94501USA

Developing an integrated and intelligent approach to securing the ITe(information technology environment)is an emergent and evolving concern for every organization and consumer entity during the last few *** topics of concern include“SI”(security intelligence),“D-DA”(data-driven analytics),“Pe”(proven expertise),and“R-TD”(real-time defense)capabilities.“DRBTs”(dynamic response behavior types)include“incident response”,“endpoint management”,“threat intelligence”,“network security”,and“fraud protection”.The consumer demand for electricity as essential public access and service is indexed to population growth ***-driven economies continue to add electrical consumption to their grids even though improvements in lower-power consumption and higher design efficiencies are present in new electric-powered *** on the production of electrical energy has no peer replacement technology and creates a societal vulnerability to targeted public electrical grid *** access to,or production of,electrical power is interrupted,the result is a“Mass effect”every consumer feels with equal *** grid security falls directly into the levels of authorized,and unauthorized,access via the“IoT”(Internet of Things)concepts,and the“IoM2M”(Internet of Machine-to-Machine)*** grid operations that include production and network management augment each other in order to support the demand for electricity every day either in peak or off-peak,thus cybersecurity plays a big role in the protection of such assets at our *** help from AI(artificial intelligence)integrated into the IoT a resilient system can be built to protect the electric grid system nationwide and will be able to detect and preempt Smart Malware attacks.

关键词： Resilience system energy flow energy storage energy grid business intelligence AI cybersecurity decision making in real-time ML(machine learning) DL(deep learning) BD(big data) cloud-based servers for repository and storage of data

Interactions between maternal parity and feed additives drive the composition of pig gut microbiomes in the post‑weaning period

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1241-1257页

作者： Kayla Law eduardo Rosa Medina Garcia Chad Hastad Deborah Murray Pedro e.Urriola Andres Gomez Department of Animal Science University of Minnesota1364 Eckles AvenueSaint PaulMN 55108USA New Fashion Pork 164 Industrial ParkwayJacksonMN 56143USA

Background Nursery pigs undergo stressors in the post-weaning period that result in production and welfare *** challenges disproportionately impact the offspring of primiparous sows compared to those of mul-tiparous *** is known regarding potential interactions between parity and feed additives in the post-weaning period and their effects on nursery pig ***,the objective of this study was to investigate the effects of maternal parity on sow and offspring microbiomes and the influence of sow parity on pig fecal microbi-ome and performance in response to a prebiotic *** weaning,piglets were allotted into three treat-ment groups:a standard nursery diet including pharmacological doses of Zn and Cu(Con),a group fed a commercial prebiotic only(Preb)based on an Aspergillus oryzae fermentation extract,and a group fed the same prebiotic plus Zn and Cu(Preb+ZnCu).Results Although there were no differences in vaginal microbiome composition between primiparous and mul-tiparous sows,fecal microbiome composition was different(R^(2)=0.02,P=0.03).The fecal microbiomes of primiparous offspring displayed significantly higher bacterial diversity compared to multiparous offspring at d 0 and d 21 post-weaning(Perences in community composition observed at d 21(R^(2)=0.03,P=0.04).When analyzing the effects of maternal parity within each treatment,only the Preb diet triggered significant microbiome distinc-tions between primiparous and multiparous offspring(d 21:R^(2)=0.13,P=0.01;d 42:R^(2)=0.19,P=0.001).Composi-tional differences in pig fecal microbiomes between treatments were observed only at d 21(R^(2)=0.12,P=0.001).Pigs in the Con group gained significantly more weight throughout the nursery period when compared to those in the Preb+ZnCu *** Nursery pig gut microbiome composition was influenced by supplementation with an Aspergillus oryzae fermentation extract,with varying effects on performance

关键词： Aspergillus prebiotic Copper Feed additives Maternal Nursery pig microbiome Parity Swine microbiome Trace minerals Zinc

A randomized controlled trial of Promoting Physical Activity in Regional and Remote Cancer Survivors(PPARCS)

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Journal of Sport and Health Science 2024年第1期13卷 81-89页

作者： Sarah J.Hardcastle Chloe Maxwell-Smith Vinicius Cavalheri Terry Boyle Marta Leyton Román Cameron Platell Michael Levitt Christobel Saunders Frank Sardelic Sophie Nightingale Jacob McCormick Craig Lynch paul A.Cohen Max Bulsara Dana Hince Sport and Physical Activity Research Centre Sheffield Hallam UniversitySheffieldS102BPUK Institute for Health Research The University of Notre DameFremantleWA 6959Australia Curtin School of Population Health Curtin UniversityPerthWA 6845Australia Curtin School of Allied Health Curtin UniversityPerthWA 6845Australia Allied Health South Metropolitan Health ServiceMurdochWA 6150Australia Australian Centre for Precision Health University of South AustraliaAdelaideSA 5001Australia Department of Didactics of Musical Plastic and Body ExpressionUniversity of ExtremaduraCaceres 10071Spain St.John of God Subiaco Hospital PerthWA 6008Australia Department of Surgery University of MelbourneMelbourneVIC 3010Australia Tamara Private Hospital TamworthNSW 2340Australia Peter MacCallum Cancer Centre MelbourneVIC 3000Australia College of Health and Medicine Australian National UniversityCanberraACT 2600Australia Division of Obstetrics and Gynaecology Medical SchoolUniversity of Western AustraliaPerthWA 6009Australia

Background:Physical activity(PA)is important for cancer *** of remotely delivered interventions are needed to assist in reaching under-served non-metropolitan cancer *** objective of this study was to ascertain whether wearable technology,coupled with health coaching was effective in increasing PA in breast and colorectal cancer survivors living in regional and remote areas in ***:Cancer survivors from 5 states were randomized to intervention and control *** participants were given a Fitbit Charge 2TMand received up to 6 telephone health coaching *** participants received PA print *** assessments at baseline and 12 weeks measured moderate-to-vigorous PA(MVPA),light PA,and sedentary ***:eighty-seven participants were recruited(age=63±11 years;74(85%)female).There was a significant net improvement in MVPA of 49.8 min/week,favoring the intervention group(95%confidence interval(95%CI):13.6-86.1,p=0.007).There was also a net increase in MVPA bouts of 39.5 min/week(95%CI:11.9-67.1,p=0.005),favoring the intervention *** groups improved light PA and sedentary behavior,but there were no between-group ***:This’s the first study to demonstrate that,when compared to standard practice(i.e.,PA education),a wearable technology intervention coupled with distance-based health coaching,improves MVPA in non-metropolitan cancer *** results display promise for the use of scalable interventions using smart wearable technology in conjunction with phone-based health coaching to foster increased PA in geographically disadvantaged cancer survivors.

关键词： Behavior change exercise Health disparities Oncology Wearable technology

Acceptance and experience of HIV-Infected Adolescents in Two Hospitals in Yaoundé

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Open Journal of Pediatrics 2024年第2期14卷 435-443页

作者： Isabelle Mekone Nkwele Nelly Kamgaing Pierrette Amanda emah Manga Jeannette Épée Ngoué Hélène Kamo Sélangai Claude Audrey Meguieze Nsoh Ndeh-Fofang Serge Tchoukoua Jean-Baptiste Fotso Djemo paul Koki Ndombo Department of Pediatrics Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon Institut Supérieur des Sciences de la Santé de Bangangté Université des Montagnes Bangangté Cameroon Faculty of Medicine and Biomedical Sciences University of Garoua Garoua Cameroon

Introduction: Access to antiretroviral drugs has improved the survival of children infected with the Human Immunodeficiency Virus (HIV). As they reach adolescence, they are confronted with various constraints related to the infection and its treatment, in addition to those of the growth period they are going through. The main aim of the study was to assess the acceptance and describe the experience of HIV infection by infected adolescents but also to investigate the factors associated with good acceptance and a positive experience. Methodology: The cross-sectional analytic study concerned HIV-infected adolescents aged 15 to 19 followed up at the Chantal Biya Foundation-Mother and Child Centre (CMe-FCB) and the Yaoundé University Hospital Centre (CHUY) between February 2020 and June 2020. The study saw participants complete a questionnaire containing socio-demographic data and assessing acceptance and experience with the infection. Data analysis was accomplished using epi info software version 7.***.2.6. Results: One hundred and thirteen HIV-infected adolescents were included in the study. The sex ratio was 0.68 and the mean age was 17 years. More than half of the adolescents had a good acceptance and positive experience with the infection. Related factors were the adolescent’s perception of good health and participation in an association with other infected adolescents. Conclusion: emphasizing the psychological and educational follow-up of infected adolescents and encouraging their participation in associations for adolescents living with HIV could reduce the consequences of poor acceptance and ensure a better transition to adulthood. .

关键词： HIV Adolescent Acceptance experience

中国社会陌生人之间合作行为的变迁:基于社会困境研究的元分析(1999~2019)

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心理学报 2024年第9期56卷 1159-1175页

作者：苑明亮伍俊辉金淑娴林靓寇彧 paul A.M.Van Lange 安徽农业大学人文社会科学学院心理学系合肥230036 中国科学院心理研究所行为科学重点实验室北京100101 中国科学院大学心理学系北京100049 萨塞克斯大学心理学院英国布莱顿BN19RH 北京师范大学发展心理研究院应用实验心理北京市重点实验室心理学国家级实验教学示范中心(北京师范大学)北京100875 阿姆斯特丹自由大学脑与行为研究院实验与应用心理学系荷兰阿姆斯特丹1081BT

陌生人间的合作行为对于解决社会公共问题,应对世界百年未有之大变局意义重大。本研究采用横断历史元分析方法,基于1999~2019年间开展的254项使用社会困境范式测量我国陌生人间合作行为的研究(共302个合作率,29249名被试,平均年龄:18~28... 详细信息

陌生人间的合作行为对于解决社会公共问题,应对世界百年未有之大变局意义重大。本研究采用横断历史元分析方法,基于1999~2019年间开展的254项使用社会困境范式测量我国陌生人间合作行为的研究(共302个合作率,29249名被试,平均年龄:18~28岁),探讨了中国社会中合作行为的变迁及一些社会发展指标在其中的解释作用,并比较中美两国的合作行为变迁趋势。结果表明,中国人的合作行为水平随时间而上升,一些社会发展指标(人均国内生产总值、城市化率、高等教育水平、互联网普及率等)可能是其上升的社会变迁基础。中美两国合作行为表现出相似的上升趋势,但中国的在更短时间内有更大上升幅度。研究结果对提振民众信心具有重要意义。

关键词：合作行为社会资本社会困境横断历史元分析社会变迁

electrochemical Analysis of Zirconiumin Aqueous and Organic Media

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American Journal of Analytical Chemistry 2024年第2期15卷 99-118页

作者： paul Mendy Démo Koita Theodore Tzedakis Cheikhou Kane Codou Guèye Mar-Diop ecole Supérieure Polytechnique Université Cheikh Anta DIOP Dakar Sénégal Laboratoire de Génie Chimique Université de Toulouse III—Paul Sabatier Toulouse France

For the challenging nature of the zirconium environment analysis, this study consists to analyze the electrochemical behavior of Zirconium in both aqueous and organic media. To that end first the electrolytic media was selected on the basis of the Pourbaix potential-pH diagram, which provides informations on the predominance of Zr(IV) ion and Zr in aqueous media. In aqueous media, analyzes were first carried out in acidic media then in basic media. Studies have thus revealed that the acidic environment is not favourable for the electrochemical analysis of zirconium. Voltammograms obtained in an acidic environment show no zirconium detection signal;this is due to the strong presence of H+ ions in the solution. We have also observed in acidic media the phenomenon of passivation of the electrode surface. In aqueous alkaline media (pH = 13), we have drawn in reduction several Intensity-Potential curves by fixingsome technical parameterslike scanning speed, rotation speed of the electrode. The obtained voltammograms show cathodic waves, starting from -1.5 V/DHW and attributed to the reduction of Zr (IV) to Zr (0). The last phase of this study focused on the electrochemical analysis of zirconium in an organic media. In this media, several intensity-potential curves were plotted in reduction and in cyclic voltammetry with various parameters. Through several reduction analysis, the Zr (IV) was reduced to Zr (0) to the potential of -1.5 V/DHW. The electrochemical analysis of zirconium in organic media seems globally easier to achieve thanks to its large solvent window (i.e. dimethylformamide (DMF) solvent window > 6 V).

关键词： Zirconium electrochemical Reduction Cyclic Voltammetry Voltammogram Dymethylformamide

experimental Study of a Solar Thermal Incubator Using a Phase-Change Material for Off-Grid Use

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Open Journal of Applied Sciences 2024年第9期14卷 2471-2481页

作者： Yéouélé Thio Bati ernest Boya Bi ekoun paul Magloire Koffi Prosper Gbaha Laboratoire des Procds Industriels de Synthse de lEnvironnement et des Energies Nouvelles Institut National Polytechnique Flix Houphout-Boigny Yamoussoukro Cte dIvoire

The aim of this study was to provide a simple, easy-to-use incubation system for small-scale rural poultry farmers far from the electricity grid. To this end, a naturally ventilated solar thermal incubator was built and experimentally tested. A U-shaped evacuated tube collector and a wooden crate holding 50 eggs were used to build the solar thermal incubator. Water was used as the heat transfer fluid, and an ePCM was integrated into the incubation chamber for operation at night or when the sun was hidden. The heat generated by the solar collector and stored in the heat transfer fluid is transported to the incubation chamber by thermosiphon to heat the chamber. Temperature and humidity probes powered by a solar panel were placed at various locations to monitor the thermo-hygrometric efficiency of the incubation system. The incubator, heated by natural convection, proved to function normally, and the incubation chamber was maintained throughout the incubation period within a temperature range of 35.53˚C to 39.53˚C and relative humidity averaging 49.4% to 68.5%. The experiment was carried out by introducing 30 eggs and the results of the experimental study showed that the incubator’s efficiency was 87%. The performance tests gave a fertility rate of 93% and a hatching rate of 93%, i.e. 28 fertile eggs and 26 hatched eggs, respectively.

关键词： Solar Incubator Vacuum Tube Collector encapsulated PCM Poultry eggs

家族性高胆固醇血症大家系在两个世纪中的死亡率:家系死亡率研究

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英国医学杂志中文版 2002年第3期5卷 129-132页

作者： eric J G Sijbrands Rudi G J Westendorp Joep C Defesche paul H e M deMeier Augustinus H M Smelt John J P Kastelein 马志毅 Department of Vascular Medicine and General Internal Medicine Clinical epidemiology Leiden University MedicalCentre Department of General Internal University MedicalCentre

目的 :评估未经治疗的无冠状动脉疾病的家族性高胆固醇血症所有原因的死亡率。设计 :家系死亡率研究。背景 :荷兰的一个大家系 ,其宗亲源自 19世纪一对夫妇。先证者 :家族中所有超过 2 0岁且有 5 0 %可能性携带家族性高胆固醇血症突变... 详细信息

目的 :评估未经治疗的无冠状动脉疾病的家族性高胆固醇血症所有原因的死亡率。设计 :家系死亡率研究。背景 :荷兰的一个大家系 ,其宗亲源自 19世纪一对夫妇。先证者 :家族中所有超过 2 0岁且有 5 0 %可能性携带家族性高胆固醇血症突变基因者。主要结果测定指标 :各种原因的死亡率。结果 :分析自 6 95 0人年的 2 5 0人中共死亡的70人。突变基因携带者的死亡率在 19世纪和 2 0世纪早期并未升高 ,1915年后开始升高 ,1935～196 4年达到高峰 (标准化死亡率比 1 78,95 %可信区间 1 13～ 2 76 ,P =0 0 0 3) ,以后下降。家系的两大分支间死亡率有显著性差异 (相对危险性3 2 6 ,95 %可信区间 1 74～ 6 11;P =0 0 0 1)。结论 :家族性高胆固醇血症患者间的死亡危险性差异显著。这种时间上及家系的不同分支间的巨大差异表明环境因素与基因有强大的相互作用。有必要进一步研究以识别那些极高危并需早期和强力预防措施的家族性高胆固醇血症患者。

关键词：家族性高胆固醇血症死亡率家系死亡率研究