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Foaming supramolecular surfactants for gas mobility control in naturally fractured carbonate reservoirs at high temperature,salinity,and hardness

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Petroleum Science 2022年第6期19卷 3134-3148页

作者： Enrique Soto-Castruita Raúl Hern andez-Altamirano Eduardo Buenrostro-González Erick-Emanuel Luna-Rojero Sung Jae Ko-Kim Violeta-Yasmín Mena-Cervantes Mirna Pons-Jiménez jorge-Francisco Ramírez-Pérez David-Aaσn Nieto-Alvarez Ricardo Cerón-Camacho Jos e-Ernesto parra Raúl oviedo-Roa Jos e-Manuel Martínez-Magadán Rodolfo Cisneros-Dévora Luis-S.Zamudio-Rivera Instituto Mexicano del Petr oleo Eje Central Lazaro Cardenas Norte 152Col.San Bartolo AtepehuacanCiudad de Mexico07730Mexico CoNACy T-Instituto Mexicano del Petroleo Eje Central Lazaro Cardenas Norte 152Col.San Bartolo AtepehuacanCiudad de Mexico07730Mexico Centro Mexicano para la Produccion mas Limpia Instituto Politecnico NacionalAvenida Acueducto s/nCol.La Laguna TicomanCiudad de Mexico07340Mexico Centro de Tecnologías para Exploracion y Produccion Camino de Terracería 800Col.San Jose NovilleroBoca delRíoVeracruz94286Mexico

oil production and mainte nance are essential issues in naturally fractured reservoirs because they are the largest and most productive on ***,they present early water and gas channeling but could be remediated by using foaming agents to control these phenomena through blocking channeling *** Mexico these reservoirs have pressure up to 5,500 psi,high temperature up to 200℃,salinity up to400,000 ppm,and hardness up to 250,000 ppm;due to these thermodynamic conditions,there has been no available technology to form stable enough *** this work,a foaming supramolecular surfactant with the capability to chelate Ca^(2+)ions is *** a result,surfactant monomers are bridged by captured Ca^(2+)cations leading to the formation of high-molecular-weight oligomers,which significantly increment the viscosity of the solution improving the foam stability,and since at this manner the Ca2+cations are no longer available to precipitate as components of solid salts,the foaming supramolecular surfactant also performs as *** observations are explained through quantum theoretical *** foam is stable,effectively blocking the gas channels,whereas in presence of oil the foam is broken leading the oil to pass into the *** characteristic rheological properties of the foam allow its injection into the formation at a range of flow rates,foam qualities,and shear stress to achieve the flooding and the blocking of a variety of fractured carbonate formations,and the change of the wettability of the matrix,which is a desirable behavior in a huff and puff process,as reported in a previous publication about a successful pilot test of this foam.

关键词： Calcium chelation Foaming composition Supramolecular surfactant Molecular design Gas mobility control Flow assurance Improved oil recovery Conformance control

Gastric endoscopic submucosal dissection:From animal model to patient

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World Journal of Gastroenterology 2013年第45期19卷 8326-8334页

作者： Nicolás González Adolfo parra-Blanco Miguel Villa-Gómez Alejandra Gamba Andrés Taullard Anaulina Silveira Alberto Sanguinetti Carolina olano Henry Cohen Department of Gastroenterology Faculty of MedicineHospital de Clínicas Montevideo 11600 Uruguay Department of Gastroenterology Escuela de Medicina Pontificia Universidad Católica de Chile Santiago 6510260 Chile Department of Quantitative Methods Hospital de Clínicas Montevideo 11600 Uruguay

AIM:To assess whether the use of porcine models is useful for learning endoscopic submucosal dissection(ESD),thus contributing to its subsequent application in human ***:This study/learning process was carried out in 3 phases:PhaseⅠ:Ex vivo animal;PhaseⅡ:In vivo animal;PhaseⅢ:*** endoscopist performed 30 gastric ESDs in porcine models,and later 5gastric ESDs in 5 *** ESD was done following the method practiced at the National Cancer Center in Tokyo,*** aspects,size,time and speed of ESD,as well as complications were *** patients,their clinical,endoscopic and histologic evolution was additionally ***:Thirty en bloc ESDs were carried out in animal *** mean±SD size of the pieces was of28.4±1.2 mm,and the time of ESD was 41.7±*** time of ESD in the first 15 procedures was 43.0±3.0 min whereas in the next 15 procedures,the time was 40.3±3.9 min,P=*** speed in the first 15ESDs was 1.25±0.11 cm2/min vs 2.12±0.36 cm2/min in the remaining 15,P=*** were no *** patients,5 lesions were resected en *** size of the pieces was 25.2±5.1 mm and the time was85.0±25.6 *** and histological controls did not show evidence of residual neoplastic ***:A sequential ESD training program of a unique endoscopist,based on the practice in porcine models,contributed to learning ESD for its subsequent application in humans,yielding good results in efficacy and safety.

关键词： Endoscopic submucosal dissection Porcine models Animal models Training

Alpha2-adrenergic receptor activation reinstates motor deficits in rats recovering from cortical injury

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Neural Regeneration Research 2023年第4期18卷 875-880页

作者： Gabriela García-Díaz Laura ERamos-Languren Carmen parra-Cid Joel Lomelí Sergio Montes Camilo Ríos Antonio Bueno-Nava Ignacio Valencia-Hernández Rigoberto González-Piña Department of Pharmacology Section of Postgraduate Studies and ResearchHigh Medical SchoolInstituto Politécnico NacionalSalvador Díaz MirónAlcaldía Miguel HidalgoMexico CityMexico Department of Neurobiology of Aging and Brain Damage Coordination of Psychobiology and NeurosciencesFaculty of PsychologyNational Autonomous University of MexicoAv.Universidad 3040Col.Copilco UniversidadAlcaldía CoyoacánMexico CityMexico Direction of Research National Institute of Rehabilitation LGIICalz.Mexico-Xochimilco 289Col.Arenal de GuadalupeAlcaldía TlalpanMexico CityMexico Department of Pharmacology Multidisciplinary Academic Unit Reynosa-Aztlan ReynosaAutonomous University of Tamaulipascalle 16 y lago de ChapalaCol.AztlánTamaulipasMexico Department of Neurochemistry National Institute of Neurology and Neurosurgery MVSAv.Insurgentes Sur 3877Col.La FamaAlcaldia TlalpanMexico CityMexico Department of Special Education University of the AmericasPuebla 223Col.RomaAlcaldía CuauhtémocMexico CityMexico

Norepinephrine plays an important role in motor functional recovery after a brain injury caused by ferrous *** of norepinephrine release by clonidine is correlated with motor deficits after motor cortex *** aim of this study was to analyze the role ofα-adrenergic receptors in the restoration of motor deficits in recovering rats after brain *** rats were randomly assigned to the sham and injury groups and then treated with the following pharmacological agents at 3 hours before and 8 hours,3 days,and 20 days after ferrous chloride-induced cortical injury:saline,clonidine,efaroxan(a selective antagonist ofα-adrenergic receptors)and clonidine+*** sensorimotor score,the immunohistochemical staining forα-adrenergic receptors,and norepinephrine levels were *** hours post-injury,the sensorimotor score and norepinephrine levels in the locus coeruleus of the injured rats decreased,and these effects were maintained 3 days ***,20 days later,clonidine administration diminished norepinephrine levels in the pons compared with the sham *** effect was accompanied by sensorimotor *** effects were blocked by *** conclusion,an increase inα-adrenergic receptor levels was observed after *** restores motor deficits in rats recovering from cortical injury,an effect that was prevented by *** underlying mechanisms involve the stimulation of hypersensitiveα-adrenergic receptors and inhibition of norepinephrine activity in the locus *** results of this study suggest thatαreceptor agonists might restore deficits or impede rehabilitation in patients with brain injury,and therefore pharmacological therapies need to be prescribed cautiously to these patients.

关键词： alpha2-adrenoceptors ambulatory behavior clonidine cortical injury efaroxan functional recovery immunohistochemistry motor deficit norepinephrine sensorimotor score

Spatiotemporal mode decomposition of ultrashort pulses in linear and nonlinear graded-index multimode fibers

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Photonics Research 2023年第5期11卷 750-756页

作者： MARIo ZITELLI VINCENT CoUDERC MARIo FERRARo FABIo MANGINI PEDRo parra-RIVAS YIFAN SUN STEFAN WABNITZ Department of Information Engineering Electronics and TelecommunicationsUniversitàdegli Studi di Roma Sapienza00184 RomeItaly Universitéde Limoges XLIMUMR CNRS 725287060 LimogesFrance CNR-INo Istituto Nazionale di Ottica80078 PozzuoliItaly

We develop a spatiotemporal mode decomposition technique to study the spatial and temporal mode power distribution of ultrashort pulses in long spans of graded-index multimode fiber,for different input laser *** find that the beam mode power content in the dispersive pulse propagation regime can be described by the Bose-Einstein law,as a result of the process of power diffusion from linear and nonlinear mode coupling among nondegenerate mode *** the soliton regime,the output mode power distribution approaches the Rayleigh-Jeans law.

关键词： ultrashort multimode mode

Neuroprotective effect of immunomodulatory peptides in rats with traumatic spinal cord injury

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Neural Regeneration Research 2021年第7期16卷 1273-1280页

作者： Dulce parra-Villamar Liliana Blancas-Espinoza Elisa Garcia-Vences Juan Herrera-García Adrian Flores-Romero Alberto Toscano-Zapien Jonathan Vilchis Villa Rodríguez Barrera-Roxana Soria Zavala Karla Antonio Ibarra Raúl Silva-García Unidad de Investigación Médica en Inmunología Hospital de PediatríaCentro Médico Nacional Siglo XXI/Instituto Mexicano del Seguro Social/Ciudad de MéxicoMéxico Centro de Investigación en Ciencias de la Salud(CICSA) Facultad de Ciencias de la SaludUniversidad Anáhuac MéxicoCampus NorteHuixquilucanEdo de MéxicoMéxico Centro de Investigación del Proyecto Camina A.C Ciudad de MéxicoMéxico

Several therapies have shown obvious effects on structural conservation contributing to motor functional recovery after spinal cord injury(SCI).Nevertheless, neither strategy has achieved a convincing *** purposed a combined therapy of immunomodulatory peptides that individually have shown significant effects on motor functional recovery in rats with *** objective of this study was to investigate the effects of the combined therapy of monocyte locomotion inhibitor factor(MLIF), A91 peptide, and glutathione monoethyl ester(GSH-MEE) on chronic-stage spinal cord *** Sprague-Dawley rats underwent a laminectomy of the T9 vertebra and a moderate *** groups were included: sham, PBS, MLIF + A91, MLIF + GSH-MEE, A91 + GSH-MEE, and MLIF + A91 + *** months after injury, motor functional recovery was evaluated using the open field *** and white matter preservation was evaluated using hematoxylin & eosin staining and Luxol Fast Blue staining, *** number of motoneurons in the ventral horn and the number of axonal fibers were determined using hematoxylin & eosin staining and immunohistochemistry, *** deposition was evaluated using Masson's trichrome *** combined therapy of MLIF, A91, and GSH-MEE greatly contributed to motor functional recovery and preservation of the medullary parenchyma, white matter, motoneurons, and axonal fibres, and reduced the deposition of collagen in the lesioned *** combined therapy of MLIF, A91, and GSH-MEE preserved spinal cord tissue integrity and promoted motor functional recovery of rats after *** study was approved by the National Commission for Scientific Research on Bioethics and Biosafety of the Instituto Mexicano del Seguro Social under registration number R-2015-785-116(approval date November 30, 2015) and R-2017-3603-33(approval date June 5, 2017).

关键词： glutathione monoethyl ester monocyte locomotion inhibitor factor motor functional recovery neuroprotection neurorestoration peptides protective autoimmunity spinal cord injury

Poly(Vinyl Alcohol)(PVAl)and Poly(N-2-Vinyl-Pyrrolidone)Hydrogels Nanostructured by Laponite Clay for Drug Delivery

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材料科学与工程（中英文B版） 2022年第3期12卷 97-107页

作者： Maria José.A.oliveira Vinicius J.Santos Lucas Freitas de Freitas Ademar B.Lugão Duclerc F.parra Nuclear and Energy Research Institute-IPEN-CNEN/SP.Av.Professor Lineu Prestes 2242Cidade UniversitáriaSão Paulo 05508-000SPBrazil

Hydrogels for wound dressings are usually developed for contact surfaces where mechanical properties are conveniently *** this sense nanocomposite hydrogels based on PVAl(poly(vinyl alcohol))and PVP(poly(N-2-vinil-pirrolidone))containing 0.5-1.5 wt%of the synthetic laponite RD clay were prepared by a gamma radiation process and compared with similar membranes composed separately of PVP or *** study aimed to evaluate the effect of clay on the properties and the differences of the polymer blend instead of a unique *** morphology of the hydrogels was evaluated by spectrometric techniques using XRD(X-ray diffraction),SEM(scanning electron microscopy),swelling assay,and FTIR(infrared spectroscopy).The swelling kinetics at 22℃and the mechanical properties by a tensile test comprised the structural properties that were *** results showed PVA/PVP network depends directly on the clay concentration in the nanocomposite *** blend PVP/PVAl proved to have potentially efficient mechanical properties for drug delivery in the treatment of wounds.

关键词： Hydrogels clay nanocomposite drug delivery.

Validation of Fujinon intelligent chromoendoscopy with high definition endoscopes in colonoscopy

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World Journal of Gastroenterology 2009年第42期15卷 5266-5273页

作者： Adolfo parra-Blanco Alejandro Jiménez Bjrn Rembacken Nicolás González David Nicolás-Pérez Antonio Z Gimeno-García Marta Carrillo-Palau Takahisa Matsuda Enrique Quintero Department of Gastroenterology University Hospital of the Canary Islandsc/Ofra s/nLa Laguna 38320TenerifeSpain Department of Gastroenterology Hospital Universitario Central de AsturiasCelestino Villamil s/n33006 OviedoPrincipado de AsturiasSpain Research Unit University Hospital of the Canary Islandsc/Ofra s/nLa Laguna 38320TenerifeSpain Centre for Digestive Diseases The General Infirmary at LeedsGreat George StLeedsLS1 3EXUnited Kingdom Department of Gastroenterology Hospital de Clínicas de MontevideoAvda.Italia s/nMontevideo 11600Uruguay Division of Endoscopy National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyo 104-0045Japan

AIM:To validate high definition endoscopes with Fujinon intelligent chromoendoscopy(FICE) in ***:The image quality of normal white light endoscopy(WLE),that of the 10 available FICE filters and that of a gold standard(0.2% indigo carmine dye) were ***:FICE-filter 4 [red,green,and blue(RGB) wavelengths of 520,500,and 405 nm,respectively] provided the best images for evaluating the vascular pattern compared to white *** mucosal surface was best assessed using filter ***,the views obtained were not rated significantly better than those observed with white *** "gold standard",indigo carmine(IC) dye,was found to be superior to both white light and filter *** 6(RGB wavelengths of 580,520,and 460 nm,respectively) allowed for exploration of the IC-stained *** assessing mucosal polyps,both FICE with magnification,and magnification following dye spraying were superior to the same techniques without magnification and to white light *** the presence of suboptimal bowel preparation,observation with the FICE mode was possible,and endoscopists considered it to be superior to observation with white ***:FICE-filter 4 with magnification improves the image quality of the colonic vascular patterns obtained with WLE.

关键词： Colonoscopy Computed virtual chromoendoscopy Fujinon intelligent chromoendoscopy Magnifying colonoscopy Polyp diagnosis

Endoscopic submucosal dissection training with pig models in a Western country

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World Journal of Gastroenterology 2010年第23期16卷 2895-2900页

作者： Adolfo parra-Blanco María Rosa Arnau David Nicolás-Pérez Antonio Z Gimeno-García Nicolás González Juan A Díaz-Acosta Alejandro Jiménez Enrique Quintero Department of Gastroenterology University Hospital of the Canary Islands Ofra s/n Endoscopy Unit Department of GastroenterologyAsturias Central University HospitalCelestino Villamil s/n Research Animal Laboratory Ofra s/nLa Laguna University Department of Gastroenterology Montevideo Clinic HospitalAvda Italia s/n Research Unit University Hospital of the Canary IslandsOfra s/n

AIM:To test a strategy for endoscopic submucosal dissection(ESD) training in animal models designed to overcome the initial learning ***:ESD was attempted in ex vivo and in vivo pig *** ESD procedures were attempted in the esophagus(n=9) or the stomach(n=21).The ex vivo model was used until initial competence was *** the in vivo model,several ESD procedures were performed in up to 3 *** following variables were analyzed:specimen size,complete and en bloc resection rate,time for circumferential incision,time for submucosal dissection,total ESD duration,and ***:Complete resection was achieved in 28 cases(en bloc 27);2 could not be completed(one perforation,one technical diff iculty).The mean ± SD time for circumferential incision was 36.2±16.8 min(range:8-87 min),and the mean±SD time for submucosal dissection was 45.1±35.7 min(range:9-196 min).The mean±SD size of the resected specimens was 45.2±17.8 *** mean±SD total resection time was signif icantly increased for the gastric cases performed in the f irst half of the study(n=13) than in the second half(n=8)(98.9±62.4 min vs 61.7±17.6 min,P=0.04),although the specimen size did not ***:Training in animal models could help endoscopists overcome the learning curve before starting ESD in humans.

关键词： Endoscopic submucosal dissection Training Animal model

URBAN PHoToVoLTAIC PoTENTIAL oF INCLINED RooFING FoR BUILDINGS IN HERITAGE CENTERS IN EQUAToRIAL AREAS

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Journal of Green Building 2018年第3期13卷 45-69页

作者： Esteban Zalamea-León Juan Mena-Campos Antonio Barragán-Escandón Diego parra-González Pablo Méndez-Santos Facultad de Arquitectura y Urbanismo Universidad de Cuenca(School of Architecture and UrbanismUniversity of Cuenca) Departamento de Ingeniería Gráfica Diseño and ProyectosUniversidad de Jaén(Department of Graphic EngineeringDesign and ProjectsUniversity of Jaén)JaénSpain.Department of Electrical EngineeringUniversidad Politécnica SalesianaCuencaEcuador Facultad de Ingeniería Universidad de Cuenca(Faculty of EngineeringUniversity of Cuenca) Departamento de Ingeniería Eléctrica Universidad Politécnica Salesiana(Department of Electrical EngineeringSalesiana Polytechnic University)

In situ renewable energy production is a favourable alternative for reducing pollu-tion and combating climate *** research area,Cuenca,Ecuador,is located in the Andes near the equator with optimal conditions for energy self-supply due to its low energy demands and low levels of irradiation *** this study,tem-porary fluctuations in consumption based on 2016 electricity consumption data are *** GIS,available roofing polygons are obtained,and the amount of usable solar radiation is estimated based on these *** available surface,orientation,and inclination information,electricity generation based on photovoltaic performance is estimated and compared for monocrystalline silica panels and pho-tovoltaic solar roof tiles,which are architectural alternatives.A potential net supply of 148%is found for monocrystalline silica photovoltaic panels in a typical format,whereas that of photovoltaic tiles is only 61%.In addition,production-demand imbalances are predicted in extreme months and average months and on extreme days due to variations in irradiation and demands.

关键词： solar energy photovoltaic on buildings photovoltaic architectural integration heritage centres energy efficiency