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Real-world disease activity and sociodemographic,clinical and treatment characteristics of moderate-to-severe inflammatory bowel disease in Brazil

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World Journal of Gastroenterology 2021年第2期27卷 208-223页

作者： Cyrla Zaltman Rogério Serafim parra Ligia Yukie Sassaki Genoile oliveira Santana Maria de Lourdes Abreu Ferrari Sender J Miszputen Heda M B S Amarante Roberto Luiz Kaiser Junior Cristina Flores Wilson R Catapani JoséMiguel Luz Parente Mauro Bafutto odery Ramos Carolina D Gonçalves Isabella Miranda Guimaraes Jose J R da Rocha Marley R Feitosa omar Feres Rogerio Saad-Hossne Francisco Guilherme Cancela Penna Pedro Ferrari Sales Cunha Tarcia NF Gomes Rodrigo Bremer Nones Mikaell Alexandre Gouvea Faria Mírian Perpétua Palha Dias Parente António S Scotton Rosana Fusaro Caratin Juliana Senra Júlio Maria Chebli Department of Internal Medicine Federal University of Rio de JaneiroRio de Janeiro 21941-913Brazil Department of Surgery and Anatomy Ribeirão Preto Medical SchoolUniversity of São PauloRibeirao Preto 14049-900São PauloBrazil Department of Internal Medicine São Paulo State University(UNESP)Medical SchoolBotucatu 18618-687São PauloBrazil IBD Unit Federal University of BahiaSalvador 41150-000BahiaBrazil Department of Clinical Medicine Medical SchoolUniversidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Department of Gastroenterology Escola Paulista de MedicinaSão Paulo 04023-900Brazil Hospital de Clinicas Universidade Federal do ParanaCuritiba 80060-900ParanaBrazil Department of Proctology Beneficencia Portuguesa Hospital/Kaiser Day HospitalSao Jose do Rio Preto 15015110São PauloBrazil Department of Gastroenterology and Hepatology Sciences Hospital de ClínicasUniversidade Federal do Rio Grande do SulPorto Alegre 90560002Rio Grande do SulBrazil Department of Gastroenterology Faculdade de Medicina do ABCSanto Andre 09060-870São PauloBrazil Department of General Medicine Gastroenterology UnitUniversity HospitalFederal University of PiauiTeresina 64049-550PiauíBrazil Department of Gastroenterology Faculdade de MedicinaUniversidade Federal de GoiásGoiania 74535-170GoiasBrazil Department of Surgery Botucatu Medical School at São Paulo State University(UNESP)Botucatu 18618687São PauloBrazil Department of Gastroenterology UNIFESPSão Paulo 04040-002Brazil IBD unit Gastroenterology DepartmentHospital Nossa Senhora das GraçasCuritiba 80810-040ParanaBrazil Department of Proctology Kaiser Hospital DiaSao Jose do Rio Preto 15015-110São PauloBrazil Health Sciences Center Epidemiology UnitState University of PiauiTeresina 64001-280PiauíBrazil Department of Gastroenterology CMIP Centro Mineiro de PesquisaJuiz de Fora 36010-570Minas GeraisBrazil Scientific Affairs Takeda Pharmaceuticals BrazilSão Paulo 04709-011Brazil Clinical Research Takeda Pharma

BACKGRoUND Understanding the treatment landscape of inflammatory bowel diseases(IBD)is essential for improving disease management and patient *** is the largest Latin American country,and it presents socioeconomic and health care differences across its geographical *** country has the highest increase in IBD incidence and prevalence in Latin America,but information about the clinical and treatment characteristics of IBD is *** To describe the sociodemographic,clinical,and treatment characteristics of IBD outpatients in Brazil overall and in the Southeast,South and Northeast/Midwest *** Multicenter,cross-sectional study with a 3-year retrospective chart review *** with moderate-to-severe Crohn’s disease(CD)or ulcerative colitis(UC)were consecutively enrolled between october 2016 and February *** CD at enrollment was defined as a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or a calprotectin level>200μg/g or an active result based on colonoscopy suggestive of inadequate control during the previous year;active UC was defined as a partial Mayo score≥*** statistics were used to analyze all *** In a total of 407 included patients,CD was more frequent than UC,both overall(264 CD/143 UC patients)and by region(CD:UC ratios of 2.1 in the Southeast,1.6 in the South and 1.2 in the Northeast/Midwest).The majority of patients were female(54.2%of CD;56.6%of UC),and the mean ages were 45.9±13.8 years(CD)and 42.9±13.0 years(UC).The median disease duration was 10.0(range:0.5-45)years for both IBD *** enrollment,44.7%[95%confidence interval(CI):38.7-50.7]of CD patients and 25.2%(95%CI:18.1-32.3)of UC patients presented with active *** than 95%of IBD patients were receiving treatment at enrollment;CD patients were commonly treated with biologics(71.6%)and immunosuppressors(67.4%),and UC patients were commonly treated with mesalazine[5-Aminosalicylic acid(5-ASA)]derivates(69.9%)and

关键词： Inflammatory bowel disease Crohn's disease Ulcerative colitis Disease activity Epidemiology Treatment

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石油系统及勘探基于地震及重磁数据解释西澳大利亚坎宁盆地的区域横剖面

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海洋地质 2013年第1期29卷 18-18页

作者： Marien parra MikeDENTITH Annette D. GEoRGE

澳大利亚西北部陆地坎宁盆地目前正处于勘探中，勘探密度为每1000km。大致布置一口井。坎宁盆地是一个长期沉降中心，其沉积物厚度超过17km，且至少有6个含油气系统。然而迄今未见有横跨整个盆地的区域性地层剖面的成果公开发表。

关键词：西澳大利亚盆地勘探石油系统数据解释横剖面重磁地震

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评估子宫胎盘血流与氧化应激及内皮细胞功能异常的生化指标作为先兆子痫的筛查试验

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世界核心医学期刊文摘（妇产科学分册） 2006年第3期2卷 10-10页

作者： parra M. Rodrigo R. Barja P. 翁梨驹 Unidad Medicina Fetal Hospital Clnico Universidad de Chile Santos Dumont 999 Independencia Santiago Chile Dr.

objective: This study was undertaken to evaluate whether screening through a uterine artery (UtA) Doppler and biochemical markers of oxidative stress and endothelial dysfunction predict preeclampsia. Study design: UtA Doppler was performed at 11 to 14 and 22 to 25 weeks on 1447 asymptomatic pregnant women. oxidative stress, endothelial dysfunction, and antiangiogenic state were assessed in women who later developed preeclampsia and normotensive controls. Results: There was a significantly increased of UtA pulsatility index (PI), plasma levels of soluble fms-like tyrosine kinase 1 (s-Flt1), PAI-1/PAI-2 ratio, and F-2 isoprostane in women who subsequently developed preeclampsia compared with control pregnancies. Multivariate logistic regression showed that increased UtA PI performed at 23 weeks was the best predictor for preeclampsia. Conclusion: This study demonstrates early changes in markers of impaired placentation, antiangiogenic state, oxidative stress, and endothelial dysfunction suggesting that these derangements may play a role in the pathogenesis of preeclampsia. our data point to UtA as the best test to predict preeclampsia at 23 weeks of gestation.

关键词：胎盘血流氧化应激先兆子痫生化指标搏动指数最佳预测内皮细胞功能胎盘功能前列腺素多普勒

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RCS梁柱节点基于变形能力的设计

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建筑钢结构进展 2003年第2期5卷 63-63页

作者： G.J.parra-Montesinos X.Liang J.K.Wight 周昊圣

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谎言重复千遍也不会成为真理

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友声 2021年第2期 26-26页

作者：胡安·德·迪奥斯·帕拉拉丁美洲人权协会中国-拉丁美洲加勒比旅游、科技、文化交流促进联盟

当拉斐尔·莱姆金1944年首次提出"种族灭绝"这一说法时,一定想不到这个概念在人类历史上将会变得多么重要。莱姆金将种族灭绝定义为旨在全部或部分地消灭一个国家、民族、种族或宗教群体的行为。如果将他的定义稍作泛化,种族灭绝可以被... 详细信息

当拉斐尔·莱姆金1944年首次提出"种族灭绝"这一说法时,一定想不到这个概念在人类历史上将会变得多么重要。莱姆金将种族灭绝定义为旨在全部或部分地消灭一个国家、民族、种族或宗教群体的行为。如果将他的定义稍作泛化,种族灭绝可以被认为是"对于人类族群生存权的剥夺"。1948年联合国大会通过的《防止及惩治灭绝种族罪公约》第二条将种族灭绝行为定义为"蓄意全部或局部消灭某一民族、人种、种族或宗教团体"的所有行为。

关键词：种族灭绝灭绝种族罪宗教团体生存权拉斐尔联合国大会行为定义宗教群体

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内窥镜机械技术处理结肠Dieulafoy病变:两例病例报道

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世界核心医学期刊文摘（胃肠病学分册） 2005年第2期1卷 20-20页

作者： Gimeno-Garca A.Z. parra-Blanco A. Nicols-Pérez D. E. Quintero 赵天智 Hospital Universitario de Canarias Unidad de Investigacion La Laguna Ofra s/n. 38320 Tenerife SpainDr.

Although Dieulafoy lesion is generally located in the proximal stomach, other locations have been reported. We present two cases of bleeding colonic Dieulafoy in patients with chronic renal failure who were treated with mechanical methods . In the first case, an active arterial bleeding without mucosal defectwas local ized in the descending colon. In the second case, a protruding vessel with activ e bleeding was found in the transverse colon. The two patients were initially tr eated with epinephrine and hemostatic clips. In the second patient, an endoloop was attached to the base of the previously placed hemoclips because of rebleedin g. To our knowledge, this is the first case of combined endoscopic approach with hemostatic clips and endoloop to treat a colonic Dieulafoy lesion. Colonic Dieu lafoy lesions reported in the relevant literature and the hemostatic treatments used are reviewed.

关键词： Dieulafoy病机械技术近端止血夹动脉出血止血治疗慢性肾衰竭黏膜缺损活动性出血套扎

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孕期补充DHA与新生儿状况:在墨西哥进行的一项双盲、随机、对照研究

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营养健康新观察 2009年第3期 46-46页

作者： Ramakrishnan Usha Stein Aryeh D. parra-Cabrera Socorro Juarez-Marquez Sergio River-Dommarco Juan Martorell Reynaldo 张喆庆 Emory University Institute Nacional de Salud Publica Insitute Mexicano del Seguro Social(IMSS)

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哥伦比亚大学的公司治理

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国际行政科学评论（中文版） 2019年第3期85卷 161-182页

作者：杰森斯·马里奥·弗洛瑞·帕拉玛丽亚·维多利亚·洛佩斯·佩雷斯安东尼奥·曼努埃尔·洛佩斯·赫尔南德斯丁晶晶(译) 王秋蕾(审校) 格拉纳达大学不详

在对问责制和管理透明度提出更高要求的背景下,我们分析了公司治理(CG)机制的采用程度,并定义了哥伦比亚所有大学的治理模型。在高等教育领域,通常没有与公司治理相关的强制性要求。然而,如今治理机制对于确定大学的目标、策略和方向至... 详细信息

在对问责制和管理透明度提出更高要求的背景下,我们分析了公司治理(CG)机制的采用程度,并定义了哥伦比亚所有大学的治理模型。在高等教育领域,通常没有与公司治理相关的强制性要求。然而,如今治理机制对于确定大学的目标、策略和方向至关重要。基于对哥伦比亚81个高等教育机构校长的调查,我们分析了它们所采用的公司治理模式(管理模式和利益相关者模式)。这个结果有助于更好地理解大学中的关键公司治理概念。

关键词：哥伦比亚公司治理管理教育校长大学

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