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Alpha2-adrenergic receptor activation reinstates motor deficits in rats recovering from cortical injury

Neural Regeneration Research 2023年第4期18卷 875-880页

作者： Gabriela García-Díaz Laura ERamos-Languren Carmen parra-Cid Joel Lomelí Sergio Montes Camilo Ríos Antonio Bueno-Nava ignacio Valencia-Hernández Rigoberto González-Piña Department of Pharmacology Section of Postgraduate Studies and ResearchHigh Medical SchoolInstituto Politécnico NacionalSalvador Díaz MirónAlcaldía Miguel HidalgoMexico CityMexico Department of Neurobiology of Aging and Brain Damage Coordination of Psychobiology and NeurosciencesFaculty of PsychologyNational Autonomous University of MexicoAv.Universidad 3040Col.Copilco UniversidadAlcaldía CoyoacánMexico CityMexico Direction of Research National Institute of Rehabilitation LGIICalz.Mexico-Xochimilco 289Col.Arenal de GuadalupeAlcaldía TlalpanMexico CityMexico Department of Pharmacology Multidisciplinary Academic Unit Reynosa-Aztlan ReynosaAutonomous University of Tamaulipascalle 16 y lago de ChapalaCol.AztlánTamaulipasMexico Department of Neurochemistry National Institute of Neurology and Neurosurgery MVSAv.Insurgentes Sur 3877Col.La FamaAlcaldia TlalpanMexico CityMexico Department of Special Education University of the AmericasPuebla 223Col.RomaAlcaldía CuauhtémocMexico CityMexico

Norepinephrine plays an important role in motor functional recovery after a brain injury caused by ferrous *** of norepinephrine release by clonidine is correlated with motor deficits after motor cortex *** aim of this study was to analyze the role ofα-adrenergic receptors in the restoration of motor deficits in recovering rats after brain *** rats were randomly assigned to the sham and injury groups and then treated with the following pharmacological agents at 3 hours before and 8 hours,3 days,and 20 days after ferrous chloride-induced cortical injury:saline,clonidine,efaroxan(a selective antagonist ofα-adrenergic receptors)and clonidine+*** sensorimotor score,the immunohistochemical staining forα-adrenergic receptors,and norepinephrine levels were *** hours post-injury,the sensorimotor score and norepinephrine levels in the locus coeruleus of the injured rats decreased,and these effects were maintained 3 days ***,20 days later,clonidine administration diminished norepinephrine levels in the pons compared with the sham *** effect was accompanied by sensorimotor *** effects were blocked by *** conclusion,an increase inα-adrenergic receptor levels was observed after *** restores motor deficits in rats recovering from cortical injury,an effect that was prevented by *** underlying mechanisms involve the stimulation of hypersensitiveα-adrenergic receptors and inhibition of norepinephrine activity in the locus *** results of this study suggest thatαreceptor agonists might restore deficits or impede rehabilitation in patients with brain injury,and therefore pharmacological therapies need to be prescribed cautiously to these patients.

关键词： alpha2-adrenoceptors ambulatory behavior clonidine cortical injury efaroxan functional recovery immunohistochemistry motor deficit norepinephrine sensorimotor score

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Evidence-based considerations on bowel preparation for colonoscopy

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World Journal of Gastroenterology 2022年第31期28卷 4463-4466页

作者： Konstantinos Argyriou Adolfo parra-Blanco Department of Gastroenterology University Hospital of LarisaLarisa GR41334Greece Department of Gastroenterology Nottingham University Hospitals NHS TrustNottingham NG51PBUnited Kingdom

We recently read with interest the article,“Novel frontiers of agents for bowel cleansing for colonoscopy”.This is a practical narrative review,which could be of particular importance to clinicians in order to improve their current *** we appreciate the venture of our colleagues,based on our in-depth analysis,we came across several minor issues in the article;hence,we present our comments in this *** the authors consider these comments further in their relevant research,we believe that their contribution would be of considerable importance for future studies.

关键词： Colonoscopy Bowel preparation Polyethylene glycol Post-polypectomy syndrome Post-polypectomy complications

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Reconstructing the puzzle of the role of therapeutic endoscopy in the management of post-bariatric surgery complications

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World Journal of Gastroenterology 2022年第23期28卷 2633-2635页

作者： Konstantinos Argyriou Adolfo parra-Blanco Department of Gastroenterology University Hospital of LarisaLarisa GR41110Greece Department of Gastroenterology Nottingham University Hospitals NHS TrustNottingham NG51PBUnited Kingdom

We have recently read with interest the mini-review article"Therapeutic endoscopy for the treatment of post-bariatric surgery complications".The abovementioned article is a brief overview of the different endoscopic modalities employed in the management of bariatric surgery complications and represents an important decision support tool for clinicians to improve their current *** we appreciate the endeavor of Larsen and Kozarek,based on our indepth analysis,we came across several minor issues in this article;thus,we present our comments in this *** case the authors contemplate these comments in their relevant research,we believe that their contribution would be considerable for future studies.

关键词： Endoscopic treatment Bariatric surgery Complications Obesity Sleeve gastrectomy Roux-en-Y gastric bypass

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Simulation of Biogas Production from Solid Organic Wastes

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Journal of Chemistry and Chemical Engineering 2015年第2期9卷 107-112页

作者： ignacio Contreras-Andrade Jonathan parra-Santiago Carlos Alberto Guerrero-Fajardo Doctor Chemical Engineering Autonomous University of Sinaloa Culiacan Rosales 80040 Mexico Chemical Engineering(C) National University of Colombia Bogota 11001 Colombia Chemical Engineering and Mechanical National University of Colombia Bogota 11001 Colombia

The design and building of new alternative fuel plants is an increasing necessity to replace old technology and non-renewable fossil fuels. To optimize the performance of these plants and to obtain an economically feasible production of these types of fuels, it is necessary to have a total control of each variable involved in the process of production and how these factors affect the yield of fuel production. In this paper it is proposed a model of a digester to generate gas using a Vensim software designed to generate simulations in dynamic state. This simulation was developed using differential equations to model the behavior at each stage of the process and auxiliary conditions to complement the mathematical description of the model. The main factors in the biogas production are the retention time and the methanogen mortality ratio. For retention time lower than 10 h the process loses effectiveness due to bacterial growth is not completed efficiently, but a high retention time involves a bigger reactor and the yield of production decreases considerably for retention time higher than 40 h. The best yields were obtained for a mortality ratio in methanogen and acidogenic bacteria lower than 0.2 and a retention time of 30 h with a final production of 3.33 L by each kilogram of biomass.

关键词： Bio-digester bio-digestion gas synthesis renewable energy.

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Stroke and sleep-disordered breathing: A relationship under construction

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World Journal of Clinical Cases 2016年第2期4卷 33-37页

作者： Olga parra Adrià Arboix Service of Pneumology Hospital Universitari del Sagrat CorUniversity of Barcelona Cerebrovascular Division Service of NeurologyUniversity of Barcelona Hospital del Sagrat Cor

The association between sleep-disordered breathing(SDB) and cardiovascular risk has been the focus of attention in recent *** disorders are emerging risk factors for cardiovascular disease and have been related to the whole spectrum of stroke,including transient ischemic attack,ischemic cerebral infarction and intracerebral *** has been shown that lacunar stroke or lacunar infarctions affecting the internal capsule or the protuberance are associated with a higher frequency of *** stroke patients with associated SDB have a worse prognosis and a higher mortality as compared to patients with first-ever stroke without *** studies provide evidence of the usefulness of treatment with continuous positive airway pressure when SDB is present in stroke patients.

关键词： Apnea-hypopnea index Cardiovascular risk factors Continuous positive airway pressure Ischemic stroke Lacunar infarction Sleep disordered

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Bidirectional relationship between gastrointestinal cancer and depression: The key is in the microbiota-gut-brain axis

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World Journal of Gastroenterology 2024年第48期30卷 5104-5110页

作者： Bryan Adrian Priego-parra Jose Maria Remes-Troche Digestive Physiology and Gastrointestinal Motility Laboratory Instituto de Investigaciones Médico-BiológicasUniversidad VeracruzanaVeracruz 91700Mexico

In this Editorial,we review the recent publication in the World Journal of Gastroen-terology,which explores the complex relationship between depression and gastric cancer and offers *** topics discussed include the microbiota-gut-brain axis,dysbiosis,and the influence of microbial metabolites in ***,we address toxic stress caused by hypothalamic-pituitary-adrenal axis dysregulation,psychological assessments,and future research *** Editorial aims to expand the understanding of the bidirectional relationship between depression and gastrointestinal cancer.

关键词： Gastric cancer Depression Psychogastroenterology Microbiota-gut-brain axis Mood disorders Dysbiosis

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A model for strong attenuation and dispersion of seismic P-waves in a partially saturated fractured reservoir

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Science China(Physics,Mechanics & Astronomy) 2010年第8期53卷 1383-1387页

作者： BRAJANOVSKI Miroslav MüLLER Tobias M parra Jorge O Department of Exploration Geophysics Curtin University of Technology Geophysical Institute University of Karlsruhe Southwest Research Institute

In this work we interpret the data showing unusually strong velocity dispersion of P-waves (up to 30%) and attenuation in a relatively narrow frequency range. The cross-hole and VSP data were measured in a reservoir, which is in the porous zone of the Silurian Kankakee Limestone Formation formed by vertical fractures within a porous matrix saturated by oil, and gas patches. Such a medium exhibits significant attenuation due to wave-induced fluid flow across the interfaces between different types of inclusions (fractures, fluid patches) and background. Other models of intrinsic attenuation (in particular squirt flow models) cannot explain the amount of observed dispersion when using realistic rock properties. In order to interpret data in a satisfactory way we develop a superposition model for fractured porous rocks accounting also for the patchy saturation effect.

关键词： attenuation dispersion Biot’s slow wave poroelasticity fractures patchy-saturation

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Does wetland watershed land use influence amphibian larval development? A relevant effect of agriculture on biota

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Journal of Oceanology and Limnology 2019年第1期37卷 160-168页

作者： GARCíA-MU?OZ Enrique GUERRERO Francisco ARECHAGA Garbi?e parra Gema Departamento de Biología Animal Biología Vegetal y Ecología Campus de las Lagunillas Centro de Estudios Avanzados en Ciencias de la Tierra Campus de las Lagunillas Departamento de Ciencias de la Salud Campus de las Lagunillas

Agriculture practices have been widely proposed as the major cause of amphibian population decline. However, the majority of these results have been based on laboratory experiments. The present study was conducted to test the repercussion of wetland sediment provenance on amphibian larval *** bufo larvae were used in two dif ferent treatments in an outdoor experiment, the ?rst one using sediment from one wetland surrounded by intensive agricultural practices, and the second using sediment with no record of agrochemical uses. A negative ef fect was observed in the agricultural treatment, from subcellular to individual level. The results showed that the sediment from agricultural practices watershed generates a reduction in survival. Furthermore, individuals that developed under this treatment showed a lower total length and a delay in the time necessary to complete metamorphosis; these features are connected with recruitment success. In the same way, biochemical analysis showed high values of lipid peroxidation in metamorphs developing in sediments from an agricultural area. Finally, the results obtained highlight the importance of considering the sediments, not only the water, as origin treatment, allowing us to understand the consequences on amphibian populations that inhabit areas af fected by intensive agriculture.

关键词： amphibian decline Bufo bufo survival ecotoxicology agricultural practices

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Emerging therapeutic options in inflammatory bowel disease

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World Journal of Gastroenterology 2021年第48期27卷 8242-8261页

作者： Jesus K Yamamoto-Furusho Norma N parra-Holguín Gastroenterology Unit Inflammatory Bowel Disease ClinicInstituto Nacional de Ciencias Medicas y NutricionMexico City 14080Mexico

Inflammatory bowel disease(IBD)is a chronic disease that requires chronic treatment throughout the evolution of the disease,with a complex physiopathology that entails great challenges for the development of new and specific treatments for ulcerative colitis and Crohn's *** anti-tumor necrosis factor alpha therapy has impacted the clinical course of IBD in those patients who do not respond to conventional treatment,so there is a need to develop new therapies and markers of treatment *** pathways involved in the development of the disease are known and the new therapies have focused on blocking the inflammatory process at the gastrointestinal level by oral,intravenous,subcutaneous,and topical *** these new therapies can lead to more personalized treatments with higher success rates and fewer *** treatments have not only focused on clinical remission,but also on achieving macroscopic changes at the endoscopic level and microscopic changes by achieving mucosal *** treatments are mainly based on modifying signaling pathways,by blocking receptors or ligands,reducing cell migration and maintaining the integrity of the epithelial ***,this review presents the efficacy and safety of the new treatments that are currently under study and the advances that have been made in this area in recent years.

关键词： Inflammatory bowel disease Review Emerging Treatment Ulcerative colitis Crohn's disease

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Shell geometric morphometrics in Biomphalaria glabrata (Mollusca： Planorbidae) uninfected and infected with Schistosoma mansoni

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Zoological Systematics 2017年第1期42卷 59-64页

作者： Cesar parra Jonathan Liria Departamento de Hgilancia y Control de Fauna de Moluscos Coordinacion de Zoonosis Reservorios y Fauna Nociva. Ministerio del Poder Popular para la Salud Aragua Venezuela Centro de Estudios en Zoologia Aplieada. FACYT Universidad de Carabobo Carabobo Venezuela Universidad Regional Amazonica IKIAM km7 via Muyuna Napo Ecuador

Freshwater planorbid mollusks belonging to the genus Biomphalaria act as intermediate hosts for Schistosoma mansoni, the etiological agent of human intestinal schistosomiasis, in the Neotropical Region. Identification ofBiomphalaria spp. are carried out based on morphological characters, and the Schistosoma infection are determined by the presence of cercariae （verified through microscope preparation and mounting）. Recently, the geometric morphometrics has proven to be a useful tool for determining shape differences in disease vectors arthropods. Due to this, we used geometric morphometrics to determine Biomphalaria glabrata shell differences （shape and size） between uninfected and infected specimens. We digitalized 12 anatomical points over the shell left side （from umbilicus to the last whorl） by combining type I and II landmarks and sliding semilandmarks; the coordinates were aligned by generalized Procrustes analysis. Principal component analyses were implemented for examining main variation axes, and discriminant analysis for testing group membership significance. We found significant separation between infected and uninfected shell conformation. All specimens were 100% correctly classified. The main differences occur in the peristome. The Kruskal-Wallis test finds significant differences in shell isometric size among infected and uninfected specimens. These findings correspond to other studies of traditional morphometrics, that infected snails showed the reduction in shell size in contrast to those uninfected specimens

关键词： Schistosomiasis Gastropoda peristome landmarks Procrustes.

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