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Rare Metals 2006年第z2期25卷 184-188页

作者： park sook hee KANG Chan Hyoung Department of Advanced Materials Engineering Korea Polytechnic University Shihung Kyonggi-do 429-793 Korea

Employing Li2CO3, NiO, Co3O4, and MnCO3 powders as starting materials, Li[Ni1/3Co1/3Mn1/3]O2 was synthesized by solid-state reaction method. Various grinding aids were applied during milling in order to optimize the synthesis process. After successive heat treatments at 650 and 950 ℃, the prepared powders were characterized by X-ray diffraction (XRD) analysis, scanning electron microscopy, and transmission electron microscopy. The powders prepared by adding salt (NaCl) as grinding aid exhibit a clear R3m layer structure. The powders by other grinding aids like heptane show some impurity peaks in the XRD pattern. The former powders show a uniform particle size distribution of less than 1 μm average size while the latter shows a wide distribution ranging from 1 to 10 μm. Energy dispersive X-ray (EDX) analysiss show that the ratio of Ni, Co, and Mn content in the powder is approximately 1/3, 1/3, and 1/3, respecively. The EDX data indicate no incorporation of sodium or chlorine into the powders. Charge-discharge tests gave an initial discharge capacity of 160 mAh·g-1 for the powders with NaCl addition while 70 mAh·g-1 for the powders with heptane.

关键词： lithium ion battery cathode materials layered structure solid-state method discharge density

Optimization of an Artificial Intelligence Database and Camera Installation for Recognition of Risky Passenger Behavior in Railway Vehicles

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Computers, Materials & Continua 2025年第1期82卷 1277-1293页

作者： Min-kyeong Kim Yeong Geol Lee Won-hee park Su-hwan Yun Tae-Soon Kwon Duckhee Lee Railroad Test&Certification Division Korea Railroad Research Institute(KRRI)Cheoldo BangmulgwanroUiwang-si16105Republic of Korea Railroad Safety Division Korea Railroad Research Institute(KRRI)Cheoldo BangmulgwanroUiwang-si16105Republic of Korea

Urban railways are vital means of public transportation in *** than 30%of metropolitan residents use the railways,and this proportion is expected to *** enhance safety,the government has mandated the installation of closed-circuit televisions in all carriages by ***,cameras still monitored *** address this limitation,we developed a dataset of risk factors and a smart detection system that enables an immediate response to any abnormal behavior and intensive monitoring *** created an innovative learning dataset that takes into account seven unique risk factors specific to Korean railway *** data collection was conducted across the Shinbundang Line of the Incheon Transportation Corporation,and the Ui-Shinseol *** observed several behavioral characteristics and assigned unique annotations to *** also considered carriage *** performance was evaluated by camera placement and *** the camera installation plan was *** dataset will find immediate applications in domestic railway *** artificial intelligence algorithms will be verified shortly.

关键词： AI railway vehicle risk factor smart detection AI training data

Comprehensive molecular characterization to predict immunotherapy response in advanced biliary tract cancer: a phase II trial of pembrolizumab

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Oncology research 2025年第1期33卷 57-65页

作者： Ryul Kim Joo Kyung park Minsuk Kwon Minae An Jung Yong Hong Joon Oh park Sung hee Lim Seung Tae Kim Division of Hematology-Oncology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea. Division of Gastroenterology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea. Department of Hematology-Oncology Ajou University School of Medicine Suwon-si Gyeonggi-do Korea. Samsung Advanced Institute of Health Science and Technology Sungkyunkwan University School of Medicine Seoul Korea.

Background:Immune checkpoint inhibitors (ICIs) are effective in a subset of patients with metastatic solid tumors. However, the patients who would benefit most from ICIs in biliary tract cancer (BTC) are still controversial.Materials and methods:We molecularly characterized tissues and blood from 32 patients with metastatic BTC treated with the ICI pembrolizumab as second-line therapy.Results:All patients had microsatellite stable (MSS) type tumors. Three of the 32 patients achieved partial response (PR), with an objective response rate (ORR) of 9.4% (95% confidence interval [CI], 2.0-25.2) and nine showed stable disease (SD), exhibiting a disease control rate (DCR) of 37.5% (95% CI, 21.1-56.3). For the 31 patients who had access to PD-1 ligand 1 (PD-L1) combined positive score (CPS) testing (cut-off value ≥1%), the ORR was not different between those who had PD-L1-positive (PD-L1+; 1/11, 9.1%) and PDL1-(2/20, 10.0%) tumors ( = 1.000). The tumor mutational burden (TMB) of PD-L1+ BTC was comparable to that of PD-L1-BTC ( = 0.630). TMB and any exonic somatic mutations were also not predictive of pembrolizumab response. Molecular analysis of blood and tumor samples demonstrated a relatively high natural killer (NK) cell proportion in the peripheral blood before pembrolizumab treatment in patients who achieved tumor response. Moreover, the tumors of these patients presented high enrichment scores for NK cells, antitumor cytokines, and Th1 signatures, and a low enrichment score for cancer-associated fibroblasts.Conclusions:This study shows the molecular characteristics associated with the efficacy of pembrolizumab in BTC of the MSS type.

关键词： Biliary tract cancer Pembrolizumab Whole-exome sequencing Whole-transcriptome sequencing

Metal stents placement for refractory pancreatic duct stricture in children

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World Journal of Gastroenterology 2018年第3期24卷 408-414页

作者： In sook Jeong Sung hee Lee Seak hee Oh Do Hyun park Kyung Mo Kim Department of Pediatrics University of Ulsan College of MedicineAsan Medical Center Children’s Hospital Department of Internal Medicine University of Ulsan College of MedicineAsan Medical Center

AIM To evaluate the use of fully covered self-expandable metal stents(FCSEMSs) for pancreatic duct strictures in children with chronic *** Eight patients with refractory benign dominant stricture of the main pancreatic duct(MPD) were enrolled through chart reviews between December 2014 and June 2017 in a single center. Endoscopic retrograde cholangiopancreatography(ERCP) with placement of a 6-mm FCSEMS with dual flaps was performed. Endoscopic removal of FCSEMSs was performed with a snare or rat-tooth forceps. All procedures were performed by a pediatric gastroenterologist. For the assessment of outcomes, technical and clinical success, adverse events, and stent patency were evaluated *** The placement and removal of the FCSEMSs were successful in all 8 patients. Five patients were boys and 3 were girls. The median age at initial FCSEMS placement was 12 years(range, 5-18 years). The diameters of all the inserted stents were 6 mm, and the lengths were 4-7 cm. The median indwelling time was 6 mo(range, 3-10 mo). No pancreatic sepsis, pancreatitis, cholestasis, or mortality occurred. There was no proximal and distal migration. All subjects showed a patent stent. On follow-up ERCP, the mean diameter of the stricture improved from 1.1 mm to 2.8 mm(P < 0.05), whereas that of upstream dilation improved from 8.4 mm to 6.3 mm(P < 0.05).CONCLUSION This initial experience showed that temporary FCSEMS placement is feasible and safe for the management of refractory benign MPD stricture in children.

关键词： Chronic pancreatitis Pancreatic duct Selfexpandable metal stent Child Endoscopic retrograde cholangiopancreatography

Intestinal Behet's disease appearing during treatment with adalimumab in a patient with ankylosing spondylitis

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World Journal of Gastroenterology 2013年第32期19卷 5389-5392页

作者： sook hee Chung Soo Jung park Sung Pil Hong Jae hee Cheon Tae Il Kim Won Ho Kim Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine

Behet’s disease(BD)is a chronic inflammatory disease affecting multiple organ systems,such as the skin,joints,blood vessels,central nervous system,and gastrointestinal *** BD is characterized by intestinal ulcerations and gastrointestinal *** medical treatment of intestinal BD includes corticosteroids and *** have been several reports of tumor necrosis factor-α (TNF-α)blockers being successful in treatment of refractory intestinal ***,we report on a patient who was diagnosed with intestinal BD despite treatment with the fully humanized TNF-α blocker(adalimumab)for underlying ankylosing *** patient achieved clinical remission and complete mucosal healing through the addition of a steroid and azathioprine to the adalimumab regimen.

关键词： Intestinal Behet's disease Tumor necrosis factor-α Adalimumab

Periodontitis-induced systemic inflammation exacerbates atherosclerosis partly via endothelial–mesenchymal transition in mice

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International Journal of Oral Science 2019年第3期11卷 201-212页

作者： Jin sook Suh Sol Kim Kristina I.Bostrom Cun-Yu Wang Reuben H.Kim No-hee park The Shapiro Family Laboratory of Viral Oncology and Aging Research UCLA School of DentistryLos AngelesCAUSA Department of Medicine David Geffen School of Medicine at UCLALos AngelesCAUSA Division of Oral Biology and Medicine UCLA School of DentistryLos AngelesCAUSA UCLA Jonsson Comprehensive Cancer Center Los AngelesCAUSA Department of Bioengineering UCLA Samueli School of EngineeringLos AngelesCAUSA

Growing evidence suggests close associations between periodontitis and *** further understand the pathological relationships of these associations,we developed periodontitis with ligature placement around maxillary molars or ligature placement in conjunction with Porphyromonas gingivalis lipopolysaccharide injection at the ligature sites (ligature/***) in Apolipoprotein E knock out mice and studied the atherogenesis process in these *** mice were fed with high fat diet for 11 weeks and sacrificed for analyzing periodontitis,systemic inflammation,and *** did not develop periodontitis or systemic inflammation and had minimal lipid deposition in the aortas,but mice receiving ligature or ligature/*** showed severe periodontitis,systemic inflammation,and aortic plaque *** aortic plaque contained abundant macrophages and cells expressing both endothelial and mesenchymal cell *** severity of periodontitis was slightly higher in mice receiving ligature/*** than ligature alone,and the magnitude of systemic inflammation and aortic plaque formation were also notably greater in the mice with ligature/*** observations indicate that the development of atherosclerosis is due to systemic inflammation caused by severe *** vitro,*** enhanced the secretion of pro-inflammatory cytokines from macrophages and increased the adhesion of monocytes to endothelial cells by upregulating the expression of adhesion molecules from endothelial ***,secretory proteins,such as TNF-α,from macrophages induced endothelial–mesenchymal transitions of the endothelial *** together,systemic inflammation induced by severe periodontitis might exacerbate atherosclerosis via,in part,causing aberrant functions of vascular endothelial cells and the activation of macrophages in mice.

关键词： via aortic cells TNF-α did had but was

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World Journal of Gastroenterology 2014年第45期20卷 17120-17126页

作者： sook hee Chung Soo Jung park Hye Sun Lee Sung Pil Hong Jae hee Cheon Tae Ⅱ Kim Won Ho Kim Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine Department of Internal Medicine and institute of Gastroenterology Ajou University College of Medicine Department of Biostatistics Yonsei University College of Medicine

AIM: To investigate differences of clinical characteristics and disease courses between familial and sporadic inflammatory bowel disease (IBD) patients.

关键词： Inflammatory bowel disease Family history Crohn’ s disease Ulcerative colitis Clinical characteristics

Analysis of interval constants in calendars affiliated with the Shoushili

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Research in Astronomy and Astrophysics 2014年第4期14卷 485-496页

作者： Byeong-hee Mihn Ki-Won Lee Young sook Ahn Advanced Astronomy and Space Science Division Korea Astronomy and Space Science Institute Department of Astronomy and Space Science Chungbuk National University Institute of Liberal Education Catholic University of Daegu

We study interval constants that are related to motions of the Sun and Moon, i.e., the Qi, Intercalation, Revolution and Crossing interval, in calendars affiliated with the Shoushi calendar （Shoushili）, such as Datongli and Chiljeongsannaepyeon. It is known that these interval constants were newly introduced in the Shoushili calendar and revised afterward, except for the Qi interval constant, and the revised values were adopted in later calendars affiliated with the Shoushili. We first investigate the accu- racy of these interval constants and then the accuracy of calendars affiliated with the Shoushili in terms of these constants by comparing times for the new moon and the maximum solar eclipse calculated by each calendar with modem methods of calcula- tion. During our study, we found that the Qi and Intercalation interval constants used in the early Shoushili were well determined, whereas the Revolution and Crossing interval constants were relatively poorly measured. We also found that the interval constants used by the early Shoushili were better than those of the later one, and hence better than those of Datongli and Chiljeongsannaepyeon. On the other hand, we found that the early Shoushili is, in general, a worse calendar than Datongli for use in China but a better one than Chiljeongsannaepyeon for use in Korea in terms of times for the new moon and when a solar eclipse occurs, at least for the period 1281 - 1644. Finally, we verified that the times for sunrise and sunset in the Shoushili-Li-Cheng and Mingshi are those at Beijing and Nanjing, respectively.

关键词： history and philosophy of astronomy: general -- celestial mechanics --ephemerides

Bloch theorem dictated wave chaos in microcavity crystals

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Light(Science & Applications) 2023年第6期12卷 994-1000页

作者： Chang-Hwan Yi hee Chul park Moon Jip park Center for Theoretical Physics of Complex Systems Institute for Basic Science(IBS)Daejeon 34126Republic of Korea Department of Physics Pukyong National UniversityBusan 48513Republic of Korea Department of Physics Hanyang UniversitySeoul 04763Republic of Korea

Universality class of wave chaos emerges in many areas of science,such as molecular dynamics,optics,and network *** this work,we generalize the wave chaos theory to cavity lattice systems by discovering the intrinsic coupling of the crystal momentum to the internal cavity *** cavity-momentum locking substitutes the role of the deformed boundary shape in the ordinary single microcavity problem,providing a new platform for the in situ study of microcavity light *** transmutation of wave chaos in periodic lattices leads to a phase space reconfiguration that induces a dynamical localization *** degenerate scar-mode spinors hybridize and non-trivially localize around regular islands in phase *** addition,we find that the momentum coupling becomes maximal at the Brillouin zone boundary,so the intercavity chaotic modes coupling and wave confinement are significantly *** work pioneers the study of intertwining wave chaos in periodic systems and provide useful applications in light dynamics control.

关键词： theory. chaos wave

Strong interlayer coupling and stable topological flat bands in twisted bilayer photonic Moiré superlattices

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Light(Science & Applications) 2022年第10期11卷 2523-2529页

作者： Chang-Hwan Yi hee Chul park Moon Jip park Center for Theoretical Physics of Complex Systems Institute for Basic Science(IBS)Daejeon 34126Republic of Korea

The moiré superlattice of misaligned atomic bilayers paves the way for designing a new class of materials with wide *** this work,we propose a photonic analog of the moiré superlattice based on dielectric resonator *** sharp contrast to van der Waals materials with weak interlayer coupling,we realize the strong coupling regime in a moiré superlattice,characterized by cascades of robust flat bands at large ***,we find that these flat bands are characterized by a non-trivial band topology,the origin of which is the moiré pattern of the resonator *** physical manifestation of the flat band topology is a robust one-dimensional conducting channel on edge,protected by the reflection symmetry of the moiré *** explicitly breaking the underlying reflection symmetry on the boundary terminations,we show that the first-order topological edge modes naturally deform into higher-order topological corner *** work pioneers the physics of topological phases in the designable platform of photonic moiré superlattices beyond the weakly coupled regime.

关键词： topological bands coupling