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第九届全国药物和化学异物代谢学术会议

作者： QIU Hong-xia~1,YIN Jian~2,MENG Qin~2 1 Roche R&D Center(China) Ltd,720 Cai Lun Road,Zhangjiang Hi-Tech park,Shanghai 201203,China 2 College of Materials Science and Chemical Engineering,Zhejiang University,Hangzhou 310027,Zhejiang,China

AIM:Gel entrapment culture of primary hepatocytes has been demonstrated to retain the expression and function of metabolic *** objective of the current study was to evaluate the utilization of gel entrapped primary human and rat hepatocytes model to predict in vivo hepatic ***:Twenty model compounds ranging from low(cyclosporine A) to high(testosterone) metabolic liability were selected for evaluation of gel entrapped rat hepatocytes, and four among which(warfarin,clozapine,midazolam,and verapamil) for gel entrapped human hepatocytes. The reaction mixture was incubated for 1,2,4,6,8,12,22,and 26 hr with the density of 2×10 cells/ml culture medium at an initial concentration of 10μ*** temporal profile of the parent compound concentrations were quantitated using an HPLC/MS/MS *** clearance of the test compounds were calculated from the substrate disappearance rate in hepatocytes using the method by Naritomi Y *** the predicted human and rat hepatic clearance was scaled and calculated using the well-stirred ***-specific binding was not accounted for during the calculation. A correlation analysis was conducted between the predicted hepatic clearance and the reported values of in vivo hepatic clearance in human and ***:Metabolic stability of these test compounds spanned a wide range from 0. 06 ml/min/kg for rifampicin to 50.30 ml/min/kg for testosterone in rat *** compounds with intermediate to high metabolic rate,the predicted hepatic clearance were mostly within 2-fold of the observed values from the literature. The in vitro-in vivo correlation was less significant for compounds with low hepatic *** the slowly metabolized compounds,tolbutamide,warfarin,rifampicin and cyclosporine A,the predicted hepatic clearance differed from in vivo data for about 10- *** might be due to indistinctive substrate depletion during the incubation *** predicted human hepatic clearance was 0.06 ml/m

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Analysis of the Transcriptional Networks for Arabidopsis Pollen Development

Analysis of the Transcriptional Networks for Arabidopsis Pol...

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中国植物生理学会第十次会员代表大会暨全国学术年会

作者： Hong MaState Key Laboratory of Genetic Engineering and Institute of Plant Biology, Center for Evolutionary Biology, School of Life Sciences, Fudan University, Shanghai, China 200433 Institutes of Biomedical Sciences, Fudan University, Shanghai, China 200032 Department of Biology and the Huck Institutes of the Life Sciences, the Pennsylvania State University, University park, PA 16802

＜正＞Pollen development occurs in the male organ anther, which has both sporogenous （the germ-line） and somatic

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Insensitivity of a turbulent laser-plasma dynamo to initial conditions

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Matter and Radiation at Extremes 2022年第4期7卷 50-64页

作者： A.F.A.Bott L.Chen P.Tzeferacos C.A.J.Palmer A.R.Bell R.Bingham A.Birkel D.H.Froula J.Katz M.W.Kunz C.-K.Li H-S.park R.Petrasso J.S.Ross B.Reville D.Ryu F.H.Séguin T.G.White A.A.Schekochihin D.Q.Lamb G.Gregori Department of Physics University of OxfordOxfordUnited Kingdom Department of Astrophysical Sciences University of PrincetonPrincetonNew Jersey 08544USA Department of Physics and Astronomy University of RochesterRochesterNew York 14627USA Laboratory for Laser Energetics University of RochesterRochesterNew York 14623USA School of Mathematics and Physics Queens University BelfastBelfastUnited Kingdom Rutherford Appleton Laboratory ChiltonDidcotUnited Kingdom Department of Physics University of StrathclydeGlasgowUnited Kingdom Massachusetts Institute of Technology CambridgeMassachusetts 02139USA Lawrence Livermore National Laboratory LivermoreCalifornia 94550USA Max-Planck-Institut für Kernphysik HeidelbergGermany Department of Physics School of Natural SciencesUNISTUlsanSouth Korea Department of Physics University of NevadaRenoNevada 89557USA Department of Astronomy and Astrophysics University of ChicagoChicagoIllinois 60637USA

It has recently been demonstrated experimentally that a turbulent plasma created by the collision of two inhomogeneous,asymmetric,weakly magnetized,laser-produced plasma jets can generate strong stochastic magnetic fields via the small-scale turbulent dynamo mechanism,provided the magnetic Reynolds number of the plasma is sufficiently *** this paper,we compare such a plasma with one arising from two pre-magnetized plasma jets whose creation is identical save for the addition of a strong external magnetic field imposed by a pulsed magnetic field *** investigate the differences between the two turbulent systems using a Thomson-scattering diagnostic,x-ray selfemission imaging,and proton *** Thomson-scattering spectra and x-ray images suggest that the external magnetic field has a limited effect on the plasma dynamics in the *** the external magnetic field induces collimation of the flows in the colliding plasma jets and although the initial strengths of the magnetic fields arising from the interaction between the colliding jets are significantly larger as a result of the external field,the energies and morphologies of the stochastic magnetic fields post-amplification are *** conclude that,for turbulent laser-plasmas with supercritical magnetic Reynolds numbers,the dynamo-amplified magnetic fields are determined by the turbulent dynamics rather than the seed fields or modest changes in the initial flow dynamics of the plasma,a finding consistent with theoretical expectations and simulations of turbulent dynamos.

关键词： turbulent initial stochastic

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The biodiversity of Paecilomyces cicadae

The biodiversity of Paecilomyces cicadae

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中国植物病理学会2007年学术年会

作者： Liu Ai Ying~(**) Zou Xiao Hu Hai Yan Luo Li Liang zong Qi(Institute of Fungus Resource Guizhou University,Guiyang 550025) Chul Soo Shin Kim Yong Ook park Hae Wong(Department of Biotechnology,College of Engineering,Yonsei University,Seoul,Republic Korea)

＜正＞The purpose of this paper is to study the feasible evaluation of Paecilomyces cicadae abroad *** the classical methods,some physiological and biochemical indexes were tested. combining with the reference information,we could get follow results:1,In virtue of its high content of cordycep polysaccharide,Paecilomyces cicadae has been successfully developed as modem traditional chinese pharmacy.2,It could be developed to biocontrol fungus because of its drought-resistance, UV-Resistant,high activities of chitinase,proteinase,and lysozyme,and heterokaryon or diploid strain with high pathogenicity.3,It could be developed as health-care foods and cosmetic products basing on its bioactive substances,such as hyaluronic acid,polysaturated fatty acids,SOD,POD,lysozyme, protein,amino acids,nucleoside,mannitol,ergosterol,***,Paecilomyces cicadae which came from different ecological conditions had physiological,biochemical,and genetic ***, we could screen and cultivate high functional strains according to our development purpose.

关键词： Paecilomyces cicadae polysaccharide pathogenicity heterokaryon bioactivè substances

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双能CT灌注成像征象为基础的定量评价在弥漫性间质性肺疾病中的应用:与生理损伤和预后的关系

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国际医学放射学杂志 2016年第4期 450-451页

作者： J.W.Moon J.P.Bae H.Y.Lee N.Kim M.P.Chung H.Y.park 方壮念 Department of Radiology and Center for Imaging Science Samsung Medical Center Sungkyunkwan University School of Medicine

摘要目的利用软件自动分割基于纹理的弥漫性间质性肺疾病(DILD)病人的双能CT(DECT)影像,并采用全肺形态学和灌注成像信息的重合度进行预后分层的评价。方法纳入即将行手术病理检查的可疑DILD病人。肺纹理征象包括磨玻璃密度影(GGO)、网... 详细信息

摘要目的利用软件自动分割基于纹理的弥漫性间质性肺疾病(DILD)病人的双能CT(DECT)影像,并采用全肺形态学和灌注成像信息的重合度进行预后分层的评价。方法纳入即将行手术病理检查的可疑DILD病人。肺纹理征象包括磨玻璃密度影(GGO)、网状影及实变影。对CT征象和灌

关键词：弥漫性间质性肺疾病 CT IPF 征象灌注成像双能预后

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冀北变质杂岩的地球化学、Nd同位素特征与地壳增生

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地质学报 2006年第12期80卷 1907-页

作者：刘树文田伟刘超辉李秋根凤有刚 park K H SONG Y S 北京大学造山带与地壳演化教育部重点实验室北京大学地球与空间科学学院 Department of Environmental Geosciences Pukyong National University599-1 Dayeong-dongNam-guBusan 608-737Korea

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肺结节C形臂锥形束CT引导下经皮经胸穿刺活检:1108例病人的临床经验总结

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国际医学放射学杂志 2014年第3期 290-291页

作者： S.M.Lee C.M.park K.H.Lee Y.E.Bahn J.I.Kim J.M.Goo 郭小超 Department of Radiology Seoul National University College of Medicine101 DaehangnoJongnoguSeoul 110-744Korea

摘要目的回顾性评价1 108例病人C形臂锥形束CT引导下经皮经胸穿刺活检(PTNB)的诊断操作和并发症。材料与方法该回顾性研究经学院审查委员会批准,免除病人

关键词：锥形束穿刺活检经胸病人经皮 CT

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胃肠道间质瘤破裂CT特征与预测性指征的研究

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国际医学放射学杂志 2017年第4期 494-495页

作者： J.S.Kim H.J.Kim S.H.park J.S.Lee A.Y.Kim H.K.Ha 吕岳华 Department of Radiology and Research Institute of Radiology University of Ulsan College of MedicineAsan Medical Center

摘要目的通过比较破裂前和无破裂胃肠道间质瘤(GIST)的CT影像,了解GIST破裂的CT特征和相关预测性因素。方法分别纳入49例GIST破裂病人和49例GIST未破裂病人,根据年龄、性别和病灶部位进行配对。回顾分析临床资料包括化疗情况。分析影像...

摘要目的通过比较破裂前和无破裂胃肠道间质瘤(GIST)的CT影像,了解GIST破裂的CT特征和相关预测性因素。方法分别纳入49例GIST破裂病人和49例GIST未破裂病人,根据年龄、性别和病灶部位进行配对。回顾分析临床资料包括化疗情况。分析影像特征,评估破裂前CT影像。结果破裂的GIST最常见部位为小肠,平均大小约12.1 cm。

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菜豆白霉病抗性的QTL图谱研究

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国外作物育种 2002年第1期21卷 67-67页

作者： SoonO.park 向平

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Primary Study on the Fungus *** and Its Sectors

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中国植物病理学会2007年学术年会

作者： Hu Hai Yan Liu Ai Ying Liang Zong Qi Zou Xiao Luo Li(Institute of Fungus Resource Guizhou University,Guiyang 550025) Chul Soo Shin Kim Yong Ook park Hae Wong(Department of Biotechnology,College of Engineering,Yonsei University,Seoul,Republic Korea)

＜正＞Two sectors,sporing-type（JZD3-1）and hypha-type（JZD3-2）,were isolated from *** on Sabouraud *** colony characters and conidiation between two sector isolates and the original strain（JZD3）were compared on different *** contents of exopolysaccharide and protein, the activities of proteinase,SOD,POD and their pathogenicities to *** were *** results showed:The growth of the strain JZD3 was the fastest and the conidiation was largest on most media. As far as the contents of exopolysaccharide,SOD,POD and the pathogenicity to ***,JZD3 was also the best;however,the isolates JZD3-1 and JZD3-2 had the most proteinase and protein respectively.

关键词： P.cicadae sector pathogenicity exopolysaccharide enzyme

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