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Tailoring strength-ductility balance of caliber-rolled AZ31 Mg alloy through subsequent annealing

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Journal of Magnesium and Alloys 2020年第1期8卷 163-171页

作者： Taein Kong Byung Je Kwak Jonghyun Kim jeong hun Lee Sung Hyuk park Ji Hoon Kim Young Hoon Moon Hyun Sik Yoon Taekyung Lee School of Mechanical Engineering Pusan National UniversityBusan 46241Republic of Korea Advanced Forming Process R&D Group Korea Institute of Industrial TechnologyUlsan 44413Republic of Korea College of Materials Science and Engineering Chongqing UniversityChongqing 400044China School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Department of Naval Architecture and Ocean Engineering Pusan National UniversityBusan 46241Republic of Korea

Recently,multi-pass caliber rolling has been shown to be effective for Mg *** study investigated the effect of subsequent annealing on the mechanical properties of a caliber-rolled AZ31 Mg alloy to modulate the strength-ductility *** annealing gave rise to different trends in mechanical properties depending on the temperature ***-temperature annealing(T≤473 K)exhibited a typical trade-off relationship,where an increase in annealing temperature resulted in increased ductility but decreased strength and *** a heat treatment did not degrade the high strength-ductility balance of the caliber-rolled alloy,suggesting that the mechanical properties could be tailored for different potential *** contrast,high-temperature annealing(T>473 K)caused a simultaneous deterioration in strength,hardness,and ductility with increasing annealing *** differences are discussed in terms of the varying microstructural features under the different investigated annealing regimes.

关键词： AZ31 Mg alloy Caliber rolling Annealing Grain growth Mechanical improvement Twinning

Habitat Use, Home Range, and Hibernaculum of the Mongolian Racerunner, Eremias argus (Lacertidae, Reptilia) in a Coastal Sand Dune in South Korea

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Asian Herpetological Research 2012年第2期3卷 133-140页

作者： Il-hun KIM Nam-Yong RA Daesik park Department of Biology Kangwon National University Division of Science Education Kangwon National University

Information on habitat use is critical in sizing protected areas for endangered reptile species. To investigate habitat use, home range, and hibernaculum of the endangered Mongolian Racerunner(Eremias argus), we radio-tracked 40 specimens in a coastal sand dune in South Korea. Of the 163 locations recorded during the breeding season, 150(92.0%) were in grass sand dunes, and the rest(8.0%), all associated with the same lizard, were in shrub sand dunes. All of the 123 locations recorded during the non-breeding season were in grass sand dunes. No lizards were found in the grasslands abutting the dunes. The four lizards with identifiable hibernation sites were found under an average of 17.8 cm of sand and were all located in grass sand dunes. The lizards moved approximately 5 m daily and used 162 m2of home range(computed by minimum convex polygon, MCP) during the breeding season, and they moved approximately 2 m and used 68 m2of home range during the non-breeding season. However, the mean daily moved distances and MCP home ranges were not statistically significantly different between the seasons or between males and females. Our results suggest that in coastal sand dunes, E. argus uses grass sand dunes as its main habitat throughout the year. This finding could be used to determine the appropriate habitat size and to designate for the conservation of this endangered species.

关键词： coastal sand dune spatial ecology Eremias argus lizard radio-telemetry

Label-free Detection for a DNA Methylation Assay Using Raman Spectroscopy

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Chinese Medical Journal 2017年第16期130卷 1961-1967页

作者： jeongho Kim Hae jeong park Jae Hyung Kim Boksoon Chang hun-Kuk park Department of Biomedical Engineering College of Medicine Kyung Hee University Seoul 02447 Korea Department of Pharmacology College of Medicine Kyung Hee University Seoul 02447 Korea Department of Pulmonary and Critical Care Medicine Kyung Hee University Hospital at Gangdong Seoul 05278 Korea Department of Medical Engineering Graduate School Kyung Hee University Seoul 02447 Korea

Background： DNA methylation has been suggested as a biomarker for early cancer detection and treatment. Varieties of technologies for detecting DNA methylation have been developed, but they are not sufficiently sensitive for use in diagnostic devices. The aim of this study was to determine the suitability of Raman spectroscopy for label-free detection of methylated DNA. Methods： The methylated promoter regions of cancer-related genes cadherin 1 （CDH1） and retinoic acid receptor beta （RARB） served as target DNA sequences. Based on bisulfite conversion, oligonucleotides ofmethylated or nonmethylated probes and targets were synthesized for the DNA methylation assay. Principal component analysis with linear discriminant analysis （PCA-DA） was used to discriminate the hybridization between probes and targets （methylated probe and methylated target or nonmethylated probe and nonmethylated target） of CDH! and RARB from nonhybridization between the probe and targets （methylated probe and nonmethylated target or nonmethylated probe and methylated target）. Results： This study revealed that the CDH1 and RARB oligo sets and their hybridization data could be classified using PCA-DA. The classification results for CDH1 methylated probe ＋ CDH1 methylated target versus CDH! methylated probe ＋ CDHI unmethylated target showed sensitivity, specificity, and error rates of 92%, 100%, and 8%, respectively. The classification results for the RARB methylated probe ＋ RARB methylated target versus RARB methylated probe ＋ RARB unmethylated target showed sensitivity, specificity, and error rates of 92%, 93%, and 11%, respectively. Conclusions： Label-free detection ofDNA methylation could be achieved using Raman spectroscopy with discriminant analysis.

关键词： DNA Methylation Label-free Detection Linear Discriminant Analysis Principal Component Analysis RamanSpectroscopy

Leptin and peroxisome proliferator-activated receptor γ expression in colorectal adenoma

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World Journal of Gastroenterology 2012年第6期18卷 557-562页

作者： Hyung hun Kim You Sun Kim Yun Kyung Kang jeong Seop Moon Department of Internal Medicine Seoul Paik HospitalInje University College of MedicineSeoul 100-032South Korea Department of Pathology Seoul Paik HospitalInje University College of MedicineSeoul 100-032South Korea Hyung Hun Kim Department of Internal Medicine Kosin University College of MedicineBusan 602-702South Korea

AIM： To investigate the expressions of leptin and per- oxisome proliferator-activated receptor y （PPARG） in relation to body mass index （BMI）. METHODS： We evaluated leptin and PPARG expres- sion in 30 adenomas over 1 cm in size by immunohisto- chemical staining. In addition, clinicopathologic features including BMI were assessed. RESULTS： PPARG and leptin expression showed a strong positive correlation （P = 0.035）. The average BMI of the leptin-positive group was higher than that of the leptin-negative group （25.4 ＋ 3.4 kg/m2 vs 22.6 ＋ 2.4 kg/m2, P = 0.018）, and leptin expression was sig- nificantly correlated with high BMI （P = 0.024）. Leptinexpression was more frequently observed in intermedi- ate/high grade dysplasia than in low grade dysplasia （P = 0.030）. However, PPARG expression was not cor- related with BMI and grade of dysplasia. CONCLUSION： BMI has influenced on the leptin ex- pression of colorectal adenoma. The exact mechanism underlies the strong correlation between leptin and PPARG expression needs further study.

关键词： Leptin Peroxisome proliferator-activated re-ceptor y Obesity Body mass index Colorectal adenoma

Rhamnus crenata leaf extracts exhibit anti-inflammatory activity via modulating the Nrf2/HO-1 and NF-κB/MAPK signaling pathways

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Asian Pacific Journal of Tropical Biomedicine 2022年第10期12卷 430-436页

作者： Hyun Ji Eo Da Som Kim Gwang hun park Special Forest Resources Division Department of Forest Bio-ResourcesNational Institute of Forest ScienceSuwon 16631Korea Forest Medicinal Resources Research Center National Institute of Forest ScienceYeongju 36040Korea

Objective:To elucidate the potential anti-inflammatory mechanisms of Rhamnus crenata leaf extracts using RAW264.7 ***:We used 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay to measure cell *** oxide(NO)production was measured using Griess *** blotting and RT-PCR assays were carried out for analyzing the protein and gene expressions of pro-inflammatory mediators,***,PD98059(ERK1/2 inhibitor),SB203580(p38 inhibitor),SP600125(JNK inhibitor),and BAY11-7082(NF-κB inhibitor)were used to evaluate the anti-inflammatory mechanism of Rhamnus crenata leaf ***:Rhamnus crenata leaf extracts significantly inhibited the production of the pro-inflammatory mediators such as NO,iNOS,COX-2,IL-1β,and TNF-αin lipopolysaccharide(LPS)-stimulated RAW264.7 *** crenata leaf extracts also suppressed LPS-induced degradation of IκB-αand nuclear accumulation of p65,which resulted in the inhibition of NF-κB activation in RAW264.7 ***,the extracts attenuated the phosphorylation of p38,ERK1/2,and JNK in LPS-stimulated RAW264.7 ***,HO-1 expression induced by Rhamnus crenata leaf extracts was significantly downregulated by SB230580,PD98059,SP600125 and ***:Rhamnus crenata leaf extract may upregulate HO-1 expression through inhibition of p38,ERK1/2,and NF-κB activation,which may contribute to the anti-inflammatory activity of the *** crenata leaf extracts may have great potential for the development of anti-inflammatory drugs to treat acute and chronic inflammatory diseases.

关键词： Anti-inflammatory activity Heme oxygenase-1 Nrf2 Mitogen-activated protein kinase Nuclear factor kappa B Rhamnus crenata

Helicobacter pylori infection in gastric mucosa-associated lymphoid tissue lymphoma

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World Journal of Gastroenterology 2014年第11期20卷 2751-2759页

作者： jeong Bae park Ja Seol Koojeong Department of Internal Medicine College of MedicineDongguk UniversityGyeongju 780-350South Korea Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University Ansan HospitalAnsan 425-707South Korea

Gastrointestinal lymphoma is the most common type of extranodal lymphoma,and most commonly affects the *** zone B-cell lymphoma of the mucosa-associated lymphoid tissue(MALT)and diffuse large B-cell lymphoma are the most common histologic types of gastric *** its increasing incidence,diagnosis of gastric lymphoma is difficult at an earlier stage due to its nonspecific symptoms and endoscopic findings,and,thus,a high index of suspicion,and multiple,deep,repeated biopsies at abnormally and normally appearing sites in the stomach are *** addition,testing for Helicobacter pylori(***)infection and endoscopic ultrasonography to determine the depth of tumor invasion and involvement of regional lymph nodes is essential for predicting response to *** eradication and for assessment of disease *** addition,*** infection and MALT lymphoma development are associated,and complete regression of low-grade MALT lymphomas after *** eradication has been *** and/or chemotherapy can be used in cases that show poor response to *** eradication,negativity for *** infection,or high-grade lymphoma.

关键词： Mucosa-associated lymphoid tissue Lymphoma Helicobacter pylori Eradication Remission

Successful treatment of relapsed acute promyelocytic leukemia with arsenic trioxide in a hemodialysis-dependent patient: A case report

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World Journal of Clinical Cases 2020年第21期8卷 5347-5352页

作者： Hee jeong Lee Sang-Gon park Department of Hemato-Oncology Chosun University HospitalGwang-ju 501-717South Korea Department of Internal Medicine Hemato-oncologyChosun University HospitalGwangju 61453South Korea

BACKGROUND Arsenic trioxide(ATO)is recommended for patients who do not achieve molecular remission or who have molecular or morphologic ***,there are no guidelines for adjusting ATO dosage in patients with severe renal failure or on ***,we report the successful treatment of relapsed acute promyelocytic leukemia(APL)in a patient on hemodialysis with ATO single agent and review the cases in *** SUMMARY A 46-year-old woman who has been on hemodialysis to chronic glomerulonephritis for 15 years visited our hospital for *** had been seen for pancytopenia 3 years ago and had been diagnosed with *** also received chemotherapy for APL but unfortunately was lost to follow-up after her second consolidation *** was noted to have pancytopenia by her nephrologist during hemodialysis 1 mo *** marrow biopsy and reverse transcriptase-polymerase chain reaction(RT-PCR)tests revealed a diagnosis of relapsed *** for relapsed APL with ATO single agent was started and she achieved molecular remission after administering 24 doses of *** far,four consolidation therapies have been performed with the ATO single agent,and,to date,the molecular remission has been maintained as negative promyelocytic leukemia/retinoic acid receptor-αfusion gene as confirmed by RTPCR testing for two *** This is a rare case of relapsed APL successfully treated with the single agent ATO in a patient on hemodialysis.

关键词： Arsenic trioxide Acute promyelocytic leukemia Pancytopenia Hemodialysis Promyelocytic leukemia/retinoic acid receptor-αfusion gene Case report

Effects of PWHT on Microstructure and Mechanical Properties of Weld Metals of Ni-Based Superalloy 617 and 263 for Hyper-Supercritical Power Plants

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Acta Metallurgica Sinica(English Letters) 2016年第12期29卷 1107-1118页

作者： jeong Kil Kim Hae Ji park Deog Nam Shim Doosan Heavy Industries and Construction ChangwonGeongnam Korea

It is well known that solid solution-strengthened alloy 617 and γ′ precipitation-strengthened alloy 263 have excellent mechanical properties and corrosion resistance at high temperatures. Hyper-supercritical power plants work at temperatures above 700 ℃, and these superalloys are considered candidate materials for steam turbines components of these power plants. In this study, gas tungsten arc weldability of these superalloys was evaluated, and the effects of post- weld heat treatment （PWHT） on the microstructural characteristics and the mechanical properties of their weld metals were investigated. Scanning transmission electron microscopy, energy-dispersive spectroscopy and electron probe microanalysis were utilized for the investigation. The experimental results confirmed that these weld metals had different characteristics in microstructure and mechanical properties. PWHT resulted in the precipitation of intergranular carbides, γ′ particles and an increase in tensile strength of these superalloy weld metals. Furthermore, fine γ′ particles, which were not detected in the as-welded metal of alloy 263, were precipitated after PWHT and those particles were the reason for the drastic increase in tensile strength.

关键词： Superalloy Welding Precipitation Segregation

Diagnosing isolated superior mesenteric artery dissection and thrombosis using point-of-care ultrasonography:A case series

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World Journal of Emergency Medicine 2022年第3期13卷 239-241页

作者： Sin Youl park Won Joon jeong Department of Emergency Medicine Yeungnam University Medical CenterDaegu 42415Republic of Korea Department of Emergency Medicine Chungnam National University HospitalDaejeon 301721Republic of Korea

Dear editor,Most superior mesenteric artery (SMA) dissections occuralongwithaorticdissections;isolatedSMA dissectionsarerare(incidencerateof0.06%).[1] A diagnosis of SMA dissection is generally made using contrast-enhancedcomputedtomography(CECT);however, bedside point-of-care ultrasound (POCUS)may hasten the process. Herein, we present a case series of isolated SMA dissections that were suspected and confirmed using POCUS and CECT, respectively.

关键词： point process editor