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Heterogeneous fenton oxidation of methylene blue with Fe-impregnated biochar catalyst

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Biochar 2020年第2期2卷 164-175页

作者： Jong‑Hwan park Jim J.Wang Ki Hun park dong‑Cheol Seo Divison of Applied Life Science(BK21 Plus)and Institute of Agriculture and Life Science Gyeongsang National UniversityJinju 52828South Korea School of Plant Environmental and Soil SciencesLouisiana State University Agricultural CenterBaton RougeLA 70803USA

Fe-impregnated biochar(Fe-BC)as high-efficiency heterogeneous Fenton catalyst was synthesized and evaluated in detail for its catalytic activity,stability and reusability under various *** optimal conditions for the Fenton oxidation of methylene blue(MB)as model dye were determined as 0.075 g/L H_(2)O_(2),0.5 g/L Fe-BC for 0.1 g/L MB,which resulted in optimum Dye:Fe_(cat):H_(2)O_(2) ratio of 1:5:0.75(on g/L basis)or[Dye]:[Fe_(total)]:[H_(2)O_(2)]molar ratio of 1:6.2:7.0 *** effective degradation of MB was identified over a wider pH range,and even after four consecutive runs Fe-BC maintained above 95%MB removal rate within 3 min of treatment with low Fe release,indicating strong stability and *** the optimum Dye:Fe_(cat):H_(2)O_(2)(g/L)condition at initial pH 4,the Fe-BC achieved 99.9%removal efficiency of MB within 3 min in heterogeneous Fenton reaction(HEFR)with much less H_(2)O_(2) concentration and low catalyst dosage,demonstrat-ing its efficiency and cost-effectiveness compared to other Fenton reaction *** removal velocity of MB showed two rate steps:a fast first stage followed by a slow stage with the rate in the order of H_(2)O_(2)/Fe-BC⋙H_(2)O_(2)/biochar>biochar>H_(2)O_(2).Overall,the developed Fe-BC is more economical with strong stability and recyclability for use in HEFR for treating recalcitrant pollutants.

关键词： Fe-impregnated biochar catalyst Heterogeneous fenton reaction Impregnation and pyrolysis Removal velocity Methylene blue Sugarcane residue

Overview of emerging treatment of non-alcoholic fatty liver disease: more than one drug needed?

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Hepatobiliary Surgery and Nutrition 2019年第5期8卷 522-524页

作者： dong Yun Kim Jun Yong park Department of Pharmacology Yonsei University Graduate School of MedicineSeoulSouth Korea Department of Internal Medicine Yonsei University College of MedicineSeoulSouth Korea Institute of Gastroenterology Yonsei University College of MedicineSeoulSouth Korea Yonsei Liver Center Severance HospitalSeoulSouth Korea

Non-alcoholic fatty liver disease(NAFLD)comprisesisolated hepatic steatosis,non-alcoholic steatohepatitis(NASH),liver failure-associated complications of livercirrhosis,and liver *** are forecasted to be theleading li... 详细信息

关键词： liver NAFLD drug

4-Hydroxycinnamic acid attenuates neuronal cell death by inducing expression of plasma membrane redox enzymes and improving mitochondrial functions

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Food Science and Human Wellness 2023年第4期12卷 1287-1299页

作者： Sujin park YoonA Kim Jaewang Lee Hyunsoo Seo Sang-Jip Nam dong-Gyu Jo dong-Hoon Hyun Department of Life Science Ewha Womans UniversitySeoul 03760South Korea Department of Chemistry and Nano Science Ewha Womans UniversitySeoul 03760South Korea School of Pharmacy Sungkyunkwan UniversitySuwon 16419South Korea

Many approaches to neurodegenerative diseases that focus on amyloid-βclearance and gene therapy have not been *** therapeutic applications focus on enhancing neuronal cell survival during the pathogenesis of neurodegenerative diseases,including mitochondrial *** membrane(PM)redox enzymes are crucial in maintaining cellular physiology and redox homeostasis in response to mitochondrial *** phytochemicals are known to induce the expression of detoxifying enzymes under stress *** this study,mechanisms of neuroprotective effects of 4-hydroxycinnamic acid(HCA)were examined by analyzing cell survival,levels of abnormal proteins,and mitochondrial functions in two different neuronal *** protected two neuronal cells exhibited high expression of PM redox enzymes and the consequent increase in the NAD^(+)/NADH *** cultured with HCA showed delayed apoptosis and decreased oxidative/nitrative damage accompanied by decreased ROS production in the *** increased the mitochondrial complexes I and II activities and ATP ***,HCA increased mitochondrial fusion and decreased mitochondrial ***,HCA maintains redox homeostasis and energy metabolism under oxidative/metabolic stress *** findings suggest that HCA could be a promising therapeutic approach for neurodegenerative diseases.

关键词： NADH-quinone oxidoreductase 1(NQO1) Cytochrome b5 reductase 4-Hydroxycinnamic acid Neuroprotection Improved mitochondrial functions

维普期刊数据库

Deposition rate and interaction of human-riverine from height increase and permanent function of an 1180 years weir in Southeast China

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Science China Earth Sciences 2014年第2期57卷 323-336页

作者： SHANG YanJun park Hyeong-dong YANG ZhiFa CHEN SiGuang LIN DaMing Key Laboratory of Engineering Geomechancis Institute of Geology and GeophysicsChinese Academy of Sciences Department of Energy Systems Engineering Seoul National University Institute of Cultural Relics Preservation of Yinxian County

This paper is to present an efficient approach to enriching the quantification model of human-riverine interactions and its anthropogenic impact by a retrospective study on one of the four most famous historical hydraulic projects in China,the Tuoshan *** was constructed in 833 AD and had trajectories of natural resilience and hydraulic engineering maturity more than thousand *** historical data and maturation procedure of the hydraulic system were used judiciously to examine the spatial patterns of the long-term water conservancy system with agriculture,urbanization and civilization of Ningbo City in Zhejiang Province,Southeast *** framework is assessed from historical perspective and the deposition rate(DR)is calculated by analyzing the continuous increase of the Tuoshan Weir *** results show that the declining DR during the 1180 years guaranteed the beneficial role the Tuoshan Weir played in spite of some negative river responses caused by the increase of sediment deposition and decrease of fresh water-retention *** following up revamped workings and well matured hydraulic system around the Tuoshan Weir also contribute a lot to the designed mission of the *** conclude that hydraulic system maturation is very important for the proper function and life span of huge hydraulic projects.

关键词： Tuoshan Weir flooding saline water intrusion deposition rate historical hydraulic engineering system

维普期刊数据库

Genetic risk factors associated with NAFLD

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Hepatoma Research 2020年第12期6卷 42-51页

作者： dong Yun Kim Jun Yong park Department of Medicine Yonsei University Graduate School of MedicineSeoul 03722Korea Department of Medicine Physician-Scientist ProgramYonsei University Graduate School of MedicineSeoul 03722Korea Division of Gastroenterology Department of Internal MedicineYonsei University College of MedicineSeoul 03722Korea Yonsei Liver Center Severance HospitalSeoul 03722Korea

Non-alcoholic fatty liver disease(NAFLD)is estimated to affect 25%of the worldwide population,and is the leading cause of chronic liver disease in developed *** research on NAFLD has included heritability studies,candidate gene studies,familial aggregation studies,and genome-wide association studies(GWAS).Next-generation sequencing approaches,such as whole-genome sequencing and whole-exon sequencing,are emerging as the post-GWAS era of genetic ***,GWAS remains more practical for elucidating the genetic factors related to NAFLD,which is affected by thousands of common genetic variants and does not follow Mendelian *** the present review,we summarize the current knowledge regarding five GWAS-identified genetic loci that are associated with *** also discuss the relationships between NAFLD-predisposing polymorphisms and cardiovascular disease,and potential applications for these identified genetic loci.

关键词： Genome-wide association study non-alcoholic fatty liver disease PNPLA3 TM6SF2 GCKR MBOAT7 HSD17B13

Fruits extracts of Hovenia dulcis *** lipopolysaccharide—stimulated inflammatory responses through nuclear factor—kappaB pathway in Raw 264.7 cells

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Asian Pacific Journal of Tropical Medicine 2016年第4期9卷 349-355页

作者： Ju-Yeon park Jin-Young Moon Sun-dong park Won-Hwan park Hyuck Kim Jai-Eun Kim Department of Acupoint College of Korean Medicine.Dongguk University Department of Prescription College of Korean MedicineDongguk University Department of Diagnostics College of Korean Medicine.Dongguk University Department of Pathology College of Korean Medicine.Dongguk University

Objective:To investigate the anti-inflammatory effects and the action mechanism of the fruits of Horenia dulcis(***) in lipopolysaccharide(LPS)-induced mouse macrophage Raw ***:The extract of *** fruits(EHDF) were extracted with 70%*** macrophages were treated with different concentrations of EHDF in the presence and absence of LPS(1 μg/mL).To demonstrate the inflammatory mediators including nitric oxide,inducible nitric oxide synthase and cyclooxygenase(COX)-2 expression levels were analyzed by usingin vitro assay ***-derived pro-inflammatory cytokines including interleukin-1 β.tumor necrosis factor- α and prostaglandin F_2 were determined using ELISA *** viability,heme oxygenase-1 expression,nuclear factor-kappaB and nuclear factor F.2-related factors 2 translocation were also ***:EHDF potently inhibited the LPS-stimulated nitric oxide,inducible nitric oxide ***-2,interleukin-1 β and tumor necrosis factor- α expression in a dose-dependent *** suppressed the phosphorylation of inhibited kappaB-alpha and p65 nuclear *** of macrophage cells with EHDF alone induced the heme oxygenase-1 and nuclear translocation of nuclear factor E2-reIated factor ***:These results suggest that the ethanol extract of *** fruit exerts its anti-inflammatory effects by inhibiting inhibited kappaBalpha phorylation and nuclear translocation of nuclear factor-kappaB.

关键词： Fruits of Hovenia dulcis Inflammation Macrophage Nuclear factor-kappaB Heme oxygenase-1

Fake News Detection on Social Media: A Temporal-Based Approach

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Computers, Materials & Continua 2021年第12期69卷 3563-3579页

作者： Yonghun Jang Chang-Hyeon park dong-Gun Lee Yeong-Seok Seo Department of Computer Engineering Yeungnam UniversityGyeongsan38541Korea

Following the development of communication techniques and smart devices,the era of Artificial Intelligence(AI)and big data has *** increased connectivity,referred to as hyper-connectivity,has led to the development of smart *** in these smart cities can access numerous online contents and are always *** developments,however,also lead to a lack of standardization and consistency in the propagation of information throughout communities due to the consumption of information through social media *** cannot often be verified,which can confuse the *** increasing influence of social media has thus led to the emergence and increasing prevalence of fake *** this study,we propose a methodology to classify and identify fake news emanating from social *** collected content from Twitter to detect fake news and statistically verified that the temporal propagation pattern of quote retweets is effective for the classification of fake *** verify this,we trained the temporal propagation pattern to a two-phases deep learning model based on convolutional neural networks and long short-term *** fake news classifier demonstrates the ability for its early ***,it was verified that the temporal propagation pattern was the most influential feature compared to other feature groups discussed in this paper.

关键词： Artificial intelligence deep learning fake news rumor smart city data analysis

MicroRNAs are key regulators controlling iNKT and regulatory T-cell development and function

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Cellular & Molecular Immunology 2011年第5期8卷 380-387页

作者： Li Zhou Jang-June park Quanhui Zheng Zheng dong Qingsheng Mi Henry Ford Immunology Program Henry Ford Health SystemDetroitMIUSA Department of Dermatology Henry Ford Health SystemDetroitMIUSA Department of Internal Medicine Henry Ford Health SystemDetroitMIUSA Department of Cellular Biology and Anatomy Medical College of GeorgiaAugustaGAUSA

MicroRNAs(miRNAs)are an abundant class of evolutionarily conserved,small,non-coding RNAs that post-transcriptionally regulate expression of their target *** evidence indicates that miRNAs are important regulators that control the development,differentiation and function of different immune *** CD4^(+)CD25^(+)Foxp3^(+) regulatory T(Treg)cells and invariant natural killer T(iNKT)cells are critical for immune homeostasis and play a pivotal role in the maintenance of self-tolerance and ***,we review the important roles of miRNAs in the development and function of iNKT and Treg cells.

关键词： invariant natural killer T cells microRNA regulatory T cells

Curcumin attenuates the release of pro-inflammatory cytokines in lipopolysaccharide-stimulated BV2 microglia

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Acta Pharmacologica Sinica 2007年第10期28卷 1645-1651页

作者： Jae-dong LEE Cheol park Yung hyun CHOI Gi-young KIM Department of Microbiology College of Natural Sciences Pusan National UniversityBusan 609-735 Department of Biochemistry Dongeui University College of Oriental MedicineBusan 614-054Korea Faculty of Applied Marine Science Cheju National UniversityJeju-siJeju Special Self-Governing Province 690-756Korea

Aim:Pro-inflammatory mediators,such as prostaglandin E2（PGE2） and nitric oxide（NO）,and pro-inflammatory cytokines such as interleukin （IL）-1β,IL-6,and TNF-α,play pivotal roles in brain *** anti-inflammatory properties are knownto be associated with significant reductions in pro-inflammatory mediators in *** the present study we investigate whether the effects of curcumin onthe production of pro-inflammatory mediators in lipopolysaccharide （LPS）-stimu-lated BV2 ***:Curcumin were administered and their effects onLPS-induced pro-inflammatory mediators were monitored by Western blottingand ***:Curcumin significantly inhibited the release of NO,PGE2,and pro-inflammatory cytokines in a dose-dependent *** alsoattenuated the expressions of inducible NO synthase and cyclooxygenase-2 mRNAand protein ***,curcumin suppressed NF-kB activation via thetranslocation of p65 into the *** data also indicate that curcumin exertsanti-inflammatory properties by suppressing the transcription of proinflammatorycytokine genes through the NF-kB signaling ***:Anti-inflam-matory properties of curcumin may be useful for treating the inflammatory anddeleterious effects of microglial activation in response to LPS stimulation.

关键词： curcumin inducible nitric oxide synthase cyclooxygenase-2 pro-inflammatory cytokines NF-kB