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Carbon Nanotube Coating on Titanium Substrate Modified with TiO_2 Nanotubes

Journal of Wuhan University of Technology(Materials Science) 2011年第5期26卷 867-871页

作者：白玉 park ilsong BAE Taesung KIM Kyounga WATARI Fumio UO Motohiro LEE Minho Department of Dental Biomaterials School of Dentistry and Institute of Oral BioscienceBrain Korea 21 ProjectChonbuk National University School of Materials Science and Engineering Inner Mongolia University of Technology Department of Conservative Dentistry Institute of Oral Bioscience and BK 21 ProjectSchool of DentistryChonbuk National University Biomedical Dental Materials and EngineeringDepartment of Oral Health ScienceGraduate School of Dental MedicineHokkaido University Advanced Biomaterials Section Graduate School of Medical and Dental SciencesTokyo Medical and Dental University

A combination of carbon nanotubes （CNTs） and titanium （Ti） modified with TiO2 nanotubes （TiO2 NTs） was fulfilled with the aim of improving bioactivity of Ti ***,well-ordered TiO2 NTs were prepared by the electrochemical anodization of Ti in an ethylene glycol electrolyte containing 1 wt% NH4F and 10 wt% H2O at 20 V for 50 min,followed by ***,the carboxylated CNTs were coated onto the TiO2 NTs using electrophoretic deposition （EPD） *** growth of hydroxyapatite （HA） on the samples was investigated by soaking them in simulated body fluid （SBF）.The result showed the CNTs-coated Ti with the modification of TiO2 NTs （CNTs-TiO2 NTs） was more efficient to induce HA formation than the CNTs-coated smooth Ti （CNTs-Ti）.The vitro cell response was evaluated using osteoblast cells （MC3T3-E1）.The good cell proliferation and strong cell adhesion could be obtained on the CNTs-TiO2 *** results indicated that CNT coating on the Ti modified with TiO2 NTs could be potentially useful for the periodontal ligament combination on dental implants.

关键词： carbon nanotubes TiO2 nanotubes apatite-forming ability cell adhesion

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γ-aminobutyric acid secreted from isletβ-cells modulates exocrine secretion in rat pancreas

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World Journal of Gastroenterology 2006年第19期12卷 3026-3030页

作者： Yong-Deuk park Zheng-Yun Cui Guang Wu Hyung-Seo park Hyoung-Jin park Department of MedicoLife Science Youngdong University Chungbuk Korea Department of Physiology College of Medicine and Ilsong Institute of Life Science Hallym University Chuncheon Gangwon-do Korea Department of Physiology College of Medicine Konyang University Daejeon Korea

AIM： To investigate the role of endogenous γ-aminobutyric acid （GABA） in pancreatic exocrine secretion. METHODS： The isolated, vascularly perfused rat pancreas was employed in this study to eliminate the possible influences of extrinsic nerves and hormones. Cholecystokinin （CCK; 10 pmol/L） was intra-arterially given to stimulate exocrine secretion of the pancreas. RESULTS： Glutamine, a major precursor of GABA, which was given intra-arterially at concentrations of 1, 4 and 10 mmol/L, dose-dependently elevated the CCK-stimulated secretions of fluid and amylase in the normal pancreas. Bicuculline （10 μmol/L）, a GABAA receptor antagonist, blocked the enhancing effect of glutamine （4 mmol/L） on the CCK-stimulated exocrine secretions. Glutamine, at concentrations of 1, 4 and 10 mmol/L, dose-dependently increased the GABA concentration in portal effluent of the normal pancreas. The effects of glutamine on the CCK-stimulated exocrine secretion as well as the GABA secretion were markedly reduced in the streptozotocintreated pancreas. CONCLUSION： GABA could be secreted from β-cells into the isletoacinar portal system after administration of glutainine, and could enhance the CCK-stimulated exocrine secretion through GABAA receptors. Thus, GABA in islet β-cells is a hormone modulating pancreatic exocrine secretion.

关键词： GABA GABA receptor GABA secretion Cholecystokinin Islet of langerhans Pancreas

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C-terminal domain of hepatitis C virus core protein is essential for secretion

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World Journal of Gastroenterology 2005年第25期11卷 3887-3892页

作者： Soo-Ho Choi Kyu-Jin park So-Yeon Kim Dong-Hwa Choi Jung-Min park Soon B. Hwang ilsong Institute of Life Science

AIM: We have previously demonstrated that hepatitis C virus (HCV) core protein is efficiently released into the culture medium in insect cells. The objective of this study is to characterize the HCV core secretion in insect cells. METHODS: We constructed recombinant baculoviruses expressing various-length of mutant core proteins, expressed these proteins in insect cells, and examined core protein secretion in insect cells. RESULTS: Only wild type core was efficiently released into the culture medium, although the protein expression level of wild type core was lower than those of other mutant core proteins. We found that the shorter form of the core construct expressed the higher level of protein. However, if more than 18 amino acids of the core were truncated at the C-terminus, core proteins were no longer secreted into the culture medium. Membrane flotation data show that the secreted core proteins are associated with the cellular membrane protein, indicating that HCV core is secreted as a membrane complex. CONCLUSION: The C-terminal 18 amino acids of HCV core were crucial for core secretion into the culture media. Since HCV replication occurs on lipid raft membrane structure, these results suggest that HCV may utilize a unique core release mechanism to escape immune surveillance, thereby potentially representing the feature of HCV morphogenesis.

关键词： Hepatitis C virus Core secretion Morphogenesis Virus assembly

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