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Poly(d,L-lactic-co-glycolic acid)-based artesunate nanoparticles:formulation,antimalarial and toxicity assessments

journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第11期18卷 977-985页

作者： Kabiru dAUdA Zulaikha BUSARI Olajumoke MORENIKEjI Funmilayo AFOLAyAN Oyetunde OyEyEMI jairam MEENA debasis SAHU Amulya pand A department of Zoology University of IbadanIbadan 200284Nigeria department of Basic Sciences(Biology Programme) Babcock Universityllishan-Remo 121103Nigeria Product development Cell National Institute of ImmunologyAruna Asaf Ali MargNew Delhi 110067India

Objective： The aim of this study was to formulate polymer-based artesunate nanoparticles for malaria treatment. Methods： Artesunate was loaded with poly（d,L-lactic-co-glycolic acid）（PLGA） by solvent evaporation from an oil-in-water single emulsion. Nanoparticles were characterized by X-ray diffraction and differential scanning calo- rimetry analyses. In vivo antimalarial studies at 4 mg/kg were performed on Swiss male albino mice infected with Plasmodium berghei. Hematological and hepatic toxicity assays were performed. In vitro cytotoxicity of free and en- capsulated artesunate （Art-PLGA） to cell line RAW 264.7 was determined at concentrations of 7.8-1000 pg/ml. Re- sults： The particle size of the formulated drug was （329.3±21.7） nm and the entrapment efficiency was （38.4±10.1）%. Art-PLGA nanoparticles showed higher parasite suppression （62.6%） compared to free artesunate （58.2%, P〈0.05）. Platelet counts were significantly higher in controls （305 000.00±148 492.40） than in mice treated with free artesunate （139 500.00±20 506.10） or Art-PLGA （163 500.00±3535.53）（P〈0.05）. There was no sign of hepatic toxicity following use of the tested drugs. The half maximal inhibitory concentration （IC50） of Art-PLGA （468.0 pg/ml） was significantly higher （P〈0.05） than that of free artesunate （7.3 pg/ml） in the in vitro cytotoxicity assay. Conclusions： A simple treatment of PLGA-entrapped artesunate nanoparticles with dual advantages of low toxicity and better antiplasmodial efficacy has been developed.

关键词： Poly(d,L-lacUc-co-glycolic acid) (PLGA) Artesunate-PLGA delivery system Antiplasmodial Toxicity

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Spectroscopic investigations on yb^3+ doped and Pr^3+/yb^3+ codoped tellurite glasses for photonic applications

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journal of Rare Earths 2021年第1期39卷 33-42,I0002页

作者： M.Seshadri M.j.V.Bell V.Anjos y.Messaddeq Grupo de Engenharia e Espectroscopia de Materiais Departamento de Fisica-ICEUniversidade Federal de Juiz de ForaJuiz de ForaMG36036-900Brazil Centre d'Optique Photonique et Laser2375 Rue de la TerrasseUniversite LavalQuebecQCG1V 0A6Canada

In this work we repo rt on structural and spect roscopic properties of yb^3+doped and Pr^3+/yb^3+co-doped TeO2-Bi2 O3-ZnO-Li2 O-Nb2 O5(TBZLN)tellurite *** and stretching modes of TeO2 and Te-OH bond(strong and weak)were analysed from the deconvolution of observed Raman and FT-IR *** on the absorption measurements,the energy bands of yb^3+and Pr^3+ions are *** spectroscopic properties for the radiative transitions of yb^3+and Pr^3+ions were reported using McCumber and j.d.-Ofelt *** emission bands originating from 3 P1 and 3 P0 to lower lying levels of Pr^3+were registered under 447 nm *** emission band around 1334 nm assigned to the Pr3:1 G4→3 H5 was observed when excited at 980 *** stimulated emission cross-section(σemi(λ))and effective linewidth(Δλeff)for the 3 P1→3 H6,3 P1→3 H5,3 P0→3 H6,3 P0→3 F2,3 P1→3 F3,3 P1→3 F4,3 P0→3 F4 and 1 G4→3 H5 transitions of Pr^3+are *** luminescence in Pr^3+/yb^3+codoped glass upon 980 nm excitation was *** resonant transfer processes between yb^3+and Pr^3+ions are presented and *** chromaticity co-ordinates were also evaluated from the visible emission spectra showing that Pr^3+/yb^3+co-doped glass may be suitable for the development of yellow-orange(λexc=447 nm)and near white light(λexc=980 nm)emitting devices in photonics.

关键词： Rare earth ions Tellurite glass Spectroscopic properties Upconversion luminescence

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溶藻弧菌Hy9901 vscH基因克隆及生物信息学分析

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广东海洋大学学报 2018年第4期38卷 85-91页

作者：梁彩凤庞欢瑛刘建勇广东海洋大学水产学院广东湛江524088

【目的】克隆溶藻弧菌(Vibrio alginolyticus)Hy9901 vscH基因,并分析其序列结构。【方法】参照Gen Bank上的溶藻弧菌全基因组序列设计1对特异性引物,PCR扩增溶藻弧菌Hy9901株的Ⅲ型输出蛋白yop R核心家族蛋白vscH基因全长,用生物信息... 详细信息

【目的】克隆溶藻弧菌(Vibrio alginolyticus)Hy9901 vscH基因,并分析其序列结构。【方法】参照Gen Bank上的溶藻弧菌全基因组序列设计1对特异性引物,PCR扩增溶藻弧菌Hy9901株的Ⅲ型输出蛋白yop R核心家族蛋白vscH基因全长,用生物信息学手段分析VscH序列,构建VscH系统进化树及亚基三维结构模型。【结果】vscH基因序列全长636 bp,编码211个氨基酸,推导的蛋白分子质量为24.09 ku。经预测,VscH不存在信号肽与跨膜区;含有2个ASN-糖基化位点,14个磷酸化位点,2个N-豆蔻酰化位点,2个内质网靶向序列及2个微体C-末端靶信号位点;有1个主要功能域,T3SS_needle_reg(第71-211氨基酸);α-螺旋占66.35%,无规则卷曲占23.22%,延伸链占5.69%,β-折叠占4.74%;可能的B细胞抗原优势表位,分别是第20~23,25~28,37~40,48~51和109~112区段。溶藻弧菌VscH系统进化树与弧菌(Vibrio)聚为一簇。VscH亚基三维结构模型与鼠疫耶尔森菌毒力因子yop R蛋白的编码基因ysc H相似。

关键词：溶藻弧菌 vscH基因基因克隆生物信息学分析

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晕核^6He（25MeV／u）在^9Be上的弹性散射研究

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原子核物理评论 2005年第1期22卷 6-10页

作者：庞丹阳叶沿林江栋兴郑涛王全进李智焕李湘庆陈志强胡青元张高龙王佳 A.Ozawa y.yamaguchi C.Wu R.Kanungo d.Fang I.Tanihata 北京大学物理学院技术物理系教育部重离子物理开放实验室北京100871 RIKEN 2-1 Hirosawa Wako Saitama 351-0198Japan

分析了北京大学核物理实验小组在日本RIKEN实验室完成的 25MeV/u6He和9Be的弹性散射实验数据, 得到了弹性散射微分截面角分布. 利用双折叠模型, 并通过拟合弹性散射微分截面得到了此弹靶体系在此能量下的弹性散射光学势.

关键词：弹性散射微分截面晕核核物理实验角分布实验数据光学实验室研究分析

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Measurement of Reaction Cross Section at Intermediate Energies for Neutron-deficient Nuclei(A<30)and Possible Proton Halo Structure on 23Al and 27P

Measurement of Reaction Cross Section at Intermediate Energi...

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CCAST“放射性束物理”研讨会

作者： X.Z. Cai, W.Q. Shen, Z.Z. Ren, d.Q. Fang, H.y. Zhang, j. Feng, Z.y.Zhu, W.Z. jiang, y.G. Ma, C. ZhongW.L. Zhan, Z.y. Guo, G.Q. Xiao, j.S. Wang, y.T. Zhu, j.C. Wang, j.X. Li, M. Wang, Q.j. Wang, Z.Q.Chen, j.F. Wang, Z.j. Ning’Shanghai Institute of Nuclear Research, Chinese Academy of Sciences,Shanghai 201800, China 2CCAST(WorldLaboratory) P.O.Box 8730, Beijing WOOSO.China .Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou730000, ChinaPhysics department of Nanjing University, Nanjing 210008, ChinaPhysics department ofNingbo University, Ningbo 315211, China

Reaction cross section σ of proton-rich isoto谱es (A<30) on C target have beenmeasured at intermediate energies around 30MeV/u by a transmission *** increases of the experimentalσ are observed for Al and P compared...

Reaction cross section σ of proton-rich isoto谱es (Ad at intermediate energies around 30MeV/u by a transmission *** increases of the experimentalσ are observed for Al and P compared withtheir neighboring *** suggests that there is an anomalously large matter RMSradius in these nuclei. Together with their very weakly binding of the last proton,itindicates that there is a one-proton halo in Al and P. This conclusion is also supportedby the difference factor d which is deduced from the measured and theoreticalσ in theGlauber or BUU model and is used for the manifest of halo phenomena. The theoreticalcalculation based on the RddH model also shows that there is a one proton halo in pand in Al when the last proton of Al is in the 2s orbit. The significance of theproton halo in Al is discussed.

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Retrieval of Elastic Green’s Tensor near a Cylindrical Inhomogeneity from Vector Correlations

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Communications in Computational Physics 2008年第1期3卷 250-270页

作者： juan AP´erez-Ruiz Francisco Luzon Francisco j.Sanchez-Sesma Grupo de Geof´ısica Aplicada Departamento de F´ısica AplicadaUniversidad de Almer´ıaCa˜nada de San Urbano s/n04120-Almer´ıaSpain departamento de Sismolog´ıa Instituto de IngenieriaUniversidad Nacional Aut´onoma de M´exicoCd.UniversitariaCircuito Escolar s/nCoyoac´an 04510M´exico D.F.Mexico.

Multiple scattering of elastic waves in realistic media makes that averagefield intensities or energy densities follow diffusive processes. In such regime the successiveP to S energy conversions by distributed random inhomogeneities give rise toequipartition which means that in the phase space the available elastic energy is distributedin averagewith equal amounts among the possible states of P and S waves. Insuch diffusive regime the P to S energy ratio equilibrates in an universal way independentof the particular details of the scattering. It has been demonstrated that averagingthe cross correlations at any two points of an elastic medium subjected to diffuse elasticwavefields leads to the emergence of the Green function, which is the wave fieldthat would be observed at one position if an impulsive load is applied at the other. Inthis work we study the problem of the retrieval of the 2d tensor elastodynamic Greenfunction in an infinite elastic space containing a circular cylinder inclusion. We illuminateisotropically the elastic spacewith plane waves. We assume the spectra for both pand S waves uniform but such that the energy ratio ES/EP=(a/b)2, which is the onepredicted by equipartition theory in two-dimensions. We then show that the Fouriertransform of azimuthal average of the cross-correlation of motion between two pointswithin an elastic medium is proportional to the imaginary part of the exact Green tensorfunction between these points. The numerical results presented here point out thepossibility of detection and imaging of diffractors and resonant diffractors by crosscorrelation even in presence of attenuation exists.

关键词： Multiple scattering elastic waves elastic Green’s tensor

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鳖甲煎丸对肝纤维化大鼠作用机制研究

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中国中西医结合消化杂志 2013年第11期21卷 572-575页

作者：文彬贺松其庞杰贾文燕孙海涛解放军第四五八医院中医科广东广州510602 南方医科大学中医药学院广东广州510515

[目的]探讨鳖甲煎丸抗肝纤维化的作用机制。[方法]采用复合因素建立肝纤维化大鼠模型。将大鼠随机分为正常组、模型组、秋水仙碱组、鳖甲煎丸高剂量组、鳖甲煎丸等剂量组。秋水仙碱组[0.11mg/(kg·d)]、鳖甲煎丸高剂量组[2.2g/(kg·d]... 详细信息

[目的]探讨鳖甲煎丸抗肝纤维化的作用机制。[方法]采用复合因素建立肝纤维化大鼠模型。将大鼠随机分为正常组、模型组、秋水仙碱组、鳖甲煎丸高剂量组、鳖甲煎丸等剂量组。秋水仙碱组[0.11mg/(kg·d)]、鳖甲煎丸高剂量组[2.2g/(kg·d]及鳖甲煎丸等剂量组[1.1g/(kg·d]分别予以相应药物灌胃,模型组及正常组给予等剂量的0.9%氯化钠灌胃,共6周。采用比色法检测血清丙氨酸氨基转移酶,天冬氨酸转氨酶(ALT、AST)水平,苏木精-伊红染色观察肝组织病理学变化及肝纤维化程度,免疫组化方法检测肝组织瘦素、瘦素受体表达水平。[结果]鳖甲煎丸能降低大鼠血清ALT、AST水平,减轻肝脏炎症及纤维化程度(均P<0.01);抑制模型大鼠肝组织瘦素及瘦素受体的表达(P<0.01)。[结论]鳖甲煎丸能有效减轻模型大鼠肝纤维化的病理程度。其作用机制可能与降低大鼠血清ALT、AST水平,抑制大鼠肝组织瘦素及瘦素受体的表达密切相关。

关键词：鳖甲煎丸肝纤维化瘦素瘦素受体

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Evaluation of para-aortic nodal dissection for locoregionally advanced gastric cancer with 1-3 involved para-aortic nodes

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Chinese Medical journal 2014年第3期127卷 435-441页

作者： Zhang Changhua He yulong Roderich E.Schwarz david d.Smith Wang Liang Liu Fakeng Zhan Wenhua department of Gastrointestinopancreatic Surgery the First Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong 510080 China Gastric Cancer Center of Sun yat-sen University Guangzhou Guangdong 510080 China department of Surgery University of Texas Southwestern Medical Center Dallas TX 75235 USA division of Biostatistics City of Hope National Medical Center Duarte CA 91010 USA

Background Prophylactic para-aortic nodal dissection （pand） has no proven benefits for potentially curable advanced gastric ***,the value of therapeutic pand for involved para-aortic nodes （PANs） in patients with locally advanced gastric cancers has not been determined *** Between 1998 and 2010,157 gastric cancer patients with 1-3 involved PANs underwent extended d2 （d2＋） lymphadenectomy plus pand （pand group,n=69） or extended d2 lymphadenectomy alone （non-pand group,n=88）.The clinicopathologic features and prognostic data were compared between the two groups.A propensity score-adjusted analysis was used for a balanced *** The rate of PAN metastasis was 40.6％（28/69） in the pand *** 5-year survival rate was significantly higher in the pand group than in the non-pand group （43.7％ vs.31.8％,P=-0.044）.Compared to the non-pand group,the death hazard ratios in the pand group were 0.45 （95％ CI 0.274-0.739; P=0.002） and 0.536 （95％ CI 0.328-0.861; P=-0.0097） by multivariate analysis without and with propensity score adjustment *** rate at 5 years was 39.1％ in the pand group and 43.2％ in the non-pand group （P=0.628）.Conclusion Extended d2 lymphadenectomy plus pand is associated with superior outcomes for advanced gastric cancer patients with 1-3 involved PANs.

关键词： gastric cancer lymphadenectomy para-aortic node prognosis

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S-1与顺铂新辅助化疗后d2并腹主动脉旁淋巴结清扫治疗腹主动脉旁淋巴结转移胃癌

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消化肿瘤杂志（电子版） 2014年第4期6卷 196-196页

作者： Tsuburaya A Mizusawa j Tanaka y 吴晖不详

背景合并胃周或腹主动脉旁淋巴结广泛转移的局部进展期胃癌是典型的不可切除胃癌,预后不良。目的本研究探究S-1+顺铂化疗后行胃周并腹主动脉旁淋巴结清扫治疗腹主动脉旁淋巴结转移胃癌患者的安全性及有效性。方法合并腹腔动脉及其分支... 详细信息

背景合并胃周或腹主动脉旁淋巴结广泛转移的局部进展期胃癌是典型的不可切除胃癌,预后不良。目的本研究探究S-1+顺铂化疗后行胃周并腹主动脉旁淋巴结清扫治疗腹主动脉旁淋巴结转移胃癌患者的安全性及有效性。方法合并腹腔动脉及其分支周围淋巴结肿大转移和/或腹主动脉旁淋巴结转移的胃癌患者,接受23周期(每28天重复)的S-1+顺铂化疗,而后接受根治性d2+腹主动脉旁淋巴结清扫(pand)术。观察的主要终点为原发肿瘤无切缘残留(R0)切除率。目标样本量为50例,单侧检验α值及β值分别为0.105、0.2。R0的期望切除率为65%,临界值为50%。

关键词：淋巴结淋巴组织腹主动脉主动脉腹部 S-1 新辅助化疗

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反射式泪液半月面视频检查仪在正常成人及功能性或原发性鼻泪管阻塞患者中的应用研究

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世界核心医学期刊文摘（眼科学分册） 2005年第8期1卷 25-26页

作者： Francis I.C. Papalkar d. 张鹏 Chatswood GroveEye Clinic 12-14 Malvern Avenue Chatswood NSW 2067 Australia

PURPOSE: Videoreflective dacryomeniscometry (VRd) for evaluation of marginal t ear film has not been performed in patients with watery eye or in a controlled s tudy. We used VRd to evaluate the height of the central marginal lower lid tear film in normal adults and compared it with two watery-eye groups and a postoper ative dacryocystorhinostomy (dCR) group. dESIGN: Case-controlled interventional case series. METHOdS: We evaluated with VRd 20 subjects with normal lacrimal dr ainage function, 21 patients with primary acquired nasolacrimal duct obstruction (pandO), 28 patients with functional nasolacrimal duct obstruction (FNLdO), and a postoperative group of 14 patients derived from the previous two pathologic groups. Comparison between the four groups was performed to determine statisti cally significant differences between tear film height. RESULTS: pandO and FNLdO groups were shown to have significantly greater median tear meniscus heights ([ TMH] pandO: 620 μm, interquartile range [IQR] 453 μm; FNLdO: 731 μm, IQR 529 μm) than normal subjects (296 μm, IQR 214 μm; Pd postoperative pand O patients (265 μm, IQR 159 μm). There was no significant difference in TMH be tween pandO and FNLdO groups preoperatively (P=.275). There was a reduction in m edian TMH postoperatively of 355 μm (P=.008) in pandO and 360 μm (P=.068) in F NLdO. CONCLUSIONS: pandO and FNLdO patients have similar preoperative TMH. In bo th these groups, TMH is significantly greater than in normal control subjects. L acrimal drainage surgery substantially reduces TMH as measured using VRd in pand O.

关键词：鼻泪管阻塞检查仪反射式泪囊鼻腔吻合术下睑应用研究泪液膜泪膜病理学研究边缘部

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