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Roles of the ocular pressure, pressure-sensitive ion channel, and elasticity in pressure-induced retinal diseases

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Neural Regeneration Research 2021年第1期16卷 68-72页

作者： Ji-jie pang Department of Ophthalmology Baylor College of MedicineHoustonTXUSA

The intraocular pressure inside the human eye maintains 10–21 mmHg above the atmospheric *** of intraocular pressure is highly correlated with the retinopathy in glaucoma,and changes in the exterior pressure during mountain hiking,air traveling,and diving may also induce vision decline and *** pathophysiological mechanism of these pressure-induced retinal disorders has not been completely *** neurons express pressure-sensitive channels intrinsically sensitive to pressure and membrane stretch,such as the transient receptor potential channel(TRP)family permeable to Ca^2+and Na^+and the two-pore domain K channel *** data have shown that pressure excites the primate retinal bipolar cell by opening TRP vanilloid 4 to mediate transient depolarizing currents,and TRP vanilloid 4 agonists enhance the membrane excitability of primate retinal ganglion *** eyeball wall is constructed primarily by the sclera and cornea of low elasticity,and the flow rate of the aqueous humor and intraocular pressure both fluctuate,but the mathematical relationship between the ocular elasticity,aqueous humor volume,and intraocular pressure has not been *** review will briefly review recent literature on the pressure-related retinal pathophysiology in glaucoma and other pressure-induced retinal disorders,the elasticity of ocular tissues,and pressure-sensitive cation channels in retinal *** data support the global volume and the elasticity and thickness of the sclera and cornea as variables to affect the intraocular pressure level like the volume of the aqueous *** results also suggest some potential routes for TRPs to mediate retinal ganglion cell dysfunction:TRP opening upon intraocular pressure elevation and membrane stretch,enhancing glutamate release from bipolar cells,increasing intracellular Na^+,Ca^2+concentration in retinal ganglion cells and extracellular glutamate concentration,inactivating voltage-ga

关键词： glaucoma ocular elasticity patch-clamp pressure-sensitive ion channel retina retinal bipolar cell retinal ganglion cell TRP

Ti-Zr-Cu-Fe-Sn-Si-Ag-Ta bulk metallic glasses with good corrosion resistance as potential biomaterials

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Rare Metals 2020年第6期39卷 688-694页

作者： Ying Liu Hao-jie Wang Shu-jie pang Tao Zhang Key Laboratory of Aerospace Materials and Performance(Ministry of Education) School of Materials Science and EngineeringBeihang UniversityBeijing 100191China School of Physics and Nuclear Energy Engineering Beihang UniversityBeijing 100191China Beijing Advanced Innovation Centre for Biomedical Engineering Beihang UniversityBeijing 100191China

Ti47Cu38-xZr7.5Fe2.5Sn2 Si1 Ag2 Tax(x=1-4;at%,the same below)bulk metallic glasses(BMGs)with good bio-corrosion resistance and mechanical properties were fabricated by copper mold *** diameter of the Ti-based BMGs with 1 at%-4 at%Ta was 3 *** Ta-incorporated Ti-based BMGs exhibit higher open current potential and parallel passive current density in comparison with those of Ti-6 Al-4 V alloy in 0.9 wt%NaCl and Hank’s solution,implying their good corrosion *** pitting corrosion potential of the Ti-based BMGs gradually increases up to about 1.25 V with Ta addition increasing up to 4 at%in 0.9 wt%NaCl *** the present Ti-based BMGs,the alloy bearing2 at%Ta exhibits the optimal integration of mechanical properties,including the compressive fracture strength exceeding 2000 MPa,relative low Young’s modulus of98 GPa,plastic strain of 3.4%and high hardness of *** Ta-bearing Ti-based bulk metallic glasses with integration of relative high GFA,good mechanical properties and high bio-corrosion resistance are beneficial for biomedical applications.

关键词： Ti-based alloy Bulk metallic glass Glass forming ability Bio-corrosion resistance Mechanical properties

Formation Sites and Microscopic Conformation Study on the Konjac Glucomannan Molecular Helices

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Chinese Journal of Structural Chemistry 2010年第7期29卷 1084-1090页

作者： JIAN Wen-jie WANG Meng YAO Min-Na pang jie Department of Biological Technology Xiamen Ocean Vocational College Xiamen 361012 China College of Food Science Fujian Agriculture and Forestry University Fuzhou 350002 China

In this work, the formation sites, helical parameters and hydrogen bond positions of Konjac glucomannan molecular helices were investigated using molecular dynamic simulation method. To our interest, the KGM chain is mainly composed by local left and right helix struetttres. The formation sites of KGM chain might locate at the chain-segments containing acetyl groups, and the left helix is the favorable conformation of KGM. Temperature-dependent molecule conformation study indicates that the right helix is dominant when the temperature is lower than 343 K, above which, however, the left helix is dominating （right helix disappears）. In addition, intramolecular hydrogen bonds in the left helix can be found at the -OH groups on C（2）, C（4） and C（6） of mannose residues; comparably, the intramolecular hydrogen bonds in the right helix can be mainly observed at the -OH groups on C（4） and C（6） of the mannose residues and C（3） of the glucose residues. In conclusion, molecular dynamic simulation is an efficient method for the microscopic conformation study of glucomannan molecular helices.

关键词： Konjac glucomannan helical structure formation sites helical parameters,hydrogen bond sites

Thermal stability,mechanical properties and corrosion behavior of a Mg–Cu–Ag–Gd metallic glass with Nd addition

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Rare Metals 2017年第3期36卷 183-187页

作者： Guan Wang Cui-Xia Guo Shu-jie pang Key Laboratory of Aerospace Materials and Performance(Ministry of Education) School of Materials Science and EngineeringBeihang UniversityBeijing 100191China

By the minor addition of Nb to a Mg-Cu-Ag-Gd alloy,a Mg-Cu-Ag-Gd-Nb bulk metallic glass （BMG） with improved thermal stability and corrosion resistance as well as good mechanical properties was ***54Cu26.5Ag8.5Gd11-xNbx （x=0,1） BMGs with a diameter of 2 mm were fabricated by copper-mold *** Mg54Cu26.5Ag8.5Gd10Nb1 BMG exhibits enlarged supercooled liquid region of 58 *** measurements indicate that the addition of Nb improves the corrosion resistance of the Mg-based BMG in NaCl solution evidenced by the increased corrosion potential,though no significant effect of Nb on the corrosion behavior of the BMG in NaOH solution is *** Mg-Cu-Ag-Gd-Nb BMG also shows high compressive strength up to 890 MPa and elastic strain of about 1.9%.

关键词： Mg-based alloy Metallic glass Thermalstability Mechanical properties Corrosion resistance

Effects of crystallization on corrosion behaviours of a Ni-based bulk metallic glass

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International Journal of Minerals,Metallurgy and Materials 2012年第2期19卷 146-150页

作者： Sen Liu Lu Huang Shu-jie pang Tao Zhang Key Laboratory of Aerospace Materials and Performance(Ministry of Education) School of Materials Science and EngineeringBcibang UniversityBeijing 100191China

The effects of microstructure change on the corrosion behaviours of Ni55Nb20Ti10Zr8Co7 bulk glass-forming alloy were investigated in 1 mol/L HCl and 0.5 mol/L H2SO4 solutions. Different microstructures of the Ni-based alloy were achieved by annealing the bulk glassy rod prepared by copper mould casting. The microstructure, grain size, grain distribution, and phase composition were characterized. Electrochemical behaviours of the Ni-based alloy were revealed by static immersion and anodic potentiodynamic polarization tests. It is indicated that the corrosion behaviours of the Ni-based bulk glass-forming alloy are related to its microstructures, while the fully crystallized alloy exhibits a relatively lower corrosion resistance than those of the amorphous states.

关键词： bulk metallic glasses nickel alloys microstructure corrosion crystallization

Formation and properties of a Zr-based amorphous coating by laser cladding

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Rare Metals 2024年第4期43卷 1809-1814页

作者： Ning Zhang Ying Liu Wei Yang Shu-jie pang Key Laboratory of Aerospace Materials and Performance(Ministry of Education) School of Materials Science and EngineeringBeihang UniversityBeijing100191China

(Zr_(0.53)Al_(0.1)Ni_(0.05)Cu_(0.3)Ti_(0.02))_(99)Y_1(at%)coating with amorphous layer of about 180μm thick was prepared on a steel substrate by using laser cladding *** coating is compact and shows good metallurgical bonding with *** microstructure,microhardness and corrosion behavior along the depth from the coating surface to the substrate were *** is found that a gradient structure consisted of amorphous surface layer,amorphous-crystalline transitional layer and substrate is formed after the laser *** microhardness and corrosion behavior exhibit variation with the microstructural evolution at different depths from the coating *** microhardness and corrosion resistance in 3.5 wt%NaCl solution of the amorphous surface layer are comparable to those of the as-cast Zr-based BMG with the same composition,and higher than those of the steel substrate.

关键词： Laser cladding Amorphous coating Microstructure Hardness Corrosion resistance

Glass formation and properties of Ti-based bulk metallic glasses as potential biomaterials with Nb additions

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Rare Metals 2018年第10期37卷 831-837页

作者： Hui-Ming Yan Ying Liu Shu-jie pang Tao Zhang Key Laboratory of Aerospace Materials and Performance(Ministry of Education) School of Materials Science and Engineering Beihang University

Ti47Cu38-xZr7.5Fe2.5Sn2Si1Ag2Nbx（x = 0, 1, 2; at%） bulk metallic glasses （BMGs） with superior biocorrosion resistance were synthesized by copper mold casting. Although the minor addition of Nb to the Ti-Cu- Zr-Fe-Sn-Si-Ag BMG slightly decreases the glass-forming ability （GFA）, the Nb-bearing Ti-based alloys could be casted in a bulk glassy rod form with diameters up to 3 mm. It is found that partial substitution of Cu with Nb is effective on enhancing the bio-corrosion resistance of the Ti-based BMG. Potentiodynamic polarization measurements show that Nb addition to Ti-based BMG leads to higher open-circuit potential and pitting potential as well as lower passive current density in Hank＇s solution. Electrochemical impedance spectroscopy （EIS） results indicate that with Nb content increasing, the charge transfer resistance values of the Ti-based BMGs become larger, demonstrating that the surface oxide films are more protective. The Nb-bearing Ti-based BMGs also exhibit good in vitro biocompatibility comparable to that of Ti-6Al-4V alloy. The enhanced bio-corrosion resistance, excellent in vitro biocompatibility and good mechanical properties of the Nb-bearing Ti-based BMGs are favorable for biomedical applications.

关键词： Ti-based alloy Bulk metallic glass Biocorrosion Electrochemical impedance spectroscopy Biocompatibility

Formation of composite hydrogel of carboxymethyl konjac glucomannan/gelatin for sustained release of EGCG

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Food Science and Human Wellness 2022年第5期11卷 1373-1383页

作者： Lin Wang Ning zhou Shengxuan Zheng jie pang Department of Engineering Mechanics Tsinghua UniversityBeijing 100084China Institute of Superlubricity Technology Research Institute of Tsinghua University in ShenzhenShenzhen 518057China College of Food Science Fujian Agriculture and Forestry UniversityFuzhou 350002China

Development of functional bioinspired hydrogels that have good releases control character is necessary for the application of these materials in biomedical ***,we report a composite hydrogel prepared from several biocompatible carboxymethyl konjac glucomannan(CKGM)/gelatin(G)/tannic acid(TA)functional nano-hydroxyapatite(TA@n-HA),which has good biodegradability and pH *** mechanism of interaction between hydrogels was confirmed by Fourier transform infrared spectroscopy,X-ray diffraction,Scanning electron microscopy and Thermogravimetric *** physico-chemical properties of CKGM/G hydrogels have been significantly improved through the incorporation of TA@n-HA within the *** in the sustained release of epigallocatechin gallate(EGCG)demonstrated that the TA@n-HA/CKGM/G hydrogels exhibit not only better pH sensitive properties,but also enhanced biocompatibility and encapsulation in comparison to the matrix devoid of TA@***,TA@n-HA/CKGM/G hydrogels using EGCG as a drug release model show the potential for drug delivery.

关键词： Hydrogel Carboxymethyl konjac glucomannan Gelatin Tannic acid Biodegradation Sustained release

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Controlled Microstructure and Photochromism of Inorganic-organic Thin Films by Ultrasound

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Journal of Materials Science & Technology 2007年第4期23卷 477-480页

作者： Yanhua pang Wei FENG jie CHEN Yan LIU Weimin CAI College of Environmental Science and Engineering Dalian Maritime University Dalian 116026 China

A series of inorganic-organic thin films based on uniformly dispersed nanoparticles of polyoxometalates （POM）entrapped in polyacrylamide （PAM） matrix were prepared by ultrasonic method with different irradiation *** microstructure, photochromic behavior and mechanism of the films were studied by transmission electron microscopy （TEM）, ultraviolet-visible spectra （UV-VIS） and Fourier transform-infrared spectroscopy （FT-IR）.The microstructure and photochromic properties of the hybrid thin films could be controlled by *** image revealed that the average size of phosphotungstic acid （PWA） nanoparticles decreased from 20 to 10 nm with the ultrasound irradiation time from 30 to 60 min. After irradiated with ultraviolet light,the transparent films changed from colorless to blue and showed reversible photochromism. The hybrid film, with ultrasound irradiation for 60 min had higher photochromic efficiency and faster bleaching reaction than the one with ultrasound irradiation for 30 min. FT-IR spectra showed that the Keggin geometry of heteropolyoxometalate was still preserved inside the composites, and the interactions between polyanions and polymer matrix increased as the ultrasound time prolonged. It is suggested that the mechanism of the different photochromic properties for the inorganic-organic thin films is the variation of the microstructure and interfacial interactions induced by ultrasound.

关键词： Inorganic-organic Thin Films sonochemical controlled microstruture photochromism