检索结果-南通市图书馆

Unraveling brain aging through the lens of oral microbiota

Neural Regeneration Research 2025年第7期20卷 1930-1943页

作者： Qinchao Hu si Wang Weiqi Zhang Jing Qu Guang-Hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijingChina CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijingChina University of Chinese Academy of Sciences BeijingChina Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina Aging Biomarker Consortium BeijingChina State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute for Stem Cell and Regenerative Medicine BeijingChina

The oral cavity is a complex physiological community encompassing a wide range of *** of oral microbiota can lead to various oral infectious diseases,such as periodontitis and tooth decay,and even affect systemic health,including brain aging and neurodegenerative *** studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration,indicating potential avenues for intervention *** this review,we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases,and dissect potential mechanisms by which oral microbes contribute to brain aging and *** also highlight advances in therapeutic development grounded in the realm of oral microbes,with the goal of advancing brain health and promoting healthy aging.

关键词： Alzheimer's disease brain aging multiple sclerosis neurodegeneration neurodegenerative diseases oral microbiota Parkinson's disease periodontitis bacteria Porphyromonas gingivalis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Steady-state and transient investigation of a small pressurized water reactor ACPR50S for different ATFs based on Bamboo-C code

引用

Nuclear Science and Techniques 2025年第1期36卷 192-206页

作者： Kun Zhuang Ying-Zhen Wang Li-Na Deng Yong-Zhan Wang Wen Shang si-Peng Wang Department of Nuclear Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China

Small modular reactors have received widespread attention owing to their inherent safety,low investment,and *** pressurized water reactors(SPWRs)have become important candidates for SMRs owing to their high technological *** the Fukushima accident,research on accident-tolerant fuels(ATFs),which are more resistant to serious accidents than conventional fuels,has gradually *** study analyzes the neutronics and thermal hydraulics of an SPWR(ACPR50S)for different ATFs,BeO+UO_(2)−siC,BeO+UO_(2)−FeCrAl,U_(3)si_(2)−siC,and U_(3)si_(2)−FeCrAl,based on a PWR fuel management code,the Bamboo-C deterministic *** the steady state,the burnup calculations,reactivity coefficients,power and temperature distributions,and control rod reactivity worth were *** transients of the control rod ejection accident for the two control rods with the maximum and minimum reactivity worth were *** results showed that 5%B-10 enrichment in the wet annular burnable absorbers assembly can effectively reduce the initial reactivity and end-of-life reactivity *** BeO+UO2−siC core exhibited superior neutronic characteristics in terms of burnup and negative temperature reactivity compared with the other three cases owing to the strong moderation ability of BeO+UO_(2)and low neutron absorption of ***,the U_(3)si_(2)core had a marginally better power-flattening effect than BeO+UO_(2),and the differential worth of each control rod group was similar between different *** the transient of a control rod ejection,the changes in the fuel temperature,coolant temperature,and coolant density were *** maximum difference was less than 10℃ for the fuel temperature and 2℃ for the coolant temperature.

关键词： ACPR50S Small pressurized water reactor ATF Steady Transient

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

AP1000核电站蒸汽发生器主给水管道双端断裂事故下第一跨空间三维流动特性数值模拟

引用

科学技术与工程 2021年第4期21卷 1388-1393页

作者：魏承君陈子佳庞思敏赵海琦张钰浩国核电力规划设计研究院有限公司北京100095 华北电力大学核科学与工程学院北京102206 非能动核能安全技术北京市重点实验室北京102206

AP1000核电厂第一跨空间内布置了设备冷却水系统(component cooling water system,CCS)驱动泵,能够保证核电厂事故工况下设备冷却水系统、余热排出系统等关键安全系统的正常运行,从而保证核电厂安全。然而在蒸汽发生器主给水管道双端断... 详细信息

AP1000核电厂第一跨空间内布置了设备冷却水系统(component cooling water system,CCS)驱动泵,能够保证核电厂事故工况下设备冷却水系统、余热排出系统等关键安全系统的正常运行,从而保证核电厂安全。然而在蒸汽发生器主给水管道双端断裂事故下,大量的水会泄放到第一跨空间内,对第一跨空间内的关键设备造成严重威胁。因此,对AP1000核电站蒸汽发生器主给水管道双端断裂事故下第一跨空间内泄放流体三维流动特性进行数值模拟。采用ANSYS系列软件,建立第一跨空间三维模型,基于流体体积模型(volume of fluid model,VOF)计算冷却剂喷放事故下,第一跨空间内流动特性及水位变化规律。计算结果表明,破口水从入口进入第一跨空间后在5.334 m层漫流,绝大部分泄放水通过该层设置的预留开孔流出,部分水在该层堆积。但是,由于设置挡水沿,泄洪水并未漫流到0 m层与-3.8 m层,随着冷却剂喷放引发给水泵跳泵,第一跨空间内水位将逐渐下降,不会造成重要设备防水台的漫流淹没。计算结果对核电厂主要泄洪途径、关键设备布置设计与优化提供了数值参考。

关键词：第一跨空间蒸汽发生器给水管道断裂防水淹计算流体体积模型(VOF) AP1000

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Probing the special angle in twisted bilayer MoS2 via angle-dependent scanning tunneling microscopy studies

引用

Science China(Physics,Mechanics & Astronomy) 2025年第2期Mechanics & Astronomy) .卷 157-164页

作者： Xueying Liu Shiying Liu Yulong Xiao Chang Xu Jiaxin Wu Kaihui Li si-Yu Li Anlian Pan Key Laboratory for Micro-Nano Physics and Technology of Hunan Province Hunan Institute of Optoelectronic Integration and College of Materials Science and EngineeringHunan University School of Physics and Electronics Hunan Normal University

Twisted transition metal dichalcogenides（TMDs） homo-bilayers host unique quantum properties,which can be tuned by interlayer twist angle θ.However,the systematic evolution of their typical electronic properties with respect to the twist angle θ,which is crucial for identifying the “special angle” analogous to the “magic angle” of twisted bilayer graphene in correlation physics studies,remains incompletely ***,via scanning tunneling microscopy（STM） and spectroscopy（STS）,we investigate the variation of the moirépotential,flat band,and layer polarization characteristics across a wide range of twist angleθ in twisted bilayer MoS2（TB-MoS2）.The moirépotential of the valence band exhibits a non-monotonic variation with θ,peaking at a maximum value up to 204 me Vat θ～1.7°.Concurrently,at the same θ,the bandwidth of the flat band at the ΓVpoint of the valence band attains its minimum,precisely signifying the “special angle” θc～1.7°in ***,layer polarization in the moirésuperlattice is spatially visualized through the distribution of local density of states（LDOS） at the energies of both ΓVand KVpoints of the valence band,where the polarization degree at the ΓVpoint demonstrates a close dependency on θ.Our findings deepen understanding of twist-angle effect in TMDs,advancing both fundamental physics and practical application.

关键词： twisted bilayer MoS2 flat band moiré potential twist-angle dependence scanning tunneling microscopy

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Enhancement of bending toughness for Fe-based amorphous nanocrystalline alloy with deep cryogenic-cycling treatment

引用

China Foundry 2025年第1期22卷 99-107页

作者： Yi-ran Zhang Dong Yang Qing-chun Xiang Hong-yu Liu Jing pang Ying-lei Ren Xiao-yu Li Ke-qiang Qiu School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China Qingdao Yunlu Advanced Material Technology Co. Ltd.Qingdao 266232ShandongChina

The effects of deep cryogenic-cycling treatment(DCT)on the mechanical properties,soft magnetic properties,and atomic scale structure of the Fe_(73.5)si_(13.5)B_(9)Nb_(3)Cu_(1)amorphous nanocrystalline alloy were *** DCT samples were obtained by subjecting the as-annealed samples to a thermal cycling process between the temperature of the supercooled liquid zone and the temperature of liquid *** flat plate bending testing,hardness measurements,and nanoindentation experiment,it is found that the bending toughness of the DCT samples is improved and the soft magnetic properties are also slightly *** are attributed to the rejuvenation behavior of the DCT samples,which demonstrate a higher enthalpy of ***,DCT is an effective method to enhance the bending toughness of Fe-based amorphous nanocrystalline alloys without degrading the soft magnetic properties.

关键词： deep cryogenic-cycling treatment Fe-based amorphous nanocrystalline alloy bending toughness rejuvenation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于FLOWNEX的AP1000常规岛热力系统全范围建模及瞬态工况模拟

引用

科学技术与工程 2021年第16期21卷 6710-6717页

作者：魏承君于倩李立晓黄俊文庞思敏隋丹婷国核电力规划设计研究院有限公司北京100095 华北电力大学核科学与工程学院北京102206 非能动核能安全技术北京市重点实验室北京102206

常规岛热力系统全范围快速建模对于常规岛的安全设计有重要意义。以主给水管道破裂事故为例,按照纵深防御的要求,第一跨防水淹设计基准是保证布置在第一跨的设备冷却水系统(component cooling water system,CCS)CCS泵组功能不会因为水... 详细信息

常规岛热力系统全范围快速建模对于常规岛的安全设计有重要意义。以主给水管道破裂事故为例,按照纵深防御的要求,第一跨防水淹设计基准是保证布置在第一跨的设备冷却水系统(component cooling water system,CCS)CCS泵组功能不会因为水淹工况而丧失。因此,建立完整的常规岛二回路汽水系统工质流动模型,并进一步确定泄漏量最大的主给水管道破裂工况,能为AP1000及后续电厂的常规岛主厂房第一跨防水淹设计提供数据支撑和指导策略。基于FLOWNEX计算软件,通过建立汽轮机、汽水分离再热器、凝汽器、除氧器、高低压加热器、主泵、凝结水泵等部件的关键模型,完成AP1000二回路汽水系统建模,实现了对凝汽器水位、除氧器水位、抽汽量等关键参数的模拟,并实现了对泵跳闸等关键控制逻辑的建模,通过简单修改边界条件即可实现不同功率台阶的切换以及功率的瞬态变化。模型稳态计算工况与热力系统平衡图符合较好,降功率瞬态计算快速准确,为下一步事故工况的建模计算提供了模型基础。

关键词： FLOWNEX AP1000 常规岛建模

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Genomic insights into ecological adaptation of oaks revealed byphylogenomic analysis of multiple species

引用

Plant Diversity 2025年第1期47卷 53-67页

作者： Tian-Rui Wang Xin Ning si-si Zheng Yu Li Zi-Jia Lu Hong-Hu Meng Bin-Jie Ge Gregor Kozlowski Meng-Xiao Yan Yi-Gang Song Eastern China Conservation Centre for Wild Endangered Plant Resources Shanghai Chenshan Botanical GardenShanghai 201602China College of Forestry and Biotechnology Zhejiang A&F UniversityHangzhou 311300China College of Life Sciences Shanghai Normal UniversityShanghai 200234China Plant Phylogenetics and Conservation Group Centre for Integrative ConservationXishuangbanna Tropical Botanical GardenChinese Academy of SciencesKunming 650223China Department of Biology and Botanic Garden University of FribourgFribourgSwitzerland Natural History Museum Fribourg FribourgSwitzerland

Understanding the ecological adaptation of tree species can not only reveal the evolutionary potential but also benefit biodiversity conservation under global climate *** is a keystone genus in Northern Hemisphere forests,and its wide distribution in diverse ecosystems and long evolutionary history make it an ideal model for studying the genomic basis of ecological *** we used a newly sequenced genome of Quercus gilva,an evergreen oak species from East Asia,with 18 published Fagales genomes to determine how Fagaceae genomes have evolved,identify genomic footprints of ecological adaptability in oaks in general,as well as between evergreen and deciduous *** found that oak species exhibited a higher degree of genomic conservation and stability,as indicated by the absence of large-scale chromosomal structural variations or additional whole-genome duplication *** addition,we identified expansion and tandem repetitions within gene families that contribute to plant physical and chemical defense(e.g.,cuticle biosynthesis and oxidosqualene cyclase genes),which may represent the foundation for the ecological adaptation of oak *** rhythm and hormone-related genes may regulate the habits of evergreen and deciduous *** study provides a comprehensive perspective on the ecological adaptations of tree species based on phylogenetic,genome evolutionary,and functional genomic analyses.

关键词： Quercus Ecological adaptation Phylogenomics Transcriptomes Fagaceae

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Polypropylene-based blend with enhanced breakdown strength under gamma-ray irradiation for cable insulation

引用

Nuclear Science and Techniques 2025年第1期36卷 35-48页

作者： Bai-Xin Liu Yu Gao Jing Li Chen-Yi Guo Bo-Sen si Jun-Guo Gao Yu Chen Bo-Xue Du School of Electrical and Information Engineering Tianjin UniversityTianjin 300072China Key Laboratory of Engineering Dielectrics and Its Application Ministry of EducationHarbin University of Science and TechnologyHarbin 150080China State Key Laboratory of Electrical Insulation and Power Equipment Xi’an Jiaotong UniversityXi’an 710049China

This study focuses on the electrical properties and microstructure of polypropylene(PP)-based blends used for cable insulation in nuclear power plants(NPPs).The PP-based blend,comprising isotactic PP and propylene-based elastomer(PBE)at concentrations ranging from 0 to 50 wt%,underwent a melt blending process and subsequent cobalt-60 gamma-ray irradiation with doses ranging from 0 to 250 *** conductivity,trap distribution,and alternating(AC)breakdown strength were chosen to assess the insulation *** results indicate that the addition of PBE significantly improves the electrical properties of PP under *** PP,the electrical conductivity increased with irradiation,whereas the trap depth and breakdown strength decreased ***,for the blend,these changes initially exhibit opposite *** the irradiation was increased to 250 kGy,the AC breakdown strength of the blend improved by more than 21%compared to that of *** physical and chemical structures of the samples were investigated to explore the improvement *** results offer insights into the design of new cable-insulation materials suitable for NPPs.

关键词： Nuclear power plant Cable insulation Polypropylene Electrical properties Gamma-ray irradiation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Review of Raman spectroscopy of two-dimensional magnetic van der Waals materials

引用

Chinese Physics B 2021年第11期30卷 1-11页

作者： Yu-Jia Sun si-min pang Jun Zhang State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China CAS Center of Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing 100049China Beijing Academy of Quantum Information Science Beijing 100193China

Ultrathin van der Waals(vdW)magnets provide a possibility to access magnetic ordering in the two-dimensional(2D)limit,which are expected to be applied in the spintronic *** spectroscopy is a powerful characterization method to investigate the spin-related properties in 2D vdW magnets,including magnon and spin–lattice interaction,which are hardly accessible by other optical *** this paper,the recent progress of various magnetic properties in 2D vdW magnets studied by Raman spectroscopy is reviewed,including the magnetic transition,spin-wave,spin–lattice interaction,symmetry tuning induced by spin ordering,and nonreciprocal magneto-phonon Raman scattering.

关键词： two-dimensional(2D)magnets Raman spectroscopy magnon spin-lattice interaction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

引用

Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao Lin Changzhou Ying Xiaoli si Naijia Xue Yi Liu Ran Zheng Ying Chen Jiali Pu Baorong Zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：