检索结果-南通市图书馆

Recent Highlights of Chinese Herbs in Treatment of Allergic Disease：Acting via Mitogen-activated Protein Kinase Signal Pathway

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2017年第8期23卷 570-573页

作者： HE Xu-feng pan wei-dong YAO Yi-li ZHANG Hui-min Department of Dermatol-ogy Shuguang HospitalShanghai University of Traditional Chinese Medicine Shanghai 201203 China

The histamine receptor antagonists in the treatment of allergic disease have *** treatments of Chinese herbs have some curative effects on allergic skin *** research indicates that the mitogen-activated protein kinase（MAPK）signaling pathway might be equally important in allergic *** was found that the inhibition of MAPK signaling pathways might relieve allergy symptoms,and some herbs can inhibit the MAPK pathway,which yields anti-allergy *** medicines（CMs）have immense potential in the development of treatments for allergic disease.

关键词： Chinese medicines allergic disease mitogen-activated protein kinase signalpathway

Three-dimensionally ordered macroporous cross-linked polystyrene incorporating functional group via hydrophilic spacer arm

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2010年第12期21卷 1493-1496页

作者： Li Xia Yuan Xiao Mei Wang Xu Zhang pan Ge Liu wei dong Yan Institute of Polymer Science and Engineering Hebei University of Technology Tianjin 300130 China

A versatile and effective method for incorporating functional groups on the pore wall of three-dimensionally ordered macroporous cross-linked polystyrene（3DOM CLPS） by hydrophilic spacer arm has been *** 3DOM CLPS with pore size 865 nm was prepared by sacrifice template *** hydrophilic spacer arm（polyethylene glycol,molecular weight is 600） was grafted to the 3DOM CLPS via nucleophilic substitution *** other side of active hydroxyl can be further converted into a lot of other functional *** this report,the chelating ligand 2-mercaptobenzothiazole（MBZ） group was introduced on the end of the PGE chain to evidence the versatile functionalization *** functionalized ordered macroporous materials were characterized by FT-IR,element analyzer,*** results reveal that the pores were successfully bonded with 2-mercaptobenzothiazole groups via hydrophilic spacer arms and the original morphology of ordered macroporous materials were remained after *** MBZ group density is 0.052 mmol/m^*** functionalized 3DOM CLPS are expected to application as heavy metal ions adsorbent.

关键词： Three-dimensionally ordered macroporous polymer Functionalization Hydrophilic space arm Heterocyclic functional group

Effect of a near-zero magnetic field on development and flight of oriental armyworm(Mythimna separata)

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2021年第5期20卷 1336-1345页

作者： AN Meng-meng ZHANG Lei CHENG Yun-xia Thomas W.SAPPINGTON pan wei-dong JIANG Xing-fu State Key Laboratory for Biology of Plant Disease and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193P.R.China Corn Insects and Crop Genetics Research Unit USDA-ARSAmesIA 50011USA Beijing Key Laboratory of Bioelectromagnetics Institute of Electrical EngineeringChinese Academy of SciencesBeijing 100190P.R.China

The geomagnetic field affects all living organisms on the *** this study we investigated the developmental and behavioral effects of rearing Mythimna separata in a near-zero magnetic field(weight,female reproduction,and the relative expression level of the vitellogenin(Vg)gene in newly emerged ***,the near-zero magnetic field had a considerable negative effect on the mating ratio of *** *** addition,the moths in the near-zero magnetic field displayed less flight activity late in the night than those in the Earth's normal geomagnetic field,indicating that the flight rhythm of *** may be affected by the near-zero magnetic *** in magnetic field intensity may have negative effects on the development and flight of oriental armyworm,with consequent additional effects on its migration.

关键词： development flight activity geomagnetic field Mythimna separata near-zero magnetic field

Combined Effects of 50 Hz Magnetic Field and Magnetic Nanoparticles on the Proliferation and Apoptosis of PC12 Cells

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2014年第2期27卷 97-105页

作者： JIA Hong Li WANG Chao LI Yue LU Yan WANG Ping Ping pan wei dong SONG Tao Beijing Key Laboratory of Bioelectromagnetism Institute of Electrical Engineering Chinese Academy of Sciences University of Chinese Academy of Sciences Department of Basic Theory Shandong Sport University

Objective To investigate the bioeffects of extremely low frequency （ELF） magnetic field （MF）（50 Hz, 400 μT） and magnetic nanoparticles （MNPs） via cytotoxicity and apoptosis assays on PC12 cells. Methods MNPs modified by SiO2 （MNP-SiO2） were characterized by transmission electron microscopy （TEM）, dynamic light scattering and hysteresis loop measurement. PC12 cells were administrated with MNP-SiO2 with or without MF exposure for 48 h. Cytotoxicity and apoptosis were evaluated with MTI- assay and annexin V-FITC/PI staining, respectively. The morphology and uptake of MNP-SiO2 were determined by TEM. MF simulation was performed by Ansoft Maxwell based on the finite element method. Results MNP-SiO2 were identified as -20 nm （diameter） ferromagnetic particles. MNP-SiO2 reduced cell viability in a dose-dependent manner. MF also reduced cell viability with increasing concentrations of MNP-SiO2. MNP-SiO2 alone did not cause apoptosis in PC12 cells; instead, the proportion of apoptotic cells increased significantly under MF exposure and increasing doses of MNP-SiO2. MNP-SiO2 could be ingested and then cause a slight change in cell morphology. Conclusion Combined exposure of MF and MNP-SiO2 resulted in remarkable cytotoxicity and increased apoptosis in PC12 cells. The results suggested that MF exposure could strengthen the MF of MNPs, which may enhance the bioeffects of ELF MF.

关键词： Extremely low frequency magnetic field Magnetic nanoparticles Cytotoxicity Apoptosis Morphology

Novel sesquiterpenoids isolated from Chimonanthus praecox and their antibacterial activities

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2018年第8期16卷 621-627页

作者： LOU Hua-Yong ZHANG Yu MA Xiao-pan JIANG Sai WANG Xiang-Pei YI Ping LIANG Guang-Yi WU Hong-Mei FENG Jing JIN Feng-Yun pan wei-dong Guiyang College of Traditional Chinese Medicine Guiyang 550002 China State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Guiyang 550014 China The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences Guiyang 550014 China

In the present study,four new sesquiterpenoids,chimonols A–D(compounds 1–4),together with four known compounds(5–8) were isolated from the Et OAc extract of Chimonanthus praecox *** structures of these new compounds were elucidated on the basis of spectroscopic techniques(UV,IR,MS,and 1 D and 2 D NMR),and their absolute configurations were established by comparing experimental and calculated electronic circular dichroism(ECD) *** 1–8 were evaluated for antimicrobial activities and the minimum inhibitory concentrations(MICs) were determined by the broth microdilution method in 96-well culture *** 1,2,and 7 exhibited weak antibacterial effects for ***(ATCC 6538),***(ATCC 11775),and ***(ATCC 10145) with MIC values being 158–249 μg·mL^(-1).Compounds 3–7 showed activities against ***(ATCC 2001) and ***(ATCC 43300) with MIC values being 128–197 μg·mL^(-1).Compounds 1–4 showed activity against ***(ATCC 25923) with MIC values being 162–254 μg·mL^(-1).The present study provided a basis for future evaluation of these compounds as antibacterial agents.

关键词： Sesquiterpenoids Chimonanthus praecox Electronic circular dichroism Antimicrobial activities

Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年第1期68卷 369-376页

作者： Song-Meng Wang Hao Nian Yan-Fang Wang Li-Shuo Zheng Yu-Tao Zheng Yi-wei dong Liping Huang Xiaoping Wang wei Jiang Liu-pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

关键词： host-guest interaction hydrophobic effect endo-functionalized cavity mutation pyridine

FACILE　AND　SELECTIVE　REDUCTION　OF　NTIROARENES　IN　THE　PRESENCE　OF　NITRILES　WITH　NaBH_4－BiCl_3　SYSTEM

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1995年第7期6卷 553-554页

作者： Ping Da REN, Shi Feng pan, Ting wei dong, Shi Hui WU (Department of Chemistry, Fudan University, Shanghai 200433)

Nitrarenes were selectively reduced to primary amines by treatment with sodium horolydride bismuth chloride in the presence of nitriles. The selectivity was always excellent.

关键词：

Reconstruction of heat flux profile on the HL-2A divertor plate with a three-dimensional analysis model

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2013年第1期22卷 389-393页

作者：高金明李伟夏志伟潘宇东卢杰易萍刘仪 Southwestern Institute of Physics

A three-dimensional analysis model based on the finite element method （FEM） is developed, which can derive the evolution and distribution characteristics of heat flux deposited on the divertor plate from the surface temperature measured by infrared thermography diagnostics. The numerical simulations of surface heating due to localized power bursts and the power deposition calculations demonstrate that this analysis can provide accurate results and useful information about localized hot spots compared with the normal one- and two-dimensional calculations. In this paper, the details of this three- dimensional analysis are presented, and some results in ohmic heating and electron cyclotron resonant heating （ECRH） discharge on HL-2A are given.

关键词： three-dimensional analysis heat flux divertor plate

Enantioselective reductive conjugate alkenylation of α,β-enones with keto alkenyl acetates by nickel catalysis

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年第1期68卷 157-162页

作者： Rong-De He Yun-Lei Luo Qiu-Quan pan Qi-wei Yao Xing-Zhong Shu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University

Reactions involving alkenyl acetates offer cost-effective and environmentally friendly routes for alkene synthesis, yet their asymmetric variant remains elusive. Concurrently, asymmetric conjugate alkenylation predominantly centered on nucleophilic addition using alkenyl–M. This manuscript presents an asymmetric reductive conjugate alkenylation reaction involving alkenyl acetates. The method facilitates the enantioselective addition of keto alkenyl groups to α,β-enones, resulting in the formation of unsaturated diketones—a class of useful structural motifs that are challenging to access otherwise. The use of electron-rich Pyroxy ligand is essential for achieving both high reaction efficiency and enantioselectivity.

关键词： nickel alkenylation asymmetric cross-coupling alkenes