检索结果-南通市图书馆

水电站机电技术 2007年第4期30卷 62-65页

作者：匡全忠郭光海潘佐华宁波市白溪水库管理局浙江宁海315606

根据系统要求,白溪水电站结合自身情况对机组相关参数作适当修改后成功地进行了机组进相运行试验。文章分析了机组进相运行可能出现的状况,总结了白溪水电站机组在进相运行试验过程中的成果和经验,对试验数据进行了分析。

关键词：水电站机组进相运行试验成果和经验理论和实践依据

circT P63-N suppresses the proliferation and metastasis of nasopharyngeal carcinoma via engaging with HSP90AB1 to modulate the YAP1/Hippo signaling pathway

在线全文

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年

作者： Dan Wang Sicheng zuo Junshang Ge Hongke Qu Jie Wu Na Yi Lei Shi Yumin Wang Yongzhen Mo Chunmei Fan Yi He pan Chen Ming Zhou Bo Xiang Wei Xiong Wenjia Guo Zhaoyang Zeng Can Guo NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Cancer Research Institute and School of Basic Medicine Sciences Central South University Furong Laboratory Cancer Research Institute Affiliated Cancer Hospital of Xinjiang Medical University Xinjiang Key Laboratory of Translational Biomedical Engineering

Circular RNAs(circRNAs) play pivotal roles in the development and progression of various diseases, including malignant tumors. However,the biological functions and the underlying mechanisms of many circRNAs remain elusive. In this study, we identified a novel circRNA,circTP63-N, generated through the splicing of exons 2–4 of the TP63 gene in nasopharyngeal carcinoma(NPC). circTP63-N was found to be downregulated in clinical samples of NPC. Both in vitro and in vivo experiments unequivocally demonstrated that circTP63-N inhibits the proliferation and metastasis of NPC cells. Further investigations revealed that circTP63-N interacted with the HSP90AB1 protein, leading to the recruitment of LATS/YAP1 proteins. This, in turn, induced phosphorylation and ubiquitination-dependent degradation of YAP1, resulting in reduced nuclear translocation of YAP1 and inhibition of the transcriptional activation of downstream oncogenic genes, including INHBA, MMP3, and CCNE2. Our findings highlight the identification of circTP63-N, a novel circRNA encoded by an important tumor-relevant gene TP63 and elucidate its molecular mechanism as a tumor suppressor in NPC. These insights offer novel potential molecular markers and therapeutic targets for the clinical diagnosis and treatment of NPC.

关键词：

含烯烃配体的过渡金属卡宾配合物的研究 Ⅱ.异戊二烯二羰基[乙氧基(芳基)卡宾]铁配合物的异构化产物的合成、波谱和结构研究及四羰基[乙氧基(五氯苯基)卡宾]铁的晶体结构

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

化学学报 1987年第7期45卷 636-644页

作者：王天兰陈家碧徐维铧章士伟潘佐华唐有祺中国科学院上海有机化学研究所北京大学物理化学研究所北京大学物理化学研究所上海

异戊二烯三羰基铁（1）与芳基锂ArLi（Ar=C6H5,p-CH3C6H4,p-CH3OC6H4,p-CF3C6H4）在低温下反应,再用Et3OBF4烷基化,可获得组成为C5H8（CO）2FeC（OC2H5）Ar的标题化合物的异构化产物（2—5）.当用LiC6Cl5作亲核试剂,在相同条件下与1反应... 详细信息

异戊二烯三羰基铁（1）与芳基锂ArLi（Ar=C6H5,p-CH3C6H4,p-CH3OC6H4,p-CF3C6H4）在低温下反应,再用Et3OBF4烷基化,可获得组成为C5H8（CO）2FeC（OC2H5）Ar的标题化合物的异构化产物（2—5）.当用LiC6Cl5作亲核试剂,在相同条件下与1反应时,只生成已知的配合物（CO）4FeC（OC2H5）C6cl5（6）.由单晶X射线衍射数据推断出,2和6的分子结构都属于单斜晶系,Z=4.2的空间群为C2h5-P2（1/n）,α=8.544（2）,b=14.494（5）,c=12.309（4）A,β=96.16（2）°;6的空间群为C2h5-P21/c,a=14.126（3）,b=6.805（1）,c=19.182（5）A,β=103.58（2）°.2和6的结构用SHELXTL直接法程序解出并经块矩阵最小二乘法修正,R分别为0.066和0.043.

关键词：配合物异构化配体芳基取代基卡宾羰基碳酰基赤道平面异戊二烯甲基丁二烯二烯烃烯烃脂肪族不饱和烃键角化学键三角双锥乙氧基烷氧基产物氯苯基

Extreme storm surge induced coastal inundation in Yangtze Estuary regions

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2019年第6期31卷 1127-1138页

作者： Zhen-hua pan hua Liu Key Laboratory of Hydrodynamics(Ministry of Education) School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China DHI China Shanghai 200235China

Coastal inundation induced by the storm surge belongs to one of the major natural hazards in Shanghai and other regions around the Yangtze *** worst scenarios of coupling the extreme storm and the sea level rise are presented to assess the storm surge hazard in the Yangtze *** numerical model MIKE 21 FM is adopted to implement the numerical study,which includes wind,current,tide and *** storm surge induced by typhoon 9711 is simulated,and the measurements of six tide gauges are used to validate the numerical *** identify the worst case scenario of severe typhoon(9711)and super typhoon(5612),we propose seven typhoon tracks through the Yangtze Estuary and fourteen scenarios of landfall time for each typhoon track,which generates 196 ***,based on the worst case scenario and the relative sea level rise in the range of 0 m to 0.7 m,the coastal inundation maps of Pudong New District and Changxing Island are provided and discussed.

关键词： Storm surge inundation Yangtze Estuary sea level rise numerical simulation

Mechanism of magnetic field-modulated luminescence from lanthanide ions in inorganic crystal:a review

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2020年第10期39卷 1113-1126页

作者： Shan-Ling zuo Ping Chen Cao-Feng pan Guangxi Key Laboratory for Relativistic Astrophysics Center On Nanoenergy ResearchSchool of Physical Science and TechnologyGuangxi UniversityNanning 530004China Beijing Institute of Nanoenergy and Nanosystems National Center for Nanoscience and TechnologyChinese Academy of SciencesBeijing 100083China

The luminescence from lanthanide ions has potential applications in light emitting diodes,biomedical,solar cells,sensors,display,***,the luminescence is suffered from the various problems,such as low luminescence efficiency and inharmonious wavelength for energy *** field is an efficient method to modulate the wavelength and intensity of luminescence from lanthanide *** field redistributes the populated electrons in the excited states to tune the wavelength of lanthanide ions by Zeeman effect,mixing effect,and quantum confinement *** field enhances or suppresses the luminescence intensity by the administration of cross-relaxation,energy transfer,and Boltzmann *** this review,we first introduce the various phenomena and mechanisms of magnetic field modulated downshift luminescence from lanthanide ions,including Zeeman effect,cross-relaxation,crystal structure,absorption,quantum confinement effect,and magneticoptical ***,we explain the regulation of upconversion luminescence by magnetic field,containing energy transfer and mixing ***,different options regarding how to understand the mechanism of magnetic field-modulated luminescence from lanthanide ions in the future are outlined.

关键词： Magnetic field Lanthanide ions Luminescence Microscopic mechanism

Drugging the undruggable molecules by a DNA nanorobot

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2018年第7期61卷 763-764页

作者： hua zuo Chengde Mao Key Laboratory of Luminescence and Real-Time Analytical Chemistry Ministry of Education College of Pharmaceutical Sciences Southwest University Department of Chemistry Purdue University

Using synthetic nanorobots to efficiently and safely execute therapeutic functions in human bodies is a long-standing *** the recent issue of Nature Biotechnology,a paper describes the latest development in such an attempt to implement an autonomous DNA robot in cancer therapy[1].Upon being injected into animals,the DNA nanorobots can find and destroy life-threatening tumors.

关键词： DNA 分子癌症治疗治疗学机器人生物动物肿瘤

Design and Mechanical Performance Analysis of a New Wheel Propeller

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Mechanical Engineering 2011年第5期24卷 805-812页

作者： GAO Fudong pan Cunyun XU Haijun zuo Xiaobo College oJ＇Mechatronic Engineering and Automation National University of Defense Technology Changsha 410073 China

Nowadays,how to enhance the maneuverability of autonomous underwater vehicles（AUVs） is an important issue in the domain of international navigation in that most AUVs just have a single function of underwater navigation or submarine movement,while the design of thrusters is the key of solving the *** multi-moving state autonomous underwater vehicle in this paper can achieve four functions,such as wheels,legs,thrust,and course control depend on the characteristics of spatial deflexion and continual circumgyratetion of the flexible transmission shaft.A new wheel propeller for the multi-moving state autonomous underwater vehicle is presented through analyzing the mechanical characteristics of the ducted propeller and the contracted and loaded tip（CLT） *** the computational fluid dynamics（CFD） method is used to simulate numerically different propellers open-water performance by using the Reynolds-averaged Navier-Stokes（RANS） equations and Reynolds stress model（RSM） based on sub-domains hybrid *** predicted thrust coefficients,torque coefficients and pressure of the propellers agree well with the experimental data of their open-water *** good consistency shows that the numerical method has good accuracy in the prediction of propeller open-water performance,which guides to design the wheel ***,for the sake of ensuring the security and stability of the AUV when it is moving on the ground,finite element method is used to simulate numerically the intensity and vibration *** proposed final wheel propeller D4-70（WPD4-70） has preferable open-water performance and intensity characteristics,which can realize the agile maneuverability of the multi-moving state autonomous underwater vehicle.

关键词： wheel propeller numerical calculation computational fluid dynamics finite element method

Uniform and Semi-uniform Convergence for Discontinuous Skew-product Transformation and Observation

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2021年第2期37卷 333-344页

作者： Xia pan zuo huan ZHENG Zhe ZHOU College of Liberal Arts and Sciences National University of Defense TechnologyChangsha 410073P.R.China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190P.R.China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049P.R.China ollege of Mathematics and Statistics Hainan Normal UniversityHaikou 571158P.R.China

In this paper, for a discontinuous skew-product transformation with the integrable observation function, we obtain uniform ergodic theorem and semi-uniform ergodic theorem. The main assumptions are that discontinuity sets of transformation and observation function are ignorable in some measure-theoretical sense. The theorems extend the classical results which have been established for continuous transformations and continuous observation functions.

关键词： Skew-product transformation uniform ergodicity semi-uniform ergodicity

A DNA Nanodevice for Cancer Vaccination

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2020年第6期36卷 1147-1148页

作者： zuo hua MAO Chengde College of Pharmaceutical Sciences Southwest UniversityChongqing 400716P.R.China Department of Chemistry Purdue UniversityWest LafayetteIndiana 47907United States

To realize effective cancer immunotherapy,Ding et *** a structurally well-defined DNA-based nanodevice to quantitatively assemble cancer cell-specific antigen and multiple adjuvants as a cancer *** nanodevice vaccine can efficiently accumulate in the draining lymph nodes and respond to the endosomal acidic environment of dendritic cells to release the antigen and *** active payloads stimulate dendritic cells maturation and antigen presentation to elicit a robust,antigen-specific cytotoxic T-lymphocyte response to kill cancer *** work has been published online in the Nature Materials on Sept.7,2020.

关键词： vaccine al. cancer

Rehabilitation and improvement of Guilin urbanwater environment: Function-oriented management

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2013年第7期25卷 1477-1482页

作者： Yuansheng Pei hua zuo Zhaokun Luan Sijia Gao The Key Laboratory of Water and Sediment Sciences Ministry of Education School of Environment Beijing Normal University Qindao Environmental Protection Bureau No.41 Yan'anyilu Research Center for Eco-Environmental Sciences Chinese Academy of Sciences

Economicdevelopment and population growth havedeeplydamaged the urbanwater environment of Guilin City, China. Main problems involved structuraldamage and functionaldeterioration of the urbanwaters. An integrated technical schemewasdeveloped to rehabilitate the urbanwater environment and to enhance thewaters＇ functionsduring 1998-2008. Improvement ofwaters＇ functions includedwater system reconstruction,water pollution control,water safety assurance, and aquatic ecological restoration. Thewater systemwas reconstructed to connectdifferentwaters and cleanwater supplies to the lakes. Moreover,water pollutionwas controlled to improvewater quality by endogenous pollutant elimination and extraneous pollutant interception. In addition, ecological measures put in place serve to enhancewater system functions and better benefit both nature and humans. The project has brought about sound ecological, economic and social benefits in Guilin City,which can potentially be extended to similar cities.

关键词： urbanwater environment ecological engineering hydrology connectivity landscape reconstruction vegetation buffer strips water conservancy