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Current Medical Science 2024年第1期44卷 1-27页

作者： qi pan Cheng CHEN Yue-jin YANG State Key Laboratory of Cardiovascular Disease Department of CardiologyFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100037China

Atherosclerosis(AS)is characterized by impairment and apoptosis of endothelial cells,continuous systemic and focal inflammation and dysfunction of vascular smooth muscle cells,which is documented as the traditional cellular paradigm.However,the mechanisms appear much more complicated than we thought since a bulk of studies on efferocytosis,transdifferentiation and novel cell death forms such as ferroptosis,pyroptosis,and extracellular trap were reported.Discovery of novel pathological cellular landscapes provides a large number of therapeutic targets.On the other side,the unsatisfactory therapeutic effects of current treatment with lipid-lowering drugs as the cornerstone also restricts the efforts to reduce global AS burden.Stem cell-or nanoparticle-based strategies spurred a lot of attention due to the attractive therapeutic effects and minimized adverse effects.Given the complexity of pathological changes of AS,attempts to develop an almighty medicine based on single mechanisms could be theoretically challenging.In this review,the top stories in the cellular landscapes during the initiation and progression of AS and the therapies were summarized in an integrated perspective to facilitate efforts to develop a multi-targets strategy and fill the gap between mechanism research and clinical translation.The future challenges and improvements were also discussed.

关键词： atherosclerosis transdifferentiation extracellular traps efferocytosis stem cell nanoparticles

Mechanisms of liver injuries caused by traditional Chinese medicines

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Hepatobiliary & pancreatic Diseases International 2024年第3期23卷 310-312页

作者： Shui-Fang Jin qi pan Jin-Peng Zhou Xiao-Ping pan Intensive Care Unit The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou 310006China Institute of Liver Diseases College of Basic Medical SciencesZhejiang Chinese Medical UniversityHangzhou 310053China The Second Clinical Medical College of Zhejiang Chinese Medical University Hangzhou 310056China

Drug-induced liver injury(DILI)is a common adverse drug reaction,which can even result in liver failure[1,2].The Chinese Medical Association issued the Guidelines for the Diagnosis and Treatment of DILI based on the Roussel Uclaf Causality Assessment Method(RUCAM)in 2015[3].A previous study reported that traditional Chinese medicines(TCMs),herbal and dietary supplements,and antituberculosis drugs were the main causes of DILI in China[4].Herb-induced liver injury(HILI)refers to liver injury caused by TCMs,natural drugs,and their related preparations[5].

关键词： drugs tuberculosis TCM

A UWB/IMU-Assisted Fingerprinting Localization Framework with Low Human Efforts

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China Communications 2024年第6期21卷 40-52页

作者： pan Hao Chen Yu qi Xiaogang Liu Meili School of Mathematics and Statistics Xidian UniversityXi’an 710126China Science and Technology on Near-Surface Detection Laboratory Wuxi 214035China School of Software Nanchang Hangkong UniversityNanchang 330063China

With the rapid development of smart phone,the location-based services(LBS)have received great attention in the past decades.Owing to the widespread use of WiFi and Bluetooth devices,Received Signal Strength Indication(RSSI)fingerprintbased localization method has obtained much development in both academia and industries.In this work,we introduce an efficient way to reduce the labor-intensive site survey process,which uses an UWB/IMU-assisted fingerprint construction(UAFC)and localization framework based on the principle of Automatic radio map generation scheme(ARMGS)is proposed to replace the traditional manual measurement.To be specific,UWB devices are employed to estimate the coordinates when the collector is moved in a reference point(RP).An anchor self-localization method is investigated to further reduce manual measurement work in a wide and complex environment,which is also a grueling,time-consuming process that is lead to artificial errors.Moreover,the measurements of IMU are incorporated into the UWB localization algorithm and improve the label accuracy in fingerprint.In addition,the weighted k-nearest neighbor(WKNN)algorithm is applied to online localization phase.Finally,filed experiments are carried out and the results confirm the effectiveness of the proposed approach.

关键词： indoor localization machine learning ultra wideband WiFi fingerprint

Scenario Modeling-Aided AP Placement Optimization Method for Indoor Localization and Network Access

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China Communications 2024年第3期21卷 37-50页

Owing to the ubiquity of wireless networks and the popularity of WiFi infrastructures,received signal strength(RSS)-based indoor localization systems have received much attention.The placement of access points(APs)significantly influences localization accuracy and network access.However,the indoor scenario and network access are not fully considered in previous AP placement optimization methods.This study proposes a practical scenario modelingaided AP placement optimization method for improving localization accuracy and network access.In order to reduce the gap between simulation-based and field measurement-based AP placement optimization methods,we introduce an indoor scenario modeling and Gaussian process-based RSS prediction method.After that,the localization and network access metrics are implemented in the multiple objective particle swarm optimization(MOPSO)solution,Pareto front criterion and virtual repulsion force are applied to determine the optimal AP placement.Finally,field experiments demonstrate the effectiveness of the proposed indoor scenario modeling method and RSS prediction model.A thorough comparison confirms the localization and network access improvement attributed to the proposed anchor placement method.

关键词： indoor localization MOPSO network access RSS prediction

State-sensitive convolutional sparse coding for potential biomarker identification in brain signals

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Science China(Information Sciences) 2024年第5期67卷 270-286页

作者： Puli WANG Yu qi Gang pan College of Computer Science and Technology Zhejiang University State Key Laboratory of Brain-Machine Intelligence Zhejiang University MOE Frontier Science Center for Brain Science and Brain-machine Integration Zhejiang University Affiliated Mental Health Center & Hangzhou Seventh People's Hospital Zhejiang University School of Medicine

The identification of prototypical waveforms, such as sleep spindles and epileptic spikes, is crucial for the diagnosis of neurological disorders. These prototypical waveforms are usually recurrently presented in certain brain states, serving as potential biomarkers for clinical evaluations. Convolutional sparse coding(CSC) approaches have demonstrated strength in identifying recurrent patterns in time-series. However,existing CSC approaches do not explicitly explore state-specific patterns, making it difficult to identify state-related biomarkers. To address this problem, we propose state-sensitive CSC to learn state-specific prototypical waveforms. Specifically, we model signals of a certain state with specific waveforms that only appear frequently in this state and background waveforms that are independent of states. Based on this,state-sensitive CSC separates state-specific waveforms from background ones explicitly by incorporating incoherence constraints into optimizations. Experiments with epilepsy brain signals demonstrate that our approach can effectively identify prototypical waveforms in pre-ictal states, providing potential biomarkers for seizure prediction. Our approach provides a promising tool for automatic biomarker candidate identification.

关键词： convolutional sparse coding prototypical waveforms state-specific dictionary biomarker identification neural signal processing

The acceptance of traditional Chinese medicine among patients with Parkinson's disease:A hospital survey

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Journal of Integrative Medicine 2024年第2期22卷 180-187页

作者： Peng Wang Jing Hong Zhu-qian Tang Bi-zhen Gong Xiao-rong qi Han Jiang Bo pan qi Chen Postgraduate School Medical School of Chinese People’s Liberation ArmyBeijing 100853China Senior Department of Traditional Chinese Medicine the Sixth Medical Center of PLA General HospitalBeijing 100853China Department of Integration of Chinese and Western Medicine School of Basic Medical SciencesPeking UniversityBeijing 100191China Department of Integrative Oncology the First Affiliated Hospital of Naval Medical UniversityShanghai 200433China School of Traditional Chinese Medicine Naval Medical UniversityShanghai 200433China School of Pharmacy Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Department of Dermatology the First Clinical Medical CollegeAnhui University of Chinese MedicineHefei 230012Anhui ProvinceChina

Objective:The efficacy of medications for Parkinson’s disease(PD)tend to decline over time,which has a serious impact on patients’health and quality of life.To some extent,traditional Chinese medicine(TCM)can resolve the distressing problem of ineffective dopaminergic medication in PD patients.The purpose of this study was to investigate the attitude,acceptance,and independent predictors of TCM in PD patients admitted to the outpatient department of a tertiary hospital.Methods:A cross-sectional study of PD patients was conducted in the outpatient department of a large tertiary hospital in Beijing from March 2022 to June 2023.A self-report questionnaire was developed to investigate PD patients’attitudes and acceptance of TCM based on the questionnaire.Multivariate logistic regression analyses were also performed to further clarify the independent predictors influencing patients’adoption of TCM therapy.Results:A total of 397 patients completed the questionnaire,of which 78.09%were willing to be treated with TCM and 21.91%indicated that they were not willing to use TCM.Multifactorial logistic regression analysis showed that several parameters were correlated with a patient’s willingness to include TCM in their therapeutic regime.These included education level of a bachelor’s degree(odds ratio[OR)=8.554;95%confidence interval[CI]:4.112–17.794;P<0.001,vs junior high school education),living in an urban setting(OR=8.022;95%CI:4.577–14.060;P<0.001,vs rural),having other underlying diseases(OR=5.126;95%CI:3.078–8.537;P<0.001,vs none),having previously used TCM(OR=3.083;95%CI:1.852–5.134;P<0.001,vs not used),believing that TCM therapy is safe(OR=3.530;95%CI:1.446–8.616;P=0.006,vs not thought),believing that TCM therapy is effective(OR=3.859;95%CI:1.482–10.047;P=0.006,vs not understood),and being willing to discuss ongoing TCM therapy with an attending physician(OR=62.468;95%CI:30.350–128.574;P<0.001,vs not informed).Conclusion:This study initially investigated the acceptance,attitude,and independent predictors of TCM use

关键词： Parkinson's disease Traditional Chinese medicine Cross-sectional study

An ensemble and cost-sensitive learning-based root cause diagnosis scheme for wireless networks with spatially imbalanced user data distribution

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Science China(Information Sciences) 2024年第7期67卷 331-332页

作者： qi WANG Zhiwen pan Nan LIU National Mobile Communications Research Laboratory Southeast University Purple Mountain Laboratories

Root cause diagnosis, a key component of self-healing, plays a vital role in fault management. The spatially imbalanced network key performance indicators (KPIs) reported by users increase the difficulty of identifying root causes.In [1,2], the image inpainting technique is inspired to address issues caused by sparse reports across the coverage area.

关键词： Wireless networks

Nickel-Catalyzed Regio-and Stereoselective Defluorinative Arylation of gem-Difluorinated Cyclopropanes

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Chinese Journal of Chemistry 2024年第8期42卷 823-828页

作者： Shutao qi Yunkai Hua Liangkai pan Junfeng Yang Junliang Zhang Department of Chemistry Fudan University2005 Songhu RoadShanghai200438 China Fudan Zhangjiang Institute Shanghai201203 China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiangHenan 453007China

Comprehensive Summary,Herein,we report nickel-catalyzed cross-coupling of gem-difluorinated cyclopropanes with boronic acids,providing the corresponding arylated 2-fluoroallylic scaffolds.This approach used commercially available phosphine ligand Xantphos to obtain monofluorinated alkenes with high regioselectivity and Z-stereoselectivity.Mechanistic studies proposed a Ni(II)-fluoroallyl pathway and excluded the radical pathway.

关键词： Nickel Monofluoroolefin Cyclopropane Regioselectivity Stereoselectivity C-C coupling Cross-coupling Synthetic methods

Radiation build-up and dissipation in Raman random fiber laser

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Science China(Information Sciences) 2024年第1期67卷 254-260页

作者： Shengtao LIN Zinan WANG Jiaojiao ZHANG pan WANG Han WU Yifei qi Key Laboratory of Optical Fiber Sensing and Communications University of Electronic Science and Technology of China College of Electronics and Information Engineering Sichuan University

Raman random fiber laser(RRFL) is a complex physical system that arises from the distributed Raman amplification and the intrinsic stochasticity of fiber scattering.The analysis of the underlying lightwave kinetics at steady state has been the focus of considerable interest.However,the transient state,such as the RRFL build-up and dissipation,is particularly important for revealing the lightwave interaction process.Here,we investigate for the first time the RRFL dynamics at the transient state and track the RRFL temporal and spectral evolution theoretically and experimentally.Particularly,with the contribution of random distributed feedback,RRFL build-up exhibits continuous Verhulst logistic growth curves without cavity-related features,which is significantly different from the step-like growth curve of conventional fiber lasers.Furthermore,the radiation build-up duration is inversely related to the pump power,and the spectral evolution of the RRFL undergoes two phases,i.e.,from spectral density increase to spectral broadening.From the steady state to the pump switch-off state,the RRFL output power dissipates immediately,and the remaining Stokes lightwave from the Rayleigh scattering will gradually disappear after one round trip.This work provides new insights into the transient dynamic features of the RRFL.

关键词： random fiber laser stimulated Raman scattering transient phenomenon nonlinear optics łinebreak biological growth dynamics

Degradation behaviors of Nabumetone and its metabolite during UV/monochloramine process:Experimental and theoretical study

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Journal of Environmental Sciences 2024年第8期142卷 103-114页

作者： Xiang Tu Yunsong Bai qing Fu Sheng Chang Kunfeng Zhang Yang pan Ruiyang Xiao Yifu Fu qi Zhang State Key Laboratory of Environmental Criteria and Risk Assessment State Environmental Protection Key Laboratory of Drinking Water Source ProtectionResearch Centre of Lake EnvironmentNational Engineering Laboratory for Lake Pollution Control and Ecological RestorationChinese Research Academy of Environmental SciencesBeijing 100012China School of Environmental Science and Engineering Suzhou University of Science and TechnologySuzhou 215009China Institute of Environmental Engineering School of Metallurgy and EnvironmentCentral South UniversityChangsha 410083China School of Forestry Northeast Forestry UniversityHarbin 150040China

This study investigated degradation behaviors of a nonsteroidal anti-inflammatory drug Nabumetone(NMT)and its major metabolite 6-methoxy-2-naphthylacetic acid(MNA)in the coupling process of ultraviolet and monochloramine(UV/NH2Cl).The second-order rate constants of the contaminants reacting with reactive radicals(HO·,Cl·,Cl_(2)·-,and CO_(3)·^(-))were determined by laser flash photolysis experiments.HO·and Cl·contributed predominantly with 52.3%and 21.7%for NMT degradation and 60.8%and 22.3%for MNA degradation.The presence of chlorides retarded the degradation of NMT,while promoted the destruction of MNA,which was ascribed to the photosensitization effects of MNA under UV irradiation.Density functional theory(DFT)calculations revealed that radical adduct formation(RAF)was dominant pathway for both HO·and Cl·reacting with the contaminants,and hydrogen atom transfer(HAT)preferred to occur on side chains of NMT and MNA.NMT reacted with NO_(2)·through single electron transfer(SET)with the second-order rate constant calculated to be 5.35×10^(7)(mol/L)^(-1)sec^(-1),and the contribution of NO_(2)·was predicted to be 13.0%of the total rate constant of NMT in pure water,which indicated that NO_(2)·played a nonnegligible role in the degradation of NMT.The acute toxicity and developmental toxicity of NMT were enhanced after UV/NH_(2)Cl treatment,while those of MNA were alleviated.The transformation products of both NMT and MNA exhibited higher mutagenicity than their parent compounds.This study provides a deep understanding of the mechanism of radical degradation of NMT and MNA in the treatment of UV/NH2Cl.

关键词： UV/NH_(2)Cl Reactive species Degradation kinetics Reaction mechanism Degradation products