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Bullous pemphigoid associated with acquired hemophilia A: A case report

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World Journal of Clinical Cases 2025年第4期13卷 28-33页

作者： Su-Ye Hu Meng-Can Li zi-Jia Hao Xu-Ya Chai Pei-Sai Li Yang Liu Li-Xia Liu Ying Xu pan-pan Yang Ling-E Li Department of Dermatology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina Graduate School Hebei University of Traditional Chinese MedicineShijiazhuang 050051Hebei ProvinceChina Department of Pathology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated with autoimmune diseases,cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid(BP) is a chronic autoimmune subepidermal blistering disease associatedwith tissue-bound and circulating autoantibodies against BP antigens 180 (BP180)and 230 (BP230). AHA-associated BP has a high mortality rate;hence, the understandingof this disease must *** SUMMARY A 69-year-old man presented with erythema, blisters, blood blisters, and crustsaccompanied by severe pruritus for more than 20 days, and ecchymosis andswelling on his left upper arm for 3 days. Pathological examination revealed asubepidermal blister that contained eosinophils. Laboratory tests showed that theBP180 autoantibody levels had increased, isolated activated partial thromboplastintime was notably prolonged (115.6 s), and coagulation FⅧ activity wasextremely low (< 1.0%). Furthermore, the FⅧ inhibitor titer had greatlyincreased (59.2 Bethesda units). Therefore, the patient was diagnosed as having BP associated with AHA, prescribed 0.05% topical halometasone cream, and transferred to a higher-level hospitalfor effective treatment;however, he died after 2 *** AHA associated BP is rare, dangerous, and has a high mortality rate. Therefore, its timely diagnosis and effectivetreatment are necessary.

关键词： Bullous pemphigoid Acquired hemophilia A Acquired hemophilia A FactorⅧ Case report

基于功能化COFs材料的样品前处理技术在新兴污染物中的研究进展

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分析测试学报 2025年第1期44卷 12-24页

作者：潘自宇刘智敏许志刚昆明理工大学理学院云南昆明650500

新兴污染物因具有环境持久性、生物累积性、生物毒性以及在环境中痕量存在等特点而备受全球众多国家关注。因此,对环境、食品以及生物样品中的新兴污染物进行高灵敏检测至关重要。传统样品前处理技术存在耗时长、吸附剂用量大,以及对不... 详细信息

新兴污染物因具有环境持久性、生物累积性、生物毒性以及在环境中痕量存在等特点而备受全球众多国家关注。因此,对环境、食品以及生物样品中的新兴污染物进行高灵敏检测至关重要。传统样品前处理技术存在耗时长、吸附剂用量大,以及对不稳定污染物的分析准确性差等缺点,因此,亟需开发设计具有高选择性、高传质效率的新型材料作为前处理技术的吸附剂,以实现新兴污染物的高选择、高灵敏检测。共价有机骨架材料(COFs),特别是功能化的COFs材料,因具有比表面积大、结构可设计、稳定且构筑基元丰富等诸多优点而被广泛用于新兴污染物的富集。该文主要综述了近年来功能化COFs材料的合成策略及其作为样品前处理吸附剂在环境、食品和生物样品中新兴污染物中的分析应用,并对该类材料的未来发展趋势进行了展望。

关键词：新兴污染物功能化COFs材料样品前处理技术

Image-based 3D model retrieval using manifold learning

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Frontiers of Information Technology & Electronic Engineering 2018年第11期19卷 1397-1408页

作者： pan-pan MU San-yuan ZHANG Yin ZHANG Xiu-zi YE Xiang pan College of Computer Science and Technology Zhejiang University College of Mathematics and Information Science Wenzhou University College of Computer Science and Technology Zhejiang University of Technology

We propose a new framework for image-based three-dimensional(3D) model retrieval. We first model the query image as a Euclidean point. Then we model all projected views of a 3D model as a symmetric positive definite(SPD) matrix, which is a point on a Riemannian manifold. Thus, the image-based 3D model retrieval is reduced to a problem of Euclid-to-Riemann metric learning. To solve this heterogeneous matching problem, we map the Euclidean space and SPD Riemannian manifold to the same high-dimensional Hilbert space, thus shrinking the great gap between them. Finally, we design an optimization algorithm to learn a metric in this Hilbert space using a kernel trick. Any new image descriptors, such as the features from deep learning, can be easily embedded in our framework. Experimental results show the advantages of our approach over the state-of-the-art methods for image-based 3D model retrieval.

关键词： Model retrieval Euclidean space Riemannian manifold Hilbert space Metric learning

Freezing the conductance of platinum(Ⅱ)complexes by quantum interference effect

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Chinese Chemical Letters 2022年第6期33卷 3263-3266页

作者： Sai-Sai Yan Jin-Yun Wang zi-you pan Da-Sheng Zheng Qian-Chong Zhang Zhong-Ning Chen Fujian Normal University Fuzhou 350007China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China

Understanding the impact of substituents on the quantum interference effect at single molecule scale is of great importance for the design of molecular *** this work,three platinum(Ⅱ)complexes with–H,–NH_(2)and–NO_(2)groups on conductive backbones were designed and ***-molecule conductance,which was measured using scanning tunnelling microscope break junction(STM-BJ)technique,demonstrated a conductance freeze phenomenon under the variation of *** study revealed that,despite the electronic effect of the substituents shifting the energy level of molecular orbital,the quantum interference effect vanished the influence of electronic effect on the conductance and eventually leaded to the conductance freeze.

关键词： Platinum(Ⅱ)complex Electronic effect Single-molecule conductance Quantum interference Magic ratio rule

Transformation of hydroxylated and methoxylated 2,2′,4,4′,5-brominated diphenyl ether(BDE-99) in plants

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Journal of Environmental Sciences 2016年第11期28卷 197-202页

作者： Lili pan Jianteng Sun Xiaodan Wu zi Wei Lizhong Zhu Department of Environmental Science Zhejiang University Hangzhou 310058 China. Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control Hangzhou 310058 China Analysis and Measurement Center Zhejiang University Hangzhou 310058 China

The occurrence and fate of hydroxylated polybrominated diphenyl ethers（OH-PBDEs） and methoxylated polybrominated diphenyl ethers（Me O-PBDEs） have received significant attention. However, there is limited information on the metabolism relationship between OH-pentaB DEs and MeO-pentaB DEs that were frequently detected with relatively high concentrations in the environment. In this study, the biotransformation between OH-BDE-99 and MeO-BDE-99 was investigated in rice, wheat, and soybean plants. All the three plants can metabolize OH-BDE-99 to corresponding homologous methoxylated metabolites, while the transformation from MeO-BDE-99 to OH-BDE-99 could only be found in soybean. The conversion of parent compounds was the highest in soybean, followed by wheat and rice. Transformation products were found mainly in the roots, with few metabolites being translocated to the shoots and solution after exposure. The results of this study provide valuable information for a better understanding of the accumulation and transformation of OH-PBDEs and MeO-PBDEs in different plants.

关键词： OH-PBDEs MeO-PBDEs Biotransformation Plant

A sport and a pastime:Model design and computation in quantum many-body systems

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Chinese Physics B 2022年第12期31卷 435-458页

作者： Gaopei pan Weilun Jiang zi Yang Meng Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Physics and HKU-UCAS Joint Institute of Theoretical and Computational Physics The University of Hong KongPokfulam RoadHong Kong SARChina

We summarize the recent developments in the model design and computation for a few representative quantum manybody systems,encompassing quantum critical metals beyond the Hertz-Millis-Moriya framework with pseudogap and superconductivity,SYK non-Fermi-liquid with self-tuned quantum criticality and fluctuation induced superconductivity,and the flat-band quantum Moirélattice models in continuum where the interplay of quantum geometry of flat-band wave function and the long-range Coulomb interactions gives rise to novel insulating phases at integer fillings and superconductivity away from *** the narrative choreography seems simple,we show how important the appropriate model design and their tailor-made algorithmic developments-in other words,the scientific imagination inspired by the corresponding fast experimental developments in the aforementioned systems-compel us to invent and discover new knowledge and insights in the sport and pastime of quantum many-body research.

关键词： quantum Monte Carlo non-Fermi-liquid quantum phase transition twisted bilayer graphene

物理方法干预骨髓间充质干细胞分化最理想的参数

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中国组织工程研究 2025年第31期29卷 6727-6732页

作者：刘洵欧阳厚淦潘荣斌王姿杨芬田佳玄江西中医药大学江西省南昌市330004

背景:近年来研究发现物理干预手段对骨髓间充质干细胞的增殖、分化和迁移具有显著影响。但目前物理干预尚存在诸如基础研究数据有待加强、统一的参数标准尚需进一步完善等不足。目的:综述物理手段对骨髓间充质干细胞分化的影响。方法:... 详细信息

背景:近年来研究发现物理干预手段对骨髓间充质干细胞的增殖、分化和迁移具有显著影响。但目前物理干预尚存在诸如基础研究数据有待加强、统一的参数标准尚需进一步完善等不足。目的:综述物理手段对骨髓间充质干细胞分化的影响。方法:检索中国知网和PubMed数据库,以“骨髓间充质干细胞,骨髓基质细胞,成骨分化,成软骨分化,电刺激,机械刺激,低氧,脉冲电磁场,低强度脉冲超声”为中文检索词,以“bone marrow mesenchymal stem cells(BMSC),bone marrow stromal cells,osteogenesis differentiation,chondrocytes differentiation,electrical stimulation,mechanical stimulation,hypoxia,electromagnetic fields,low intensity pulsed ultrasound”为英文检索词,选取58篇文献进行综述。结果与结论:①物理手段通过改变特定的微环境调控骨髓间充质干细胞的增殖、分化等,但参数尚未统一,今后应进一步优化并探讨相关物理因素调控骨髓间充质干细胞增殖及分化的最佳参数和作用条件;②某些特殊物理环境条件难以通过低成本的常规手段开展应用,有待后续研究发展进一步降低特殊物理条件的构建难度;③物理手段干预骨髓间充质细胞增殖与分化目前尚未广泛应用于临床,未来需要进一步研究并促进临床转化。

关键词：骨髓间充质干细胞成骨分化成软骨分化物理因素机械转导干细胞组织工程

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Room-temperature and high-temperature magnetic permeability of Co-doped nanocrystalline alloys

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Rare Metals 2018年第5期37卷 427-432页

作者： Bin Fu Jie Han Sheng-Qi Guo Zhi Wang pan Zhang zi-Jiao pan Qiang Xu Tianjin Key Laboratory for Photoelectric Materials and Devices School of Materials Science and Engineering Tianjin University of Technology College of Science Tianjin University of Technology School of Science Tianjin University School of Materials Science and Engineering Tianjin University of Technology

Influence of composition and annealing temperature on structure and magnetic properties of amorphous and nanocrystalline Fe78.4-xCoxSi9B9Nb2.6Cu1 （x=27.4, 40.0, 51.0, 78.4） alloys was investigated by X-ray diffraction （XRD） and the temperature dependence of permeability. According to the initial crystallization temperature （Tx1） from differential scanning calorimetry （DSC） curves of as-quenched amorphous alloys, 490-700 ℃ isothermal annealing was carded out to obtain the characteristic nanocrystalline structure. Furthermore, the soft magnetic properties were measured by temperature evolution of magnetic permeability to obtain the correlation between Co content, annealing temperature and magnetic permeability. The results show that, on the one hand, the annealing temperature exerts a significant effect on phase structure and initial permeability （μi）. The higher-temperature （from 550 to 610 ℃） annealed Co content nanocrystalline samples can remain higher μi at elevated temperature. On the other hand, partial substitution Fe by Co can improve the high-temperature magnetic stability;however, the room-temperature permeability of higher Co content alloys decreases obviously at the same time. This phenomenon was analyzed from the viewpoint of the saturation magnetic induction （Bs）, magnetic anisotropy （〈K〉） and magnetostriction （λs）.

关键词： Nanocrystalline alloys High-temperature soft magnetic properties Initial permeability FeCo-based alloy

Enhanced Electromagnetic Interference Shielding of Mg–Zn–Zr Alloy by Ce Addition

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Acta Metallurgica Sinica(English Letters) 2015年第4期28卷 492-498页

作者： Xian-Hua Chen Li-zi Liu Juan Liu Fu-Sheng pan College of Materials Science and Engineering Chongqing University National Engineering Research Center for Magnesium Alloys Chongqing University Chongqing Academy of Science and Technology

The effects of Ce addition on microstructure and electromagnetic interference （EMI） shielding response of Mg- 6Zn-0.5Zr （ZK60） alloy have been investigated. Ce addition resulted in grain refinement and higher density of Mg-Zn-Ce and MgZn2 intermetallic particles in the alloy. In particular, this was substantially remarkable as the addition of Ce was up to 1.0 wt%. It is interesting to note that as-extruded ZK60 alloy with 1.0 wt% Ce addition exhibited an EMI shielding effectiveness （SE） exceeding 70 dB at the frequency range of 30-1,500 MHz, which was significantly higher than that of ZK60 alloy without Ce addition and reached the requirement of high protection. The superior SE was probably related to the increased reflection and multiple reflection of electromagnetic radiation induced by Ce addition. Direct artificial aging at 150 ℃ for 25 or 50 h led to a further increase of 7-10 dB in the SE of the alloy with 1.0 wt% Ce addition. The advantages of excellent shielding capacity and favorable mechanical strength make the Mg-Zn-Zr-Ce alloy an attractive shielding candidate material for a variety of technological applications.

关键词： Magnesium alloys Ce Shielding effectiveness Electromagnetic interference Intermetallicparticles