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Study on ground temperature change and characteristic response of engineering geology of permafrost along Qinghai-Tibet Railway

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science china(Technological sciences) 2003年第z1期46卷 78-90页

作者： pan weidong, wang quancai, yu shaoshui & zhang xiaoyan department of mechanics, school of physical science and technology, lanzhou university, lanzhou 730000, china Institute of Mountain Hazards and Environment, Chinese Academy of sciences and Ministry of Water Resources, Chengdu 610041, china State Key Laboratory of Frozen Soil Engineering, Cold and Arid Regions Environment and Engineering Research Institute, Chinese Academy of sciences, lanzhou 730000, china Sichuan Provincial Communications department, Chengdu 610041, china lanzhou Univ Dept Mech Sch Phys Sci & Technol Lanzhou 730000 Peoples R China Chinese Acad Sci Inst Mt Hazards & Environm Chengdu 610041 Peoples R China Minist Water Resources Chengdu 610041 Peoples R China Chinese Acad Sci State Key Lab Frozen Soil Engn Cold & Arid Reg Environm & Engn Res Inst Lanzhou 730000 Peoples R China Sichuan Prov Commun Dept Chengdu 610041 Peoples R China

Along with the global warming in the recent scores of years, comparatively big changes have taken place in the weather and other environmental conditions of the permafrost area in the Qinghai-Tibet Plateau, and very big changes have also occurred in the engineering geological conditions of the permafrost area. Based on a large volume of field survey data, this paper discusses the regularities of horizontal and vertical distribution of permafrost, with its focus of analysis on the temperature change characteristics of the soil in different frozen-soil zones, as well as presents simulation analysis and research for the engineering geologic characteristic response changes that would occur in the future when the temperature of the frozen soil in different zones rises by 1 and 2.6℃ respectively, which will have a tremendous impact on the stability of constructional work.

关键词： Qinghai-Tibet Railway, permafrost, ground temperature, engineering geological characteristic.

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Remodeling the tumor microenvironment by vascular normalization and GSH-depletion for augmenting tumor immunotherapy

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Chinese Chemical Letters 2024年第2期35卷 329-334页

作者： Jin wang Qingqing zhang Yanchen Li xiaoyan pan yuanyuan Shan Jie zhang school of Pharmacy Health Science CenterXi'an Jiaotong UniversityXi'an 710061China department of Pharmacy The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061China

Remodeling tumor microenvironment(TME)is a very promising and effective strategy to enhance the effects of chemotherapy,photodynamic therapy,and *** of tumor vasculature as well as depletion of glutathione(GSH)can improve the ***,we developed a novel therapeutic nanoparticle functional enzyme ultra QDAU5 nanoparticles(FEUQ Nps)based on a fluorescence-on and releasable strategy by combining a vascular normalization inducer,a GSH depleting agent,and an activated *** which the cleavage of disulfide bonds releases active molecules that induce vascular normalization and improve the hypoxic *** addition,it may deplete GSH in cancer cells,thus inducing the production of reactive oxygen species(ROS)and lipid peroxide(LPO)and promoting iron *** may also lead to endoplasmic stress and release of calmodulin,which activates the immune ***,quenched fluorophores are turned on in the presence of galactosidase(GLU)for tumor-specific *** summary,we developed novel therapeutic agent nanoparticles with the function of vascular normalization inducers to achieve specific labeling of hepatocellular carcinoma while exerting efficient antitumor effects in vivo.

关键词： Vascular normalization Tumor microenvironment GSH depletion Ferroptosis Activated immune

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Atherosis-associated lnc_000048 activates PKR to enhance STAT1-mediated polarization of THP-1 macrophages to M1 phenotype

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Neural Regeneration Research 2024年第11期19卷 2488-2498页

作者： yuanyuan Ding yu Sun Hongyan wang Hongqin Zhao Ruihua Yin Meng zhang Xudong pan xiaoyan Zhu department of Neurology The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina Qingdao Cadre Health Care Service Center The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina department of Critical Care Medicine The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina

Our previous study has demonstrated that lnc_000048 is upregulated in large-artery atherosclerotic stroke and promotes atherosclerosis in ApoE^(-/-)***,little is known about the role of lnc_000048 in classically activated macrophage(M1)*** this study,we established THP-1-derived testing state macrophages(M0),M1 macrophages,and alternately activated macrophages(M2).Real-time fluorescence quantitative PCR was used to verify the expression of marker genes and the expression of lnc_000048 in *** cytometry was used to detect phenotypic proteins(CD11b,CD38,CD80).We generated cell lines with lentivirus-mediated upregulation or downregulation of lnc_*** cytometry,western blot,and real-time fluorescence quantitative PCR results showed that down-regulation of lnc_000048 reduced M1 macrophage polarization and the inflammation response,while over-expression of lnc_000048 led to the opposite *** blot results indicated that lnc_000048 enhanced the activation of the STAT1 pathway and mediated the M1 macrophage ***,catRAPID prediction,RNA-pull down,and mass spectrometry were used to identify and screen the protein kinase RNA-activated(PKR),then catRAPID and RPIseq were used to predict the binding ability of lnc_000048 to ***(IF)-RNA fluorescence in situ hybridization(FISH)double labeling was performed to verify the subcellular colocalization of lnc_000048 and PKR in the cytoplasm of M1 *** speculate that lnc_000048 may form stem-loop structure-specific binding and activate PKR by inducing its phosphorylation,leading to activation of STAT1 phosphorylation and thereby enhancing STAT1 pathway-mediated polarization of THP-1 macrophages to M1 and inflammatory factor *** together,these results reveal that the lnc_000048/PKR/STAT1 axis plays a crucial role in the polarization of M1 macrophages and may be a novel therapeutic target for atherosclerosis alleviation in stroke.

关键词： atherosclerosis inflammation lnc_000048 lncRNA macrophage polarization protein kinase RNA-activated(PKR) STAT1

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Research and design of matrix operation accelerator based on reconfigurable array

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High technology Letters 2024年第2期30卷 128-137页

作者：邓军勇 zhang pan JIANG Lin XIE xiaoyan DENG Jingwen school of Electronic Engineering Xi’an University of Posts and TelecommunicationsXi’an 710121P.R.China school of Computer science and technology Xi’an University of Science and TechnologyXi’an 710054P.R.China school of Computer Xi’an University of Posts and TelecommunicationsXi’an 710121P.R.China

In the case of massive data,matrix operations are very computationally intensive,and the memory limitation in standalone mode leads to the system *** the same time,it is difficult for matrix operations to achieve flexible switching between different requirements when implemented in *** address this problem,this paper proposes a matrix operation accelerator based on reconfigurable arrays in the context of the application of recommender systems(RS).Based on the reconfigurable array processor(APR-16)with reconfiguration,a parallelized design of matrix operations on processing element(PE)array is realized with *** experimental results show that,compared with the proposed central processing unit(CPU)and graphics processing unit(GPU)hybrid implementation matrix multiplication framework,the energy efficiency ratio of the accelerator proposed in this paper is improved by about 35×.Compared with blocked alternating least squares(BALS),its the energy efficiency ratio has been accelerated by about 1×,and the switching of matrix factorization(MF)schemes suitable for different sparsity can be realized.

关键词： matrix factorization(MF) recommender system(RS) array processor reconfigurable matrix multiplication

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Rock physical characteristics of deep dolomite under complex geological conditions: A case study of 4th Member of Sinian Dengying Formation in the Sichuan Basin, china

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Petroleum science 2024年第4期21卷 2370-2382页

作者： Chuang Li Shu-Xin pan Hong-Bin wang Ji-Xin Deng Jian-Guo Zhao Zhi Li yu zhang Northwest Branch of Research Institute of Petroleum Exploration & Development department of Geophysics and Exploration College of Geophysics Chengdu University of Technology State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum (Beijing)

The deep-ultra deep carbonate reservoir in china, commonly subjected to modification of multi-stage diagenesis, has extremely high heterogeneity. Conventional rock physics analysis cannot accurately identify the elastic responses of reservoir. Here, the rock physics properties of the dolomite from the 4th Member of the Sinian Dengying Formation are experimentally measured, and the change law of rock physics characteristics is investigated within the framework of the diagenetic processes by the analysis of the elastic and petrologic characteristics, pore structure, and sedimentary environments. The results show that the differentiated diagenesis results in different pore structure characteristics and microtexture characteristics of the rock. The microbial dolomite of the algal mound-grain beach facies is subjected to the contemporaneous microbial dolomitization and seepage-reflux dolomitization, penecontemporaneous selective dissolution, burial dolomitization, and hydrothermal dolomitization. The resultant crystalline dolomite is found with one main type of the dolomite crystal contact boundaries,and the dissolution pore is extensive development. The siliceous, muddy, and limy dolomite of the interbeach sea environment mainly experiences the weak capillary concentration dolomitization, intensive mechanical compaction-induced densification, and burial dolomitization. Such crystalline dolomite is observed with four types of contact boundaries, namely the dolomite contact, clay contact, quartz contact, and calcite contact boundaries, and porosity mostly attributed to residual primary inter-granular or crystalline pores. The samples with the same crystal boundary condition have consistent correlations between the compressional-and shear-wave velocities, and between the compressional-wave velocity and the velocity ratio. Additionally, the variation of the acoustic velocity with effective pressure and the intensity of pore-scale fluid-related dispersion are controlled by t

关键词： Deep-ultra deep carbonate reservoirs Rock physics properties Dolomite Seismic elastic properties Micro-crack Pore structure types

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Multivariate statistical and bioinformatic analyses for the seasonal variations of actinobacterial community structures in a drinking water reservoir

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Journal of Environmental sciences 2024年第3期137卷 1-17页

作者： Haihan zhang Sixuan pan BenMa Tinglin Huang Dmitry B.Kosolapov Manli Ma Xiang Liu Huan Liu xiaoyan Liu Shaanxi Key Laboratory of Environmental Engineering Key Laboratory of Northwest Water ResourceEnvironment and EcologyMOEXi’an University of Architecture and TechnologyXi’an 710055China school of Environmental and Municipal Engineering Xi’an University of Architecture and TechnologyXi’an 710055China Papanin Institute for Biology of Inland Waters of Russian Academy of sciences(IBIW RAS) 109BorokNekouzYaroslavl152742Russia

Actinobacterial community is a conspicuous part of aquatic ecosystems and displays an important role in the case of biogeochemical cycle,but little is known about the seasonal variation of actinobacterial community in reservoir ecological *** this study,the high-throughput techniques were used to investigate the structure of the aquatic actinobacterial community and its inducing water quality parameters in different *** results showed that the highest diversity and abundance of actinobacterial community occurred in winter,with Sporichthya(45.42%)being the most abundant genus and Rhodococcus sp.(29.32%)being the most abundant *** analysis and correlation analysis suggested that in autumn the dynamics of actinobacterial community were infuenced by more factors and Nocardioides ***2R5S2 was the potential keystone species which was negatively correlated with temperature(R=-0.72,P<0.05).Changes in environmental factors could significantly affect the changes in actinobacterial community,and the dynamics of temperature,dissolved oxygen(DO),and turbidity are potential conspicuous factors infuencing seasonal actinobacterial community *** partial least squares path modeling further elucidated that the combined effects of DO and temperature not only in the diversity of actinobacterial community but also in other water qualities,while the physiochemical parameters(path coefficient=1.571,P<0.05)was strong environmental factors in natural mixture *** results strengthen our understanding of the dynamics and structures of actinobacterial community in the drinking water reservoirs and provide scientific guidance for further water quality management and protection in water sources.

关键词： Source water reservoir High-throughput sequencing Correlation analysis Network analysis Partial least squares path modeling

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Hydrogen-bonded organic framework modified separator for simultaneously enhancing the safety and electrochemical performance of Ni-rich lithium-ion battery

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Journal of Energy Chemistry 2024年第9期96卷 72-78页

作者： Chengyu Han yu Cao Ming Yang yuhan wang Di Tang Shaojie zhang Yiran Jia Yiming zhang Hern Kim Fusheng pan Zhongyi Jiang Jie Sun Key Laboratory for Green Chemical technology of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China science and technology on Power Sources Laboratory Tianjin Institute of Power SourcesTianjin 300384China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China Quzhou Institute for Innovation in Resource Chemical Engineering Quzhou 324000ZhejiangChina department of Energy science and technology Director Environmental Waste Recycle InstituteYongin 17058Republic of Korea school of Chemistry and Chemical Engineering Hainan UniversityHaikou 570228HainanChina

Nickel-rich layered oxide cathode(LiNi_(x)Co_(y)Mn_(1−x−y)O_(2),x>0.5,NCM)shows substantial potential for applications in longer-range electrical ***,the rapid capacity decay and serious safety concerns impede its practical *** work provides a hydrogen-bonded organic framework(HOF)modification strategy to simultaneously improve the electrochemical performance,thermal stability and incombustibility of *** cyanurate(MCA),as a low-cost and reliable flame-retardant HOF,was implemented in the separator modification layer,which can prevent the battery short circuit even at a high *** addition,the supermolecule properties of MCA provide unique physical and chemical microenvironment for regulating ion-transport behavior in *** MCA coating layer enabled the nickel-rich layered oxide cathode with a high-capacity retention of 90.3%after 300 cycles at 1.0 ***,the usage of MCA in lithium-ion batteries(LIBs)affords a simple,low-cost and efficient strategy to improve the security and service life of nickel-rich layered cathodes.

关键词： Hydrogen-bonded organic framework Modified separator Ni-richlayered oxide cathode Thermal runaway Li^(+)transference number

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Manipulating photogenerated electron flow in nickel single‐atom catalysts for photocatalytic CO_(2)reduction into tunable syngas

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Carbon Energy 2024年第8期6卷 205-213页

作者： Yida zhang Qingyu wang Lihui Wu Haibin pan Chengyuan Liu yue Lin Gongming wang Xusheng Zheng National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefeiAnhuiChina College of Chemistry and Materials science University of Science and Technology of ChinaHefeiAnhuiChina department of Chemistry Hefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefeiAnhuiChina

The key to designing photocatalysts is to orient the migration of photogenerated electrons to the target active sites rather than dissipate at inert ***,we demonstrate that the doping of phosphorus(P)significantly enriches photogenerated electrons at Ni active sites and enhances the performance for CO_(2)reduction into *** photocatalytic CO_(2)reduction,Ni single‐atom‐anchored P‐modulated carbon nitride showed an impressive syngas yield rate of 85μmol gcat^(−1)h^(−1)and continuously adjustable CO/H_(2)ratios ranging from 5:1 to 1:2,which exceeded those of most of the reported carbon nitride‐based single‐atom *** studies reveal that P doping improves the conductivity of catalysts,which promotes photogenerated electron transfer to the Ni active sites rather than dissipate randomly at low‐activity nonmetallic sites,facilitating the CO_(2)‐to‐syngas photoreduction process.

关键词： carbon nitride CO_(2)photoreduction electron flow Ni single atoms syngas

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Guest editorial:Special Issue on Artificial Intelligence and Emerging Computational Approaches for Tribology

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Friction 2024年第6期12卷 1057-1059页

作者： Zhinan zhang Shuaihang pan Bart RAEYMAEKERS State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong UniversityShanghai 200240China department of Mechanical Engineering University of UtahSalt Lake CityUT 84112USA department of Mechanical Engineering Virginia TechBlacksburgVA 24061USA

Tribo-behavior is a complex system-based time-dependent process,and it is difficult to accurately model a tribo-system and predict its ***,tribology research,in most cases,has relied on extensive *** by the artificial intelligence(AI)-for-science revolution,AI and other emerging computational approaches provide opportunities to explore the complex processes in tribo-systems and the physical mechanisms of tribo-behavior in an efficient way,significantly pushing the boundaries of tribology research.

关键词： behavior editorial artificial

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Infrared imaging of magnetic octupole domains in non-collinear antiferromagnets

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National science Review 2024年第06期11卷 197-205页

作者： Peng wang Wei Xia Jinhui Shen yulong Chen Wenzhi Peng Jiachen zhang Haolin pan Xuhao yu Zheng Liu Yang Gao Qian Niu Zhian Xu Hongtao Yang Yanfeng Guo Dazhi Hou International Center for Quantum Design of Functional Materials(ICQD) School of Emerging TechnologyUniversity of Science and Technology of China College of Mathematics and Physics Qingdao University of Science and Technology school of physical science and technology Shanghai Tech University Shanghai Tech Laboratory for Topological Physics Shanghai Tech University department of Physics University of Science and Technology of China CAS Key Laboratory of Strongly-Coupled Quantum Matter Physics University of Science and Technology of China Xi'an Institute of Optics and Precision mechanics of Chinese Academy of sciences

Magnetic structure plays a pivotal role in the functionality of antiferromagnets（AFMs）, which not only can be employed to encode digital data but also yields novel phenomena. Despite its growing significance,visualizing the antiferromagnetic domain structure remains a challenge, particularly for non-collinear AFMs. Currently, the observation of magnetic domains in non-collinear antiferromagnetic materials is feasible only in Mn3Sn, underscoring the limitations of existing techniques that necessitate distinct methods for in-plane and out-of-plane magnetic domain imaging. In this study, we present a versatile method for imaging the antiferromagnetic domain structure in a series of non-collinear antiferromagnetic materials by utilizing the anomalous Ettingshausen effect（AEE）, which resolves both the magnetic octupole moments parallel and perpendicular to the sample surface. Temperature modulation due to AEE originating from different magnetic domains is measured by lock-in thermography, revealing distinct behaviors of octupole domains in different antiferromagnets. This work delivers an efficient technique for the visualization of magnetic domains in non-collinear AFMs, which enables comprehensive study of the magnetization process at the microscopic level and paves the way for potential advancements in applications.

关键词： non-collinear antiferromagnet domain structure infrared imaging anomalous Ettingshausen effect

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