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Viral hepatitis update: Progress and perspectives

World Journal of Gastroenterology 2021年第26期27卷 4018-4044页

作者： María B Pisano cecilia G Giadans Diego M Flichman Viviana E Ré María V Preciado pamela Valva Virology Institute CONICETSchool of Medical SciencesNational University of CórdobaCordoba X5016Argentina Multidisciplinary Institute for Investigation in Pediatric Pathologies(IMIPP)cONIcET-GcBA Laboratory of Molecular BiologyPathology DivisionRicardo Gutiérrez Children’s HospitalCABA C1425Buenos AiresArgentina Institute of Biomedical Investigations in Retrovirus and AIDS(INBIRS) School of MedicineUniversity of Buenos AiresCONICETCABA C1121ABGBuenos AiresArgentina

Viral hepatitis,secondary to infection with hepatitis A,B,c,D,and E viruses,are a major public health problem and an important cause of morbidity and *** the huge medical advances achieved in recent years,there are still points of conflict concerning the pathogenesis,immune response,development of new and more effective vaccines,therapies,and *** review focuses on the most important research topics that deal with issues that are currently being solved,those that remain to be solved,and future research *** hepatitis A virus we will address epidemiology,molecular surveillance,new susceptible populations as well as environmental and food *** the case of hepatitis B virus,we will discuss host factors related to disease,diagnosis,therapy,and vaccine *** hepatitis c virus,we will focus on pathogenesis,immune response,direct action antivirals treatment in the context of solid organ transplantation,issues related to hepatocellular carcinoma development,direct action antivirals resistance due to selection of resistanceassociated variants,and *** hepatitis D virus,we describe diagnostic methodology,pathogenesis,and ***,for hepatitis E virus,we will address epidemiology(including new emerging species),diagnosis,clinical aspects,treatment,the development of a vaccine,and environmental surveillance.

关键词： Viral hepatitis Hepatitis A virus Hepatitis B virus Hepatitis c virus Hepatitis D virus Hepatitis E virus

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DOES PSYcHOLOGIcAL TESTING HELP TO PREDIcT THE RESPONSE TO AcUPUNcTURE OR MASSAGE/ RELAXATION THERAPY IN PATIENTS PRESENTING TO A GENERAL NEUROLOGY cLINIc WITH HEADAcHE?

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Journal of Traditional chinese Medicine 1997年第2期17卷 130-139页

作者： KEVAN R. WYLIE, M.R.c. Psych.cHRISTINE JAcKSON pamela M. cRAWFORD, M.R.c.P.Department of Neuropsychiatry, Bootham Park Hospital, Bootham, York, Y03 7BY, U.K. Department of Neuropsychiatry Bootham Park Hospital Bootham York Y03 7BY U.K.cHRISTINE JAcKSON Department of Neuropsychiatry Bootham Park Hospital Bootham York Y03 7BY U.K.PAMELA M. CRAWFORD M.R.C.P.Department of Neuropsychiatry Bootham Park Hospital Bootham York Y03 7BY U.K.

Patients with chronic headache were offered treatment by acupuncture or massage with relaxation instead of a change in their prescribed medication. They were randomly allocated to either treatment. There was a significant improvement in pain ratings with both treatment types. Specifically a greater effect was seen in migraine patients treated by massage with relaxation when compared to acupuncture. No psychological factors were found to predict response to either treatment. At the end of the study, 13% of patients were significantly more worried that there may be a more serious cause underlying their headache despite reassurance and an improvement in their headache scores.

关键词： acupuncture headache relaxation migraine medication Acupuncture instead prescribed psychological illness

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Integrative taxonomy of the Russet Bush Warbler Locustella mandelli complex reveals a new species from central china

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chinese Birds 2015年第2期6卷 60-91页

作者： Per Alstrom canwei Xia pamela c Rasmussen Urban Olsson Bo Dai Jian Zhao Paul J Leader Geoff J carey Lu Dong Tianlong cai Paul I Holt Hung Le Manh Gang Song Yang Liu Yanyun Zhang Fumin Lei Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of Sciences Swedish Species Information centre Swedish University of Agricultural Sciences Ministry of Education Key Laboratory for Biodiversity and Ecological Engineering College of Life SciencesBeijing Normal University Department of Integrative Biology and MSU Museum Michigan State University Bird Group The Natural History Museum at Tring Department of Biology and Environmental Sciences Systematics and BiodiversityUniversity of Gothenburg college of Life Sciences Leshan Normal University State Key Laboratory of Biocontrol and college of Ecology and Evolution Sun Yat-sen University c/o AEc Ltd 121–127 Commercial CentrePalm SpringsYuen LongHong Kong college of Life Sciences University of Chinese Academy of Sciences Bracken Dean PendletonClitheroeLancashire BB7 1PTUK Institute of Ecology and Biological Resources Vietnam Academy of Science and Technology

Background: The Russet Bush Warbler Locustella(previously Bradypterus) mandelli complex occurs in mountains in the eastern Himalayas, southern china, Vietnam, the Philippines, and Indonesia. The taxonomy has been debated,with one(L. seebohmi) to four(L. seebohmi, L. mandelli, L. montis and L. timorensis) species having been ***: We used an integrative approach, incorporating analyses of morphology, vocalizations and a molecular marker, to re-evaluate species limits in the L. mandelli ***: We found that central chinese L. mandelli differed from those from India through northern Southeast Asia to southeast china in plumage, morphometrics and song. All were easily classified by song, and(wing + culmen)/tail ratio overlapped only marginally. Both groups were reciprocally monophyletic in a mitochondrial cytochrome b(cytb) gene tree, with a mean divergence of 1.0 ± 0.2%. They were sympatric and mostly altitudinally segregated in the breeding season in southern Sichuan province. We found that the Mt Victoria(western Myanmar) population differed vocally from other L. mandelli, but no specimens are available. Taiwan Bush Warbler L. alishanensis was sister to the L. mandelli complex, with the most divergent song. Plumage, vocal and cytb evidence supported the distinctness of the south Vietnamese L. mandelli idonea. The Timor Bush Warbler L. timorensis, Javan Bush Warbler *** and Benguet Bush Warbler L. seebohmi differed distinctly in plumage, but among-population song variation in L. montis exceeded the differences between some populations of these taxa, and mean pairwise cytb divergences were only 0.5–0.9%. We also found that some L. montis populations differed ***: We conclude that the central chinese population of Russet Bush Warbler represents a new species,which we describe herein, breeding at mid elevations in Sichuan, Shaanxi, Hubei, Hunan and Guizhou *** taxonomic status of the other allopatric populati

关键词： Bradypterus cryptic species Locustella seebohmi Locustella mandelli Locustella montis Locustella timorensis Locustella alishanen

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Luminometric Studies of Yeast Response to complex Environmental calcium Variations Demonstrate Sensing of External calcium Ion changes

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Advances in Microbiology 2022年第9期12卷 555-567页

作者： Augustus c. Parker David A. Mintz Francisco J. Solis pamela A. Marshall School of Mathematical and Natural Sciences Arizona State University Glendale USA

The response of yeast to sharp environmental increases in calcium concentration has been extensively studied. However, systematic studies of the response under more general changes are still lacking. Only limited exploration of cellular responses has been conducted where calcium concentration is decreased. This article describes a set of luminometric experiments that monitor the cytosolic calcium concentration under changing external concentration conditions. As a decrease in external calcium concentrations requires the use of large sample volumes, the experiments require the use of equipment adapted for this purpose. We describe the modification of commercial luminometric equipment to make the exploration possible. We explore the yeast cellular behavior when an increase in external calcium concentration is followed by a decrease in external calcium concentration. We compare these results with those from the case of a double pulse of concentration increase. Results from the experiment show that the first, concentration increasing pulse produces the well-known sharp increase in cytosolic calcium followed by calcium sequestration to return to a cytosolic concentration near its initial condition. Surprisingly, the calcium decrease step shows similar results with a cytosolic increase followed by a return to lower levels. The results suggest the presence of a calcium sensing mechanism regulating calcium influx from external sources. This mechanism would produce channel opening as a response to any changes in external concentration, be it an enhancement or a depletion.

关键词： Saccharomyces cerevisiae calcium Homeostasis Extracellular Ion changes

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Dissect the rice immune system using a whole-genome sequenced mutant population

Dissect the rice immune system using a whole-genome sequence...

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中国植物病理学会2019年学术年会

作者： Li Guotian Sha Gan Jain Rashmi Jenkins Jerry Shu Shengqiang chern Mawsheng copetti Dario Xing Feng Xie Weibo Wing Rod A Schmutz Jeremy ronald pamela c State Key Laboratory of Agricultural Microbiology and college of Plant Science and Technology Huazhong Agricultural University Department of Plant Pathology University of California Joint BioEnergy Institute Lawrence Berkeley National Laboratory U.S.Department of Energy Joint Genome Institute Arizona Genomics Institute School of Plant SciencesUniversity of Arizona National Key Laboratory of crop Genetic Improvement National Center of Plant Gene ResearchHuazhong Agricultural University HudsonAlpha Institute for Biotechnology

Rice provides food for more than half of the world’s population and also serves as a model for studies of other monocotyledonous ***,we report the de novo genome sequencing and analysis of an early flowering Geng/japonica variety KitaakeX,which completes its life cycle in 9 *** KitaakeX sequence assembly contains 377.6 Mb,consisting of 33 scaffolds（476 contigs） with a contig N50 of 1.4 *** the assembly are detailed gene annotations of 35 594 protein coding *** high-quality genome of the model rice plant KitaakeX will accelerate rice functional *** further facilitate rice research,we generated and sequenced a fast-neutron-induced mutant population in *** sequenced 1 504 mutant lines at 45-fold coverage and identified 91 513 mutations affecting 32 307 genes,i.e.,58% of all rice *** detected an average of 61 mutations per *** types include single-base substitutions,deletions,insertions,inversions,translocations,and tandem *** observed a high proportion of loss-of-function *** facilitate public access to this genetic resource,we established an open access database called KitBase that provides access to sequence data and seed *** have screened this mutant population for lines altered in plant immunity and identified multiple mutant *** on these mutants will be presented.

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强制结构理论及实验检验

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社会 2013年第4期33卷 176-192页

作者：刘军 David Willer pamela Emanuelson 哈尔滨工程大学社会学系美国南卡罗来纳大学社会学系美国北达科他州立大学社会学与人类学系

学术界对强制关系的研究较少,尽管它无处不在。本文基于要素论探讨强制结构的含义、分类及模型,重点探讨了间接强制结构的效应。间接强制是涉及至少三个行动者的一类"不给钱就制裁,给钱就‘保护’你"的结构关系。实验研究结果表明,在边... 详细信息

学术界对强制关系的研究较少,尽管它无处不在。本文基于要素论探讨强制结构的含义、分类及模型,重点探讨了间接强制结构的效应。间接强制是涉及至少三个行动者的一类"不给钱就制裁,给钱就‘保护’你"的结构关系。实验研究结果表明,在边界条件内,间接强制结构与直接强制结构一样有效力,即有类似的强制幅度和力度,二者都使强制者获得最大的剥夺率。本文最后讨论了影响强制效果的因素,包括强制者的贪欲与策略、强—强联盟及受制者联盟的效应等。

关键词：强制社会网络三方关系网络交换论

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Experimental models to study cholangiocyte biology

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World Journal of Gastroenterology 2002年第1期8卷 1-4页

作者： pamela S.Tietz Robert c.Huebert Anatoliy Masyuk Tatyana Masyuk Patrick L.Splinter Nicholas F.LaRusso center for Basic Research in Digestive Diseases Department of Internal Medicine and Biochemistry and Molecular BiologyMayo Medical SchoolClinic and FoundationRochesterMN 55905

cholangiocytes-the epithelial cells which line the bileducts-are increasingly recognized as importanttransporting epithelia actively involved in the absorptionand secretion of water,ions,and *** is due in part to the recent development ofnew experimental *** biologic concepts haveemerged including the identification and topography ofreceptors and flux proteins on the apical and/orbasolateral membrane which are involved in the molecularmechanisms of ductal bile *** isolatedand/or perfused bile duct units from livers of rats andmice serve as new,physiologically relevant in vitromodels to study cholangiocyte *** treedimensions and novel insights into anatomic remodeling ofproliferating bile ducts have emerged from three-dimensional reconstruction using cT scanning andsophisticated ***,new pathologicconcepts have arisen regarding the interaction ofcholangiocytes with pathogens such as *** concepts and associated methodologiesmay provide the framework to develop new therapies forthe cholangiopathies,a group of important hepatobiliarydiseases in which cholangiocytes are the target cell.

关键词： Animals Bile Ducts Biological Transport Epithelial cells Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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Temporal and spatial comparisons of angiosperm diversity between eastern Asia and North America

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National Science Review 2022年第6期9卷 38-42页

作者： Haihua Hu Jianfei Ye Bing Liu Lingfeng Mao Stephen A.Smith Russell L.Barrett pamela S.Soltis Douglas E.Soltis Zhiduan chen Limin Lu State Key Laboratory of Systematic and Evolutionary Botany Institute of Botany Chinese Academy of Sciences University of chinese Academy of Sciences Sino-Africa Joint Research center Chinese Academy of Sciences Beijing Botanical Garden Institute of BotanyChinese Academy of Sciences co-Innovation center for Sustainable Forestry in Southern china College of Biology and the Environment Nanjing Forestry University Department of Ecology and Evolutionary Biology University of Michigan National Herbarium of New South Wales Royal Botanic Gardens and Domain Trust Florida Museum of Natural History University of Florida Department of Biology University of Florida

comparative approaches that examine floras with similar environments, but different diversity patterns, provide good opportunities to elucidate how uneven distributions of biodiversity were assembled. Eastern Asia(EA) and North America north of Mexico(NA; see definitions of EA and NA in Fig. S1 A) share similar geographical environments with comparable latitude, land area and climate,

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Radio Pet Therapy of Healthy Wistar Rats with 64cucl2Labeled to 64cu(AcAc)2Supported in Functionalized TiO2Nanoparticles

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Journal of Encapsulation and Adsorption Sciences 2017年第3期7卷 121-126页

作者： Tessy López Juan c. Manrique-Arias Paola Ramírez pamela Larraza Francisco Rodríguez Reinoso Departamento de Atención a la Salud Universidad Autónoma Metropolitana-Xochimilco CdMx México Unidad Radiofarmacia-ciclotrón Facultad de Medicina Universidad Nacional Autónoma de México CdMx México Departamento de Química Universidad de Alicante Espa&ntilde a

In recent years copper-64 in the chemical form of copper chloride ([64cu]cucl2) has been identified as a potential agent for PET imaging and radionuclide therapy. The aim of this research was to determine the biodistribution and the labeling of radio nanoparticle with 64cucl2, the nanoparticles cu(acac)2/F-TiO2 were mixed with 64cucl2 (20-37 MBq), then the final solution was used to injected healthy Wistar rats to probe the absorption of nanoparticle inside tissue trough of the groups OH that are formed during the functionalization of the cu(acac)2/F-TiO2. The “in vivo” evaluation after realize the images study in micro PET equipment, uptake of the radio-nanoparticle was observed in the digestive system in the healthy Wistar rats.

关键词： PET Therapy Nanoparticles Functionalized Titania (F-Tio2) Titanium Acetylacetonate [cu (AcAc)2] cu(Acac)2/F-Tio2 PET Lesion Detection Imaging

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Design and Implementation of Low-Pass, High-Pass and Band-Pass Finite Impulse Response (FIR) Filters Using FPGA

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circuits and Systems 2015年第2期6卷 30-48页

作者： Emmanuel S. Kolawole Warsame H. Ali Penrose cofie John Fuller c. Tolliver pamela Obiomon Department of Electrical and computer Engineering Prairie View A&M University Prairie View USA

This paper presents the design and implementation of a low-pass, high-pass and a hand-pass Finite Impulse Response (FIR) Filter using SPARTAN-6 Field Programmable Gate Array (FPGA) device. The filter performance is tested using Filter Design and Analysis (FDA) and FIR tools from Mathworks. The FDA Tool is used to define the filter order and coefficients, and the FIR tool is used for Simulink simulation. The FPGA implementation is carried out using Spartan-6 LX75T-3FGG676c for different filter specifications and simulated with the help of Xilinx ISE (Integrated Software Environment). System Generator ISE design suit 14.6i is used in synthesizing and co-simulation for FPGA filter output verification. Finally, comparison is done between the results obtained from the software simulations and those from FPGA using hardware co-simulation. The simulation waveforms and synthesis reports verify the parallel implementation of FPGA which proves its effectiveness in terms of speed, resource usage and power consumption.

关键词： Digital Filters FIR Filter Matlab Simulink FDA Tool FIR Tool Distributed Arithmetic FPGA Xilinx System Generator

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