In the traumatic brain injury(TBI) the initial impact causes both primary injury,and launches secondary injury *** consequence,and a factor that may contribute to these secondary changes and functional outcome,is alte...
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In the traumatic brain injury(TBI) the initial impact causes both primary injury,and launches secondary injury *** consequence,and a factor that may contribute to these secondary changes and functional outcome,is altered *** relative cerebral blood volume(CBV) changes in rat brain after severe controlled cortical impact injury were characterized to assess their interrelations with motor function *** resonance imaging(MrI) was performed 1,2,4 h,and 1,2,3,4,7,and 14 days after TBI to quantify CBV and water *** test was conducted before,and 2,7,and 14 days after the *** found distinct temporal profile of CBV in the perilesional area,hippocampus,and in the primary *** all regions,the first response was drop of *** CBV was reduced for over 4 days thereafter gradually *** the initial drop,the hippocampal CBV was increased for 2 *** demonstrated severely impaired motor functions 2 days after injury(33% decrease),which then slowly recovered in 2 *** recovery parallelled the recovery of perifocal *** MrI can detect cerebrovascular pathophysiology after TBI in the vulnerable perilesional area,which seems to potentially associate with time course of sensory-motor deficit.
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