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泼尼松龙加扑热息痛（对乙酰氨基酚）治疗急性痛风性关节炎与吲哚美辛加扑热息痛疗效相同且副作用更少

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英国医学杂志中文版 2008年第3期11卷 177-178页

作者： Man CY Cheung IT Cameron pa, et al 李君(译) Prince of Wales Hospital Shaft n HongKongChina 不详

问题：相比吲哚美辛加扑热息痛。泼尼松龙加扑热息痛在急性痛风性关节炎患者中的止痛效果如何？

关键词：急性痛风性关节炎扑热息痛吲哚美辛泼尼松龙对乙酰氨基酚副作用疗效治疗

Two-Dimensional Riemann Problems for the Compressible Euler System

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Chinese Annals of Mathematics,Series B 2009年第6期30卷 845-858页

作者： Yuxi ZHENG Dedicated to Professor Andrew Majda for his 60th Birthday

Riemann problems for the compressible Euler system in two space dimensions are complicated and difficult,but a viable alternative remains *** author lists merits of one-dimensional Riemann problems and compares them with those for the current two-dimensional Riemann problems,to illustrate their ***-dimensional Riemann problems are approached via the methodology promoted by Andy Majda in the spirits of modern applied mathematics;that is,simplified model is built via asymptotic analysis,numerical simulation and theoretical analysis.A simplified model called the pressure gradient system is derived from the full Euler system via an asymptotic ***-of-the-art numerical methods in numerical simulations are used to discern small-scale structures of the solutions,e.g.,semi-hyperbolic *** methods are used to establish the validity of the structure revealed in the numerical *** entire process,used in many of Majda's programs,is shown here for the two-dimensional Riemann problems for the compressible Euler systems of conservation laws.

关键词： Characteristic decomposition Guderley reflection Hodograph transform Pressure gradient system Self-similar Semi-hyperbolic wave Triple point paradox Riemann problem Riemann variable

Pharmacokinetic characteristics of L-valyl-ara-C and its implication on the oral delivery of ara-C

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Acta Pharmacologica Sinica 2007年第2期28卷 268-272页

作者： Eun-pa CHEON Hyo-kyung HAN College of Pharmacy Chosun UniversityGwangju 501-759Korea

Aim:To evaluate the pharmacokinetic characteristics of L-valyl-ara-C,apeptidomimetic prodrug of ***:After the synthesis of L-valyl-ara-C,the in vitro stability of L-valyl-ara-C was examined in various biological *** pharmacokinetic profiles of ara-C and L-valyl-ara-C were also evaluated ***:The degradation of L-valyl-ara-C was negligible in fresh plasmaand also in the presence of plasmin over a 2 h incubation ***,L-valyl-ara-C appeared to be stable in the leukemia cell homogenates,andsubsequently,it was far less cytotoxic than the parent,ara-C in AML2 and *** chemical hydrolysis of L-valyl-ara-C was rather accelerated in *** an oral administration of L-valyl-ara-C,the appearance of ara-Cwas observed in plasma although the systemic exposure of the prodrug was muchhigher than that of *** bioavailability of ara-C was about 4% via ***:The amide bond of L-valyl-ara-C was stable againstthe enzymatic hydrolysis,and the utility of L-valyl-ara-C as an oral delivery sys-tem of ara-C appeared to be limited by its low metabolic conversion to ara-C in rats.

关键词： ara-C L-valyl-ara-C prodrug pharmacokinetics rats

Evaluation and Comparison Research on the Support of Websites to Enterprise's E-Commerce

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Journal of Electronic Science and Technology of China 2004年第3期2卷 162-166,193页

作者： SHAO Peiji, HUANG Yixiao, WAN Jie, YANG Jing ( School of Management, University of Electronic Science and Techonology of China Chengdu 610054 China Johnson & Johnson, Philadelphia pa 19104 USA) School of Management University of Electronic Science and Techonology of China Chengdu 610054 China Johnson & Johnson Philadelphia PA 19104 USA

This paper comparatively analyzes the existing evaluation index of websites, and puts forward the evaluation index and method about the support of a website to enterprise's e-commerce. Through researching on 56 super enterprises of information industry in Sichuan province, throughout China and the world, analyzing and comparatively studying the support ability of a website to an enterprise's e-commerce, this paper brings forward using five levels to categorize the support ability of a website to enterprise's e-commerce. In the end, the flaw of enterprise's e-commerce practice in Sichuan province and corresponding countermeasure will be illustrated.

关键词： e-commerce websites evaluation

渗透树脂与氟化物涂布对青少年前牙白垩斑的治疗效果比较

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临床医学研究与实践 2020年第14期5卷 105-107页

作者：张梦葩西安大兴医院陕西西安710082

目的比较渗透树脂与氟化物涂布对青少年前牙白垩斑的治疗效果。方法选择100例青少年前牙白垩斑患者为研究对象,根据抓阄随机化方式将其分为对照组和观察组,各50例。对照组采用多乐氟进行治疗,观察组采用ICON渗透树脂进行治疗。比较两组... 详细信息

目的比较渗透树脂与氟化物涂布对青少年前牙白垩斑的治疗效果。方法选择100例青少年前牙白垩斑患者为研究对象,根据抓阄随机化方式将其分为对照组和观察组,各50例。对照组采用多乐氟进行治疗,观察组采用ICON渗透树脂进行治疗。比较两组的病损面积比、治疗效果、表面显微硬度、L^*值、患牙白垩斑评分以及治疗后6个月的DIANGOdnet、ICDAS数值。结果治疗后,观察组的病损面积比、治疗总有效率、表面显微硬度、L^*值、专业医师评分、计算机评分、DIANGOdnet和ICDAS数值均优于对照组(P<0.05)。结论对青少年前牙白垩斑患者采用渗透树脂治疗的效果更为显著,能够提高渗透树脂的渗透能力,改善患牙的外观美感。

关键词：渗透树脂氟化物涂布前牙白垩斑

Comprehensive profiling of CTP-binding proteins using a biotinylated CTP affinity probe

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Chinese Chemical Letters 2021年第11期32卷 3479-3482页

作者： Mengting pa Yunming Liu Xiaofang Zheng Meijuan Zhou Changjun You Xiaoxia Dai State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringMolecular Science and Biomedicine LaboratoryHunan Provincial Key Laboratory of Biomacromolecular Chemical BiologyHunan UniversityChangsha 410082China

Recent studies have shown that CTP may act as a ligand to regulate the activity of its target proteins in many biological ***,proteome-wide identification of CTP-binding proteins remains ***,we employed a biotinylated CTP affinity probe coupled with stable isotope labeling by amino acids in cell culture(SILAC)-based quantitative proteomics approach to capture,identify and quantify CTP-binding proteins in human *** performing two types of competitive SILAC experiments with high *** concentrations of CTP probe(100 vs.10µmol/L)or with CTP probe in the presence of free CTP,we identified 90 potential CTP-binding proteins which are involved in a variety of biological processes,including protein folding,nucleotide binding and cell-cell ***,we developed a chemical proteomic method for uncovering the CTP-binding proteins in human cells,which could be widely applicable for profiling CTP-binding proteins in other biological samples.

关键词： CTP-binding proteins CTP affinity probe Mass spectrometry SILAC Quantitative proteomics

Long-term records of glacier evolution and associated proglacial lakes on the Tibetan Plateau(1976‒2020)

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Big Earth Data 2022年第4期6卷 435-452页

作者： Drolma Lhakpa Yubao Qiu pa Lhak Lijuan Shi Maoce Cheng Bin Cheng Tibet Institute of Plateau Atmospheric and Environmental Sciences Tibet Meteorological BureauLhasaChina Key Laboratory of Atmospheric Environment of Tibet Autonomous Region LhasaTibet Autonomous RegionChina School of Geography and Ocean Science Nanjing UniversityNanjingChina International Research Center of Big Data for Sustainable Development Goals BeijingChina Aerospace Information Research Institute Chinese Academy of SciencesBeijingChina FMI-AIR Joint Research Center for Arctic Observations Finnish Meteorological Institute and Aerospace Information Research InstituteChinese Academy of SciencesSodankyläFinland Climate Center of Tibet Autonomous Region Tibet Meteorological BureauLhasaTibet Autonomous RegionChina School of Earth Resources China University of GeosciencesWuhanChina Finnish Meteorological Institute HelsinkiFinland

The glaciers on the Tibetan Plateau(TP)constitute critical sources of water for the proglacial lakes and many rivers found *** better understand the evolution of glaciers and the impact of this on proglacial lakes,seven glaciers corresponding to continenṅtal,sub-continental,and marine climate types that are influenced by wester-lies and the Indian summer monsoon were selected for *** evolution of the edges of these glaciers and their associated progla-cial lakes were identified based on the visual interpretation of Landsat TM/ETM+/OLI images.A dataset covering the period 1976-2020 that included the glacier and proglacial lake edge vectors was then *** relative errors in the areas of the individual glaciers were less than 3%,and for the proglacial lakes these errors were in the range 0%-7%.The dataset was used to effectively compare the changes in glaciers and proglacial lakes that have occurred over the past four *** most striking changes that were found were the retreat of glaciers and the formation of small proglacial *** dataset could also be used as a proxy to support research on changes in mountain glaciers,particularly their response to climate change and water *** response is of great scientific significance and is important in many applications,including assessments of the ecological problems caused by melting *** dataset can be downloaded from http://***/10.57760/sciencedb.j00076.00131.

关键词： Glacier and proglacial lake long-term changes Landsat Tibetan Plateau

THE PRELIMINARY STUDY ON HMBA-INDUCED DIFFERENTIATION OF THE DRUG-PRETREATED MURINE ERYTHROLEUKEMIA CELLS

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Chinese Journal of Cancer Research 1989年第2期1卷 27-31页

作者：陈子兴 Michaeli J Marks pa Rifkind RA Jiangsu Hematology Institute Suzhou Sloan-kettering Institute for Cancer Research USA Sloan-kettering Institute for Cancer Research USAeveral drug-resistant variants have been developed by growing the parental MEL cells in presence of colchicine adriamycin and vincristine respectively with stepwise increasing concentration. Both the colchicine-resistant Sc9(ColO) and vincristine-resis-tant Sc9(VCR5) cells displayed an accelerated HMBA-induced commitment to terminal cell differentiation whereas the adriamycin-resistant SC9 (A 120) showed no acceleration but rather a substantial delay in HMBA-induced differentiation. The studies provide more clues as well as experimental models for further study on the mechanism of induced differentiation of MEL cells.

Several drug-resistant variants have been developed by growing the parental MEL cells in presence of colchicine, adriamycin and vincristine respectively with stepwise increasing concentration. Both the colchicine-resistant Sc9(ColO) and vincristine-resis-tant Sc9(VCR5) cells displayed an accelerated HMBA-induced commitment to terminal cell differentiation, whereas the adriamycin-resistant SC9 (A 120) showed no acceleration but rather a substantial delay in HMBA-induced differentiation. The studies provide more clues as well as experimental models for further study on the mechanism of induced differentiation of MEL cells.

关键词： HMBA MEL THE PRELIMINARY STUDY ON HMBA-INDUCED DIFFERENTIATION OF THE DRUG-PRETREATED MURINE ERYTHROLEUKEMIA CELLS line

Effect of heat treatment on mechanical and wear properties of Zn−40Al−2Cu−2Si alloy

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Transactions of Nonferrous Metals Society of China 2021年第9期31卷 2651-2663页

作者： Temel SAVAŞKAN Zeki AZAKLI Ali paşa HEKÌMOĞLU Mechanical Engineering Department HaliçUniversity34445İstanbulTurkey Mechanical Engineering Department Gümüşhane University29010GümüşhaneTurkey Mechanical Engineering Department Recep Tayyip Erdogan University53100RizeTurkey

In order to determine the effect of heat treatment on the mechanical and wear properties of Zn−40Al−2Cu−2Si alloy,different heat treatments including homogenization followed by air-cooling(H1),homogenization followed by furnace-cooling(H2),stabilization(T5)and quench−aging(T6 and T7)were *** effects of these heat treatments on the mechanical and tribological properties of the alloy were studied by metallography and,mechanical and wear tests in comparison with SAE 65 *** wear tests were performed using a block on cylinder type test *** hardness,tensile strength and compressive strength of the alloy increase by the application of H1 and T6 heat treatments,and all the heat treatments except T6,increase its elongation to fracture.H1,T5 and T6 heat treatments cause a reduction in friction coefficient and wear volume of the ***,this alloy exhibits the lowest friction coefficient and wear volume after T6 heat ***,T6 heat treatment appears to be the best process for the lubricated tribological applications of this alloy at a pressure of 14 ***,Zn−40Al−2Cu−2Si alloy in the as-cast and heat-treated conditions shows lower wear loss or higher wear resistance than the bronze.

关键词： Zn−Al based alloys heat treatment structural features mechanical properties lubricated friction and wear