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Incidence and histopathology of encysted progenetic metacercaria of Clinostomum complanatum(Digenea:Clinostomidae) in Channa punctatus and its development in experimental host

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Asian pacific Journal of Tropical Biomedicine 2012年第6期2卷 421-426页

作者： pa Ahammed Shareef SMA Abidi Section of parasitology Department of Zoology Aligarh Muslim University

Objective:To study the incidence of encysted progenetic metacercariae of Clinostomum complanatum(C. complanatum) in Channa punctatus(C. punctatus), associated histopathology and the experimental infection to laboratory chicken to obtain ovigerous adult ***:Live C. punctatus were brought from local fish market of Aligarh, India, dissected and examined on a monthly basis for the presence of C. complanatumcysts. For histochemistry, infected tissue sections with attached cysts were processed for haematoxylene and eosin staining. Cysts were aseptically fed to 4 day old leghorn chicken to obtain adult worms. Mechanically excysted metacercaria and the ovigerous adult worms were stained in carmine to prepare permanent ***:One year survey for the infection of encysted progenetic metacercaria of ***. punctatusrevealed the prevalence, intensity and abundance of 24.7%, 2.27and 0.608, respectively. Histopathology showed heavy infiltration of immune cells at the site of cyst attachment and some tissue damage was also evident. Following feeding to experimental chicken, about 41.07% of the encysted metacercariae were able to excyst and migrate back to bucco-pharyngeal region where they tenaciously attached and fed on blood, and transformed into ovigerous adult worms from 62 hours onwards of post ***:The parasite is potentially pathogenic to the host, and the availability of a suitable intermediate host can be a contributing factor for the occurrence of C. complanatummetacercaria either in the excysted or encysted form, indicating loose host specificity and zoonotic potential.

关键词： Clinostomum complanatum Encysted progenetic metacercaria Channa punctatus Histopathology Experimental infection Ovigerous adult worm Incidence Host-parasite interaction Metacercarial transformation

Antimicrobial and antispasmodic activity of leaf extract and fractions of Stachytarpheta cayennensis

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Asian pacific Journal of Tropical Medicine 2010年第3期3卷 189-192页

作者： Okoye TC Akah pa Okoli CO Ezike AC Mbaoji FN Department of Pharmacology & Toxicology Faculty of Pharmaceutical SciencesUniversity of Nigeria

Objective:To investigate the antimicrobial activity of the methanol leaf extract(ME),n-hexane fraction(HF),ethylacetate fraction(EF) and methanol fraction(MF),of Stachytarpheta cayennensis ***(verbenaceae) as well as to ascertain the antispasmodic effects of the ME and the various fractions(HF,EF and MF) on acetylcholine(Ach) and histamine(H) induced contractions on isolated guinea pig ***:The in vitro agar well diffusion method was used for the antimicrobial studies while the isolated tissue method was employed for the antispasmodic test. Organisms used were all clinical isolates of Bacillus subtilis,Staphylococcus aureus,Pseudomonas aeruginosa,Salmonella paratyphi,Candida albicans and Aspergillus ***:The extract and fractions exhibited dose dependent inhibition against all the bacteria tested and also exhibited insignificant antifungal activity against Candida albicans and Aspergillus *** minimum inhibitory concentration(MIC) of the extract and fractions(mg/mL) on Bacillus subtilis, Staphylococcus aureus,Pseudomonas aeruginosa and Salmonella paratyphi respectively were ME 5.62,14.12,22.38,2.11;EF 1.25,6.30,9.40,9.40 and MF 3.98,8.81,39.80,*** n-hexane fraction exhibited MIC of 1.07 mg/mL against only Bacillus *** extract and fractions exhibited significant(Ppasmodic effects confirming the claimed use in folkloric medicine

关键词： Antimicrobial Antispasmodic Stachytarpheta cayennensis Acetylcholine Histamine

Asymmetric Cyclopropanation Catalyzed by Four Stereoisomers of a Copper-(Schiff-base) Complex with Double Chiral Centers

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Chinese Chemical Letters 2002年第12期13卷 1143-1146页

作者： Chang Sheng JIANG You Gui LI Chen JIANG Fang WANG Tian pa YOU Department of Chemistry Universtity of Science&Technology of ChinaHefei 230026

Four stereoisomers of a copper-(Schiff-base) complex with double chiral centers were applied to catalyze the asymmetric cyclopropanation. Two of the stereoisomers were also efficient catalysts affording high enantiom... 详细信息

关键词： Asymmetric cyclopropanation copper-(Schiff-base) olefins diazoacetates.

Signal transduction mediated by Bid, a pro-death Bcl-2 family proteins, connects the death receptor and mitochondria apoptosis pathways

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Cell Research 2000年第3期10卷 161-167页

作者： YIN XIAO-MING (Department of pathology, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, pa 15261, USA) Departmentofpathology UniversityofPittsburghSchoolofMedicinePA15261USA.xmyin@pitt.edu

Two major apoptosis pathways have been defined in mammalian cells, the Fas/TNF-R1 death receptor pathway and the mitochondria pathway. The Bcl-2 family proteins consist of both anti-apoptosis and pro- apoptosis members that regulate apoptosis, mainly by controlling the release of cytochrome c and other mitochondrial apoptotic events. However, death signals mediated by Fas/TNF-R1 receptors can usually activate caspases directly, bypassing the need for mitochondria and escaping the regulation by Bcl-2 family proteins. Bid is a novel pro-apoptosis Bcl-2 family protein that is activated by caspase 8 in response to Fas/TNF-R1 death receptor signals. Activated Bid is translocated to mitochondria and induces cytochrome c release, which in turn activates downstream caspases. Such a connection between the two apoptosis pathways could be important for induction of apoptosis in certain types of cells and responsible for the pathogenesis of a number of human diseases.

关键词： Apoptosis Bcl-2 family proteins Bid Fas TNF.

HNF1A mutation in a Thai patient with maturity-onset diabetes of the young: A case report

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World Journal of Diabetes 2019年第7期10卷 414-420页

作者： Nattachet Plengvidhya Watip Tangjittipokin Nipaporn Teerawattanapong Tassanee Narkdontri pa-thai Yenchitsomanus Division of Endocrinology and Metabolism Department of MedicineFaculty of Medicine Siriraj HospitalMahidol UniversityBangkok 10700Thailand Siriraj Center of Research Excellence for Diabetes and Obesity Faculty of Medicine Siriraj HospitalMahidol UniversityBangkok 10700Thailand Department of Immunology Faculty of Medicine Siriraj HospitalMahidol UniversityBangkok 10700Thailand Research Division Department of Research and DevelopmentFaculty of Medicine Siriraj HospitalMahidol UniversityBangkok 10700Thailand Siriraj Center of Research Excellence for Molecular Medicine Faculty of Medicine Siriraj HospitalMahidol UniversityBangkok 10700Thailand

BACKGROUND Maturity-onset diabetes of the young(MODY)is the most common form of monogenic *** disease is transmitted in autosomal dominant mode and diabetes is usually diagnosed before age 25 *** 3 is caused by mutation of hepatocyte nuclear factor(HNF)1A genes and is the most common MODY *** of MODY 3 is crucial since glycemic control can be accomplished by very low dose of *** this report we described a Thai MODY 3 patient who had excellence plasma glucose control by treating with glicazide 20 mg per day and insulin therapy can be *** SUMMARY A 31-year-old woman was diagnosed diabetes mellitus at 14 years *** disease was transmitted from her grandmother and mother compatible with autosomal dominant *** sequencing of proband’s DNA identified mutation of HNF1A at codon 203 which changed amino acid from arginine to cysteine(R203C).This mutation was carried only by family members who have *** patient has been treated effectively with a combination of oral hypoglycemic agents and must include a very low dose of glicazide(20 mg/d).Insulin therapy was successfully *** We demonstrated a first case of pharmacogenetics in Thai MODY 3 *** findings underscore the essential role of molecular genetics in diagnosis and guidance of appropriate treatment of diabetes mellitus in particular patient.

关键词： Oral sulfonylureas Maturity-onset diabetes of the young HNF1A Case report

Catalytic Asymmetric Cyclopropanation using a New Chiral β-Diketone Cu (Ⅱ) Complex as a Catalyst

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Chinese Chemical Letters 1998年第7期9卷 607-608页

作者： Yu XU Zhong Yi WANG and Tian pa YOU(Department of Chemistry, University of Science and Technology of China, Hefei 230026) Department of Chemistry Univ. of Sci./Technology of China Hefei 230026 China

A new chiral β-diketone Cu (Ⅱ) catalyst was synthesized and used for the asymmetric cyclopropanation of styrene with diazoester. A high optical yield (~90%) was achieved. The effect of the structure of substrate on the enantioselectivity was studied. Both chendcal yield and optical yield being reduced when the steric bulky substrate was employed. The reaction mechanism and the chiral model of the transition state are under fufther investigation.

关键词： Asymmetric cyclopropanation β-Diketone Cu (Ⅱ) Complex

Hepatitis A vaccine associated with autoimmune hepatitis

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World Journal of Gastroenterology 2007年第15期13卷 2238-2239页

作者： pa Berry G Smith-Laing Medway Maritime Hospital Windmill Road GillinghamKentUnited Kingdom

To describe a case of probable relapsing autoimmune hepatitis associated with vaccination against hepatitis A virus （HAV）. A case report and review of literature were written concerning autoimmune hepatitis in association with hepatitis A and other hepatotropic viruses. Soon a^er the administration of formalin-inactivated hepatitis A vaccine, a man who had recently recovered from an uncharacterized but self-limiting hepatitic illness, experienced a severe deterioration （AST 1687 U/L, INR 1.4）. Anti-nuclear antibodies were detectable, and liver biopsy was compatible with autoimmune hepatitis. The observation supports the role of HAV as a trigger of autoimmune hepatitis. Studies in helper T-cell activity and antibody expression against hepatic proteins in the context of hepatitis A infection are summarized, and the concept of molecular mimicry with regard to other forms of viral hepatitis and autoimmunity is briefly explored.

关键词： Hepatitis A virus Vaccine Autoimmune hepatitis Helper T-cell Molecular mimicry

Asymmetric Cyclopropanation Catalyzed by a Copper-(Schiff-base) Complex with Double Chiral Centers

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Chemical Research in Chinese Universities 2003年第2期19卷 238-239页

作者： JIANG Chang sheng LI You gui JIANG Chen WEN Ji wu YOU Tian pa Department of Chemistry Universtity of Science&Technology of ChinaHefei 230026 P.R.China

The catalytic asymmetric Cyclopropanation of olefins with diazoacetate estershas been one of the most important methodologies for the formation of chiral cyclopropanecompounds. The design and the synthesis of an efficient catalyst are a challenging task for organicchemists. The catalysts containing various metals and optically active ligands have been employedfor the reaction. The copper-(Schiff-base) complex was reported by Nazoki et al., which exploitedthe area of catalytic asymmetric reaction though the degree of enantios-election was low. Nearly 10years later extensive systematic screening of salicylaldimine ligands by Aratani and his coworkersbrought about design changes in the copper-(Schiff-base) complex that gave dramatic improvements onoptical yields for the selected intermolecular Cyclopropanation reactions.

关键词： Asymmetric cyclopropanation Catalysis Copper-(Schiff-base)

Cardiovascular rehabilitation in patients aged 70-year-old or older:benefits on functional capacity,physical activity and metabolic profile in younger *** patients

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Journal of Geriatric Cardiology 2020年第9期17卷 544-553页

作者： Marta Fontes-Oliveira Maria Trêpa patrícia Rodrigues Preza Fernandes Sandra Magalhães Sofia Cabral Mário Santos Severo Torres Cardiology Department University Hospital Centre of PortoPortoPortugal Cardiac Rehabilitation Unit Cardiology DepartmentUniversity Hospital Centre of PortoPortoPortugal Pulmonary Vascular Disease Unit University Hospital Centre of PortoPortoPortugal

Background The benefits of exercise-based cardiac rehabilitation(EBCR)programs in post-acute myocardial infarction(AMI)patients have been *** aim was to assess the impact of EBCR in³70-years-old *** post-AMI *** We retrospectively evaluated patients who underwent a supervised EBCR protocol,twice a week during 6-12 *** evaluated changes in several outcomes based on pre-and post-CRP *** Of a total of 1607 patients,333(21%)were³*** the EBCR,an overall improvement on functional capacity,daily physical activity,lipid profile,body mass index,glycated hemoglobin(HbA1c),N-terminal pro-brain natriuretic peptide(NT-pro-BNP)and C-reactive protein was observed in both younger and older patients(Ppatients showed a smaller benefit on the increment of daily physical activity and lipid profile improvement,but a larger reduction in *** the multivariate analysis,only improvements on daily physical activity and HbA1c were dependent on *** As their younger counterparts,older patients,significantly improved functional capacity,metabolic parameters and level of daily physical activity after EBCR.

关键词： Aging Cardiovascular prevention Exercise-based cardiac rehabilitation