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Oncometabolite modification of Keap1 links GSTZ1 deficiency with cancer

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Genes & Diseases 2019年第4期6卷 333-334页

作者： Weijie Guo Binhua p.zhou Department of Biochemistry Markey Cancer CenterUniversity of Kentucky College of MedicineLexingtonKY40536USA

Metabolic abnormalities are emerging as an active driver to the development,progression and metastasis of various *** the recent issue of the EMBO Journal,Yang and colleagues identified that succinylacetone(SA)could act as an oncometabolite and that accumulation of SA activates the NRF2/IGF1R axis in hepatocellular carcinoma(HCC)*** discoveries not only yield great insights in the understanding of tumor biology,but also hold significant clinical ramifications,as these findings may pave a new way for the early diagnosis and treatment of HCC.

关键词： IGF1R diagnosis metastasis

Total factor carbon emission performance: A Malmquist index analysis

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Total factor carbon emission performance: A Malmquist index ...

国家自然科学基金委员会管理科学部宏观管理与政策学科青年基金获得者交流研讨会

作者： p.zhou B.W.Ang J.Y.Han College of Economics and Management Nanjing University of Aeronautics and Astronautics Department of Industrial and Systems Engineering National University of Singapore

This paper introduces a Malmquist CO2 emission performance index(MCpI) for measuring changes in total factor carbon emission performance over time. The MCpI is derived by solving several data envelopment analysis models. Bootstrapping MCpI is proposed to perform statistical inferences on the MCpI results. Using the index the emission performance of the world’s 18 top CO2 emitters from 1997 to2004 is studied. The results obtained show that the total factor carbon emission performance of the countries as a whole improved by 24% over the period and this was mainly driven by technological progress. The results of a cross-country regression analysis to investigate the determinants of the resulting MCpI are presented.

关键词： Carbon dioxide emissions Malmquist index Data envelopment analysis Total factor productivity Bootstrap

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可持续的移动性:东南非运输业的前景

生态毒理学报 2001年第4期23卷 42-46页

作者： peter p.zhou EECG Consultants pty Ltd Energy EnvironmentComputer and Geophysical ApplicationsPO BOX 402339GaboroneBotswana

研究了旨在东非和南非能够发生改善的许多举措.能够在这些国家明显地改善能源效率、减少温室气体的排放.从本地区缺乏资金来源的角度看,给需要的措施提供资金帮助仍然是个问题.

关键词：可持续移动性东南非资金来源温室气体能源效率排放国家东非地区措施

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Aldh2 deficiency plays a dual role in lung tumorigenesis and tumor progression

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Genes & Diseases 2024年第3期11卷 144-147页

作者： Hongjia Zhang Xueqian Sun Zhanming Li Tingting Liu Fang Zhang Xinyu Meng Kaimi Li Jianhua Xu Wei He Bo Jing Tong Wang Na Ni Beibei Sun Feng Yao Yadi Wu Qi Wang Jing Du Eugene Y.Chin Binhua p.zhou ping Jiang Lishun Wang Jiong Deng Key Laboratory of Cell Differentiation and Apoptosis of Chinese Minister of Education Department of PathophysiologyShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Key Laboratory for Tumor Microenvironment and Inflammation Shanghai Jiao Tong University School of MedicineShanghai200025China Department of pathology Kunming Medical UniversityKunmingYunnan 650500China Medical Research Center Binzhou Medical University HospitalBinzhouShandong 256600China Center for Traditional Chinese Medicine and Gut Microbiota Minhang HospitalFudan UniversityShanghai 201100China Department of Radiation Oncology Yantai Affiliated Hospital of Binzhou Medical UniversityYantaiShandong 264100China Department of pathology Molecular Pathology Research CenterPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Laboratory Medicine Shanghai Pulmonary Hospital Affiliated Tongji UniversityShanghai 200080China Department of physiology School of Basic Medical SciencesWeifang Medical UniversityWeifangShandong 261021China Department of Thoracic Surgery Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China Department of Molecular and Celular Biochemistry Markey Cancer CenterUniversity of Kentucky College of MedicineLexingtonKY40506USA Department of Respiratory Medicine The Second Affiliated HospitalDalian Medical UniversityDalianLiaoning116023China peninsular Cancer Center Binzhou Medical UniversityYantaiShandong 264003China

Alcohol consumption contributes to global mortality and cancer ***(ACE),the oxidized metabolite of alcohol,is highly reactive towards DNA,resulting in DNA *** can be detoxified to acetate by acetaldehyde dehydrogenase... 详细信息

关键词： mortality damage ALDH2

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炎症--加速癌症转移的驱动力

中国肺癌杂志 2009年第11期12卷 1194-1201页

作者： Yadi WU Binhua p.zhou 丁燕(翻译) 南娟(翻译) 刘谦(校对) Departments of Molecular and Biomedical pharmacology University of Kentucky School of MedicineLexingtonKY USA Molecular and Cellular Biochemistry University of Kentucky School of MedicineLexingtonKY USA Markey Cancer Center University of Kentucky School of MedicineLexingtonKY USA 天津医科大学总医院天津市肺癌研究所天津市肺癌转移与肿瘤微环境重点实验室

肿瘤微环境在癌变中发挥重要作用,这一点已经得到越来越多的共识。炎症组分存在并有助于肿瘤增殖、血管生成、转移以及对激素和化疗的抵抗。本文聚焦炎症在肿瘤转移中的作用。我们关注促炎因子特别是细胞因子在肿瘤转移中的作用。了解... 详细信息

肿瘤微环境在癌变中发挥重要作用,这一点已经得到越来越多的共识。炎症组分存在并有助于肿瘤增殖、血管生成、转移以及对激素和化疗的抵抗。本文聚焦炎症在肿瘤转移中的作用。我们关注促炎因子特别是细胞因子在肿瘤转移中的作用。了解炎症促进肿瘤转移的机制将为癌症治疗带来创新性的突破。

关键词：炎症上皮-间质转化转移

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Electronic properties and elastic instability of ZnS under pressure

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Electronic properties and elastic instability of ZnS under p...

LHAASO detection of very-high-energy γ-ray emission surrounding pSR J0248+6021

中国化学会第十五届全国化学热力学和热分析学术会议

作者： H.Y.Wu~(a*),X.F.Su~b,p.zhou~a a College of Science,Chongqing Jiaotong University,Chongqing 400074,China b School of Science,Beijing University of Civil Engineering and Architecture,Beijing 100044,China

＜正＞The electronic properties and elastic instability with the zinc-blende（B3） and rocksalt（B1） structures of ZnS under pressure have been investigated using pseudopotential and plane wave basis based on the den... 详细信息

关键词： Semiconductor ZnS Electronic properties Elastic instability High pressure

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Science China(physics,Mechanics & Astronomy) 2025年

作者： Zhen Cao F.Aharonian Axikegu Y.X.Bai Y.W.Bao D.Bastieri X.J.Bi Y.J.Bi W.Bian A.V.Bukevich Q.Cao W.Y.Cao Zhe Cao J.Chang J.F.Chang A.M.Chen E.S.Chen H.X.Chen Liang Chen Lin Chen Long Chen M.J.Chen M.L.Chen Q.H.Chen S.Chen S.H.Chen S.Z.Chen T.L.Chen Y.Chen N.Cheng Y.D.Cheng M.C.Chu M.Y.Cui S.W.Cui X.H.Cui Y.D.Cui B.Z.Dai H.L.Dai Z.G.Dai Danzengluobu X.Q.Dong K.K.Duan J.H.Fan Y.Z.Fan J.Fang J.H.Fang K.Fang C.F.Feng H.Feng L.Feng S.H.Feng X.T.Feng Y.Feng Y.L.Feng S.Gabici B.Gao C.D.Gao Q.Gao W.Gao W.K.Gao M.M.Ge T.T.Ge L.S.Geng G.Giacinti G.H.Gong Q.B.Gou M.H.Gu F.L.Guo J.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han O.A.Hannuksela M.Hasan H.H.He H.N.He J.Y.He Y.He Y.K.Hor B.W.Hou C.Hou X.Hou H.B.Hu Q.Hu S.C.Hu C.Huang D.H.Huang T.Q.Huang W.J.Huang X.T.Huang X.Y.Huang Y.Huang Y.Y.Huang X.L.Ji H.Y.Jia K.Jia H.B.Jiang K.Jiang X.W.Jiang Z.J.Jiang M.Jin M.M.Kang I.Karpikov D.Khangulyan D.Kuleshov K.Kurinov B.B.Li C.M.Li Cheng Li Cong Li D.Li F.Li H.B.Li H.C.Li Jian Li Jie Li K.Li S.D.Li W.L.Li W.L.Li X.R.Li Xin Li Y.Z.Li Zhe Li Zhuo Li E.W.Liang Y.F.Liang S.J.Lin B.Liu C.Liu D.Liu D.B.Liu H.Liu H.D.Liu J.Liu J.L.Liu M.Y.Liu R.Y.Liu S.M.Liu W.Liu Y.Liu Y.N.Liu Q.Luo Y.Luo H.K.Lv B.Q.Ma L.L.Ma X.H.Ma J.R.Mao Z.Min W.Mitthumsiri H.J.Mu Y.C.Nan A.Neronov K.C.Y.Ng L.J.Ou p.pattarakijwanich Z.Y.pei J.C.Qi M.Y.Qi B.Q.Qiao J.J.Qin A.Raza D.Ruffolo A.Sáiz M.Saeed D.Semikoz L.Shao O.Shchegolev X.D.Sheng F.W.Shu H.C.Song Yu.V.Stenkin V.Stepanov Y.Su D.X.Sun Q.N.Sun X.N.Sun Z.B.Sun J.Takata p.H.T.Tam Q.W.Tang R.Tang Z.B.Tang W.W.Tian L.H.Wan C.Wang C.B.Wang G.W.Wang H.G.Wang H.H.Wang J.C.Wang Kai Wang Kai Wang L.p.Wang L.Y.Wang p.H.Wang R.Wang W.Wang X.G.Wang X.Y.Wang Y.Wang Y.D.Wang Y.J.Wang Z.H.Wang Z.X.Wang Zhen Wang Zheng Wang D.M.Wei J.J.Wei Y.J.Wei T.Wen C.Y.Wu H.R.Wu Q.W.Wu S.Wu X.F.Wu Y.S.Wu S.Q.Xi J.Xia G.M.Xiang D.X.Xiao G.Xiao Y.L.Xin Y.Xing D.R.Xiong Z.Xiong D.L.Xu R.F.Xu R.X.Xu W.L.Xu L.Xue D.H.Yan J.Z.Yan T.Yan C.W.Yang C.Y.Yang F.Yang F.F.Yang L.L.Yang M.J.Yang R.Z.Yang W.X.Yang Y.H.Yao Z.G.Yao L.Q.Yin N.Yin X.H.You Z.Y.You Y.H Southwest Jiaotong University School of Astronomy and Space Science Nanjing University Center for Astrophysics Guangzhou University Tsung-Dao Lee Institute & School of physics and Astronomy Shanghai Jiao Tong University Institute for Nuclear Research of Russian Academy of Sciences Hebei Normal University University of Science and Technology of China LHAASO Collaboration State Key Laboratory of particle Detection and Electronics Key Laboratory of Dark Matter and Space Astronomy & Key Laboratory of Radio Astronomy purple Mountain Observatory Chinese Academy of Sciences Research Center for Astronomical Computing Zhejiang Laboratory Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical Observatory Chinese Academy of Sciences School of physics and Astronomy Key Laboratory of particle Astrophysics & Experimental physics Division & Computing Center Yunnan University Key Laboratory of Cosmic Rays (Tibet University) Ministry of Education Department of physics The Chinese University of Hong Kong Key Laboratory of Radio Astronomy and Technology National Astronomical Observatories Chinese Academy of Sciences School of physics and Astronomy (Zhuhai) & School of physics (Guangzhou) & Sino-French Institute of Nuclear Engineering and Technology (Zhuhai) Sun Yat-sen University Institute of High Energy physics Institute of Frontier and Interdisciplinary Science Shandong University ApC Université paris Cité CNRS/IN2p3 CEA/IRFU Observatoire de paris Department of Engineering physics & Department of Astronomy Tsinghua University School of physics and Microelectronics Chinese Academy of Sciences Zhengzhou University Yunnan Observatories Chinese Academy of Sciences China Center of Advanced Science and Technology College of physics Sichuan University School of physics peking University Guangxi Key Laboratory for Relativistic Astrophysics School of physical Science and Technology University of Chinese Academy of Sciences Guangxi University Department of physics Faculty of Science Mahidol University Moscow Institute

We report the detection of an extended very-high-energy(VHE) γ-ray source coincident with the location of middle-aged(62.4 kyr) pulsar pSR J0248+6021, by using the LHAASO-WCDA data of live 796 d and LHAASO-KM2A data of live 1216d. A significant excess of γ-ray induced showers is observed both by WCDA in energy bands of 1-25 Te V and KM2A in energy bands of >25 TeV with 7.3σ and 13.5σ, respectively. The best-fit position derived through WCDA data is R.A. = 42.06°± 0.12°and Dec. = 60.24°± 0.13°with an extension of 0.69°±0.15°and that of the KM2A data is R.A.= 42.29°± 0.13°and Dec. =60.38°± 0.07°with an extension of 0.37°±0.07°. No clear extended multiwavelength counterpart of this LHAASO source has been found from the radio band to the GeV band. The most plausible explanation of the VHE γ-ray emission is the inverse Compton process of highly relativistic electrons and positrons injected by the pulsar. These electrons/positrons are hypothesized to be either confined within the pulsar wind nebula or to have already escaped into the interstellar medium, forming a pulsar halo.

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Deep view of composite SNR CTA1 with LHAASO in γ-rays up to 300 TeV

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Science China(physics,Mechanics & Astronomy) 2025年

The ultra-high-energy（UHE） gamma-ray source 1LHAASO J0007+7303u is positionally associated with the composite SNR CTA1 that is located at high Galactic Latitude b ≈ 10.5°. This provides a rare opportunity to spatially resolve the component of the pulsar wind nebula（pWN） and supernova remnant（SNR） at UHE. This paper conducted a dedicated data analysis of 1LHAASO J0007+7303u using the data collected from December 2019 to July 2023. This source is well detected with significances of 21σ and 17σ at 8-100 TeV and >100 TeV, respectively. The corresponding extensions are determined to be 0.23°±0.03°and 0.17°±0.03°. The emission is proposed to originate from the relativistic electrons accelerated within the pWN of pSR J0007+7303. The energy spectrum is well described by a power-law with an exponential cutoff function dN/dE =（42.4 ± 4.1）(E/（20 TeV）)-2.31±0.11exp(-E/（110±25 TeV）) TeV-1cm-2s-1in the energy range from 8 to 300 TeV, implying a steady-state parent electron spectrum dNe/dEe∝(Ee/（100 TeV）)-3.13±0.16exp[(-Ee/（373±70 TeV）)2] at energies above ≈ 50 TeV. The cutoff energy of the electron spectrum is roughly equal to the expected current maximum energy of particles accelerated at the pWN terminal shock. Combining the X-ray and gamma-ray emission, the current space-averaged magnetic field can be limited to≈ 4.5 μG. To satisfy the multi-wavelength spectrum and the γ-ray extensions, the transport of relativistic particles within the pWN is likely dominated by the advection process under the free-expansion phase assumption.

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Observation of the γ-ray emission from W43 with LHAASO

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Science China(physics,Mechanics & Astronomy) 2025年

In this paper, we report the detection of the very-high-energy (VHE, 100 Ge V100 TeV) γ-ray emissions from the direction of the young star-forming region W43, observed by the Large High Altitude Air Shower Observation (LHAASO). The extended γ-ray source was detected with a significance of～16σby KM2A and～17σby WCDA, respectively. The angular extension of this γ-ray source is about 0.5 degrees, corresponding to a physical size of about 50pc. We discuss the origin of the γ-ray emission and possible cosmic ray acceleration in the W43 region using multi-wavelength data. Our findings suggest that W43 is likely another young star cluster capable of accelerating cosmic rays (CRs) to at least several hundred TeV.

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