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Deep learning identification of novel autophagic protein-protein interactions and experimental validation of beclin 2-Ubiquilin 1 axis in triple-negative breast cancer

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Oncology research 2025年第1期33卷 67-81页

作者： Xiang Li Wenke Jin Lifeng Wu Huan Wang Xin Xie Wei Huang b O Liu State Key Laboratory of Southwestern Chinese Medicine Resources School of Pharmacy and College of Medical Technology Chengdu University of Traditional Chinese Medicine Chengdu 611137 China. Department of biotherapy Cancer Center and State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu 610041 China.

background:Triple-negative breast cancer (TNbC), characterized by its lack of traditional hormone receptors and HER2, presents a significant challenge in oncology due to its poor response to conventional therapies. Autophagy is an important process for maintaining cellular homeostasis, and there are currently autophagy biomarkers that play an effective role in the clinical treatment of tumors. In contrast to targeting protein activity, intervention with protein-protein interaction (ppI) can avoid unrelated crosstalk and regulate the autophagy process with minimal interference pathways.Methods:Here, we employed Naive bayes, Decision Tree, and k-Nearest Neighbors to elucidate the complex ppI network associated with autophagy in TNbC, aiming to uncover novel therapeutic targets. Meanwhile, the candidate proteins interacting with beclin 2 were initially screened in MDA-Mb-231 cells using beclin 2 as bait protein by immunoprecipitation-mass spectrometry assay, and the interaction relationship was verified by molecular docking and CO-Ip experiments after intersection. Colony formation, cellular immunofluorescence, cell scratch and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) tests were used to predict the clinical therapeutic effects of manipulating candidate ppI.Results:by developing three ppI classification models and analyzing over 13,000 datasets, we identified 3733 previously unknown autophagy-related ppIs. Our network analysis revealed the central role of beclin 2 in autophagy regulation, uncovering its interactions with 39 newly identified proteins. Notably, the CO-Ip studies identified the substantial interaction between beclin 2 and Ubiquilin 1, which was anticipated by our model and discovered in immunoprecipitation-mass spectrometry assay results. Subsequently, investigations showed that overexpressing beclin 2 increased Ubiquilin 1, promoted autophagy-dependent cell death, and inhibited proliferation and metastasis in MDA-Mb-231 cells.

关键词： Artificial intelligence (AI) Autophagy beclin 2 protein-protein interactions (ppI) Triple-negative breast cancer (TNbC) Ubiquilin 1

Ultrasound enhanced friction stir welding of aluminum and steel： process and properties of EN AW 6061/DC04-Joints

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Journal of Materials Science & Technology 2018年第1期34卷 163-172页

作者： Marco thoma Guntram Wagner benjamin Straβ bernd Wolter Sigrid benferc Wolfram Furbeth Chair of Composites and Material Compounds Chemnitz University of Technology Chemnitz 09125 Germany Fraunhofer Institute for Nondestructive Testing IZFp Saarbrucken 66123 Germany DECHEMA-Forschungsinstitut Frankfurt am Main 60486 Germany

In this work, the joining of aluminum to steel was conducted by ultrasound enhanced friction stir weld- ing （USE-FSW）. The power ultrasound was introduced into one of the metal sheets by an ultrasonic roll seam module synchronously to the FSW-process. The effect of the ultrasound on the resulting welds, their microstructure and their corrosion properties was investigated by light and scanning electron microscopy and corrosion investigations. The USE-FSW-joints showed less and smaller steel particles in the nugget zone as well as a thinner continuous intermetallic phase of FeAl3 at the interface. The nondestructive testing method of computed laminography proved the observations made by optic microscopy due to non-porous joints for both techniques. Corrosion investigations showed only low corrosion current densities and no enhanced galvanic corrosion for the EN AW-6061/DC04-hybrid joints in sodium chloride solution.

关键词： Friction stir welding Ultrasound enhancement Dissimilar joints Corrosion

perturbative Quantum Chromodynamics α_(s)^(4)-Order Corrections to the Ratio R for τ Decay

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Chinese physics Letters 1998年第10期15卷 711-712页

作者： b.p.Nigam Department of physics&Astronomy Box 871504Arizona State University TempeArizonaUSA 85287-1504

The perturbative quantum chromodynamics correction to the semihadronic decay rate R of the heavy leptonτwas expressed by braaten as an expansion in powers ofαs to orderα*** had found theα_(s)^(4)order correction to be significant and conjectured that theα_(s)^(4)order corrections might also be *** et *** corrected theα_(s)^(4)-order *** have extended the analytic calculations to orderαs4;it involves an unknown constant K3 which occurs inαs4 *** order to estimate the effect ofα_(s)^(4)order correction,we have chosen K3 to range from-1000 to+1000 and we find that the value of R changes by about-11%to+10%,respectively,compared to the value of R=3.5 obtained toα_(s)^(4)-order result.

关键词： correction α dynamics

piling up multidecker pyrgos[n]cages as antibacterial materials

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Science China Materials 2025年第01期 314-316页

作者： Miguel A.Liuzzi-Vaamonde Jackson b.Lancaster Samantha A.Mason Yuanning Feng Department of Chemistry and biochemistry The University of Oklahoma

The development of antibiotics is regarded as one of the most significant scientific advances in modern medicine. before the commercialization of antibiotics, infectious diseases were catastrophic throughout history [1]. penicillin was used to treat serious infections in the 1940s, but unfortunately, with the introduction of antibiotics came the emergence of antibiotic resistance [2,3]. Evolved and adapted methicillin-resistant Staphylococcus aureus (MRSA) strains are presently impacting community and healthcare systems across the globe [4].

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Machine learning applications in healthcare clinical practice and research

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World Journal of Clinical Cases 2025年第1期13卷 16-21页

作者： Nikolaos-Achilleas Arkoudis Stavros p papadakos Research Unit of Radiology and Medical Imaging School of MedicineNational and Kapodistrian University of AthensAthens 11528Greece 2^(nd)Department of Radiology “Attikon”General University HospitalMedical SchoolNational and Kapodistrian University of AthensChaidari 12462Greece Department of Gastroenterology Laiko General HospitalNational and Kapodistrian University of AthensAthens 11527Greece

Machine learning(ML)is a type of artificial intelligence that assists computers in the acquisition of knowledge through data analysis,thus creating machines that can complete tasks otherwise requiring human *** its various applications,it has proven groundbreaking in healthcare as well,both in clinical practice and *** this editorial,we succinctly introduce ML applications and present a study,featured in the latest issue of the World Journal of Clinical *** authors of this study conducted an analysis using both multiple linear regression(MLR)and ML methods to investigate the significant factors that may impact the estimated glomerular filtration rate in healthy women with and without non-alcoholic fatty liver disease(NAFLD).Their results implicated age as the most important determining factor in both groups,followed by lactic dehydrogenase,uric acid,forced expiratory volume in one second,and *** addition,for the NAFLD-group,the 5th and 6th most important impact factors were thyroid-stimulating hormone and systolic blood pressure,as compared to plasma calcium and body fat for the NAFLD+***,the study's distinctive contribution lies in its adoption of ML methodologies,showcasing their superiority over traditional statistical approaches(herein MLR),thereby highlighting the potential of ML to represent an invaluable advanced adjunct tool in clinical practice and research.

关键词： Machine Learning Artificial Intelligence Clinical practice Research Glomerular filtration rate Non-alcoholic fatty liver disease Medicine

Rockburst management in Canadian hard rock mines

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第5期11卷 1036-1043页

作者： b.p.Simser Glencore’s Sudbury Integrated Nickel Operations

Rockburst is a complex mining-induced phenomenon that remains difficult to be *** particular,geological conditions contributing to rockbursts are more variable than those in many conventional engineering ***,intact rock properties,and other rock mass conditions vary,sometimes,within small *** levels that store energy or drive structures can change with geological *** example,faults may channel stress between the void and the discontinuity,and/or alter the local stress ***-strength rock masses may be very massive at shallow depth,allowing for large/stable *** same rock type may store excessive strain energy at depth or high mineral extraction,and lead to *** robust ground support systems that can bear dynamic loading are now commonplace in mining industry.A typical approach would be able to evaluate rockburst potential,and selectively deploy more robust ground support *** resistant support is more expensive in installation than most support systems designed for gravity ***,an excessively conservative risk assessment can affect both direct support costs and *** mines continue to go deeper,selective use of burst-prone support may not be an optimal choice,and pervasive installation may become *** implies a need to maintain a reasonable installation speed,and the time to get to deep orebodies is a major economic *** paper shows field examples of rockbursts to highlight some of the complex issues related to the rockburst.A multi-tiered risk mitigation approach is used for rockburst *** of risk reduction strategies are given and some examples from a deep hard rock mine are used to illustrate the relative success of the *** that some residual risks to worker safety remain,discussion is presented on where more research or process improvements would be beneficial.

关键词： Rockburst Dynamic support Seismic monitoring

Evolution of the paleogene succession of the western Himalayan foreland basin

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Geoscience Frontiers 2013年第2期4卷 199-212页

作者： b.p.Singh CAS in Geology.banaras Hindu University

The paleogene succession of the Himalayan foreland basin is immensely important as it preserves evidence of India-Asia collision and related records of the Himalayan *** this paper,the depositional regime of the paleogene succession of the Himalayan foreland basin and variations in composition of the hinterland at different stages of the basin developments are *** paleogene succession of the western Himalayan foreland basin developed in two stages,*** stage and post-collisional *** the onset,chert breccia containing fragments derived from the hanging walls of faults and reworked bauxite developed as a result of erosion of the forebulge. The overlying early Eocene succession possibly deposited in a coastal system,where carbonates represent barriers and shales represent ***-section,the middle Eocene marl beds likely deposited on a tidal *** late Eocene/Oligocene basal Murree beds,containing tidal bundles,indicate that a mixed or semi-diurnal tidal system deposited the sediments and the sedimentation took place in a tidedominated *** the higher-up,the succession likely deposited in a river-dominated estuary or in meandering *** the beginning of the basin evolution,the sediments were derived from the precambrian basement or from the metasediments/volcanic rocks possessing terrains of the *** early and middle Eocene（54.7-41.3 Ma） succession of the embryonic foreland possibly developed from the sediments derived from the Trans-Himalayan schists and phyllites and Indus ophiolite of the north during syn-collisional *** detrital minerals especially the lithic fragments and the heavy minerals suggest the provenance for the late Eocene/Oligocene sequences to be from the recycled orogenic belt of the Higher Himalaya,Tethyan Himalaya and the Indus-suture zone from the north during post-collisional *** is also supported by the paleocurrent measurements those suggest main flows directed towards sou

关键词： Facies architecture provenance basin evolution paleogene Himalayan foreland Tectonics

Contrasting REE Signatures on Manganese Ores of Iron Ore Group in North Orissa, India

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Journal of Rare Earths 2007年第6期25卷 749-758页

作者： p.p.Mishra b.K.Mohapatra p.p.Singh Institute of Minerals and Materials Technology Bhubaneswar 751013 India post Graduate Department of Geology Utkal University Bhubaneswar 751004 India

The distribution pattern of Rare Earth Elements （REE） in three categories of manganese ores viz. stratiform, stratabound-replacement, and detrital of precambrian Iron Ore Group from north Orissa, India was reported. These categories of Mn-ore differed in their major and trace chemistry and exhibited contrasting REE signature. The stratiform ores were relatively enriched in ∑REE content （697 μg·g^-1） and their normalized pattern showed both positive Ce and Eu anomalies, whereas the stratabound-replacement types were comparatively depleted in ∑REE content （211 μg·g^-1） and showed negative Ce and flat Eu signatures. The detrital categories showed mixed REE pattern. The data plotted in different discrimination diagrams revealed a mixed volcaniclastic and chemogenic source of material for stratiform categories, and LREE （Light Rare Earth Elements） and HREE （Heavy Rare Earth Elements） are contributed by such sources, respectively. In contrast, the stratabound ore bodies were developed during the remobilization of stratiform ores, and associated Mncontaining rocks under supergene condition followed by the redeposition of circulating mineralized colloidal solutions in structurally favorable zones. During this process, some of the constituents were found only in very low concentration within stratabound ores, and this is attributed to their poor leachability/mobility. The detrital ores did not exhibit any significant characteristic in respect of REE as their development was via a complex combination of processes involving weathering, fragmentation, recementation, and burial under soil cover.

关键词： manganese ore REE normalization geochemistry bonai-Keonjhar belt Orissa rare earths

Corrosion Inhibition of Leucaena Leucocephala pod on Mild Steel in Sulphuric Acid Solution

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Acta Metallurgica Sinica(English Letters) 2013年第4期26卷 416-424页

作者： p.Muthukrishnan b.Jeyaprabha p.prakash Department of Chemistry Thiagarajar College Department of Civil Engineering Fatima Michael College of Engineering & Technology

The corrosion of the mild steel in i mol/L H2SO4 was investigated using Leucaena leucocephala pod extract （LLpE） as corrosion inhibitor by weight loss and electrochemical techniques. Inhibition efficiency of 95% was achieved with 500×10^-6 of LLpE at 308 K. The polarization studies showed that LLpE acted as mixed type inhibitor. The adsorption of the studied inhibitor on mild steel obeyed Langmuir adsorption isotherm. protective film formation against acid attack was confirmed by FT-IR, XRD and SEM techniques.

关键词： Mild steel polarization SEM Acid corrosion XRD