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A validated stability-indicating LC method for the separation of enantiomer and potential impurities of Linezolid using polar organic mode

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Journal of pharmaceutical Analysis 2012年第4期2卷 272-278页

作者： T.Satyanarayana Raju O.Vishweshwari Kutty V.Ganesh p.Yadagiri Swamy Dr.reddy's Laboratories Ltd.Active pharmaceutical Ingredients IPDOBachupallyHyderabad 500072A.PIndia Department of Chemistry University College of EngineeringOsmania University

Although a number of methods are available for evaluating Linezolid and its possible impurities, a common method for separation if its potential impurities, degradants and enantiomer in a single method with good efficiency remain unavailable. With the objective of developing an advanced method with shorter runtimes, a simple, precise, accurate stability-indicating LC method was developed for the determination of purity of Linezolid drug substance and drug products in bulk samples and pharmaceutical dosage forms in the presence of its impurities and degradation products. This method is capable of separating all the related substances of Linezolid along with the chiral impurity. This method can also be used for the estimation of assay of Linezolid in drug substance as well as in drug product. The method was developed using Chiralpak IA (250 mm 4.6 mm, 5 mm) column. A mixture of acetonitrile, ethanol, n-butyl amine and trifluoro acetic acid in 96:4:0.10:0.16 (v/v/v/v) ratio was used as a mobile phase. The eluted compounds were monitored at 254 nm. Linezolid was subjected to the stress conditions of oxidative, acid, base, hydrolytic, thermal and photolytic degradation. The degradation products were well resolved from main peak and its impurities, proving the stability-indicating power of the method. The developed method was validated as per International Conference on Harmonization (ICH) guidelines with respect to specificity, limit of detection, limit of quantification, precision, linearity, accuracy, robustness and system suitability.

关键词： HpLC Linezolid Validation polar organic mode Stability-indicating

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Different Susceptibility in the Two Sympatric Sweet potato Weevils, Cylas formicarius and Euscepes postfasciatus , to the Entomopathogenic Fungus Metarhizium anisopliae

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Agricultural Sciences（农业科学） 2023年第9期

作者： Gadi V. p. reddy Susumu Shimizu Katsuya Ichinose USDA-ARS-Southern Insect Management Research Unit Stoneville USA

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微微照射对大豆种子组织超微结构和固有菌的影响

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国外作物育种 2001年第3期20卷 100-100页

作者： p·reddy D·J·Mycock

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亚理想水平的钙和非植酸磷日粮中添加高水平维生素D_3对肉鸡生产性能的影响

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饲料与畜牧（新饲料） 2008年第4期 60-60页

作者： S.V.rama Rao M.V.L.N.Raju M.R.reddy 李亚君(译) 刘泉雨(校)

本试验研究了在亚理想水平的钙和非植酸磷日粮中添加高水平维生素D3对雌性肉鸡的生产性能、骨骼中矿物质含量、矿物质排泄和沉积的影响。此研究采用2×2因子设计，使用了4种含有不同钙（5g／kg、6g／kg）和非植酸磷（2．5g／kg、3g／kg... 详细信息

本试验研究了在亚理想水平的钙和非植酸磷日粮中添加高水平维生素D3对雌性肉鸡的生产性能、骨骼中矿物质含量、矿物质排泄和沉积的影响。此研究采用2×2因子设计，使用了4种含有不同钙（5g／kg、6g／kg）和非植酸磷（2．5g／kg、3g／kg）含量的玉米-豆粕型基础日粮。这4种日粮中分别添加了200、1200、2400和3600ICU／Kg的维生素D30560只雌性肉鸡随机分配到112个装有不锈钢地板的育雏笼中。每个处理有7个重复，肉鸡从2～42日龄自由采食日粮。

关键词：肉鸡生产性能基础日粮非植酸磷高水理想维生素D3 矿物质含量钙

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印度的柑桔线虫

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贵州农业科学 1982年第3期 77-77页

作者： reddy p.p.dSingh D.B. ,邓乃朋

柑桔栽培面积105,396公顷,年产1,211,869吨。在印度以桔Mandgrin orange占重要地位,占总栽培面积的41.2％,柑桔总产的39.9％。次为来姆(Lime),为26.9与28、93％,及甜橙(Sweet orange)23.2与22.95％。柠檬、萄葡柚…等属次要位置,仅占8.0... 详细信息

柑桔栽培面积105,396公顷,年产1,211,869吨。在印度以桔Mandgrin orange占重要地位,占总栽培面积的41.2％,柑桔总产的39.9％。次为来姆(Lime),为26.9与28、93％,及甜橙(Sweet orange)23.2与22.95％。柠檬、萄葡柚…等属次要位置,仅占8.07与9.03％。在全印度,线虫是柑桔生产的限制因子。在柑桔根部发现Meloidogyne sp,是首次认识到根与线虫的关系,这是在1956年。

关键词：柑桔树线虫蠕虫甜橙印度南亚

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Treatment-plan Comparison of Three Advanced Radiation Treatment Modalities for Fractionated Stereotactic Radiotherapy to the Head and Neck

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International Journal of Medical physics, Clinical Engineering and Radiation Oncology 2019年第2期8卷 106-120页

作者： He Wang James N. Yang Xiaodong Zhang Jing Li Steven J. Frank Zhongxiang Zhao Dershan Luo Xiaorong Zhu Congjun Wang Samuel Tung Adam S. Garden David I. Rosenthal Clifton David Fuller Gary Brandon Gunn Amol J. Ghia Jay p. reddy Shaan M. Raza Franco De Monte Mark S. Chambers paul D. Brown Shirley Su Jack phan Department of Radiation physics The University of Texas MD Anderson Cancer Center Houston TX USA Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston TX USA Department of Neurosurgery The University of Texas MD Anderson Cancer Center Houston TX USA Department of Oncologic Dentistry prosthodontics Thoracic/Head &Neck Surgery The University of Texas MD Anderson Cancer Center Houston TX USA Department of Radiation Oncology The Mayo Clinic Rochester MN USA

purpose: Fractionated stereotactic radiosurgery (FSRS) can be given with at least three modalities: Gamma Knife, with the noninvasive frameless extend system (GKE);linear accelerator-based volumetric modulated arc therapy (VMAT);and intensity-modulated proton therapy (IMpT). We extracted treatment plans for patients who had received FSRS with GKE for recurrent skull base or intracranial tumors, created corresponding plans for VMAT and IMpT, and compared the quality of the three sets of plans. Methods and materials: plans were extracted for 9 patients with recurrent malignant skull-base tumors (n = 6) or large intracranial tumors (n = 3) who had received FSRS with GKE (median dose 24 Gy in 3 fractions) in 2013 through 2015. plans for VMAT were generated with a TrueBeam STx LINAC machine using 6-MV photons, and plans for IMpT were generated with multi-field optimization. The optimized VMAT and IMpT plans were normalized to achieve the best possible target coverage while meeting the same dose-volume constraints on organs at risk (OARs) as the GKE plans. plans were evaluated on the basis of target coverage, conformity index, homogeneity index, gradient index, and treatment efficiency. Results: The median target volume was 10.2 cm3 (range 1.9 - 33.8 cm3). The VMAT and IMpT plans met all OAR constraints, and target coverage and conformity were comparable among all plans. VMAT and IMpT plans showed significantly better target uniformity and treatment delivery efficiency (p p Conclusion: FSRS for skull base and large intracranial lesions delivered by VMAT and IMpT can achieve comparable target coverage, conformity, and sparing of critical structure as the GKE while providing superior target uniformity and treatment delivery efficiency. The GKE had superior high-dose gradients outside the target and thus better protected surrounding normal structures.

关键词： Gamma Knife Extend System Stereotactic Radiosurgery Volumetric Modulated Arc Therapy Intensity-Modulated proton Therapy Spot Scanning proton Therapy

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preparation and optimization of various parameters of enteric coated pellets using the Taguchi L9 orthogonal array design and their characterization

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Acta pharmaceutica Sinica B 2011年第1期1卷 56-63页

作者： D.Shravani p.K.Lakshmi J.Balasubramaniam Department of pharmaceutics G.Pulla Reddy College of PharmacyHyderabad 500028Andhra PradeshIndia Formulation Research and Development CentreRA Chem Pharma LimitedHyderabad 500076Andhra

Duloxetine hydrochloride enteric coated pellets were formulated using fluidized *** separate layers,the drug layer,the barrier layer,and the enteric layer,were coated onto the inert core *** pellets were optimized with the acid resistance and drug release in simulated intestinal fluid as the process parameters,using the Taguchi L9 orthogonal *** other properties,such as surface morphology,bulk and tapped density,Hausner’s ratio,hardness,friability,yield of pellets,moisture content,and particle size distribution,were also studied in the optimized *** concentration of the enteric polymer played a vital role in acid resistance,while the type of enteric polymer affected the drug release in simulated intestinal *** both cases,it was determined that binder polymer concentration was not affected *** comparisons between the optimized pellets and a market formulation yielded f1 and f2 values within a range of 4–5 and 60–65,*** month stability studies,conducted at accelerated conditions,showed the optimized pellets to be *** plays an important role in optimizing parameters,and optimization of duloxetine hydrochloride can be achieved with minimal trials.

关键词： Duloxetine pellet Enteric polymer Barrier layer Taguchi L9 orthogonal array

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GC-MS analysis of Cocus nucifera flower extract and its effects on heterogeneous symptoms of polycystic ovarian disease in female Wistar rats

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Chinese Journal of Natural Medicines 2014年第9期12卷 677-684页

作者： V.Soumya Y.Indira Muzib p.Venkatesh K.Hariprasath Department of pharmaceutical Technology Sri Padmavathi Mahila Viswavidyalayam Tirupathi- 517502 Andhra Pradesh India Department of pharmaceutical Chemistry Sir C.R.Reddy College of Pharmaceutical Sciences

AIM: To evaluate the effect of Cocus nucifera L. flowers in reducing the major multiple symptoms of letrozole-induced polycystic ovarian disease(pCOD) in female rats. METHOD: Female, virgin Wistar rats were treated with letrozole(1 mg/kg body wt) to induce pCOD, and after 21 days of induction rats were administered orally with 100 and 200 mg·kg-1 of Cocus nucifera flower aqueous extract, respectively. Estrus cycle and blood sugar were monitored once a week throughout the study. After scarification, various biochemical parameters, such as antioxidant status(superoxide dismutase(SOD) and glutathione reductase(GSH)) of the uterus homogenate, lipid profile(total cholesterol(TC), high density lipoprotein(HDL), low density lipoprotein(LDL), and triglycerides(TG)) of the serum were determined. Weights of the uterus and ovaries were separately monitored. The characteristics of changes in the ovary were evaluated by histopathological studies. RESULTS: GC-MS analysis of the aqueous extract showed the presence of volatile and pharmacologically active phytoconstituents. C. nucifera flower extract-treated groups showed estrus cyclicity and increased uterus weight which indicates the estrogenic effect. The improved blood sugar level, ideal lipid profile, good antioxidant status, and histopathology results revealed the recovery from poly cystic ovaries. CONCLUSION: The results indicate that C. nucifera flower is a potential medicine for the treatment of pCOD and this study supports the traditional uses of C. nucifera flower.

关键词： flower uterus superoxide ovary monitored virgin cycle Female glutathione volatile

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一项褥疮预防的系统性回顾

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世界核心医学期刊文摘（皮肤病学分册） 2006年第11期2卷 1-1页

作者： reddy M. Gill S.S. Rochon p.A. 冯义国 Hebrew Rehabilitation Center Department of Medicine Boston MA 02131 United StatesDr.

Context: pressure ulcers are common in a variety of patient settings and are associated with adverse health outcomes and high treatment costs. Objective: To systematically review the evidence examining interventions to prevent pressure ulcers. Data Sources and Study Selection: MEDLINE, EMBASE, and CINAHL (from inception through June 2006) and Cochrane databases (through issue 1, 2006) were searched to identify relevant randomized controlled trials (RCTs). UMI proquest Digital Dissertations, ISI Web of Science, and Cambridge Scientific Abstracts were also searched. All searches used the terms pressure ulcer, pressure sore, decubitus, bedsore, prevention, prophylactic, reduction, randomized, and clinical trials. Bibliographies of identified articles were further reviewed. Data Synthesis: Fifty-nine RCTs were selected. Interventions assessed in these studies were grouped into 3 categories, ie, those addressing impairments in mobility, nutrition, or skin health. Methodological quality for the RCTs was variable and generally suboptimal. Effective strategies that addressed impaired mobility included the use of support surfaces, mattress overlays on operating tables, and specialized foam and specialized sheepskin overlays. While repositioning is a mainstay in most pressure ulcer prevention protocols, there is insufficient evidence to recommend specific turning regimens for patients with impaired mobility. In patients with nutritional impairments, dietary supplements may be beneficial. The incremental benefit of specific topical agents over simple moisturizers for patients with impaired skin health is unclear. Conclusions: Given current evidence, using support surfaces, repositioning the patient, optimizing nutritional status, and moisturizing sacral skin are appropriate strategies to prevent pressure ulcers. Although a number of RCTs have evaluated preventive strategies for pressure ulcers, many of them had important methodological limitations. There is a need for well-des

关键词：系统性回顾随机对照试验方法学质量患者建议索引数据库皮肤受损科学引文索引外用药物英文词

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印度结核病患者中的HIV感染率估算

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国际结核病与肺部疾病杂志 2010年第1期5卷 39-41页

作者： p.K.Dewan D.Gupta B.G.Williams R.Thakur D.Bachani A.Khera D.F.Wares S.Sahu D.C.S.reddy N.Raizada L.S.Chauhan 王冬梅王雪静 Office of the World Health Organization Representative to India New Delhi Central Tuberculosis Division Directorate General of Health ServicesMinistry of Health and Family WelfareGovernment of IndiaNew DelhiIndia Consultant GenevaSwitzerland National AIDS Control Organization Ministry of Health and Family WelfareGovernment of IndiaNew Delhi Foundation for Innovative New Diagnostics New DelhiIndia

使用全球的数据已经对印度结核病(TB)患者的人类免疫缺陷病毒(HIV)感染状况进行了间接估算。为了使用当地数据对HIV感染状况进行更加准确的估算,我们将县/区级产前门诊的HIV监测数据与结核病诊断中心的HIV监测数据联系起来,并将这一关... 详细信息

使用全球的数据已经对印度结核病(TB)患者的人类免疫缺陷病毒(HIV)感染状况进行了间接估算。为了使用当地数据对HIV感染状况进行更加准确的估算,我们将县/区级产前门诊的HIV监测数据与结核病诊断中心的HIV监测数据联系起来,并将这一关联性应用到省级对孕妇人群的HIV感染状况估算中。我们估计,2007年196万新发结核病患者的HIV感染率为4.85%(95%可信区间为4.12～5.73)或HIV感染人数为95 240(95%可信区间为80 730～112 478)例。从使用这些当地数据所进行的估算中,国家结核病防治规划能够更好的制定TB/HIV双重感染防治联合行动,并监控在这一大规模人群中发现HIV感染者的结果。

关键词： HIV 结核监测印度

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