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Management of proximal tibial stress fracture associated with advanced knee osteoarthritis:A systematic review

Chinese Journal of Traumatology 2024年第3期27卷 147-152页

作者： Mukesh Kumar Saini Mahendra Singh Devendra Singh prem Manohar Seervi pera Jayavardhan reddy Neelam ramana reddy Department of Orthopaedics Dr SN Medical CollegeJodhpur342011India Department of Orthopaedics Star HospitalsB Block Banjara HillsHyderabad500034India

purpose:Tibial stress fracture associated with knee osteoarthritis is an unusual and difficult clinical *** is no clear existing treatment guideline for this uncommon clinical *** aim of this study is to review the impact of various treatment options for patients with advanced knee osteoarthritis associated with proximal tibial stress ***:The study was performed using the databases of pubMed and *** index for non-randomized studies score was used to evaluate the included studies’*** concluded data included the treatment approach,reported outcome measure,and time to fracture *** literature search was started in December 2021 and accomplished in January 2022.A narrative description of the different methods and comparison of their results were ***:Out of total assessed 69 studies,9 studies were included in our *** commonest treatment approach used was total knee arthroplasty by long tibial stem *** mean preoperative knee society score and knee functional score were 30.62 and 23.17,*** mean postoperative knee society knee score was 86.87,while the functional score was *** average reported time to achieve fracture union was 4 months(a range of 2.07-5.50 months).Conclusion:The optimal clinical outcome for treating either acute or mobile tibial stress fracture in patients with advanced knee osteoarthritis can be achieved with long stem total knee ***,due to heterogeneity of data,comparison of different treatment options for chronic proximal tibial stress fracture mal-union/non-union coexisting with knee osteoarthritic and such inferences need to be judged cautiously.

关键词： Tibial stress fracture Knee osteoarthritis Total knee arthroplasty

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Combatting Antibiotic resistance:regulatory Exclusivities for New Antibiotic Development in the United States and Europe

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Infectious Diseases & Immunity 2024年第2期4卷 79-85页

作者： Vivek reddy Murthannagari Vaishnavi parimala Thumpati Ganesh GNK Department of pharmaceutics JSS College of PharmacyJSS Academy of Higher Education&ResearchOotyNilgirisTamil Nadu 643001India.

Antimicrobial resistance is a global concern that has led to millions of deaths *** changes occur naturally in pathogens such as viruses,bacteria,parasites,and *** overcome these concerns,there is a need to develop a new generation of *** an effort to encourage innovation,both the United States(US)and the European Union have introduced exclusivity *** US offered 5 years of additional nonpatent exclusivity for Qualified Infectious Disease products under the Generating Antibiotic Incentives Now *** parallel,the European Commission offers a patent extension of 12 months across Europe(EU)countries or the option to sell the vouchers to other pharmaceutical companies through transferable exclusivity extension *** review focuses on the most important innovative strategies of antibiotic development the drug approvals,their mode of action,spectra of activity,and targeting of microorganisms,in past 5 years were mentioned,and discusses how to overcome the challenges of drug approval under antibiotic exclusivity in the US and EU,which will benefit the companies to develop novel drugs in several nations.

关键词： Drug resistance,microbial Exclusivity FDA EMA New antibiotics WHO

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ZnO/CeO_(2)/carbon xerogel composites with direct Z-scheme heterojunctions:Enhancing photocatalytic remediation of 4-chlorophenol under visible light

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Journal of rare Earths 2024年第2期42卷 314-322,I0003页

作者： Nicolas perciani de Moraes Maite Birkett de Campos Sanmartin robson da Silva rocha Abner de Siervo Marcos roberto de Vasconcelos Lanza D.Amaranatha reddy Lianqing Yu Liana Alvares rodrigues Escola de Engenharia de Lorena-EEL/USp Estrada Municipal do Campinho S/NCEP 12602-810LorenaSao PauloBrazil Institute of physics"Gleb Wataghin" Applied Physics DepartmentState University of Campinas13083-859CampinasSPBrazi Instituto de Quimica de Sao Carlos Universidade de Sao PauloAv.Trab.Sao Carlense400-Parque Arnold SchimidtSao CarlosSP13566-590Spain Department of Sciences Indian Institute of Information Technology Design and ManufacturingKurnoolAndhra Pradesh518007India School of Materials Science and Engineering China University of PetroleumQingdao266580China

This paper aims to create visible light driven ternary photocatalysts using zinc oxide(ZnO),cerium(IV)oxide(CeO_(2)),and carbon xerogel(CX) as constituent *** use of CeO_(2) is based on the creation of direct-Z-scheme heterojunctions with the ZnO and the consequent diminishing of charge recombination,whereas the carbon xerogel inclusion is predicted to minimize bandgap energy,decrease electro n-hole reco mbination,and boost specific surface *** re,the choice of the black-wattle tannin as a carbonaceous precursor was targeted at the development of an environmentally friendly and affordable *** existence of the hexagonal phase of zinc oxide and cubic structure of the cerium(IV) oxide in the ternary material was confirmed by X-ray diffractometry and X-ray photoelectron spectroscopy,with the latter also suggesting chemical bonding between the ZnO and the CX due to the creation of zinc oxycarbide *** inclusion of the carbon xerogel provokes a significant modification in the morphology of the ternary material,resulting in an increased surface area and smaller particle *** CX/ZnO-CeO_(2) ternary composite obtains the highest photocatalytic efficiency among all the materials studied,degrading 100% of 4-chlorophenol under simulated sunlight and 68% under visible radiation,after 5 *** increased photocatalytic activity can be attributed to the formation of direct Z-scheme heterojunctions between the semiconductors,higher visible light response,and higher specific surface area,as evidenced by the results obtained by active radical scavenging,chronoamperometry,diffuse reflectance spectroscopy,and N_(2) adsorption-desorption isotherms.

关键词： Zinc oxide Cerium(Ⅳ)oxide Carbon xerogel photocatalysis Direct Z-scheme heterojunction 4-Chlorophenol rare earths

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Fabrication and Characterization of Bamboo—Epoxy reinforced Composite for Thermal Insulation

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Open Journal of Composite Materials 2024年第1期14卷 15-32页

作者： Nandavardhan reddy Kopparthi Jens Schuster Yousuf pasha Shaik Institute of polymer Technology West palatine University of Applied Sciences Kaiserslautern Pirmasens Germany

As global warming intensifies, researchers worldwide strive to develop effective ways to reduce heat transfer. Among the natural fiber composites studied extensively in recent decades, bamboo has emerged as a prime candidate for reinforcement. This woody plant offers inherent strengths, biodegradability, and abundant availability. Due to its high cellulose content, its low thermal conductivity establishes bamboo as a thermally resistant material. Its low thermal conductivity, enhanced by a NaOH solution treatment, makes it an excellent thermally resistant material. researchers incorporated Hollow Glass Microspheres (HGM) and Kaolin fillers into the epoxy matrix to improve the insulating properties of bamboo composites. These fillers substantially enhance thermal resistance, limiting heat transfer. Various compositions, like (30% HGM + 25% Bamboo + 65% Epoxy) and (30% Kaolin + 25% Bamboo + 45% Epoxy), were compared to identify the most efficient thermal insulator. Using Vacuum Assisted resin Transfer Molding (VArTM) ensures uniform distribution of fillers and resin, creating a structurally sound thermal barrier. These reinforced composites, evaluated using the TOpSIS method, demonstrated their potential as high-performance materials combating heat transfer, offering a promising solution in the battle against climate change.

关键词： Thermal Insulator rooftiles Hollow Glass Microspheres Bamboo Kaolin Epoxy VArTM process Thermal Conductivity Mechanical properties

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Ipsilateral fractures of the acromion and coracoid processes of the scapula

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Chinese Journal of Traumatology 2024年第2期27卷 121-124页

作者： Yusuf Omar Qalib Srinivasa reddy Medagam Sunil Dachepalli Department of Orthopaedics The Fifth Affiliated Hospital of Sun Yat-Sen UniversityZhuhai519000GuangdongChina Department of Orthopaedics Yashoda HospitalsSomajigudaHyderabadTelangana500082India

A fracture of the acromion and coracoid processes of scapula is rarely seen in the outpatient clinic,due to the acromion's anatomical position and shape,as well as the strong ligaments and muscles that are attached to *** fractures are caused by either direct or indirect high-energy trauma injuries to the shoulder joint,leading to severe pain and a grossly restricted range of *** acromial classifications were reported,but this type of longitudinal plane fracture of the acromion process in our case is yet to be described in the current *** present a rare combination of the coracoid process and unstable acromion bony projection fractures that have not previously been noted for this type of *** closest to this is Kuhn's type III classification.A 51-year-old male presented to our emergency department complaining of the right shoulder pain and difficulty raising his arm following a 2-wheeler *** patient was managed by open reduction and internal fixation with 3 cannulated cancellous screws fixation and progressed well with no postoperative *** was asymptomatic postoperatively and regained full range of motion after 4 months.

关键词： Acromion Scapular fracture Coracoid process

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Development of Morus alba reinforced poly-Lactic Acid with Elevated Mechanical and Thermal properties

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Materials Sciences and Applications 2024年第7期15卷 186-200页

作者： Girish Kumar reddy Madda Jens Schuster Yousuf pasha Shaik Department of Applied Logistics and polymer Sciences University of Applied Sciences Kaiserslautern Institute for Plastics Engineering West Pfalz (IKW) Pirmasens Germany

This research investigates the mechanical and thermal properties of Morus alba combined with polylactic acid in comparison with other natural fibers. The study uses three different fiber and pLA compositions - 20%, 30%, and 40% respectively - to produce composite materials. In addition, another composite with the same fiber volume is treated with a 4% NaOH solution to improve mechanical properties. The composites are processed by twin-screw extrusion, granulation, and injection molding. Tensile strength measurements of raw fibers and NaOH-treated fibers were carried out using a single-fiber tensile test with a gauge length of 40 mm. It was observed that the NaOH surface treatment increases the resistance against tensile loading and exhibited improved properties for raw fiber strands. The diameter of the fibers was measured using optical microscopy. During this research, flexural tests, impact tests, differential scanning calorimetry (DSC), and heat deflection temperature measurements (HDT) were conducted to evaluate the mechanical and thermal properties of the developed composite samples. The results indicate that the mechanical properties of NaOH-treated Morus alba-reinforced polylactic acid outperform both virgin pLA samples and untreated Morus alba samples.

关键词： Morus Alba Fiber (MAF) White Mulberry polylactic Acid (pLA) Sodium Hydroxide (NaOH) Solution Single Fiber Tensile Test Thermal Stability Optical Microscopy

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A comparative analysis of unsteady and steady Buongiorno’s Williamson nanoliquid flow over a wedge with slip effects

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Chinese Journal of Chemical Engineering 2020年第7期28卷 1767-1777页

作者： r.Chandra Sekhar reddy p.Sudarsana reddy Department of Mathematics Rajeev Gandhi Memorial Collge of Engineering&TechnologyNandyalA.P.India

Comparison between unsteady and steady MHD Buongiorno’s model Williamson nanoliquid flow through a wedge with slip effects,chemical reaction and radiation is made in this *** and Brownian motion are also considered in this *** similarity variables are presented to transmute the governing pDEs into the set of non-linear *** most widely authenticated finite element method is implemented to analyze these set of ODEs *** behavior of concentration,temperature and velocity sketches for varied values of relevant parameters is numerically calculated and the outcomes are plotted through *** numerical values of dimensionless rates of mass transfer,heat and velocity are also evaluated and depicted through *** is noted that with upsurging values of angle of wedge parameter,the distributions of temperature of the liquid intensify in both steady and unsteady cases.

关键词： Finite element method Chemical reaction Williamson nanoliquid Thermophoresis Thermal radiation Brownian motion

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Laparoscopic management of remnant gall bladder with stones: Lessons from a tertiary care centre's experience

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Laparoscopic, Endoscopic and robotic Surgery 2024年第1期7卷 27-33页

作者： Gilbert Samuel Jebakumar Jeevanandham Muthiah Loganathan Jayapal r.Santhosh Kumar Siddhesh Tasgaonkar K.S.Santhosh Anand J.K.A.Jameel Sudeepta Kumar Swain K.J.raghunath prasanna Kumar reddy Tirupporur Govindaswamy Balachandar Department of Surgical Gastroenterology Apollo HospitalsChennai 600006India Department of General Surgery Apollo HospitalsChennai 600006India Department of Minimal Access Surgery Apollo HospitalsChennai 600006India

Objective:Laparoscopic cholecystectomy is currently the gold standard for treating symptomatic gallstone *** its success,approximately 10%of patients may experience persistent biliary symptoms,leading to the post-cholecystectomy syndrome.A remnant gallbladder with cystic duct or bile duct stones is one of the causes of this *** objective of this study was to shed light on the clinical manifestations,evaluation,therapeutic strategies,and outcomes associated with laparoscopic management of symptomatic remnant ***:This was a retrospective study,conducted over a five-year period(January 2017 to December 2022)at Apollo Hospitals in South *** patients who underwent laparoscopic completion cholecystectomy for a remnant gall bladder were *** following data were collected:patient demographics,symptoms,preoperative investigations,intraoperative details and post operative ***:In total,36 patients were included and *** majority of patients were male(25,69.4%),with a mean age of 50.7±12.1 *** most common presentation was pain in the upper abdomen or right upper quadrant region(24,66.7%).The laparoscopic approach was attempted in all patients,with a success rate of 94.4%.Two patients required conversion to open *** fistula to the colon was observed in one *** was observed in 7 patients(19.4%),and stone clearance was successfully achieved using endoscopic retrograde cholangiopancreatography in all patients ***:Incomplete gall bladder removal either intentionally or unintentionally leaves a remnant gall bladder that is at risk for stone formation and *** who have this clinical entity with symptoms require a redo or complete cholecystectomy,a complex procedure associated with certain *** study highlights the feasibility and safety of laparoscopic completion cholecystectomy for the management of remnant gallbladder

关键词： remnant gall bladder Stump cholecystitis Subtotal cholecystectomy Laparoscopic completion cholecystectomy

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Laparoscopic plication for diaphragmatic eventration in adults:Unveiling the mystery of eventration

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Laparoscopic, Endoscopic and robotic Surgery 2024年第2期7卷 92-96页

作者： Balika Mahesan prasanna Kumar reddy K.S.Santhosh Anand Muvva Sri Harsha M Vijay N Sudarsan Srikanth Department of Minimal Access Surgery Apollo HospitalsChennaiIndia Department of Surgical Gastroenterology Apollo HospitalsChennaiIndia

Diaphragm eventration is the permanent elevation of a hemidiaphragm and can be due to congenital or acquired *** is a rather uncommon condition in adults and causes a spectrum of symptoms,ranging from asymptomatic incidental findings on imaging to life-threatening respiratory *** patients do not require any treatment,but plication is the conventional,well-known method for treating symptomatic *** varies depending on the *** this article,we discuss two rare cases of diaphragmatic eventration that were treated with minimal access surgery.

关键词： Diaphragmatic eventration Minimal access surgeryLaparoscopy

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Dual inhibition of sirtuins 1 and 2:reprogramming metabolic energy dynamics in chronicmyeloid leukemia as an immunogenic anticancer strategy

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Cancer Communications 2024年第8期44卷 921-925页

作者： Michael Schnekenburger Anne Lorant Sruthi reddy Gajulapalli ridhika rajora Jin-Young Lee Aloran Mazumder Haeun Yang Christo Christov Hyoung Jin Kang Bernard pirotte Marc Diederich Laboratoire de Biologie Moleculaire et Cellulaire du Cancer LuxembourgLuxembourg research Institute of pharmaceutical Sciences&Natural products research Institute College of PharmacySeoul National UniversitySeoulRepublic of Korea Faculte de Medecine Universite de LorraineVandoeuvre-les-NancyFrance Department of pediatrics Seoul National University College of MedicineSeoul National University Cancer Research InstituteSeoul National University Children’s HospitalSeoulRepublic of Korea Laboratory of Medicinal Chemistry Center for Interdisciplinary Research on Medicines(CIRM)University of LiegeLiegeBelgium

Chronicmyeloid leukemia(CML)is a lethal hematopoietic malignancy with a global incidence primarily attributed to the breakpoint cluster region-Abelson(BCr-ABL1)fusion oncogene in over 95%of *** introduction of tyrosine kinase inhibitors(TKIs)has revolutionized CML management;however,a subset of patients encounters challenges such as resistance and relapse,hindering the achievement of complete *** these challenges in CML also requires addressing persistent leukemia stem cells(LSCs)with inherent resistance *** regulators of LSC metabolism,proliferation,and survival,as well as genetic and epigenetic alterations,provide potential targets[1].

关键词： metabolism myeloid alterations

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