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Enhancing Critical path problem in Neutrosophic Environment Using python

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2957-2976页

作者： M.navya pratyusha Ranjan Kumar VIT-Ap University InavoluBesides AP SecretariatAmaravati APIndia

In the real world,one of the most common problems in project management is the unpredictability of resources and *** efficient way to resolve uncertainty problems and overcome such obstacles is through an extended fuzzy approach,often known as neutrosophic *** rigorous proposed model has led to the creation of an advanced technique for computing the triangular single-valued neutrosophic *** innovative approach evaluates the inherent uncertainty in project durations of the planning phase,which enhances the potential significance of the decision-making process in the *** proposed method,for the first time in the neutrosophic set literature,not only solves existing problems but also introduces a new set of problems not yet explored in previous research.A comparative study using python programming was conducted to examine the effectiveness of responsive and adaptive planning,as well as their differences from other existing models such as the classical critical path problem and the fuzzy critical path *** study highlights the use of neutrosophic logic in handling complex projects by illustrating an innovative dynamic programming framework that is robust and flexible,according to the derived results,and sets the stage for future discussions on its scalability and application across different industries.

关键词： Classical critical path problem fuzzy critical path problem uncertainty neutrosophic triangular single-valued neutrosophic number neutrosophic critical path problem python programming languag

Machine Learning Based Virtual Screening for Biodegradable polyesters

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Journal of Materials Science and Chemical Engineering 2024年第8期12卷 1-11页

作者： navya Nori Milton High School Milton USA

Current biodegradation timelines show that polyesters take over 200 years to break down. A crucial component of several industries, polyesters are relied upon for materials development and thus require sustainable alternatives. Recent works in generative modeling have made it possible to produce large sets of chemical structures, but current molecular screening methods are expensive, not scalable, and are oversimplified. This work evaluates whether a molecule’s biodegradability potential can be accurately predicted by training a model on recent experimental data. Additionally, three chemical descriptors were evaluated on the final molecules for their effects on biodegradability: molecular structure, bond types, and solubility. A Gradient Boosted Machine was trained on a dataset of 600 molecules and their binary labels on biodegradability. The classification model effectively captured the biodegradability property, yielding an Area Under the Receiver Operating Characteristics, AUROC, of 84% and an Area Under the precision Recall Curve, or AUpRC, of 87%. Additionally, an existing amortized synthetic tree generation model, SynNet, validated each molecule by showing chemical synthesizability and producing simple and interpretable synthesis pathways. This approach of filtering by prediction and chemical rule interpretation is inexpensive, highly scalable and can capture the necessary complexity. Using this method, novel polyester candidates can be polymerized and produced into sustainable fabrics, reducing environmental stress from textile-reliant industries.

关键词： Biodegradability Molecular Generation Virtual Screening

purification and Characterisation of a Coffee pulp Tannase produced by penicillium verrucosum

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Journal of Food Science and Engineering 2013年第6期3卷 323-331页

作者： Roopali N. Bhoite navya p. N pushpa S. Murthy plantation products Spices & Flavour Technology Department Central Food .Technological Research Institute Council of Scientificand Industrial Research New Delhi India

Tannase was extracted from a new fungal strain penicillium verrucosum using coffee pulp as a substrate by solid state fermentation. The extracellular tannase was purified using Sephadex G-100 to 86.02 folds with 34.3% yield and a single band corresponding to 81 kDa was observed in SDS-pAGE. Tannase was immobilized on alginate by entrapment method. The graphical analysis of the effect of the substrate concentration on the tannase activity yielded a Km of 48.88 mM and a Vmax of 169.49 U/mL. The optimum temperature and pH of the enzyme were 30 ℃ and pH 5. The thermal stability, as well as stability over a wide range ofpH, was significantly improved by the immobilization process. The activity was enhanced by Mg^2＋（23.5%） and K^＋（5.3%）, whereas Zn^2＋, Cu^2＋, Ca^2＋, NH^4＋ and Hg^2＋ inhibited tannase activity. Maximum substrate bioconversion （58.94%） from tannic acid to gallic acid and tea cream solubilisation （32.82%） was achieved using immobilized tannase. The extracellular tannase produced by p. verrucosum showed distinctive characteristics such as monomeric structure and activation by Mg^2＋, suggesting a new kind of fungal tannase with biotechnological potential.

关键词： Tannase penicillium verrucosum solid state fermentation purification characterization immobilization.

Hyperkalemia:Major but still understudied complication among heart transplant recipients

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World Journal of Transplantation 2021年第6期11卷 203-211页

作者： Jagmeet Singh Asim Kichloo navya Vipparla Michael Aljadah Michael Albosta Shakeel Jamal Sindhura Ananthaneni Sandesh parajuli Department of Nephrology Guthrie Robert Packer HospitalSayrePA 18840United States Department of Internal Medicine Central Michigan University College of MedicineSaginawMI 48602United States Department of Internal Medicine Medical College of WisconsinMilwaukeeWI 53226United States Department of Nephrology University of Wisconsin School of Medicine and Public HealthMadisonWI 53706United States

Hyperkalemia is a recognized and potentially life-threatening complication ofheart transplantation. In the complex biosystem created by transplantation,recipients are susceptible to multiple mechanisms for hyperkalemia which arediscussed in detail in this manuscript. Hyperkalemia in heart transplantationcould occur pre-transplant, during the transplant period, or post-transplant. pretransplantcauses of hyperkalemia include hypothermia, donor heart preservationsolutions, conventional cardioplegia, normokalemic cardioplegia, continuouswarm reperfusion technique, and ex-vivo heart perfusion. Intra-transplant causesof hyperkalemia include anesthetic medications used during the procedure,heparinization, blood transfusions, and a low output state. Finally, post-transplantcauses of hyperkalemia include hemostasis and drug-induced *** has been studied in kidney and liver transplant recipients, butthere is limited data on the incidence, causes, management, and prevention inheart transplant recipients. Hyperkalemia is associated with an increased risk ofhospital mortality and readmission in these patients. This review describes thecurrent literature pertaining to the causes, pathophysiology, and treatment ofhyperkalemia in patients undergoing heart transplantation and focuses primarilyon post-heart transplantation.

关键词： Transplantation Cardiovascular Hyperkalemia Heart transplant Medication Management

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旋转声黑洞圆盘建模与分析

旋转声黑洞圆盘建模与分析