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Highly sensitive LC–MS/MS method to estimate doxepin and its metabolite nordoxepin in human plasma for a bioequivalence study

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Journal of pharmaceutical Analysis 2018年第6期8卷 378-385页

作者： Nirav p.patel Mallika Sanyal naveen Sharma Dinesh S.patel pranav S.Shrivastav Bhavin N.patel Bio-Analytical Laboratory Cliantha Research India Ltd.BodakdevAhmedabad 380054GujaratIndia Kadi Sarva Viswavidyalaya Sector-15Ghandhinagar 382715GujaratIndia Department of Chemistry St.Xavier's CollegeNavrangpuraAhmedabad 380009GujaratIndia Department of Chemistry School of SciencesGujarat UniversityNavrangpuraAhmedabad 380009GujaratIndia

A selective, sensitive and rugged liquid chromatography–tandem mass spectrometry(LC–MS/MS) assay has been developed for the simultaneous determination of doxepin(Dox) and its pharmacologically active metabolite, nordoxepin(NDox) in human plasma. The analytes and their internal standards(IS)were extracted from 500 m L of human plasma by liquid-liquid extraction using methyl tert-butyl *** separation was achieved on Hypurity C8 column(100 mm ? 4.6 mm, 5 mm) using a mixture of acetonitrile-methanol(95:5, v/v) and 2.0 mM ammonium formate in 93:7(v/v) ratio. Detection was accomplished by tandem mass spectrometry in the positive ionization and multiple reaction monitoring acquisition mode. The protonated precursor to product ion transitions studied for Dox, NDox,and their corresponding ISs, propranolol and desipramine, were m/z 280.1-107.0, 266.0-107.0,260.1-116.1 and 267.1-72.1, respectively. A linear dynamic range of 15.0–3900 pg/mL for Dox and 5.00–1300 pg/mL for NDox was established with mean correlation coefficient(r2) of 0.9991 and 0.9993, respectively. The extraction recovery ranged from 86.6%–90.4% and 88.0%–99.1% for Dox and NDox, respectively. The intra-batch and inter-batch precision(% CV) across quality control levels was r 8.3% for both the analytes. Stability evaluated under different storage conditions showed no evidence of degradation and the % change in stability samples compared to nominal concentration ranged from 4.7% to12.3%. The method was successfully applied to a bioequivalence study of 6 mg doxepin hydrochloride orally disintegrating tablet in 41 healthy Indian subjects under fasting and fed conditions.

关键词： Doxepin Nordoxepin LC–MS/MS Liquid-liquid extraction Human plasma Bioequivalence study

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S-,N-and C-doped ZnO as semiconductor photocatalysts:A review

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Frontiers of Materials Science 2019年第1期13卷 1-22页

作者： Vijaya KUMARI Anuj MITTAL Jitender JINDAL Suprabha YADAV naveen KUMAR Department of Chemistry Maharshi Dayanand University RohtakIndia Department of Chemistry R.P.S.Degree CollegeMohindergarhIndia

In the past few decades,many novel non-metal doped ZnO materials have developed hasty interest due to their adaptable properties such as low recombination rate and high activity under the solar light *** this article,we compiled recent research advances in non-metal(S,N,C)doped ZnO,emphasizing on the related mechanism of catalysis and the effect of non-metals on structural,morphological,optical and photocatalytic characteristics of *** review will enhance the knowledge about the advancement in ZnO and will help in synthesizing new ZnO-based materials with modified structural and photocatalytic properties.

关键词： degradation recombination mechanism photocatalyst pollutant

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Toll-like receptor-4 antagonism mediates benefits during neuroinflammation

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Neural Regeneration Research 2016年第4期11卷 552-553页

作者： Sagar Gaikwad Challagundla naveen Reena Agrawal-Rajput Laboratory of Immunology School of Biological Sciences and BiotechnologyIndian Institute of Advanced Research

Neuroinflammation following immune activation in the central nervous system（CNS）leads to neuronal loss in specific areas of the CNS resulting in neurodegenerative ***,fine tuning the immune responses within the brai... 详细信息

关键词： neuronal tuning inflammation benefits aberrant microglia inappropriate cytokines bidirectional sepsis

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Soil-plant-Microbe Interactions in Stressed Agriculture Management:A Review

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pedosphere 2017年第2期27卷 177-192页

作者： Shobhit Raj VIMAL Jay Shankar SINGH naveen Kumar ARORA Surendra SINGH Department of Environmental Microbiology Babashaeb Bhimrao Ambedkar (Central) University Lucknow 226025 (India) Department of Botany Banaras Hindu University Varanasi 221005 (India)

The expected rise in temperature and decreased precipitation owing to climate change and unabated anthropogenic activities add complexity and uncertainty to agro-industry. The impact of soil nutrient imbalance, mismanaged use of chemicals, high temperature, flood or drought, soil salinity, and heavy metal pollutions, with regard to food security, is increasingly being explored worldwide. This review describes the role of soil-plant-microbe interactions along with organic manure in solving stressed agriculture problems. Beneficial microbes associated with plants are known to stimulate plant growth and enhance plant resistance to biotic （diseases） and abiotic （salinity, drought, pollutions, etc.） stresses. The plant growth-promoting rhizobemteria （pGpR） and mycorrhizae, a key component of soil microbiota, could play vital roles in the maintenance of plant fitness and soil health under stressed environments. The application of organic manure as a soil conditioner to stressed soils along with suitable microbial strains could further enhance the plant-microbe associations and increase the crop yield. A combination of plant, stress-tolerant microbe, and organic amendment represents the tripartite association to offer a favourable environment to the proliferation of beneficial rhizosphere microbes that in turn enhance the plant growth performance in disturbed agro-ecosystem. Agriculture land use patterns with the proper exploitation of plant-microbe associations, with compatible beneficial microbial agents, could be one of the most effective strategies in the management of the concerned agriculture lands owing to climate change resilience. However, the association of such microbes with plants for stressed agriculture management still needs to be explored in greater depth.

关键词： beneficial microbes fungi microbial agents rnycorrhiza organic manure pathogen plant health plant growth-promoting rhizobacteria

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Optical and structural properties of highly porous shell structured Fe doped TiO_2 thin films

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Rare Metals 2014年第5期33卷 578-582页

作者： C.S.naveen p.Raghu H.M.Mahesh K.Narasimha Rao R.Rakesh Kumar A.R.phani Department of Electronic Science Bangalore UniversityJnanabharathi Department of Instrumentation and Applied physics Indian Institute of Science Nano-Research for Advanced Materials and Technologies (Nano-RAM Technologies)

TiO2thin films with 0.2 wt%, 0.4 wt%, 0.6wt%, and 0.8 wt% Fe were prepared on glass and silicon substrates using sol–gel spin coating technique. The optical cut-off points are increasingly red-shifted and the absorption edge is shifted over the higher wavelength region with Fe content increasing. As Fe content increases, the optical band gap decreases from 3.03 to 2.48 eV whereas the tail width increases from 0.26 to 1.43 eV. The X-ray diffraction（XRD） patterns for doped films at 0.2 wt% and0.8 wt% Fe reveal no characteristic peaks, indicating that the film is amorphous whereas undoped TiO2exhibits（101） orientation with anatase phase. Thin films of higher Fe content exhibit a homogeneous, uniform, and nanostructured highly porous shell morphology.

关键词： Fe TiO2 porous shell Sol–gel

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Influence of temperature dependent heat source/sink on transient MHD free convective flow in an infinite rigid impermeable vertical cylinder with chemical reaction

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propulsion and power Research 2023年第4期12卷 568-583页

作者： naveen Dwivedi Ashok Kumar Singh Nirmal C.Sacheti Department of Mathematics Institute of ScienceBanaras Hindu UniversityVaranasi 221005India Department of Mathematics Sahu Jain CollegeNajibabadAffiliated to M.J.P.Rohilkhand UniversityBareilly 246763India Retired professor Department of MathematicsCollege of ScienceSultan Qaboos UniversityAl Khod PC 123MuscatSultanate of Oman

It is increasingly apparent that the inclusion of mass transfer aspects,together with certain thermal conditions,in the momentum and energy equations governing MHD flows leads to a numbers of real life *** this in view,we have attempted an exact analysis of heat and mass transfer aspects in transient hydromagnetic free convective flow of an incompressible viscous fluid through a vertical pipe under an externally applied magnetic field,assuming presence of chemical reaction and heat source/*** governing pDEs,which simplify to a set of 3 linear ODEs in the physical set up considered here,have been solved using Laplace transform technique,with solutions for key physical variables presented in the term of Bessel and modified Bessel *** influence of governing non-dimensional parameters,namely,Hartmann number,Schmidt number,source/sink parameter,prandtl number and chemical reaction parameter,has been illustrated on the developing velocity and some concentration *** important quantities of engineering interest-surface skin friction and volumetric flow rates-have been computed too and *** notable finding worth mentioning are:(a)heat source presence causes higher fluid velocity as compared to the heat sink;(b)all important surface shear stress can be suitably controlled,among others,by chemical reaction parameter and Schmidt *** key challenge of this study has been to obtain exact closed-form solutions of the field equations,including cumbersome Laplace *** study finds innovative applications in the emerging fields such as magnetic materials processing,chemical processes,solar energy systems,etc.

关键词： Circular cylinder Hydromagnetic transient flow Chemical reaction Source/sink Free convection

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Can non-standard recombination resolve the Hubble tension?

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Science China(physics,Mechanics & Astronomy) 2020年第9期63卷 30-34页

作者： MiaoXin Liu ZhiQi Huang XiaoLin Luo HaiTao Miao naveen KSingh Lu Huang School of physics and Astronomy Sun Yat-sen UniversityZhuhai 519082 China

The inconsistent Hubble constant values derived from cosmic microwave background(CMB) observations and from local distance-ladder measurements may suggest new physics beyond the standard ΛCDM paradigm. It has been found in earlier studies that, at least phenomenologically, non-standard recombination histories can reduce the ≥4σ Hubble tension to ~ 2σ.Following this path, we vary physical and phenomenological parameters in RECFAST, the standard code to compute ionization history of the universe, to explore possible physics beyond standard recombination. We find that the CMB constraint on the Hubble constant is sensitive to the hydrogen ionization energy and 2 s → 1 s two-photon decay rate, both of which are atomic constants, and is insensitive to other details of recombination. Thus, the Hubble tension is very robust against perturbations of recombination history, unless exotic physics modifies the atomic constants during the recombination epoch.

关键词： cosmology Hubble recombination CMB

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Salmonella enteritidis from a case of fever with thrombocytopenia

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Asian pacific Journal of Tropical Medicine 2011年第4期4卷 328-329页

作者： Shamma Arora naveen Gupta Ashwani Kumar IR Kaur Indraprastha Apollo Hospital Zoonosis Divison National Center for Disease control(NCDC) UCMS & GTB Hospital Delhi

Non typhoidal Salmonella species are thought to be potentially infectious to *** isolated Salmonella enteritidis from a 10-year-old boy with fever and *** reviewed the literature conceming infections caused by Salmone... 详细信息

关键词： Salmonella enterica serotype Enteritidis Thrombocytopenia

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Bibliometric analysis of Blockchain in the healthcare domain

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Intelligent and Converged Networks 2023年第4期4卷 305-312页

作者： Shilpi Garg Rajesh Kumar Kaushal naveen Kumar Anshul Verma Chitkara Institute of Engineering and Technology Chitkara UniversityPunjab 140401India Institute of Science Banaras Hindu UniversityVaranasi 221005India

As an innovation,Blockchain has transformed numerous industries and sparked the interest of the research community due to its abundance of benefits,opening up diverse research routes in the healthcare sector in the last *** Health 4.0 becoming ubiquitous in the healthcare industry,end-user transactions are being carried out on a decentralized network,making Blockchain profitable to meet the demands of the modern healthcare ***,a detailed analysis of Blockchain is very *** study emphasizes the evolution of science and the preliminary research of Blockchain in healthcare through bibliometric *** the data are extracted from the Scopus database,and the VOSviewer tool is used for analysis.A total of 1152 Scopus articles published between 2018 and 2022 are *** reveal that in 2022,the field of Blockchain experienced a notable increment in the number of publications and a significant growth *** Access became well known in this field and had a large number of *** is observed that China and India are the leading countries in terms of publications on *** study offers a number of recommendations that amateur and professional researchers can use as a benchmark before commencing a Blockchain investigation in the future.

关键词： Blockchain bibliometric healthcare VOSviewer

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Synthesis and Characterization of Graphene/ITO Nanoparticle Hybrid Transparent Conducting Electrode

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Nano-Micro Letters 2018年第1期10卷 169-180页

作者： Bastian Waduge naveen Harindu Hemasiri Jae-Kwan Kim Ji-Myon Lee Department of printed Electronics Engineering Sunchon National University

The combination of graphene with conductive nanoparticles, forming graphene–nanoparticle hybrid materials, offers a number of excellent properties for advanced engineering applications. A novel and simple method was developed to deposit 10 wt% tin-doped indium tin oxide(ITO) nanoparticles on graphene. The method involved a combination of a solution-based environmentally friendly electroless deposition approach and subsequent vacuum annealing. A stable organic-free solution of ITO was prepared from economical salts of In(NO_3)_3H_2 O and SnCl_4. The obtained ITO nanostructure exhibited a unique architecture, with uniformly dispersed 25–35 nm size ITO nanoparticles, containing only the crystallized In_2O_3 phase. The synthesized ITO nanoparticles–graphene hybrid exhibited very good and reproducible optical transparency in the visible range(more than 85%) and a28.2% improvement in electrical conductivity relative to graphene synthesized by chemical vapor deposition. It was observed that the ITO nanoparticles affect the position of the Raman signal of graphene, in which the D, G, and 2 D peaks were redshifted by 5.65, 5.69, and 9.74 cm^(-1),respectively, and the annealing conditions had no significant effect on the Raman signatures of graphene.

关键词： Graphene ITO nanoparticles Electroless deposition Crystallization Raman

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