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Disentangling the effects of management and climate change on habitat suitability for saproxylic species in boreal forests

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Journal of Forestry Research 2024年第2期35卷 121-133页

作者： Ellinoora Ekman María Triviño Clemens Blattert Adriano Mazziotta Maria potterf Kyle Eyvindson Department of Biological and Environmental Science University of JyvaskylaP.O.Box 3540014 JyvaskylaFinland Institute for Atmospheric and Earth System Research(INAR)/physics Faculty of ScienceUniversity of HelsinkiP.O.Box 6800014 HelsinkiFinland School of Resource Wisdom University of JyvaskylaP.O.Box 3540014 JyvaskylaFinland Natural Resources Institute Finland(LUKE) Latokartanonkaari 900790 HelsinkiFinland Ecosystem Dynamics and Forest Management Group Technical University of MunichHans‑Carl‑Von‑Carlowitz‑Platz 285354 FreisingGermany Faculty of Environmental Sciences and Natural Resource Management Norwegian University of Life SciencesP.O.Box 50031433ÅsNorway

Forest degradation induced by intensive forest management and temperature increase by climate change are resulting in biodiversity decline in boreal *** forest management and high-end climate emission scenarios can further reduce the amount and diversity of deadwood,the limiting factor for habitats for saproxylic species in European boreal *** magnitude of their combined effects and how changes in forest management can affect deadwood diversity under a range of climate change scenarios are poorly *** used forest growth simulations to evaluate how forest management and climate change will individually and jointly affect habitats of red-listed saproxylic species in *** simulated seven forest management regimes and three climate scenarios(reference,RCp4.5 and RCp8.5)over 100 *** regimes included set aside,continuous cover forestry,business-as-usual(BAU)and four modifications of *** suitability was assessed using a speciesspecific habitat suitability index,including 21 fungal and invertebrate species groups.“Winner”and“loser”species were identified based on the modelled impacts of forest management and climate change on their habitat *** found that forest management had a major impact on habitat suitability of saproxylic species compared to climate *** suitability index varied by over 250%among management regimes,while overall change in habitat suitability index caused by climate change was on average only 2%.More species groups were identified as winners than losers from impacts of climate change(52%–95%were winners,depending on the climate change scenario and management regime).The largest increase in habitat suitability index was achieved under set aside(254%)and the climate scenario RCp8.5(>2%),while continuous cover forestry was the most suitable regime to increase habitat suitability of saproxylic species(up to+11%)across all climate change *** results show that close-to-na

关键词： Biodiversity Simulations Finland Forest planning Habitat suitability Deadwood

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Jatonik polyherbal mixture induced rat liver MMpT pore opening in normal Wistar rat:In vitro and in vivo studies

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Chinese Herbal Medicines 2024年第1期16卷 113-120页

作者： olabinri p.Folashade Ibrahim Damilare Boyenle Tolulope A.oyedeji Fiyinfoluwa Demilade ojeniyi Adisa Ayobami Damilare Leonard o.Ehigie Adeola Folasade Ehigie Membrane Biochemistry and Biophysics Research Laboratory Department of BiochemistryLadoke Akintola University of TechnologyOgbomoso 210214Nigeria Computational Biology/Drug Discovery Laboratory Department of BiochemistryLadoke Akintola University of TechnologyOgbomoso 210214Nigeria College of Health Sciences Crescent University AbeokutaAbeokuta 111105Nigeria Department of Biochemistry University of LagosLagos 101017Nigeria

objective:To assess acute toxicity,the in vitro and in vivo effects of methanol and ethyl acetate extracts(JME and JEE)of Jatonik polyherbal mixture on some mitochondria-related parameters and their effect on the activity of some liver ***:Acute toxicity of JME and JEE was determined using Lorke’s *** vitro and in vivo opening of the mitochondrial membrane permeability transition pore(MMpT pore)was spectrophotometrically *** of malondialdehyde(MDA)as an index of lipid peroxidation and the activity of mitochondrial ATpase was evaluated in vitro and in vivo and the effect of JME and JEE on the activity of liver enzymes such as alkaline phosphatase(ALp),aspartate and alanine aminotransferase(AST and ALT)and gamma-glutamyl transferase(GGT)was also ***:JME had an LD_(50) of 3808 mg/kg b.w whereas JEE had an LD_(50) greater than 5000 mg/kg *** *** the rats have been fed with both extracts,a photomicrograph of a piece of liver tissue showed no apparent symptoms of *** the in vitro and in vivo studies,both extracts prompted intact mitochondria to open their MMpT *** compared to the control,lipid peroxide product release and ATpase activity were significantly increased(po and in *** activities of AST,ALT,and GGT were all reduced at 50 mg/kg when treated with JME,but the activity of AST was considerably enhanced when treated with JEE(poth JME and JEE of the Jatonik polyherbal mixture had low toxicity,profound MMpTpore induction,and enhanced ATpase activity,but an increased MDA ***:Jatonik extracts may be a promising target for drug development in diseases where there is dysregulation of apoptosis,however,further studies are needed to better clarify the molecular mechanism involved in these phenomena.

关键词： acute toxicity Ageratum conyzoides Linn. apoptosis Hunteria umbellate(K.Schum.)Hallier f. Lepidium meyenii Walp. mitochondrial ATpase mitochondrial lipid peroxidation mitochondrial membrane permeability transition pore polyherbal mixture Xylopia aethiopica(Dunal)A.Rich

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Highly Defective Dark Tio_(2) Modified with pt: Effects of precursor Nature and preparation Method on photocatalytic properties

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Transactions of Tianjin University 2024年第2期30卷 198-209页

作者： E.D.Fakhrutdinova o.A.Reutova T.A.Bugrova I.Yu.ovsyuk L.S.Kibis o.A.Stonkus D.B.Vasilchenko o.V.Vodyankina V.A.Svetlychnyi National Research Tomsk State University TomskRussia 634050 Novosibirsk State University NovosibirskRussia 630090 Boreskov Institute of Catalysis NovosibirskRussia 630090 Nikolaev Institute of Inorganic Chemistry NovosibirskRussia 630090

The study focused on the modification with platinum of dark defective titania obtained via pulsed laser ablation. Both the method of pt introduction and the nature of the pt precursor were varied. All samples exhibited similar phase compositions, specific surface areas, and pt contents. High-resolution transmission electron microscopy coupled with pulsed Co adsorption revealed increased dispersity when photoreduction and the hydroxonitrate complex (Me _(4) N) _(2) [pt _(2) (oH) _(2) (No _(3) ) _(8) ] were used. The sample featured a high content of single-atom species and subnano-sized pt clusters. The X-ray photoelectron spectroscopy results showed that the photoreduction method facilitated the appearance of a larger number of pt ^(2+) states, which appeared owing to the strong metal-support interaction (SMSI) eff ect of the transfer of electron density from the electron-saturated defects on the Tio _(2) surface to pt ^(4+) . In the hydrogen evolution reaction, samples with a significant fraction of the pt ^(2+) ionic component, capable of generating short-lived pt^(0) single-atom sites under irradiation due to the SMSI eff ect, exhibited the highest photocatalytic activity. The 0.5pt(C)/Tio_(2) -ph sample exhibited the highest hydrogen yield with a quantum efficiency of 0.53, retaining its activity even after 8 h of operation.

关键词： Dark(black)Tio_(2) pulsed laser ablation platinum reduction method precursor type photocatalysis Hydrogen evolution reaction

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Use of DREAM to assess relative risks of presence of pharmaceuticals and personal care products from a wastewater treatment plant

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Frontiers of Environmental Science & Engineering 2024年第9期18卷 91-104页

作者： Daniela M.pampanin Daniel Schlenk Matteo Vitale pierre Liboureau Magne o Sydnes Department of Chemistry Bioscience and Environmental EngineeringUniversity of StavangerStavanger 224021Norway Department of Environmental Sciences University of California RiversideRiversideCA 92521USA

Concerns related to environmental risks associated with pharmaceuticals and personal care products(ppCps)have led researchers to seek methods for assessing and monitoring these contaminants in the aquatic *** and validating risk assessment tools that can evaluate ecological concerns and risks associated with ppCps is ***,the suitability of a dose-related risk and effect assessment model,which estimates predicted environmental concentrations and allowed comparisons with predicted no effect concentrations determined,in combination with in vitro analyses of the whole effluent toxicity,was verified for the characterization of a ppCp *** of the most utilized ppCps in Norway were measured in influent and effluent samples and used to parameterize the fate *** than 90%removal was attained for 12 out of 22 detected *** was not dependent on the class or the concentration of the specific substance and varied between 12%and 100%.The ppCps detected in the discharged wastewater were utilized to assess individual contributions to the risk of the effluent,and no risk was identified for the targeted 30 *** simulations provided valuable information regarding the discharge plume distribution over time,which can aid planning of future environmental monitoring ***(using fish liver cells,pLHC-1)were used for assessing overall effluent toxicity,through cell viability,production of reactive oxygen species,and ethoxyresorufin-o-deethylase(ERoD)*** present study may allow regulators to use risk-based strategies over removal criteria for monitoring studies and confirms the importance to take ppCp contamination into consideration when establishing environmental regulations.

关键词： pharmaceuticals Wastewater effluent Ciprofloxacin Metoprolol Amitriptyline Carbamazepine Modelling Risk assessment Monitoring

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Traveling wave solutions of the nonlinear Gilson-pickering equation in crystal lattice theory

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Journal of ocean Engineering and Science 2024年第1期9卷 40-49页

作者： A.T.Nguyen o.Nikan Z.Avazzadeh Division of Applied Mathematics Science and Technology Advanced InstituteVan Lang UniversityHo Chi Minh CityVietnam Faculty of Technology Van Lang UniversityHo Chi Minh CityVietnam School of Mathematics Iran University of Science and TechnologyNarmakTehranIran Department of Applied Mathematics Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China

This paper focuses on obtaining the traveling wave solutions of the nonlinear Gilson-pickering equa-tion(GpE),which describes the prorogation of waves in crystal lattice theory and plasma *** solution of the GpE is approximated via the finite difference technique and the localized meshless radial basis function generated finite *** association of the technique results in a meshless approach that does not require linearizing the nonlinear *** the first step,the pDE is converted to a system of nonlinear oDEs with the help of the radial *** the second step,a high-order oDE solver is adopted to discretize the nonlinear oDE *** global collocation techniques pose a considerable computationl burden due to the calculation of the dense algebraic *** proposed method approx-imates differential operators over the local support domain,leading to sparse differentiation matrices and decreasing the computational *** results and comparisons are provided to confirm the efficiency and accuracy of the method.

关键词： Nonlinear Gilson–pickering equation Soliton wave solutions Meshless technique RBF LRBF-FD optimal shape parameter

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Blood biomarkers of Alzheimer’s disease:important considerations for use in clinical practice

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Neural Regeneration Research 2025年第1期20卷 205-206页

作者： Sarah Fullam Sean o’Dowd Antoinette o’Connor Department of Neurology Tallaght University HospitalDublinIreland Academic Unit of Neurology Trinity College DublinIreland

Introduction:Fluid and positron emission tomography(pET)biomarkers that enable the detection of the hallmark proteins of Alzheimer’s disease(AD)(amyloid and tau)have revolutionized our approach to the diagnosis of *** evolution of AD diagnostic criteria to include biological characterization(Alzheimer’s Association Working Group,2023)provides an appropriate framework to reduce levels of clinico-pathologic mismatch and improve in-vivo diagnostic *** the therapeutic landscape for neurodegenerative disease evolves,it is increasingly incumbent on clinicians to provide timely,and pathologically precise diagnoses for ***,the expensive and invasive nature of these tests limits their scalability.

关键词： Blood Alzheimer diagnosis

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public perspectives on AI diagnosis of mental illness

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General psychiatry 2024年第3期37卷 348-351页

作者： Cliodhna o'Connor University College Dublin DublinIreland

To the editor:psychiatric theory,policy and practice are currently grappling with the risks and opportunities presented by artificial intelligence(AI)applications in mental *** data to generate diagnosis is an aspect of mental healthcare where AI is anticipated to have the greatest and soonest impact.1-4 While such technologies remain some distance from clinical application,preliminary evidence suggests AI-derived classifications may predict certain treatment outcomes and clinical trajectories,and could soon become available to supplement or replace traditional manual-based diagnostic assessment.

关键词： diagnosis replace editor

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Response of Indonesian mineral supply to global renewable energy generation:Analysis based on gravity model approach

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Geoscience Frontiers 2024年第4期15卷 383-396页

作者： Md.Monirul Islam Kazi Sohag Suleiman o.Mamman Heyvon Herdhayinta Graduate School of Economics and Management Ural Federal UniversityYekaterinburgRussia Bangladesh Institute of Governance and Management(BIGM) University of DhakaBangladesh Department of Accounting Faculty of Economics and BusinessUniversitas Gadjah MadaIndonesia

The captivating surge of energy transitions in the major industrialized nations has elevated the global demand for critical *** demand pattern has enabled mineral-abundant emerging economies like Indonesia to enter the international market by exporting mineral ***,we investigate the Indonesian mineral export supply's response to the renewable energy production of the 18 clean energy-generating countries,considering crude oil and mineral prices,exchange rates,and economic growth of the resource and importer countries from 1990 to *** doing so,we apply the poisson pseudo-maximum Likelihood(ppML)approach to measuring the panel gravity model for mineral exports in *** a result,we observe a significant response of Indonesia's mineral export supply to the renewable energy generation of the 18 mineral importing ***,mineral and crude oil prices are insignificant,whereas the importer countries'exchange rates and income growth positively influence Indonesia's mineral export ***,Indonesia's income factor negatively affects its mineral export ***,we validate our results using an alternative estimator,the Driscoll-Kraay robust standard error estimation ***,our findings suggest implementing Indonesia's existing mineral policy to produce finished mineral goods to materialize the worldwide vision of energy transitions toward a crossroad of net-zero emissions by the middle of the current century.

关键词： Mineral export supply Energy transformation Gravity model ppML approach Indonesia Renewable energy-producing countries

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A review on the scale-up of high-shear wet granulation processes and the impact of process parameters

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particuology 2024年第9期92卷 180-195页

作者： Ana Rita Alves Marta Filipe Simões Sérgio Simões João Gomes University of Coimbra CERESDepartment of Chemical EngineeringFaculty of Sciences and TechnologyRua Sílvio Lima3030-790CoimbraPortugal Bluepharma-Indústria Farmacêutica São Martinho do BispoCoimbra3045-016Portugal Faculty of pharmacy University of CoimbraAzinhaga de Santa Comba3000-548CoimbraPortugal

Wet granulation is one of the most important agglomeration processes,and high-shear granulation(HSG)one of the most employed technologies in the pharmaceutical *** most critical process parameters of HSG are discussed in this *** main concern in scaling up the wet granulation process is the differences between scales,which prevent the particles from having the same experience across all *** scale-up of wet granulation processes is commonly divided into two categories:engineering and attribute-based *** engineering-based scale-up approach is a strategy based on dimensional analysis and an attribute-based supported on the principles of“equifinality”,where process variables are adjusted to obtain equivalent granule *** work presents the effect of different HSG process parameters on the scale-up,as well as the use of process analytical tools(pAT)and modelling *** aim is to review applied scale-up approaches in HSG and discuss benefits and *** is proven why the scale-up for oral solid pharmaceutical products is still considered a hot topic and a very challenging task for development and engineering teams.

关键词： High-shear wetgranulation parametric-based Attribute-based physics-based modelling Impeller design Scale-up

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A facile strategy for tuning the density of surface-grafted biomolecules for melt extrusion-based additive manufacturing applications

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Bio-Design and Manufacturing 2024年第3期7卷 277-291页

作者： I.A.o.Beeren G.Dos Santos p.J.Dijkstra C.Mota J.Bauer H.Ferreira Rui L.Reis N.Neves S.Camarero-Espinosa M.B.Baker L.Moroni Department of Complex Tissue Regeneration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-pT Government Associate Laboratory 4806-909 Braga/GuimarãesPortugal poLYMAT University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain IKERBASQUE Basque Foundation for Science48009 BilbaoSpain

Melt extrusion-based additive manufacturing(ME-AM)is a promising technique to fabricate porous scaffolds for tissue engi-neering ***,most synthetic semicrystalline polymers do not possess the intrinsic biological activity required to control cell *** of biomolecules on polymeric surfaces of AM scaffolds enhances the bioactivity of a construct;however,there are limited strategies available to control the surface ***,we report a strategy to tune the surface density of bioactive groups by blending a low molecular weight poly(ε-caprolactone)5k(pCL5k)containing orthogonally reactive azide groups with an unfunctionalized high molecular weight pCL75k at different *** porous three-dimensional(3D)scaf-folds were then fabricated using a high weight percentage(75 wt.%)of the low molecular weight pCL *** a proof-of-concept test,we prepared films of three different mass ratios of low and high molecular weight polymers with a thermopress and reacted with an alkynated fluorescent model compound on the surface,yielding a density of 201-561 pmol/cm^(2).Subsequently,a bone morphogenetic protein 2(BMp-2)-derived peptide was grafted onto the films comprising different blend compositions,and the effect of peptide surface density on the osteogenic differentiation of human mesenchymal stromal cells(hMSCs)was *** two weeks of culturing in a basic medium,cells expressed higher levels of BMp receptor II(BMpRII)on films with the conjugated *** addition,we found that alkaline phosphatase activity was only significantly enhanced on films contain-ing the highest peptide density(i.e.,561 pmol/cm^(2)),indicating the importance of the surface *** together,these results emphasize that the density of surface peptides on cell differentiation must be considered at the cell-material ***,we have presented a viable strategy for ME-AM community that desires to tune the bulk and surface functionality via blending of(m

关键词： Additive manufacturing Blending Surface functionalization Surface density Click chemistry Human

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