检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

肿瘤转移的分子基础及治疗选择

德国医学 1999年第5期16卷 254-258页

作者： B.m.Ghadimi p.m.schlag 武忠弼 Klinik fr Chirurgie und Chirurgische Onkologie Universittsklinikum ChariteRobert-Rssle-Klinik am Max-Delbrck-Centrum fr Molekulare MedizinHumboldt Universitt zu BerlinLindenberger Weg 80D-13122 BerlinGermany 同济医科大学

目前,大多数癌患者仍然是死于肿瘤的转移。对于肿瘤转移的分子机制,如今已了解得越来越多,因而有望作出新的治疗策略。原发性肿瘤形成子瘤是一个复杂的、由一个个互不相关的步骤组成的系列过程,其中的每个步骤对于转移的形成,都是有限... 详细信息

目前,大多数癌患者仍然是死于肿瘤的转移。对于肿瘤转移的分子机制,如今已了解得越来越多,因而有望作出新的治疗策略。原发性肿瘤形成子瘤是一个复杂的、由一个个互不相关的步骤组成的系列过程,其中的每个步骤对于转移的形成,都是有限制作用的,即若切断其中的任一步骤,肿瘤的转移就将被阻止。这是对迄今已知的肿瘤转移的各个步骤一个概括,并从而指出了今后肿瘤治疗的新途径。转移过程的第一步是,癌细胞通过肿瘤组织中细胞与细胞间粘附的松解而脱离出来,然后通过溶蛋白过程而侵入周围的细胞外基质。

关键词：肿瘤转移分子基础分子细胞生物学治疗

在线全文

学校读者我要写书评

暂无评论

肝脏转移肿瘤的根治手术原则

德国医学 2000年第2期17卷 65-66页

作者： p.m.schlag T.Benhidjeb B.Kilpert 刘斌 Klinik fr Chirurgie und Chirurgische Onkologie Universittsklinikum CharitCampus Berlin-BuchRobert-Rssle-Klinik am Max-Delbrck-Centrum fr Molekulare MedizinLindenberger Weg 80D-13125 BerlinGermany 同济医科大学附属同济医院

30％～50％的恶性肿瘤可发生肝转移,仅有少于5％的病人可行彻底清除术,其中近90％的可切除肿瘤来源于直结肠肿瘤。回顾性调查表明,未经治疗的病人平均生存时间低于24个月。在排除肝外其他转移灶和局部复发的情况下,肿瘤彻底切除术即RO... 详细信息

30％～50％的恶性肿瘤可发生肝转移,仅有少于5％的病人可行彻底清除术,其中近90％的可切除肿瘤来源于直结肠肿瘤。回顾性调查表明,未经治疗的病人平均生存时间低于24个月。在排除肝外其他转移灶和局部复发的情况下,肿瘤彻底切除术即RO术式可将5年生存时间增加到30％(15％～45％)。因而病人术前分期很重要,特别是要选择单个肝脏转移灶和具有RO术式切除适应证的病人。

关键词：肝转移瘤外科手术肿瘤转移手术适应证

肢体恶性黑色素瘤隔离高温灌注米尔法兰和肿瘤坏死因子

在线全文

学校读者我要写书评

暂无评论

德国医学 1998年第4期15卷 247-248页

作者： C.Kettelhack p.Hohenberger p.m.schlag 胡国清 Abteilung für Chirurgie und Chirurgische Onkologie Robert-Rssle-Klinik am Max-Delbrück-Centrum für Molekulare Medizin Virchow-Klinikum der Humboldt-UniversittLindenberger Weg 80 D-13122 Berlin Germany 同济医科大学附属同济医院

1957年 Creech 首次用细胞抑制剂行隔离的肢体灌注治疗有肢体范围内转移的恶性黑色素瘤病人,Cavaliere 则证明同时加温能提高细胞抑制剂的疗效。Lejeune 首次在恶性黑色素瘤病人联合用重组人体肿瘤坏死因子(rhTNF-α)和米尔法兰行隔离... 详细信息

1957年 Creech 首次用细胞抑制剂行隔离的肢体灌注治疗有肢体范围内转移的恶性黑色素瘤病人,Cavaliere 则证明同时加温能提高细胞抑制剂的疗效。Lejeune 首次在恶性黑色素瘤病人联合用重组人体肿瘤坏死因子(rhTNF-α)和米尔法兰行隔离的肢体灌注。

关键词：肢体肿瘤黑色素瘤高温灌注米尔法兰 rhTNF-α

在线全文

学校读者我要写书评

暂无评论

腹腔镜模拟训练在腔镜外科中的应用

中国微创外科杂志 2008年第1期8卷 7-10页

作者：张爱民戴一扬 S.Beller m.Huenerbein p.m.schlag 浙江省杭州市萧山区第一人民医院普通外科杭州311201 浙江省浙江医院消化内科杭州311200 Department of Surgery and Surgical Oncology Charite Medical Universityberlingermany13125

目的探讨腹腔镜模拟训练机对不同临床经验参与者的培训效果。方法在腹腔镜模拟机上培训9名无任何临床经验的志愿者(对照组)、9名6年级医学实习生(学生组)和9名有2～3年临床经验的住院医生(医生组),包括0°、30°腹腔镜的操作、眼-手协... 详细信息

目的探讨腹腔镜模拟训练机对不同临床经验参与者的培训效果。方法在腹腔镜模拟机上培训9名无任何临床经验的志愿者(对照组)、9名6年级医学实习生(学生组)和9名有2～3年临床经验的住院医生(医生组),包括0°、30°腹腔镜的操作、眼-手协调、钛夹应用、抓-钳夹、剪切、电凝和物体转运,每天训练30min,共5d,比较培训前后各组的得分。结果培训前3组在0°、30°腹腔镜的操作,抓-钳夹,电凝,眼-手协调得分都有统计学差异(ppp<0.05)。结论腹腔镜模拟训练机培训可以提高不同临床经验参与者的腹腔镜操作技巧,并且可以区分不同临床经验者。

关键词：腹腔镜模拟训练机培训效果

在线全文

学校读者我要写书评

暂无评论

远程会诊与远程外科

德国医学 1999年第3期16卷 125-126页

作者： p.m.schlag F.Engel-murke m.meyerzurHeyde S.Rakowsky G.Graschew 张伟杰 Klinik für Chirurgie und Chirurgische Onkologie Robert-Rssle-Klinik am Max-Delbrück-CentrumUniversittsklinikum CharitHumboldt-UniversittD-13122 BerlinGermany 同济医科大学附属同济医院

远程医学的重要目的之一是广泛的、不依赖时间和地点的信息交换。***定义远程医学为:“当参与者分隔异地时使用信息和电信交换技术提供健康治疗支持”。外科学对此有特殊的要求,因为大量的信息必须在线传播,各种不同的资料如动静态图像... 详细信息

远程医学的重要目的之一是广泛的、不依赖时间和地点的信息交换。***定义远程医学为:“当参与者分隔异地时使用信息和电信交换技术提供健康治疗支持”。外科学对此有特殊的要求,因为大量的信息必须在线传播,各种不同的资料如动静态图像、大体及显微结构形态学及脏器功能均须考虑。本文对术中视听信息交换的建立条件及在此基础上产生的远程外科的应用加以概述。

关键词：远程医学远程会诊远程外科

Heterogeneity of mature oligodendrocytes in the central nervous system

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam m.R.Groh moein Yaqubi Qiao-Ling Cui Jo Anne Stratton G.R.Wayne moore Jack p.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： Siva S.V.p.Sakamuri Anil Sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA Vascular Biology Center and Department of medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

Treatment of eosinophlic esophagitis with swallowed topical corticosteroids

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2020年第36期26卷 5395-5407页

作者： Simon Nennstiel Christoph schlag Klinikum rechts der Isar der Technischen Universität münchen Klinik und Poliklinik für Innere Medizin IIMunich 81675Germany

Eosinophilic esophagitis(EoE)is an emerging chronic local immune-mediated disease of the *** proton pump inhibitors and food-restrictiondiets swallowed topical corticosteroids(STC)can be offered as a first line therapy according to current *** review describes the background and practical management of STCs in *** far,mainly asthma inhalers containing either budesonide or fluticasone have been administered to the esophagus by swallowing these medications“off label”.Recently esophagus-targeted formulations of topical steroids have been developed showing clinicopathological response rates up to 85%-an orodispersible tablet of budesonide has been approved as the first“in label”medication for EoE in Europe in June *** it was shown that disease remission induction of EoE by STCs is highly effective,there is still a lack of data regarding long-term and maintenance ***,current studies on STC maintenance therapy add some movement into the game.

关键词： Eosinophilic esophagitis Swallowed topical corticosteroids Esophagustargeted formulations of topical steroids Fluticasone Budesonide Budesonide orodispersible tablet Budesonide oral suspension