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控制理论与应用（英文版） 2010年第1期8卷 12-19页

作者： p.m.ballal A.C.TRIVEDI V.GIORDANO J.mIRELES Jr. F.L.LEWIS Automation & Robotics Research Institute University of Texas at Arlington

In unstructured environments, dynamic resource assignment is required for effective cooperation of robot teams. In some scenarios, robots are in charge of executing multiple missions simultaneously. This creates risks of deadlock due to the presence of shared resources among various missions. The main contribution of this paper is the development of a novel approach that combines the one-step look-ahead deadlock avoidance policy with dynamic resource assignment. The dynamicresource assignment is achieved using greedy resource assignment for multi-mission robot teams in the framework of a matrix-based discrete event controller. Simulation results are presented in mATLAB to discuss in detail the proposed control strategy. The paper also discusses the toolkit developed in LabVIEW which is used to implement this control framework using a suitable example.

关键词： Discrete event systems Wireless sensor networks Deadlock avoidance petri nets

Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam m.R.Groh moein Yaqubi Qiao-Ling Cui Jo Anne Stratton G.R.Wayne moore Jack p.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

Enhancement of Distributed Generation by Using Custom power Device

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Journal of Electronic Science and Technology 2015年第3期13卷 246-254页

作者： Kishor V.Bhadane m.S.ballal R.m.moharil G.H.Raisoni Institute of Engineering and managem Electrical Department VNIT.Nagpur and YCCE.Nagpur India

Wind energy （WE） has become immensely popular for distributed generation （DG）. This case presents the monitoring, modeling, control, and analysis of the two-level three-phase WE based DG system where the electric grid interfacing custom power device （CpD） is controlled to perform the smart exchanging of electric power as per the Indian grid code. WE is connected to DC link of CpD for the grid integration purpose. The CpD based distributed static compensator, i.e. the distributed static synchronous compensator （DSTATCOm）, is utilized for injecting the wind power to the point of common coupling （pCC） and also acts against the reactive power demand. The novel indirect current control scheme of DSTATCOm regulates the power import and export between the WE and the electric grid system. It also acts as a compensator and performs both the key features simultaneously. Hence, the penetration of additional generated WE power to the grid is increased by 20% to 25%. The burden of reactive power compensation from grid is reduced by DSTATCOm. The modeling and simulation are done in mATLAB. The results are validated and verified.

关键词： Custom power device distributed generation (DG) distributed static synchronous compensator (DSTATCOm) indirect current control scheme reactive power

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

Effect of grass density and date of tapping on Acacia senegal gum yield in north kordofan state, Sudan

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Journal of Forestry Research 2013年第1期24卷 169-172页

作者： Idris m. Adam m. E. ballal Kamal El. m. Fadl Agricultural Research Corporation Kadugli Research StationP.O. Box 16KadugliSudan. Agricultural Research Corporation Forest Research CenterP.O. Box 13391Khartoum-Soba-Sudan. Agricultural Research Corporation El-Obeid Research StationP.O. Box 429El-ObeidSudan.

We conducted a two-factor experiment in randomized complete block design with four replications during 2004 in El Demokeya Forest Reserve and El Himaira Natural Forest, North Kordofan State, Sudan. The objective was to develop an understanding of the ecological effects of under-story vegetation and tapping date on the productivity of gum arabic from Acacia senegal as over story cover. The first factor was grass cover which was tested in four levels （100% and 50% grass cover in addition to bare and burnt）. The second factor, date of tapping was tested in three levels namely （1st Oct, 15th Oct and 1st Nov）. The first picking was done after 45 days from tapping and the gum yield up to seven pickings was collected at intervals of 15 days. Gum yield from each picking was collected and weighed using sensitive balance. Analysis of variance was carried out using mSTAT-C statistical package, and the Tukey test was applied for mean comparisons. The results showed highly significant differences （p 〈 0.01） of grass cover on gum arabic yield in the two sites for most of the first consecutive pickings （1st–4th out of seven） in addition to total yield （kg/ha）. With exception to the 4th pickings, the interaction effect between the grass densities and tapping date was not significantly different. The total gum yield was significantly （p 〈 0.05） increased in only two pickings （third and fourth） in El Demokeya Forest Reserve and two pickings （1st and 2nd） at El Himaira Natural Forest. The density of grass cover significantly （p 〈 0.05） affected the number of pickings at both sites; the number of gum pickings was directly proportional to grass density. The number of gum pickings was found to be significantly （p 〈 0.05） increased at the early date of tapping.

关键词： Acacia senegal grass density date of tapping gum arabic yield Sudan.

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis pharma plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

From single to combinatorial therapies in spinal cord injuries for structural and functional restoration

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Neural Regeneration Research 2025年第3期20卷 660-670页

作者： Ernesto Doncel-pérez Gabriel Guízar-Sahagún Israel Grijalva-Otero Hospital Nacional de parapléjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain medical Research Unit for Neurological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the spinal cord after spinal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. most published works on structural/functional restoration in acute and chronic spinal cord injury stages use a single type of treatment: a drug or trophic factor, transplant of a cell type, and implantation of a biomaterial. Despite the significant benefits reported in animal models, when translating these successful therapeutic strategies to humans, the result in clinical trials has been considered of little relevance because the improvement, when present, is usually insufficient. Until now, most studies designed to promote neuroprotection or regeneration at different stages after spinal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute phases of spinal cord injury, it is reasonable to speculate that more than one therapeutic agent could be required to promote structural and functional restoration of the damaged spinal cord. Treatments that combine several therapeutic agents, targeting different mechanisms of injury, which, when used as a single therapy, have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therapeutic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neuroprotection spinal cord injury repair spinal cord injury treatments structural restoration of spinal cord injury

Search for microglia-specific peptides:advances in the discovery toolbox

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Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss Department of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflammatory states in the central nervous system(CNS)are the hallmark of neurodegenerative pathology and every injury or stroke-related *** key mediators of these neuroinflammatory states are glial cells known as microglia,the resident immune cell at the core of the inflammatory event,and astroglia,which encapsulate inflammatory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** most neuroinflammation is exclusively based on the responses of said microglia,their phenotypes are suggested to follow those of macrophages;m1 and m2 are opposites of pro-and ***,microglial phenotypes have been identified to be on an inflammatory spectrum encompassing developmental,homeostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue formation.

关键词： inflammation pathology death

SBL-Jp-0004: A promising dual inhibitor of JAK2 and pI3KCD against gastric cancer

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Oncology research 2025年第1期33卷 235-243页

作者： Hassan m Otifi Department of pathology College of Medicine King Khalid University Abha 62521 Saudi Arabia.

Background:Gastric cancer (GC) remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional therapies. The phosphoinositide 3-kinase and pI3K and Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathways play pivotal roles in GC progression, making them attractive targets for therapeutic interventions.methods:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-Jp-0004 as a potential dual inhibitor of JAK2 and pI3KCD kinases. KATOIII and SNU-5 GC cells were used for evaluation.Results:SBL-Jp-0004 exhibited a robust binding affinity for JAK2 and pI3KCD kinases, as evidenced by molecular docking scores and molecular dynamics simulations. Binding interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target proteins. SBL-Jp-0004 displayed an half-maximal inhibitory concentration (IC) value of 118.9 nm against JAK2 kinase and 200.9 nm against pI3KCD enzymes. SBL-Jp-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells, with half-maximal growth inhibitory concentration (GI) values of 250.8 and 516.3 nm, respectively. A significant elevation in the early phase apoptosis (28.53% in KATOIII cells and 26.85% in SNU-5 cells) and late phase apoptosis (17.37% in KATOIII cells and 10.05% in SNU-5 cells) were observed with SBL-Jp-0004 treatment compared to 2.1% and 2.83% in their respective controls.Conclusion:The results highlight SBL-Jp-0004 as a promising dual inhibitor targeting JAK2 and pI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Dual inhibition Gastric cancer (GC) JAK2 molecular docking molecular dynamics simulation pI3KCD SBL-Jp-0004