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A facile strategy for tuning the density of surface-grafted biomolecules for melt extrusion-based additive manufacturing applications

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Bio-Design and Manufacturing 2024年第3期7卷 277-291页

作者： I.A.O.Beeren g.Dos Santos p.J.Dijkstra C.Mota J.Bauer H.Ferreira Rui L.Reis N.Neves S.Camarero-Espinosa M.B.Baker L.Moroni Department of Complex Tissue Regeneration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3B’s Research group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-pT government Associate Laboratory 4806-909 Braga/GuimarãesPortugal pOLYMAT University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain ikERBASQUE Basque Foundation for Science48009 BilbaoSpain

Melt extrusion-based additive manufacturing(ME-AM)is a promising technique to fabricate porous scaffolds for tissue engi-neering ***,most synthetic semicrystalline polymers do not possess the intrinsic biological activity required to control cell *** of biomolecules on polymeric surfaces of AM scaffolds enhances the bioactivity of a construct;however,there are limited strategies available to control the surface ***,we report a strategy to tune the surface density of bioactive groups by blending a low molecular weight poly(ε-caprolactone)5k(pCL5k)containing orthogonally reactive azide groups with an unfunctionalized high molecular weight pCL75k at different *** porous three-dimensional(3D)scaf-folds were then fabricated using a high weight percentage(75 wt.%)of the low molecular weight pCL *** a proof-of-concept test,we prepared films of three different mass ratios of low and high molecular weight polymers with a thermopress and reacted with an alkynated fluorescent model compound on the surface,yielding a density of 201-561 pmol/cm^(2).Subsequently,a bone morphogenetic protein 2(BMp-2)-derived peptide was grafted onto the films comprising different blend compositions,and the effect of peptide surface density on the osteogenic differentiation of human mesenchymal stromal cells(hMSCs)was *** two weeks of culturing in a basic medium,cells expressed higher levels of BMp receptor II(BMpRII)on films with the conjugated *** addition,we found that alkaline phosphatase activity was only significantly enhanced on films contain-ing the highest peptide density(i.e.,561 pmol/cm^(2)),indicating the importance of the surface *** together,these results emphasize that the density of surface peptides on cell differentiation must be considered at the cell-material ***,we have presented a viable strategy for ME-AM community that desires to tune the bulk and surface functionality via blending of(m

关键词： Additive manufacturing Blending Surface functionalization Surface density Click chemistry Human

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Emission colour tuning in KLnF_(4):Yb^(3+),Er^(3+)/Ho^(3+)phosphor

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Journal of Rare Earths 2024年第1期42卷 57-65,I0002页

作者： Janani K gayathri E Vijayatha V Ramasubramanian S Thiyagarajan p Department of Science and Humanities Nehru Institute of TechnologyKaliapuramThirumalayampalayamCoimbatoreIndia Department of Sciences Amrita School of Physical SciencesAmrita Vishwa VidyapeethamCoimbatoreIndia Department of physics Anna UniversityChennaiIndia

KLnF_(4):Yb^(3+),Er^(3+)/Ho^(3+)(Ln=Y,Yb,gd)phosphors were prepared by solid-state reaction *** each of the Yb^(3+)/Er^(3+)and Yb^(3+)/Ho^(3+)co-doped phosphors independently,phase confirmation and morphological examination were accomplished using the X-ray diffraction technique and scanning electron microscope analysis.X-ray photoelectron spectroscopy analysis shows the charge state and existence of lanthanides and *** luminescence emissions of green and red colour were detected for the synthesized *** changes in the upconverted emission intensities and colour output pertaining to the change of the lanthanide host matrix along with dopants were investigated for the prepared *** the upconversion luminescence,erbium-doped samples exhibit a predominance of red emission while holmium-doped samples display a prevalence of green *** rare-earth Er/Ho doped KYbF4shows strong red emission compared to other ***_(4):Yb,Er/Ho exhibits relatively significant green upconve rsion emissions,while Yb,Er-doped KgdF_(4)host displays a 10-fold increase in green/red emission ratio with an increase in the input power of 20-780 *** photoluminescence studies and decay curve analysis were carried out using UV light excitation for the developed phosphors.A higher lifetime of 2.2 ms was measured for the downshifting red emission in the Ho doped KYbF_(4)*** study suggests a potential for colour tunability in the upconversion and downshifting emissions through host modifications to the fluoride phosphor.

关键词： Rare earths Energy transfer upconversion Downshifting Colour coordinates

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Management of early oesophageal cancer:An overview

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World Journal of gastrointestinal Surgery 2024年第5期16卷 1255-1258页

作者： gavin g Calpin Matthew g Davey Noel E Donlon Department of Surgery Royal College of Surgeons in IrelandDublin D2Ireland Department of Upper gastrointestinal Surgery Beaumont HospitalDublin D09V2N0Ireland

The incidence of esophageal cancer,namely the adenocarcinoma subtype,continues to increase exponentially on an annual *** indolent nature of the disease renders a significant proportion inoperable at first presentation,however,with the increased utilisation of endoscopy,many early lesions are now being identified which are suitable for endotherapeutic *** article details the options available for dealing with early esophageal cancer by endoscopic mean obviating the need for surgery thereby avoiding the potential morbidity and mortality of such intervention.

关键词： Esophageal cancer Endotherapy Endoscopic submucosal resection Endoscopic mucosal resection Endoscopy

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Mean nocturnal baseline impedance in gastro-esophageal reflux disease diagnosis:Should we strictly follow the Lyon 2 Consensus?

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World Journal of gastroenterology 2024年第26期30卷 3253-3256页

作者： Theodoros A Voulgaris georgios p Karamanolis Department of gastroenterology School of MedicineNational and Kapodistrian University of AthensAthens 11527Greece

Clinical practice guidelines drive clinical practice and clinicians rely to them when trying to answer their most common *** of the most important position papers in the field of gastro-esophageal reflux disease(gERD)is the one produced by the Lyon *** an updated second version has been *** nocturnal baseline impedance(MNBI)was proposed by the first Consensus to act as supportive evidence for gERD *** a cut-off of 2292 Ohms was proposed,a value revised in the second *** updated Consensus recommended that an MNBIgly suggests gERD while a value>2500 Ohms can be used to refute *** proposed cut-offs move in the correct direction by diminishing the original cut-off,nevertheless they arise from a study of normal subjects where cut-offs were provided by measuring the mean value±2SD and not in symptomatic ***,data exist that even symptomatic patients with inconclusive disease or reflux hypersensitivity(RH)show lower MNBI values in comparison to normal subjects or patients with functional heartburn(FH).Moreover,according to the data,MNBI,even among symptomatic patients,is affected by age and body mass ***,various studies have proposed different cut-offs by using receiver operating characteristic curve analysis even lower than the one ***,no information is given for patients submitted to on-proton pump inhibitors pH-impedance studies even if new and extremely important data now ***,even if MNBI is an extremely important tool when trying to approach patients with reflux symptoms and could distinguish conclusive gERD from RH or FH,its values should be interpreted with caution.

关键词： Mean nocturnal baseline impedance gastro-esophageal reflux disease Lyon 2 Consensus pH-impedance Diagnosis

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Influence of cerium ions on structure-dependent magnetic properties of Ba-Sr M-type hexaferrite nanocrystals

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Journal of Rare Earths 2024年第2期42卷 364-372,I0005页

作者： Ram A.pawar Sunil M.patange p.M.Dighe Sher Singh Meena Abdullah gAl-Sehemi Mehboobali pannipara Santosh S.Jadhav Department of physics ArtsCommerce and Science CollegeAhmednagar413711MaharashtraIndia Department of physics Shri Krishna MahavidyalayaGunjotiDistOsmanabad413606MaharashtraIndia padmashri Vikhe patil College of Arts Science and CommercePravaranagarA/P.Loni(Kd)Tal.RahataDistAhmednagar413713MaharashtraIndia Solid State physics Division Bhabha Atomic Research CentreMumbai400085MaharashtraIndia Department of Chemistry King Khalid UniversityAbha61413Saudi Arabia Department of physics D.S.M's ArtsCommerce and Science CollegeJintur431509MaharashtraIndia

The present study is a systematic effort to investigate the structure-sensitive magnetic parameters of Ce^(3+) substituted Ba-Sr hexaferrite nanocrystals chemically formulated as Ba_(0.5)Sr_(0.5)Ce_(x)Fe_(12-x)O_(19) where x=0.0-0.2 with Δx=*** hexaferrite powders were prepared using the sol-gel self-ignition route and structurally characterized by means of powder X-ray diffraction and Fourier transform infrared *** creation of the M-type hexaferrite phase within the synthesized samples was revealed from the Rietveld refinement of the X-ray *** occurrence of a secondary phase of CeO_(2) was revealed within the hexaferrites for the substitution,x> *** refined X-ray diffraction data were utilized to compute the lattice parameters,X-ray density,and lattice parameter *** crystal structure plotted from the refined XRD data reveals the occupancy of the ions at different lattice *** XpS data of the hexaferrite were analyzed to confirm the oxidation states of the constituent *** nanocrystalline nature of the hexaferrites was revealed from the crystallite sizes calculated using Scherer's *** analysis of FTIR spectra confirms that only a fraction of Ce^(3+)accommodated in the lattice and the remaining Ce content reside in the form of the CeO_(2) *** morphology of the hexaferrites was analyzed from the FESEM profiles of the ferrite *** magnetic behavior study was performed by analyzing the Curie temperature,hysteresis loops,and hyperfine interactions by means of susceptibility,V.S.M,and Mossbauer spectroscopy,*** hexaferrites with increasing coercivity,decreasing saturation magnetization,and decreasing Curie temperature are reported in the *** substituted Ce^(3+)ions inhibit the grain growth and create lattice imperfections giving rise to hexaferrites with tuned magnetic parameters suitable for different applications.

关键词： Ba-Sr hexaferrite Ce^(3+)substitution XpS Saturation magnetization Coercivity M?ssbauer spectroscopy

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Chronic active and atrophic gastritis as significant contributing factor to the development of gastric cystica profunda

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World Journal of gastroenterology 2024年第17期30卷 2308-2310页

作者： Veronika papp pál Miheller Department of Surgery Transplantation and GastroenterologySemmelweis UniversityBudapest 1082Hungary

gastric cystica profunda(gCp)is an uncommon but underestimated gastric *** precancerous potential determines its *** addition to previous mucosa injury due to operations,biopsy or polypectomy,chronic active and atrophic gastritis may also lead to the development of *** carefully examining the stomach and taking biopsy samples from the susceptible regions,the stage of atrophy can be *** atrophic gastritis is a risk factor for cancer evolvement and it can also contribute to gCps *** frequently occur close to early gastric cancers(EgCs)or EgC can arise from the cystic *** resection is an effective and minimally invasive treat-ment in gCp.

关键词： gastric cystica profunda Chronic active gastritis Atrophic gastritis Operative Link for gastritis Assessment staging Early gastric cancer Endoscopic resection

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Exploring the potential of drill cuttings for reservoir characterization:A case study from the Volga-Ural basin,Russia

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petroleum Research 2024年第2期9卷 193-205页

作者： Ibrahem Yousef V.p.Morozov Kazan Federal University Institute of Geology and Petroleum Technologies420008Russian Federation

The research objectives are to assess the possibility of using drill cutting analysis to obtain information about the mineralogical and geochemical properties of the reservoir *** cutting samples were collected from a vertical well that penetrated the Domanik sediments(Semiluksk Formation)in one of the oil fields in the Volga-Ural petroleum *** sections from drill cuttings were examined using an optical polarizing microscope(Axio Imager A2).X-ray diffraction(XRD)analyses were performed using a Brucker D2 phaser X-ray powder *** properties were studied using an STA 449 F3 Jupiter *** pyrolytic studies were performed using the Rock-Eval *** inspection showed that the studied sediments are alternations of carbonates and siliceous-carbonate *** section examinations revealed that the carbonates are mainly limestone(mudstone and wackestone)and are characterized by a dense texture and up to 30%organic *** siliceous-carbonate rocks are dominated by siliceous mudstones and are characterized by dark colours,layered structure,and an enrichment in organic *** analyses showed that the carbonate rocks are mainly composed of calcite,dolomite,quartz,feldspar,and mica,which are minor *** siliceous-carbonate rocks are dominated by quartz,followed by calcite,although they also contain feldspars,mica,dolomite,and pyrite as *** to the simultaneous thermal analysis,the average total hydrocarbon in the carbonate and siliceous-carbonate rocks is 13.6%(for the core samples)and 11.5%(for the drill cutting samples).The content of heavy hydrocarbons in the rocks is higher than the content of light hydrocarbons,indicating the immature nature of organic *** is found sporadically in siliceous-carbonate *** to the pyrolytic studies,average S1 is 4.4 mg/g and average S2 is 19.8 mg/g(for the core samples);average S1 is 2.1 mg/g and average S2 is 17.8 mg/g(for the

关键词： Drill cuttings Reservoir characterization Domanik Semiluksk Volga-Ural Russia

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Severe acute respiratory syndrome-coronavirus-2(SARS-COV-2)infection of pneumocytes with vaccination and drug therapy:Mathematical analysis and optimal control

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International Journal of Biomathematics 2024年第2期17卷 299-334页

作者： R.Viriyapong p.Inkhao Department of Mathematics Faculty of Science Naresuan University Phitsanulok65000Thailand

We propose a mathematical model studying a within-host infection dynamics of SARSCoV-2 in *** model incorporates immune response,vaccination and antiviral *** crucial properties of the model-the existence,positivity and boundary of solutions are *** points and the basic reproduction number are *** stability of each equilibrium point is *** control is applied to the model by adding three control variables:vaccination,treatment by Favipiravir and treatment by *** results show that each individual control could reduce SARS-CoV-2 infection in some aspects;however,with a combination of three controls,we obtain the best results in reducing SARS-CoV-2 *** study has emphasized the importance of prevention by vaccine and the antiviral treatments.

关键词： SARS-CoV-2 vaccination drug therapy immune response optimal control

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Metric and Upper Dimension of Extended Annihilating-Ideal graphs

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Algebra Colloquium 2024年第2期31卷 221-238页

作者： S.Nithya g.Elavarasi genghua Fan Department of Mathematics St.Xavier's College(Autonomous)Palayamkottai 627002Tamil NaduIndia Afiliated to Manonmaniam Sundaranar University Abishekapatti Tirunelveli 627012Tamil NaduIndia pg and Research Department of Mathematics St.Xavier's College(Autonomous)Palayamkottai 627002Tamil NaduIndia Affiliated to Manonmaniam Sundaranar University Abishekapatti Tirunelveli 627012Tamil NaduIndia 不详

The metric dimension problem is called navigation problem due to its application to robot navigation in *** this concept has wide applications in motion planning,sonar and loran station,and so *** this paper,we study certain results on the metric dimension,upper dimension and resolving number of extended annihilating-ideal graph EAg(R)associated to a commutative ring R,denoted by dim M(EAg(R)),dim+(EAg(R))and res(EAg(R)),*** we prove the finiteness conditions of dim M(EAg(R))and dim+(EAg(R)).In addition,we characterize dim M(EAg(R)),dim+(EAg(R))and res(EAg(R))for artinian rings and the direct product of rings.

关键词： extended annihilating-ideal graph metric dimension upper dimension resolving number

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Multiple sclerosis drug repurposing for neuroregeneration

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Neural Regeneration Research 2024年第3期19卷 507-508页

作者： peter göttle Michael Dietrich patrick Küry Department of Neurology Medical FacultyHeinrich-Heine UniversityDüsseldorfGermany

Multiple sclerosis(MS)is an autoimmune disorder of the central nervous system(CNS)and is primarily characterized by immune cell infiltration leading to relapses followed by remission phases and a disease course turning progressive over time with neurodegenerative processes taking over(Amin and Hersh,2023).Of note,beyond relapse-associated worsening early in disease progression independent of relapse activity may arise independently of relapse activity and can occur in all ***-mediated damage of myelin sheaths and the subsequent loss of mature oligodendrocytes are resulting in impaired axonal integrity,neurodegeneration and accounts for irreversible neuronal damage(Kuhlmann et al.,2023).The current landscape of available disease-modifying therapies comprises mainly immunomodulatory drugs that effectively diminish relapses and slow down progression at the onset form of the disease,namely relapsing MS(RMS).In this regard,a number of drugs have been approved as disease-modifying therapies for MS by US Food and Drug Administration and European Medicines Agencies(Box 1).

关键词： drugs impaired irreversible

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