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Temperature and structure measurements of heavy-ion-heated diamond using in situ X-ray diagnostics

Matter and Radiation at Extremes 2024年第4期9卷 80-89页

作者： J.Lutgert p.Hesselbach M.Schorner V.Bagnoud R.Belikov p.Drechsel B.Heuser O.SHumphries p.Katrik B.Lindqvist c.Qu R.Redmer D.Riley G.Schaumann S.Schumacher A.Tauschwitz D.Varentsov K.Weyrich X.Yu B.Zielbauer Zs.Major p.Neumayer D.Kraus Institut fur physik Universitat RostockAlbert-Einstein-Str.2318059 RostockGermany GSI Helmholtzzentrum fur Schwerionenforschung Planckstr.164291 DarmstadtGermany Institut für Angewandte physik Goethe-Universität Frankfurt am MainMax-von-Laue-Str.160438 Frankfurt am MainGermany Institut fur Geowissenschaften Goethe-Universitat Frankfurt am MainAltenhoferallee 160438 Frankfurt am MainGermany Helmholtz-Zentrum Dresden-Rossendorf Bautzner Landstr.40001328 DresdenGermany European XfEL GmbH Holzkoppel 422869 SchenefeldGermany centre for plasma physics School of Mathematics and PhysicsQueen’s University BelfastUniversity RoadBelfast BT71NNUnited Kingdom Institut für Kernphysik Technische Universität DarmstadtSchlossgartenstr.964289 DarmstadtGermany State Key Laboratory of Nuclear physics and Technology Institute of Heavy Ion PhysicsPeking UniversityBeijing 100871China Helmholtz Institut Jena Frobelstieg 307743 JenaGermany

We present in situ measurements of spectrally resolved X-ray scattering and X-ray diffraction from monocrystalline diamond samples heatedwith an intense pulse of heavy *** this way,we determine the samples’heating dynamics and their microscopic and macroscopic structuralintegrity over a timespan of several *** the ratio of elastic to inelastic scattering with state-of-the-art density functionaltheory molecular dynamics simulations allows the inference of average temperatures around 1300 K,in agreement with predictions fromstopping power *** simultaneous diffraction measurements show no hints of any volumetric graphitization of the material,butdo indicate the onset of fracture in the diamond *** experiments pave the way for future studies at the facility for Antiproton andIon Research,where a substantially increased intensity of the heavy ion beam will be available.

关键词： heated intense structure

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Linking IL-10 signaling with lipid metabolic programs in macrophages:dysregulated ceramide homeostasis drives colitis

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2835-2836页

作者： Imke Atreya Markus f.Neurath Department of Medicine 1 University Hospital of ErlangenFriedrich-Alexander University Erlangen-NürnbergErlangenGermany Deutsches Zentrum Immuntherapie(DZI) ErlangenGermany

In a recent study published in Nature,York and coworkers identified the immunometabolic regulation of mono-unsaturated fatty acid(MUfA)pools and the subsequent increase in sphingolipid biosynthesis in TLR2-activated macrophages as an important link between impaired IL-10 signaling and the development of intestinal inflammation.1 Thus,targeted interference with the newly identified IL-10/MUfA/sphingolipid axis appears as a promising strategy to restore immunometabolic homeostasis in the intestine of patients with inflammatory bowel diseases(IBD).

关键词： homeostasis impaired intestine

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photosynthetic Gas Exchange and Nitrogen Assimilation in Green Bean plants Supplied with Two Sources of Silicon

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phyton-International Journal of Experimental Botany 2024年第5期93卷 963-980页

作者： Julio c.Anchondo-páez Esteban Sánchez carlos A.Ramírez-Estrada Alondra Salcido-Martínez Erick H.Ochoa-chaparro Department of plant physiology Centro de Investigación en Alimentación y DesarrolloCiudad Delicias33089México

Beans contain a wide range of vitamins,proteins,calcium,and zinc which make them an important food source for many *** meet the demand for bean production worldwide,large amounts of fertilizers and pesticides are ***,the cost of production and environmental impact *** produce food sustainably,the use of beneficial nutrients such as silicon as a biostimulant has been ***,information about the effect of different sources of silicon on the metabolism of bean plants is *** plants *** were grown in pots for 60 days and the effect of foliar application of silicon nanoparticles and the silicon-based biostimulant codasilat 4 concentrations(0,1,2,and 4 mM)on total biomass,yield,photosynthetic pigment concentration,photosynthetic activity,stomatal conductance,transpiration rate,chlorophyll fluorescence,and nitrogen assimilation were *** results obtained showed that the supply of silicon at a dose of 1 mM functioned as a biostimulant,favoring gas exchange and nitrogen assimilation within the plant,which stimulated growth and *** results of this research work allowed a better comprehension of the effects of silicon application through silicon nanoparticles and the biostimulant codasilon the physiology of green bean plants.

关键词： Nanoparticles silicon phaseolus vulgaris L.

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Selection of digital fabrication technique in the construction industry--A multi-criteria decision-making approach

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frontiers of Structural and civil Engineering 2024年第7期18卷 977-997页

作者： M.p.SALAIMANIMAGUDAM J.JAYApRAKASH Department of Structural and Geotechnical Engineering School of Civil EngineeringVellore Institute of TechnologyVellore 632014India

Digital fabrication techniques,in recent decades,have provided the basis of a sustainable revolution in the construction ***,selecting the digital fabrication method in terms of manufacturability and functionality requirements is a complex *** paper presents alternatives and criteria for selection of digital fabrication techniques by adopting the multi-criteria decision-making *** alternatives considered in the study are concrete three-dimensional(3D)printing,shotcrete,smart dynamic casting,material intrusion,mesh molding,injection concrete 3D printing,and thin forming *** criteria include formwork utilization,reinforcement incorporation,geometrical complexity,material enhancement,assembly complexity,surface finish,and build *** demonstrates different multi-criteria decision-making techniques,with both subjective and objective weighting *** given ranking is based on the current condition of digital fabrication in the construction *** study reveals that in the selection of digital fabrication techniques,the criteria including reinforcement incorporation,build area,and geometrical complexity play a pivotal role,collectively accounting for nearly 70% of the overall *** the evaluated techniques,concrete 3D printing emerged as the best performer,however the shotcrete and mesh molding techniques in the second and third positions.

关键词： digital fabrication multicriteria decision-making concrete 3D printing

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Endoplasmic reticulum stress,autophagy,neuroinflammation,and sigma 1 receptors as contributors to depression and its treatment

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Neural Regeneration Research 2024年第10期19卷 2202-2211页

作者： chika fujii charles f.Zorumski Yukitoshi Izumi Department of psychiatry Washington University School of MedicineSt.LouisMOUSA Taylor family Institute for Innovative psychiatric Research Washington University School of MedicineSt.LouisMOUSA

The etiological factors contributing to depression and other neuropsychiatric disorders are largely undefined. Endoplasmic reticulum stress pathways and autophagy are well-defined mechanisms that play critical functions in recognizing and resolving cellular stress and are possible targets for the pathophysiology and treatment of psychiatric and neurologic illnesses. An increasing number of studies indicate the involvement of endoplasmic reticulum stress and autophagy in the control of neuroinflammation, a contributing factor to multiple neuropsychiatric illnesses. Initial inflammatory triggers induce endoplasmic reticulum stress, leading to neuroinflammatory responses. Subsequently, induction of autophagy by neurosteroids and other signaling pathways that converge on autophagy induction are thought to participate in resolving neuroinflammation. The aim of this review is to summarize our current understanding of the molecular mechanisms governing the induction of endoplasmic reticulum stress, autophagy, and neuroinflammation in the central nervous system. Studies focused on innate immune factors, including neurosteroids with anti-inflammatory roles will be reviewed. In the context of depression, animal models that led to our current understanding of molecular mechanisms underlying depression will be highlighted, including the roles of sigma 1 receptors and pharmacological agents that dampen endoplasmic reticulum stress and associated neuroinflammation.

关键词： allopregnanolone fluvoxamine ketamine neurosteroids postpartum depression quercetin

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cL2ES-KDBc:A Novel covariance Embedded Selection Based on Kernel Distributed Bayes classifier for Detection of cyber-Attacks in IoT Systems

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computers, Materials & continua 2024年第3期78卷 3511-3528页

作者： Talal Albalawi p.Ganeshkumar computer Science Department College of Computer and Information SciencesImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Saudi Arabia

The Internet of Things(IoT)is a growing technology that allows the sharing of data with other devices across wireless ***,IoT systems are vulnerable to cyberattacks due to its opennes The proposed work intends to implement a new security framework for detecting the most specific and harmful intrusions in IoT *** this framework,a covariance Linear Learning Embedding Selection(cL2ES)methodology is used at first to extract the features highly associated with the IoT ***,the Kernel Distributed Bayes classifier(KDBc)is created to forecast attacks based on the probability distribution value *** addition,a unique Mongolian Gazellas Optimization(MGO)algorithm is used to optimize the weight value for the learning of the *** effectiveness of the proposed cL2ES-KDBc framework has been assessed using several IoT cyber-attack datasets,The obtained results are then compared with current classification methods regarding accuracy(97%),precision(96.5%),and other *** analysis of the cL2ES-KDBc system on IoT intrusion datasets is performed,which provides valuable insight into its performance,efficiency,and suitability for securing IoT networks.

关键词： IoT security attack detection covariance linear learning embedding selection kernel distributed bayes classifier mongolian gazellas optimization

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presynaptic endoplasmic reticulum architecture and hereditary spastic paraplegia

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Neural Regeneration Research 2024年第3期19卷 485-486页

作者： Juan Josépérez-Moreno Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen Del Rocío/CSIC/Universidad de Sevillaand Departamento de Biología CelularFacultad de BiologíaUniversidad de SevillaSevilleSpain

Hereditary spastic paraplegia(HSp)is a clinically and genetically heterogeneous neurodegenerative disorder,characterized primarily by progressive spasticity and weakness in the lower *** ients can also experience peripheral neuropathy,cognitive impairment,and other neurological *** date,more than 80 genes have been implicated in HSp,encompassing various cellular components,although mutations in genes encoding endoplasmic reticulum(ER)-shaping proteins are the most prevalent(parodi et al.,2017).ER-shaping proteins are generally known for regulating the tubulation and curvation of the ER,but most of them show additional functions,including fusion of ER tubules,microtubule-severing,ER autophagy,lipid droplet synthesis,contact sites with other organelles(Öztürk et al.,2020).This highlights the complexity of studying the role of these proteins and the link between ER function and HSp.

关键词： reticulum endoplasmic

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Role of marine natural products in the development of antiviral agents against SARS‑coV‑2:potential and prospects

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Marine Life Science & Technology 2024年第2期6卷 280-297页

作者： D.p.Nagahawatta N.M.Liyanage Thilina U.Jayawardena H.H.A.c.K.Jayawardhana Seong‑Hun Jeong Hyung‑Jun Kwon You‑Jin Jeon Department of Marine Life Sciences Jeju National UniversityJeju 690-756Republic of Korea Department of chemistry Biochemistry and PhysicsUniversitédu QuébecàTrois-RivièresTrois-RivièresQC G8Z 4M3Canada Marine Science Institute Jeju National UniversityJeju 63333Republic of Korea functional Biomaterial Research center Korea Research Institute of Bioscience and BiotechnologyJeongeup-siRepublic of Korea

A novel coronavirus,known as severe acute respiratory syndrome coronavirus 2(SARS-coV-2),has surfaced and caused global concern owing to its ***-coV-2 is the causative agent of coronavirus disease 2019;however,it was only discovered at the end of the year and was considered a pandemic by the World Health ***,the develop-ment of novel potent inhibitors against SARS-coV-2 and future outbreaks is urgently *** naturally occurring bioactive substances have been studied in the clinical setting for diverse *** intricate infection and replication mechanism of SARS-coV-2 offers diverse therapeutic drug targets for developing antiviral medicines by employing natural products that are safer than synthetic *** natural products(MNps)have received increased attention in the development of novel drugs owing to their high diversity and ***,this review article investigates the infection and replication mechanisms,including the function of the SARS-coV-2 genome and ***,we highlighted anti-SARS-coV-2 therapeutic intervention efforts utilizing MNps and predicted SARS-coV-2 inhibitor design.

关键词： SARS-coV-2 Marine natural products Drug targets Inhibitors

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Understanding the neighborhoods’in-between spaces on spatial perception,social interaction,and security

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frontiers of Architectural Research 2024年第1期13卷 21-36页

作者： Lizeth félix Mariel Organista Autonomous University of Baja california Ensenada 22860Mexico

This study reflects on the impact that the neighborhoods’in-between spaces have on:spatial perception,social interaction,and *** sites,characterized by their abandonment and deterioration,can also be seen as crucial spaces of opportunity for cities,in the architectural,urban and landscape *** paper aims to analyze the sociospatial relationships in the neighborhoods’in-between spaces and examine the impact of inbetween space configuration on urban *** investigation draws on a survey of perception to residents about the requirements for a suitable social interaction in these *** study was developed in a neighborhood in the city periphery,characterized by their social dynamics and location in a nature conservation *** findings indicate that the appropriation process,activities,and collective practices are dependent on the spatial legibility,in this case when this increases,gives rise to improve the habitability and the rehabilitation of the in-between ***,the lack of design on in-between spaces substantially affects the use of these spaces and the social interaction among residents.

关键词： In-between spaces Socio-spatial relationships Habitability Neighborhoods Security

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哲学的本质

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世界哲学 2024年第3期 132-139页

作者： [英]f.p.拉姆齐刘新文(译) 不详中国社会科学院大学哲学院中国社会科学院哲学研究所

在拉姆齐看来,哲学在本质上是一个定义体系。如果哲学是定义体系,那么哲学会遇到三个问题:如何定义;在没有定义时,对如何给出定义进行满意的描述;如何在哲学研究中避免循环论证。拉姆齐依次回答了这三个问题。

关键词：哲学定义定义体系循环论证

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