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peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

Neural Regeneration Research 2025年第6期20卷 1541-1554页

作者： Jinmei Ye Cong duan Jiaxin Han Jinrong Chen Ning Sun Yuan Li Tifei Yuan Daihui peng Division of Mood Disorder Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of psychiatry First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Shanghai Key Laboratory of psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

关键词： biomarker cytokine exosomes inflammasome major depressive disorder microglia mitochondrial DNA mitochondrial dysfunction neuroinflammation Toll-like receptor

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Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： Yan Li peng Hao Hongmei duan fei Hao Wen Zhao Yudan Gao Zhaoyang Yang Kwok-fai So Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

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Antiviral therapy for hepatitis B virus infection is beneficial for the prognosis hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 1-9页

作者： Hui Wan Yu-Xin Zhang Guan-Yue Shan Jun-Ya Cheng duan-Rui Qiao Yi-Ying Liu Wen-Na Shi Hai-Jun Li Institute of Translational Medicine The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina Department of Bioengineering Pharmacy School of Jilin UniversityChangchun 130061Jilin ProvinceChina Institute of Liver Diseases Institute of Translational MedicineThe First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina

In this editorial,we comment on the article by Mu et al,published in the recent issue of the World Journal of Gastrointestinal *** pay special attention to the immune tolerance mechanism caused by hepatitis B virus(HBV)infection,the pathogenesis of hepatocellular carcinoma(HCC),and the role of antiviral therapy in treating HCC related to HBV *** infection leads to systemic innate immune tolerance by directly inhibiting pattern recognition receptor recognition and antiviral signaling pathways,as well as by inhibiting the immune functions of macrophages,natural killer cells and dendritic *** addition,HBV leads to an immunosuppressive cascade by expressing inhibitory molecules to induce exhaustion of HBV-specific cluster of differentiation 8+T cells,ultimately leading to long-term viral *** loss of immune cell function caused by HBV infection ultimately leads to ***-term antiviral therapy can improve the prognosis of patients with HCC and prevent tumor recurrence and metastasis.

关键词： Hepatitis B virus Hepatocellular carcinoma Hepatitis B virus-DNA Immune tolerance Antiviral therapy

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Evidence for the decays of ∧_c^+→∑^+η and ∑^+η’

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Chinese physics C 2019年第8期43卷 15-23页

作者： M.Ablikim f.f.An Q.An Y.Bai Y.Ban H.Cai X.Cai G.f.Cao J.f.Chang G.Chen H.S.Chen J.C.Chen M.L.Chen p.L.Chen S.J.Chen Y.B.Chen W.Cheng H.LDai J.p.Dai Z.Y.Deng Y.Ding C.Dong J.Dong L.Y.Dong M.Y.Dong Z.L.Dou S.X.Du p.f.duan J.Z.fan J.fang S.S.fang Y.fang C.Q.feng C.D.fu Y.fu Q.Gao X.L.Gao Y.Gao Y.G.Gao Z.Gao L.Gong W.X.Gong L.M.Gu M.H.Gu Y.T.Gu A.Q.Guo L.B.Guo R.p.Guo Y.p.Guo S.Han X.Q.Hao K.L.He Y.K.Heng Z.L.Hou H.M.Hu J.f.Hu T.Hu Y.Hu G.S.Huang J.S.Huang X.T.Huang X.Z.Huang Z.L.Huang Q.Ji Q.p.Ji X.B.Ji X.L.Ji X.S.Jiang X.Y.Jiang J.B.Jiao Z.Jiao D.p.Jin S.Jin Y.Jin X.S.Kang B.C.Ke C.Li Cheng Li D.M.Li f.Li f.Y.Li G.Li H.B.Li H.J.Li J.C.Li J.W.Li Ke Li Lei Li p.L.Li p.R.Li Q.Y.Li T.Li W.D.Li W.G.Li X.L.Li X.N. Li X.Q.Li Z.B.Li H.Liang Y.f.Liang Y.T.Liang G.R.Liao L.Z.Liao C.X.Lin D.X.Lin B.Liu B.J.Liu C.X.Liu D.Liu D.Y.Liu f.H.Liu fang Liu feng Liu H.B.Liu H.L.Liu H.M.Liu Huanhuan Liu Huihui Liu J.B.Liu J.Y.Liu K.Liu K.Y.Liu Ke Liu Q.Liu S.B.Liu X.Liu Y.B.Liu Z.A.Liu Zhiqing Liu Y.f.Long X.C.Lou H.J.Lu J.D.Lu J.G.Lu Y.Lu Y.p.Lu C.L.Luo M.X.Luo T.Luo X.L.Luo X.R.Lyu f.C.Ma H.L.Ma L.L.Ma M.M.Ma Q.M.Ma X.N.Ma X.X.Ma X.Y.Ma Y.M.Ma Y.J.Mao Z.p.Mao Z.X.Meng J.Min T.J.Min X.H.Mo Y.J.Mo Z.Ning S.L.Niu S.L.Olsen Q.Ouyang Y.pan H.p.peng J.L.ping R.G.ping H.R.Qi M.Qi T.Y.Qi S.Qian C.f.Qiao N.Qin Z.H.Qin J.f.Qiu S.Q.Qu G.Rong W.Shan X.Y.Shan M.Shao C.p. Shen p.X.Shen X.Y.Shen H.Y.Sheng X.Shi J.J.Song X.Y.Song G.X.Sun J.f.Sun L.Sun S.S.Sun X.H.Sun Y.J.Sun Y.K.Sun Y.Z.Sun Z.J.Sun Z.T.Sun Y.T.Tan C.J.Tang G.Y.Tang X.Tang B.Wang B.L.Wang C.W.Wang D.Y.Wang Dan Wang K.Wang L.L.Wang L.S.Wang M.Wang Meng Wang p.Wang p.L.Wang W.p.Wang X.f.Wang Y.Wang Y.f.Wang Z.Wang Z.G.Wang Z.Y.Wang Zongyuan Wang D.H.Wei S.p.Wen L.H.Wu L.J.Wu Z.Wu L.Xia Y.Xia D.Xiao Y.J.Xiao Z.J.Xiao Y.G.Xie Y.H.Xie X.A.Xiong Q.L.Xiu G.f.Xu J.J.Xu L.Xu Q.J.Xu Q.N.Xu X.p.Xu f.Yan L.Yan w.B.Yan W.C.Yan Y.H.Yan H.J.Yang H.X.Yang L.Yang S.L.Yang Y.H.Yang Y.X.Yang Yifan Yang Z.Q.Yang M.Ye M.H.Ye J.H.Yin Z.Y.You B.X.Yu C.X.Yu J.S.Yu C.Z.Yuan Y.Yuan Y.Zeng B.X.Zhang B.Y.Zhang Institute of High Energy physics G.I.Budker Institute of Nuclear physics SB RAS(BINp) the Novosibirsk State University Helmholtz Institute Mainz Bochum Ruhr-University University of Turin INfN State Key Laboratory of particle Detection and Electronics University of Science and Technology of China Southeast University Joint Institute for Nuclear Research INfN Laboratori Nazionali di frascati peking University Institute of physics and Technology Indiana University Bloomington Carnegie Mellon University Johannes Gutenberg University of Mainz INfN Sezione di ferrara Wuhan University Ankara University University of Chinese Academy of Sciences Istanbul Bilgi University the Moscow Institute of physics and Technology the functional Electronics Laboratory Tomsk State University University of South China Nanjing University Shanghai Jiao Tong University Key Laboratory for particle physics Astrophysics and CosmologyMinistry of EducationShanghai Key Laboratory for Particle Physics and CosmologyInstitute of Nuclear and Particle Physics Liaoning University Nankai University Zhengzhou University Tsinghua University University of ferrara University of Eastern piedmont Central China Normal University University of Minnesota Minneapolis GSI Helmholtzcentre for Heavy Ion Research GmbH Guangxi University Nanjing Normal University KVI-CART University of Groningen Henan Normal University University of Hawaii Honolulu Shandong University University of the punjab University of Muenster Uppsala University Huangshan College University of Jinan Justus-Liebig-Universitaet Giessen II.Physikalisches Institut Istanbul Arel University Soochow University Beijing Institute of petrochemical Technology China Center of Advanced Science and Technology Sun Yat-Sen University Sichuan University Guangxi Normal University Indian Institute of Technology Madras Shanxi University Henan University of Science and Technology Lanzhou University Zhejiang University fudan University Key Laboratory of Nuclear physics and Ion-beam Application(MOE)and Institute of

We study the hadronic decays of ∧c+ to the final states ∑+η and ∑+η’,using an e+e-annihilation data sample of 567 pb-1 taken at a center-of-mass energy of 4.6 GeV with the BESIII detector at the BEpCⅡ *** find evidence for the decays ∧c+→∑+η and ∑+η’ with statistical significance of 2.5σ and 3.2σ,*** to the reference decays ∧c+→∑+π0 and ∑+ω,we obtain the ratios of the branching fractions■and ■to be 0.35±0.16±0.02 and 0.86±0.34±0.04,*** upper limits at the 90% confidence level are set to be■and■.Using BESIII measurements of the branching fractions of the reference decays,we determine B（∧c+→∑+η）=（0.41±0.19±0.05）%（first uncertainties are statistical and the second *** obtained branching fraction of ∧c+→∑+η is consistent with the previous measurement,and the branching fraction of ∧c+→∑+η’ is measured for the first time.

关键词： charmed baryon ∧c^+ decays branching fractions

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星形AB共聚物和A均聚物的共组装模拟研究

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原子与分子物理学报 2025年第5期42卷 90-94页

作者：段润宇新疆大学物理科学与技术学院乌鲁木齐830017

具有独特结构的纳米粒子在高分子材料领域具有广泛的应用.本文采用耗散粒子动力学模型系统的研究了三臂星形AB二嵌段共聚物和A均聚物共混体系的共组装相行为.通过调节聚集体中星形共聚物浓度和AB嵌段的长度比有效地控制了AB/A共混体系... 详细信息

具有独特结构的纳米粒子在高分子材料领域具有广泛的应用.本文采用耗散粒子动力学模型系统的研究了三臂星形AB二嵌段共聚物和A均聚物共混体系的共组装相行为.通过调节聚集体中星形共聚物浓度和AB嵌段的长度比有效地控制了AB/A共混体系中聚集体的共组装形貌.预测了一些有趣的结构,比如,具有较厚壳层的核-壳-补丁结构、具有壳层的且中心凹陷的圆盘状结构以及不规则椭球的多室结构.本文还发现对于具有较长A嵌段的星形链,增大A均聚物在聚集体中的浓度能够消除聚集体内B嵌段形成的核;对于具有较短A嵌段的星形链,少量的A均聚物能够诱导聚集体共组装成具有长条状核的多室纳米粒子.

关键词：耗散粒子动力学星形二嵌段共聚物共组装纳米粒子

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ViTAU:基于Vision transformer和面部动作单元的面瘫识别与分析

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工程科学学报 2025年第2期47卷 351-363页

作者：高嘉蔡文浩赵俊莉段福庆青岛大学计算机科学技术学院北京师范大学人工智能学院

面部神经麻痹（facial nerve paralysis,fNp），通常称为贝尔氏麻痹或面瘫，对患者的日常生活和心理健康产生显著影响，面瘫的及时识别和诊断对于患者的早期治疗和康复至关重要.随着深度学习和计算机视觉技术的快速发展，面瘫的自动识... 详细信息

面部神经麻痹（facial nerve paralysis,fNp），通常称为贝尔氏麻痹或面瘫，对患者的日常生活和心理健康产生显著影响，面瘫的及时识别和诊断对于患者的早期治疗和康复至关重要.随着深度学习和计算机视觉技术的快速发展，面瘫的自动识别变得可行，为诊断提供了一种更准确和客观的方式.目前的研究主要集中关注面部的整体变化，而忽略了面部细节的重要性.面部不同部位对识别结果的影响力并不相同，这些研究尚未对面部各个区域进行细致区分和分析.本项研究引入结合Vision transformer(ViT)模型和动作单元（Action unit,AU）区域检测网络的创新性方法用于面瘫的自动识别及区域分析.ViT模型通过自注意力机制精准识别是否面瘫，同时，基于AU的策略从StyleGAN2模型提取的特征图中，利用金字塔卷积神经网络分析受影响区域.这一综合方法在YouTube facial palsy(Yfp)和经过扩展的Cohn Kanade(CK+)数据集上的实验中分别达到99.4%的面瘫识别准确率和81.36%的面瘫区域识别准确率.通过与最新方法的对比，实验结果展示了所提的自动面瘫识别方法的有效性.

关键词： Transformer 面部动作单元多分辨率特征图生成器热力图回归

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Impact of discretization methods on the rough set-based classification of remotely sensed images

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International Journal of Digital Earth 2011年第4期4卷 330-346页

作者： Y.Ge f.Cao R.f.duan State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences&Natural Resources ResearchChinese Academy of SciencesBeijing 100101P.R.China

In recent years,the rough set(RS)method has been in common use for remotesensing classification,which provides one of the techniques of information extraction for Digital *** discretization of remotely sensed data is an important data preprocessing approach in classical RS-based remote-sensing *** discretization methods can improve the adaptability of the classification rules and increase the accuracy of the remote-sensing *** assess the performance of discretization methods this article adopts three indicators,which are the compression capability indicator(CCI),consistency indicator(CI),and number of the cut points(NCp).An appropriate discretization method for the RS-based classification of a given remotely sensed image can be found by comparing the values of the three indicators and the classification accuracies of the discretized remotely sensed images obtained with the different discretization *** investigate the effectiveness of our method,this article applies three discretization methods of the Entropy/MDL,Naive,and SemiNaive to a TM image and three indicators for these discretization methods are then *** comparing the three indicators and the classification accuracies of the discretized remotely sensed images,it has been found that the SemiNaive method significantly reduces large quantities of data and also keeps satisfactory classification accuracy.

关键词： remote sensing classification rough set discretization image processing data mining

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Large Spaceborne Deployable Antennas(LSDAs)——A Comprehensive Summary

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Chinese Journal of Electronics 2020年第1期29卷 1-15页

作者： duan Baoyan Research Institute on Mechatronics Xidian University

This paper provides a survey of research activities of Large spaceborne deployable antennas(LSDAs) in the past, present and future. firstly,three main kinds of spaceborne antennas, such as solid reflector, inflatable reflector and mesh reflector, are issued by showing the strengths and weaknesses. Secondly,a detailed research situation of LSDAs with mesh is discussed, for majority of the in-orbit large diameter and high frequency antennas are made in this type of structures. Thirdly, new conception of antenna is proposed as it does have both advantages of large aperture(high gain) and high precision(high frequency). fourthly, the design theory and approach of LSDAs are *** includes thermal-electromechanical multidisciplinary optimization, shaped beam design technique, performance testing technology and evaluation method, passive intermodulation of mesh, and application of new ***, the ultra large spaceborne deployable antennas of the next generation are presented, such as the deployable frame and inflatable reflector antennas, space-assembled ultra large antennas, smart array antennas and so on.

关键词： Large spaceborne deployable antenna Solid surface reflector antenna Inflatable antenna Mesh reflector antenna Electrostatic membrane-control antenna Thermal electromechanical coupling model Design theory and method Next generation of ultra large aperture antennas

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Nanomaterials for lubricating oil application:A review

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friction 2023年第5期11卷 647-684页

作者： Linlin duan Jian LI Haitao duan State Key Laboratory of Special Surface protection Materials and Application Technology Wuhan Research Institute of Materials ProtectionWuhan 430030China

friction and wear are ubiquitous,from nano-electro-mechanical systems in biomedicine to large-scale integrated electric propulsion in aircraft *** of nanomaterials as lubricating oil additives have achieved great advances,which are of great significance to control friction and *** review focuses on the applications of nanomaterials in lubricating oil and comprehensively compares their tribological characteristics as lubricating oil *** analysis of tribology data is provided and discussed accordingly;moreover,the interaction between nanomaterials and sliding surface,lubricating oil,other additives,and synergistic lubrication in nanocomposites are systematically ***,suggestions for future research on nanomaterials as lubricating oil additives are ***,this review will promote a better fundamental understanding of nanomaterials for lubricating oil application and help to achieve the superior design of nanoadditives with outstanding tribological performances.

关键词： nanomaterial additive friction modifier lubrication wear

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Existence and Global Exponential Stability of pseudo Almost periodic Solutions of a General Delayed BAM Neural Networks

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Journal of Systems Science & Complexity 2018年第3期31卷 608-620页

作者： duan Lian School of Mathematics and Big Data Anhui University of Science and Technology

This paper studies a class of general BAM neural networks with multiple delays. Em- ploying the exponential dichotomy theory and fixed point method, together with constructing suitable Lyapunov functionals, easily verifiable delay-independent criteria are established to ensure the exis- tence and global exponential stability of pseudo almost periodic solutions, which not only generalize but also complement some existing ones. These theoretical results are also supported with numerical simulations.

关键词： General BAM neural network global exponential stability pseudo almost periodic solu-tion

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